CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis

Characteristics and Significance of the Pre-metastatic Niche

(2016) Yang Liu et al.   CANCER CELL

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts

(2016) Qingzhu Sun et al.   CELLULAR SIGNALLING

Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche

(2015) Amber Jin Giles et al.   CANCER RESEARCH

The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung

(2015) Ching-Fang Wu et al.   INTERNATIONAL JOURNAL OF CANCER

Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-β (TGF-β) Activation and Fibroblast Differentiation

(2015) Cynthia Dayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulmonary Alveolar Macrophages Contribute to the Premetastatic Niche by Suppressing Antitumor T Cell Responses in the Lungs

(2015) Sharad K. Sharma et al.   JOURNAL OF IMMUNOLOGY

M1 to M2 macrophage polarization in heparin-binding epidermal growth factor-like growth factor therapy for necrotizing enterocolitis

(2015) Jia Wei et al.   JOURNAL OF SURGICAL RESEARCH

Clinical and Translational Assessment of VEGFR1 as a Mediator of the Premetastatic Niche in High-Risk Localized Prostate Cancer

(2015) S. K. Pal et al.   MOLECULAR CANCER THERAPEUTICS

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF

(2015) Yanke Chen et al.   Oncotarget

Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs

(2014) Xuemei Jia et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumor-associated macrophages promote the metastatic potential of thyroid papillary cancer by releasing CXCL8

(2014) Weiyuan Fang et al.   CARCINOGENESIS

HET0016, a Selective Inhibitor of 20-HETE Synthesis, Decreases Pro-Angiogenic Factors and Inhibits Growth of Triple Negative Breast Cancer in Mice

(2014) Thaiz Ferraz Borin et al.   PLoS One

Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion

(2014) Hao Zheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6

(2014) Haixia Zhao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The pre-metastatic niche: finding common ground

(2013) Jaclyn Sceneay et al.   CANCER AND METASTASIS REVIEWS

CYP4 Enzymes As Potential Drug Targets: Focus on Enzyme Multiplicity, Inducers and Inhibitors, and Therapeutic Modulation of 20- Hydroxyeicosatetraenoic Acid (20-HETE) Synthase and Fatty Acid ω- Hydroxylase Activities

(2013) Katheryne Edson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice

(2012) A. M. Gil-Bernabe et al.   BLOOD

S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites

(2012) Jiehui Deng et al.   CANCER CELL

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer

(2010) Wei Yu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects

(2010) W. Zhang et al.   CLINICAL CANCER RESEARCH

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

(2010) M. Kowanetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA