Redox-Modulating Agents in the Treatment of Viral Infections

In Vitro Anti-HSV-1 Activity of Polyphenol-Rich Extracts and Pure Polyphenol Compounds Derived from Pistachios Kernels (Pistacia vera L.)

(2020) Maria Musarra-Pizzo et al.   Plants-Basel

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

The interplay between vitamin D and viral infections

(2019) Majid Teymoori-Rad et al.   REVIEWS IN MEDICAL VIROLOGY

Counteraction of HCV-Induced Oxidative Stress Concurs to Establish Chronic Infection in Liver Cell Cultures

(2019) Simona Anticoli et al.   Oxidative Medicine and Cellular Longevity

Drug repurposing of N-acetyl cysteine as antiviral against dengue virus infection

(2019) Gopinathan Pillai Sreekanth et al.   ANTIVIRAL RESEARCH

Is curcumin bioavailability a problem in humans: lessons from clinical trials

(2019) Ajaikumar B. Kunnumakkara et al.   Expert Opinion on Drug Metabolism & Toxicology

Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of N-acetyl-cysteine and β-mercaptoethylamine

(2019) Rita Crinelli et al.   Nutrients

Overview of Current Therapeutics and Novel Candidates Against Influenza, Respiratory Syncytial Virus, and Middle East Respiratory Syndrome Coronavirus Infections

(2019) Mohammad Amin Behzadi et al.   Frontiers in Microbiology

Corrigendum: GSH-C4 Acts as Anti-inflammatory Drug in Different Models of Canonical and Cell Autonomous Inflammation Through NFκB Inhibition

(2019) Dolores Limongi et al.   Frontiers in Immunology

Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies

(2019) Carolina Jasso-Miranda et al.   Infection and Drug Resistance

The Role of Micronutrients in the Infection and Subsequent Response to Hepatitis C Virus

(2019) Sunil Gupta et al.   Cells

Influence of curcumin supplementation on metabolic and lipid parameters of people living with HIV/AIDS: a randomized controlled trial

(2019) Tatiane Andreza Lima Silva et al.   BMC Complementary and Alternative Medicine

Repression of Nrf2/ARE regulated antioxidant genes and dysregulation of the cellular redox environment by the HIV Transactivator of Transcription

(2019) Ari Simenauer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

(2019) Pallab Shaw et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of SARS-CoV 3CL protease by flavonoids

(2019) Seri Jo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Role of Glutathionylation in Infection and Inflammation

(2019) Paola Checconi et al.   Nutrients

Selenium, Selenoproteins and Viral Infection

(2019) Olivia M. Guillin et al.   Nutrients

Synthesis of Stilbene and Chalcone Inhibitors of Influenza A Virus by SBA-15 Supported Hoveyda-Grubbs Metathesis

(2019) Bruno Mattia Bizzarri et al.   Catalysts

Antiviral activity of plants and their isolated bioactive compounds: An update

(2019) Marcella Denaro et al.   PHYTOTHERAPY RESEARCH

Quercetin pentaacetate inhibits in vitro human respiratory syncytial virus adhesion

(2019) Bruno Rafael Pereira Lopes et al.   VIRUS RESEARCH

Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways

(2018) Jianping Dai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways

(2018) Yinghua Li et al.   International Journal of Nanomedicine

Preventive Effects of Vitamin D on Seasonal Influenza A in Infants

(2018) Jian Zhou et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis

(2018) Ming-Dar Lee et al.   Nutrients

Effect of Tea Catechins on Influenza Infection and the Common Cold with a Focus on Epidemiological/Clinical Studies

(2018) Daisuke Furushima et al.   MOLECULES

A Polyphenol Rich Extract from Solanum melongena L. DR2 Peel Exhibits Antioxidant Properties and Anti-Herpes Simplex Virus Type 1 Activity In Vitro

(2018) Antonella Di Sotto et al.   MOLECULES

Antiviral and Antioxidant Activity of a Hydroalcoholic Extract from Humulus lupulus L.

(2018) Antonella Di Sotto et al.   Oxidative Medicine and Cellular Longevity

Antiviral Activity of Fermented Ginseng Extracts against a Broad Range of Influenza Viruses

(2018) Ye Wang et al.   Viruses-Basel

Redox Biology of Respiratory Viral Infections

(2018) Olga Khomich et al.   Viruses-Basel

Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview

(2018) Giuseppe Annunziata et al.   Viruses-Basel

Selenium, Selenoproteins, and Immunity

(2018) Joseph Avery et al.   Nutrients

The Cranberry Extract Oximacro® Exerts in vitro Virucidal Activity Against Influenza Virus by Interfering With Hemagglutinin

(2018) Anna Luganini et al.   Frontiers in Microbiology

Differential Redox State Contributes to Sex Disparities in the Response to Influenza Virus Infection in Male and Female Mice

(2018) Ignacio Celestino et al.   Frontiers in Immunology

Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture

(2018) Pritom Chowdhury et al.   PLoS One

The Role of Vitamin E in Immunity

(2018) Ga Lee et al.   Nutrients

Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials

(2018) Jessie Hawkins et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent

(2018) Asadollah Mohammadi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

HCV-induced oxidative stress by inhibition of Nrf2 triggers autophagy and favors release of viral particles

(2017) Regina Medvedev et al.   FREE RADICAL BIOLOGY AND MEDICINE

Almond Skin Extracts Abrogate HSV-1 Replication by Blocking Virus Binding to the Cell

(2017) Carlo Bisignano et al.   Viruses-Basel

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

(2017) Eunice E. To et al.   Nature Communications

Antiviral Properties of the Natural Polyphenols Delphinidin and Epigallocatechin Gallate against the Flaviviruses West Nile Virus, Zika Virus, and Dengue Virus

(2017) Ángela Vázquez-Calvo et al.   Frontiers in Microbiology

Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties

(2017) Marina Diotallevi et al.   Frontiers in Immunology

Redox regulation of proteasome function

(2017) Maria Lefaki et al.   Redox Biology

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of herpes simplex type 1 and type 2 infections by Oximacro®, a cranberry extract with a high content of A-type proanthocyanidins (PACs-A)

(2016) Maria Elena Terlizzi et al.   ANTIVIRAL RESEARCH

Glutathione – From antioxidant to post-translational modifier

(2016) Henry Jay Forman   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection

(2016) Hyemin Kim et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Glutathione Depletion Is Linked with Th2 Polarization in Mice with a Retrovirus-Induced Immunodeficiency Syndrome, Murine AIDS: Role of Proglutathione Molecules as Immunotherapeutics

(2016) Serena Brundu et al.   JOURNAL OF VIROLOGY

Oxidative Stress during HIV Infection: Mechanisms and Consequences

(2016) Alexander V. Ivanov et al.   Oxidative Medicine and Cellular Longevity

HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis

(2016) Regina Medvedev et al.   Oxidative Medicine and Cellular Longevity

HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells

(2016) Roberta Mastrantonio et al.   PLoS One

Antiviral Effects of Black Raspberry (Rubus coreanus) Seed and Its Gallic Acid against Influenza Virus Infection

(2016) Ji-Hye Lee et al.   Viruses-Basel

Quercetin, Inflammation and Immunity

(2016) Yao Li et al.   Nutrients

The Angiotensin-Converting Enzyme 2/Angiotensin (1–7)/Mas Axis Protects Against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-Derived ROS-Mediated RhoA/Rho Kinase Pathway

(2015) Ying Meng et al.   ANTIOXIDANTS & REDOX SIGNALING

Upregulation of endoplasmic reticulum stress and reactive oxygen species by naturally occurring mutations in hepatitis B virus core antigen

(2015) HyunJoo Lee et al.   JOURNAL OF GENERAL VIROLOGY

Highly Pathogenic H5N1 and Novel H7N9 Influenza A Viruses Induce More Profound Proteomic Host Responses than Seasonal and Pandemic H1N1 Strains

(2015) Philippe François Simon et al.   JOURNAL OF PROTEOME RESEARCH

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action

(2015) Noémie Calland et al.   JOURNAL OF VIROLOGY

Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents

(2015) Valentina Gandin et al.   MOLECULES

A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C

(2015) Nu T. Lu et al.   PHYTOTHERAPY RESEARCH

Redox Proteomics of the Inflammatory Secretome Identifies a Common Set of Redoxins and Other Glutathionylated Proteins Released in Inflammation, Influenza Virus Infection and Oxidative Stress

(2015) Paola Checconi et al.   PLoS One

Induction of endoplasmic reticulum-derived oxidative stress by an occult infection related S surface antigen variant

(2015) In-Kyung Lee et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Occult infection related hepatitis B surface antigen variants showing lowered secretion capacity

(2015) Hong Kim   WORLD JOURNAL OF GASTROENTEROLOGY

HCV Core Protein Uses Multiple Mechanisms to Induce Oxidative Stress in Human Hepatoma Huh7 Cells

(2015) Alexander Ivanov et al.   Viruses-Basel

Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections

(2015) Holger Steinbrenner et al.   Advances in Nutrition

The immunoproteasome and viral infection: a complex regulator of inflammation

(2015) Mary K. McCarthy et al.   Frontiers in Microbiology

The Anti-Inflammatory Activity of Curcumin Protects the Genital Mucosal Epithelial Barrier from Disruption and Blocks Replication of HIV-1 and HSV-2

(2015) Victor H. Ferreira et al.   PLoS One

Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS

(2014) Donatella Amatore et al.   CELLULAR MICROBIOLOGY

Pharmacological Applications of Antioxidants: Lights and Shadows

(2014) Luciano Saso et al.   CURRENT DRUG TARGETS

Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?

(2014) Rossella Sgarbanti et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages

(2014) E. E. To et al.   FREE RADICAL RESEARCH

N-acetyl-l-cystine (NAC) protects against H9N2 swine influenza virus-induced acute lung injury

(2014) Rui-Hua Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dual Role of NOX2 in Respiratory Syncytial Virus- and Sendai Virus-Induced Activation of NF- B in Airway Epithelial Cells

(2014) K. Fink et al.   JOURNAL OF IMMUNOLOGY

Resveratrol Inhibits the TRIF-Dependent Pathway by Upregulating Sterile Alpha and Armadillo Motif Protein, Contributing to Anti-Inflammatory Effects after Respiratory Syncytial Virus Infection

(2014) T. Liu et al.   JOURNAL OF VIROLOGY

Effect of the N-butanoyl glutathione (GSH) derivative and acyclovir on HSV-1 replication and Th1 cytokine expression in human macrophages

(2014) Alessandra Fraternale et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells

(2014) David Olagnier et al.   PLoS Pathogens

Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers

(2013) Bharat B Aggarwal et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure-activity relationship analysis of curcumin analogues on anti-influenza virus activity

(2013) Jun-Lin Ou et al.   FEBS Journal

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study

(2013) Meri P Nantz et al.   Nutrition Journal

Inhibitory Effect of Glutathione on Oxidative Liver Injury Induced by Dengue Virus Serotype 2 Infections in Mice

(2013) Juan Wang et al.   PLoS One

HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1

(2013) A Shah et al.   Cell Death & Disease

Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection

(2013) Yejin Kim et al.   Immune Network

Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt’s lymphoma cells by affecting multiple molecular targets

(2012) Alessandra De Leo et al.   ANTIVIRAL RESEARCH

Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action

(2012) Rossella Fioravanti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

EGCG inhibits Tat-induced LTR transactivation: Role of Nrf2, AKT, AMPK signaling pathway

(2012) Hong-Sheng Zhang et al.   LIFE SCIENCES

Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus

(2012) Beata Kosmider et al.   RESPIRATORY RESEARCH

Redox Regulation of the Influenza Hemagglutinin Maturation Process: A New Cell-Mediated Strategy for Anti-Influenza Therapy

(2011) Rossella Sgarbanti et al.   ANTIOXIDANTS & REDOX SIGNALING

N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)

(2011) Manuel Mata et al.   BIOCHEMICAL PHARMACOLOGY

Effects of Flavonoids and other Polyphenols on Inflammation

(2011) R. González et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Intracellular Redox Signaling as Therapeutic Target for Novel Antiviral Strategy

(2011) Lucia Nencioni et al.   CURRENT PHARMACEUTICAL DESIGN

Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells

(2011) Matthew J. Kesic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatitis C Virus Impairs the Induction of Cytoprotective Nrf2 Target Genes by Delocalization of Small Maf Proteins

(2011) Monica Carvajal-Yepes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

(2011) Noboru Uchide et al.   MOLECULES

Hepatitis C Virus Proteins Activate NRF2/ARE Pathway by Distinct ROS-Dependent and Independent Mechanisms in HUH7 Cells

(2011) Alexander V. Ivanov et al.   PLoS One

Modulation of Th1/Th2 immune responses to HIV-1 Tat by new pro-GSH molecules

(2011) Alessandra Fraternale et al.   VACCINE

Antiviral activity of four types of bioflavonoid against dengue virus type-2

(2011) Keivan Zandi et al.   Virology Journal

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

(2011) Ross Vlahos et al.   PLoS Pathogens

Protection from H1N1 Influenza Virus Infections in Mice by Supplementation with Selenium: A Comparison with Selenium-Deficient Mice

(2010) Lei Yu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Glutathione-Redox Balance Regulates c-rel-Driven IL-12 Production in Macrophages: Possible Implications in Antituberculosis Immunotherapy

(2010) K. Alam et al.   JOURNAL OF IMMUNOLOGY

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice

(2010) Alessandra Fraternale et al.   VACCINE

Respiratory Syncytial Virus Induces Oxidative Stress by Modulating Antioxidant Enzymes

(2009) Yashoda M. Hosakote et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Curcumin inhibits influenza virus infection and haemagglutination activity

(2009) Da-Yuan Chen et al.   FOOD CHEMISTRY

Dendritic cells treated with resveratrol during differentiation from monocytes gain substantial tolerogenic properties upon activation

(2009) Urban Švajger et al.   IMMUNOLOGY

Bcl-2 Expression and p38MAPK Activity in Cells Infected with Influenza A Virus

(2009) Lucia Nencioni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Effect of CYSTUS052®and green tea on subjective symptoms in patients with infection of the upper respiratory tract

(2009) Ulrich Kalus et al.   PHYTOTHERAPY RESEARCH

Oxidative stress induced changes in plasma protein can be a predictor of imminent severe dengue infection

(2008) R. Soundravally et al.   ACTA TROPICA

A Novel and Efficient Synthesis of Tocopheryl Quinones by Homogeneous and Heterogeneous Methyltrioxorhenium/Hydrogen Peroxide Catalytic Systems

(2008) Raffaele Saladino et al.   ADVANCED SYNTHESIS & CATALYSIS

Anti-herpes simplex virus (HSV-1) activity of oxyresveratrol derived from Thai medicinal plant: Mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice

(2008) Taksina Chuanasa et al.   ANTIVIRAL RESEARCH

Advances and Challenges in the Synthesis of Highly Oxidised Natural Phenols with Antiviral, Antioxidant and Cytotoxic Activities

(2008) Raffaele Saladino et al.   CURRENT MEDICINAL CHEMISTRY

Glucose-6-phosphate dehydrogenase deficiency enhances enterovirus 71 infection

(2008) H.-Y. Ho et al.   JOURNAL OF GENERAL VIROLOGY

Glucose‐6‐Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection

(2008) Yi‐Hsuan Wu et al.   JOURNAL OF INFECTIOUS DISEASES

(+)-Vitisin A Inhibits Influenza A Virus-Induced RANTES Production in A549 Alveolar Epithelial Cells through Interference with Akt and STAT1 Phosphorylation

(2008) Yu-Ling Huang et al.   PLANTA MEDICA

Inhibition of murine AIDS by pro-glutathione (GSH) molecules

(2007) A. Fraternale et al.   ANTIVIRAL RESEARCH