Macrophages and Extracellular Matrix in Breast Cancer: Partners in Crime or Protective Allies?

Matrix-Targeting Immunotherapy Controls Tumor Growth and Spread by Switching Macrophage Phenotype

(2020) Claire Deligne et al.   Cancer Immunology Research

Shaping Up the Tumor Microenvironment With Cellular Fibronectin

(2020) Georgios Efthymiou et al.   Frontiers in Oncology

Biomechanical Contributions to Macrophage Activation in the Tumor Microenvironment

(2020) Erica J. Hoffmann et al.   Frontiers in Oncology

The roles of tumor-associated macrophages in tumor angiogenesis and metastasis

(2020) Luo-Qin Fu et al.   CELLULAR IMMUNOLOGY

Alternative splicing controls cell lineage-specific responses to endogenous innate immune triggers within the extracellular matrix

(2020) Sean P Giblin et al.   MATRIX BIOLOGY

Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination

(2020) Angelica Avagliano et al.   Cancers

Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells

(2020) Genevra Kuziel et al.   Cancers

Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment

(2019) Luke Bu et al.   ONCOGENE

Extracellular matrix protein tenascin C increases phagocytosis mediated by CD47 loss of function in glioblastoma

(2019) Shuli Xia et al.   CANCER RESEARCH

Hyaluronan preconditioning of monocytes/macrophages affects their angiogenic behavior and regulation of TSG ‐6 expression in a tumor type‐specific manner

(2019) Fiorella M. Spinelli et al.   FEBS Journal

Immune-checkpoint inhibition for metastatic triple-negative breast cancer: safety first?

(2019) Nina D’Abreo et al.   Nature Reviews Clinical Oncology

CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

(2019) Andrea Walens et al.   eLife

Tenascin-C increases lung metastasis by impacting blood vessel invasions

(2019) Zhen Sun et al.   MATRIX BIOLOGY

Extracellular Matrix Alterations in Metastatic Processes

(2019) Paolillo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis

(2019) Martha Gschwandtner et al.   Frontiers in Immunology

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

(2018) Elham Azizi et al.   CELL

The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?

(2018) Teizo Yoshimura   Cellular & Molecular Immunology

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer

(2018) Huimin Lu et al.   MATRIX BIOLOGY

Tumor-associated macrophages in breast cancer: Innocent bystander or important player?

(2018) Si-Qi Qiu et al.   CANCER TREATMENT REVIEWS

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

(2018) Tamara Muliaditan et al.   Nature Communications

Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor

(2018) Salida Mirzoeva et al.   NEOPLASIA

Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?

(2018) Susan R Aungier et al.   ANNALS OF THE RHEUMATIC DISEASES

Tenascin-C accelerates adverse ventricular remodelling after myocardial infarction by modulating macrophage polarization

(2018) Taizo Kimura et al.   CARDIOVASCULAR RESEARCH

Role of Extracellular Matrix in Development and Cancer Progression

(2018) Cameron Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeted delivery of calreticulin to ED-A fibronectin leads to tumor-growth retardation

(2018) Barbara Ziffels et al.   JOURNAL OF BIOTECHNOLOGY

Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

(2018) Jun Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent advances in understanding the roles of matrix metalloproteinases in tumour invasion and metastasis

(2018) Guy A Conlon et al.   JOURNAL OF PATHOLOGY

ATF3 promotes migration and M1/M2 polarization of macrophages by activating tenascin-C via Wnt/β-catenin pathway

(2017) Hao Sha et al.   Molecular Medicine Reports

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

The immune contexture in cancer prognosis and treatment

(2017) Wolf H. Fridman et al.   Nature Reviews Clinical Oncology

Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment

(2017) Frank Szulzewsky et al.   NEURO-ONCOLOGY

CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis

(2017) X W Chen et al.   ONCOGENE

Macrophage phenotype in response to ECM bioscaffolds

(2017) Luai Huleihel et al.   SEMINARS IN IMMUNOLOGY

Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature

(2017) Xixi Zhao et al.   Oncotarget

Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model

(2017) Janina Kuen et al.   PLoS One

The extracellular matrix in breast cancer

(2016) Jacob Insua-Rodríguez et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor macrophages are pivotal constructors of tumor collagenous matrix

(2016) Ran Afik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The extracellular matrix: Tools and insights for the “omics” era

(2016) Alexandra Naba et al.   MATRIX BIOLOGY

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion

(2016) Anna Mazur et al.   PLoS One

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages

(2016) Anna M. Piccinini et al.   Science Signaling

Fibronectin induces macrophage migration through a SFK-FAK/CSF-1R pathway

(2016) Graziana Digiacomo et al.   Cell Adhesion & Migration

The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization

(2016) Florian Finkernagel et al.   Oncotarget

Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell Activity

(2016) Sabina Sangaletti et al.   Cell Reports

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages

(2016) Anna M. Piccinini et al.   Science Signaling

Osteopontin-Expressing Macrophages in Non-Small Cell Lung Cancer Predict Survival

(2015) Yue Li et al.   ANNALS OF THORACIC SURGERY

Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4Significance

(2015) Prakash Doddapattar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay

(2015) L. A. Ridnour et al.   CANCER RESEARCH

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

(2015) Satu Tiainen et al.   HISTOPATHOLOGY

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

The sweet spot: how GAGs help chemokines guide migrating cells

(2015) Yoan Monneau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical management of breast cancer heterogeneity

(2015) Dimitrios Zardavas et al.   Nature Reviews Clinical Oncology

Tumor-extracellular matrix interactions: Identification of tools associated with breast cancer progression

(2015) Marta Giussani et al.   SEMINARS IN CANCER BIOLOGY

Therapeutic targeting of the thrombospondin-1 receptor CD47 to treat liver cancer

(2015) David D. Roberts et al.   Journal of Cell Communication and Signaling

Osteopontin Shapes Immunosuppression in the Metastatic Niche

(2014) Sabina Sangaletti et al.   CANCER RESEARCH

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

The potential to target CCL5/CCR5 in breast cancer

(2014) Marco Velasco-Velázquez et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

The Endothelin-Integrin Axis Is Involved in Macrophage-induced Breast Cancer Cell Chemotactic Interactions with Endothelial Cells

(2014) Chia-Chi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Production of Type VI Collagen by Human Macrophages: A New Dimension in Macrophage Functional Heterogeneity

(2014) M. Schnoor et al.   JOURNAL OF IMMUNOLOGY

Two Faces of TGF-Beta1 in Breast Cancer

(2014) Joanna Magdalena Zarzynska   MEDIATORS OF INFLAMMATION

Extracellular matrix components in breast cancer progression and metastasis

(2013) Thordur Oskarsson   BREAST

Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway

(2013) Yanzhang Li et al.   Cellular & Molecular Immunology

Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer

(2013) Young Kyung Bae et al.   HUMAN PATHOLOGY

Tumor-associated macrophages and stromal TNF-α regulate collagen structure in a breast tumor model as visualized by second harmonic generation

(2013) Ryan M. Burke et al.   JOURNAL OF BIOMEDICAL OPTICS

Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression

(2013) G Comito et al.   ONCOGENE

Collagen as a double-edged sword in tumor progression

(2013) Min Fang et al.   TUMOR BIOLOGY

A Fusion Protein between Streptavidin and the Endogenous TLR4 Ligand EDA Targets Biotinylated Antigens to Dendritic Cells and Induces T Cell ResponsesIn Vivo

(2013) Laura Arribillaga et al.   Biomed Research International

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition

(2012) D. Gao et al.   CANCER RESEARCH

Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer

(2012) G. Rao et al.   CLINICAL CANCER RESEARCH

RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration

(2012) Neveen Said et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

The immune score as a new possible approach for the classification of cancer

(2012) Jérôme Galon et al.   Journal of Translational Medicine

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin

(2011) Cristina Mansilla et al.   INTERNATIONAL JOURNAL OF CANCER

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

The tumour-targeting human L19-IL2 immunocytokine: Preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma

(2010) Manfred Johannsen et al.   EUROPEAN JOURNAL OF CANCER

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease

(2009) A. Kukreja et al.   BLOOD

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Macrophage-Derived SPARC Bridges Tumor Cell-Extracellular Matrix Interactions toward Metastasis

(2008) Sabina Sangaletti et al.   CANCER RESEARCH

Macrophages define the invasive microenvironment in breast cancer

(2008) Jeffrey W. Pollard   JOURNAL OF LEUKOCYTE BIOLOGY