The sweet spot: how GAGs help chemokines guide migrating cells

C5-Epimerase and 2-O-Sulfotransferase Associate in Vitro to Generate Contiguous Epimerized and 2-O-Sulfated Heparan Sulfate Domains

(2015) Aurélie Préchoux et al.   ACS Chemical Biology

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

(2015) P. R. B. Joseph et al.   BIOCHEMICAL JOURNAL

Synthesis of a chondroitin sulfate disaccharide library and a GAG-binding protein interaction analysis

(2015) Masahiro Wakao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stereocontrolled preparation of biotinylated chondroitin sulfate E di-, tetra-, and hexasaccharide conjugates

(2015) Jean-Claude Jacquinet et al.   CARBOHYDRATE RESEARCH

Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology

(2015) Gordon C. Jayson et al.   CHEMICAL COMMUNICATIONS

Chemokine-guided cell positioning in the lymph node orchestrates the generation of adaptive immune responses

(2015) Jeffrey Lian et al.   CURRENT OPINION IN CELL BIOLOGY

Current structural biology of the heparin interactome

(2015) Vitor H Pomin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular interactions between chondroitin–dermatan sulfate and growth factors/receptors/matrix proteins

(2015) Shuji Mizumoto et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra

(2015) John Gallagher   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Cysteine Cathepsins Activate ELR Chemokines and Inactivate Non-ELR Chemokines

(2015) Urska Repnik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74–103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice

(2015) Vincent Vanheule et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interaction of Heparin Tetrasaccharides with Chemokine CCL5 Is Modulated by Sulfation Pattern and pH

(2015) Arunima Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Structural analysis of the interleukin-8/glycosaminoglycan interactions by amide hydrogen/deuterium exchange mass spectrometry

(2015) Tommy Hofmann et al.   METHODS

Modular Synthesis of Heparin-Related Tetra-, Hexa- and Octasaccharides with Differential O-6 Protections: Programming for Regiodefined 6-O-Modifications

(2015) Marek Baráth et al.   MOLECULES

Interactions of the Chemokine CCL5/RANTES with Medium-Sized Chondroitin Sulfate Ligands

(2015) Courtney Deshauer et al.   STRUCTURE

Cytokines and growth factors cross-link heparan sulfate

(2015) Elisa Migliorini et al.   Open Biology

A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins

(2015) Aurijit Sarkar et al.   PLoS One

Mechanisms Regulating the Secretion of the Promalignancy Chemokine CCL5 by Breast Tumor Cells: CCL5's 40s Loop and Intracellular Glycosaminoglycans

(2015) Gali Soria et al.   NEOPLASIA

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

NMR characterization of the electrostatic interaction of the basic residues in HDGF and FGF2 during heparin binding

(2014) Liang-Yuan Chiu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Well-defined biomimetic surfaces to characterize glycosaminoglycan-mediated interactions on the molecular, supramolecular and cellular levels

(2014) Elisa Migliorini et al.   BIOMATERIALS

A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans

(2014) Dhruv Thakar et al.   CHEMICAL COMMUNICATIONS

Heparin-Binding Proteins (Chemokines and Defensins) and their Complexes with Glycosaminoglycans from the Solution NMR Perspective

(2014) Vitor Pomin   CURRENT PROTEIN & PEPTIDE SCIENCE

Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture 13C-glucose metabolic labeling

(2014) Mathieu Pegeot et al.   GLYCOBIOLOGY

Macrophage polarization alters the expression and sulfation pattern of glycosaminoglycans

(2014) Pierre Martinez et al.   GLYCOBIOLOGY

Multiple Glycosaminoglycan-binding Epitopes of Monocyte Chemoattractant Protein-3/CCL7 Enable It to Function as a Non-oligomerizing Chemokine

(2014) Catherina L. Salanga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Inhibits Hematopoietic Stem and Progenitor Cell Migration and Engraftment in Mucopolysaccharidosis I

(2014) H. Angharad Watson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies

(2014) Sucharita Roy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemoenzymatic synthesis of heparan sulfate and heparin

(2014) Jian Liu et al.   NATURAL PRODUCT REPORTS

The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes

(2014) Maria H Ulvmar et al.   NATURE IMMUNOLOGY

Extracellular matrix assembly: a multiscale deconstruction

(2014) Janna K. Mouw et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blood Vessels Pattern Heparan Sulfate Gradients between Their Apical and Basolateral Aspects

(2014) Liat Stoler-Barak et al.   PLoS One

Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: Molecular modeling and experimental validation

(2014) Irina Kufareva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: The N-Terminal Region of CCR3 Bound to CCL11/Eotaxin-1

(2014) Christopher J. Millard et al.   STRUCTURE

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs

(2014) Yaeli Lebel-Haziv et al.   NEOPLASIA

Sulfopeptide Probes of the CXCR4/CXCL12 Interface Reveal Oligomer-Specific Contacts and Chemokine Allostery

(2013) Joshua J. Ziarek et al.   ACS Chemical Biology

The structural role of receptor tyrosine sulfation in chemokine recognition

(2013) Justin P Ludeman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanical guidance of cell migration: lessons from chemotaxis

(2013) Pere Roca-Cusachs et al.   CURRENT OPINION IN CELL BIOLOGY

Synthetic heparin and heparan sulfate oligosaccharides and their protein interactions

(2013) Medel Manuel L Zulueta et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthetic probes of glycosaminoglycan function

(2013) Matthew E Griffin et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity

(2013) Amal Seffouh et al.   FASEB JOURNAL

Comparative glycomics of leukocyte glycosaminoglycans

(2013) Chun Shao et al.   FEBS Journal

Investigation of lysine side chain interactions of interleukin-8 with heparin and other glycosaminoglycans studied by a methylation-NMR approach

(2013) K. Mobius et al.   GLYCOBIOLOGY

The Solution Structure of Heparan Sulfate Differs from That of Heparin

(2013) Sanaullah Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

(2013) Joshua H. Y. Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis of Glycosaminoglycan Heparin Binding to the Chemokine CXCL1 Dimer

(2013) Krishna Mohan Poluri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of High Endothelial Venule-Expressed Heparan Sulfate in Chemokine Presentation and Lymphocyte Homing

(2013) K. Tsuboi et al.   JOURNAL OF IMMUNOLOGY

Differentiation of CC vs CXC Chemokine Dimers with GAG Octasaccharide Binding Partners: An Ion Mobility Mass Spectrometry Approach

(2013) Youjin Seo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CCL18 Exhibits a Regulatory Role through Inhibition of Receptor and Glycosaminoglycan Binding

(2013) Sonja C. Krohn et al.   PLoS One

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

Molecular Mechanisms of Fibroblast Growth Factor Signaling in Physiology and Pathology

(2013) A. A. Belov et al.   Cold Spring Harbor Perspectives in Biology

Age-related impairment of endothelial progenitor cell migration correlates with structural alterations of heparan sulfate proteoglycans

(2012) Kate A. Williamson et al.   AGING CELL

A Model of GAG/MIP-2/CXCR2 Interfaces and Its Functional Effects

(2012) Deepa Rajasekaran et al.   BIOCHEMISTRY

Use of biosynthetic enzymes in heparin and heparan sulfate synthesis

(2012) Elizabeth P. Chappell et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Synthetic Heparan Sulfate-Mimetic Peptide Conjugated to a Mini CD4 Displays Very High Anti- HIV-1 Activity Independently of Coreceptor Usage

(2012) Bridgette Janine Connell et al.   CHEMISTRY & BIOLOGY

Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/Proteoglycan Interactions

(2012) Patricia Rueda et al.   CIRCULATION

Inflammatory Chemokines Direct and Restrict Leukocyte Migration within Live Tissues as Glycan-Bound Gradients

(2012) Milka Sarris et al.   CURRENT BIOLOGY

Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines

(2012) Shuji Mizumoto et al.   GLYCOCONJUGATE JOURNAL

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

The biochemistry and biology of the atypical chemokine receptors

(2012) G.J. Graham et al.   IMMUNOLOGY LETTERS

Heparan Sulfate Biosynthesis

(2012) Johan Kreuger et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Hydrogen Exchange Mass Spectrometry: Are We Out of the Quicksand?

(2012) Roxana E. Iacob et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: The role of structural dynamics in function

(2011) C.L. Salanga et al.   EXPERIMENTAL CELL RESEARCH

Directing the biological activities of heparan sulfate oligosaccharides using a chemoenzymatic approach

(2011) Yongmei Xu et al.   GLYCOBIOLOGY

Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells

(2011) F. Di Giacomo et al.   HAEMATOLOGICA

Biochemical Analysis of Matrix Metalloproteinase Activation of Chemokines CCL15 and CCL23 and Increased Glycosaminoglycan Binding of CCL16

(2011) Amanda E. Starr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

13C-Labeled Heparan Sulfate Analogue as a Tool To Study Protein/Heparan Sulfate Interactions by NMR Spectroscopy: Application to the CXCL12α Chemokine

(2011) Cédric Laguri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

A competitive binding study of chemokine, sulfated receptor, and glycosaminoglycan interactions by nano-electrospray ionization mass spectrometry

(2010) Connie H. Jen et al.   ANALYTICAL BIOCHEMISTRY

Desorption Electrospray Ionization Mass Spectrometry of Glycosaminoglycans and Their Protein Noncovalent Complex

(2010) C. Przybylski et al.   ANALYTICAL CHEMISTRY

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Bioactive synthetic heparan sulfate and heparin derivatives: From long fragments mimetics to chimeras

(2010) David Bonnaffé   COMPTES RENDUS CHIMIE

Effect of posttranslational processing on the in vitro and in vivo activity of chemokines

(2010) Anneleen Mortier et al.   EXPERIMENTAL CELL RESEARCH

Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes

(2010) Xingfeng Bao et al.   IMMUNITY

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

(2010) Kathrin Schumann et al.   IMMUNITY

Serglycin Is a Major Proteoglycan in Polarized Human Endothelial Cells and Is Implicated in the Secretion of the Chemokine GROα/CXCL1

(2010) Astri J. Meen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Heparan Sulfate Motif (GlcNS6S-IdoA2S)3, Common in Heparin, Has a Strict Topography and Is Involved in Cell Behavior and Disease

(2010) Nicole C. Smits et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Chemokine CXCL11-Heparin Interaction Suggests Two Different Affinities for Glycosaminoglycans

(2010) India C. Severin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemoenzymatic Design of Heparan Sulfate Oligosaccharides

(2010) Renpeng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Domain Organization and Sulfation Modulate FGF-induced Cell Signaling

(2010) Nadja Jastrebova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of Chemokine–Glycosaminoglycan Interactions Control Neutrophil Migration into the Airspaces of the Lungs

(2010) Yoshi Tanino et al.   JOURNAL OF IMMUNOLOGY

CCR1- and CCR5-mediated inactivation of leukocytes by a nonglycosaminoglycan (non-GAG)-binding variant of n-Nonanoyl-CCL14 (NNY-CCL14)

(2010) S. Gupta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NMR Analyses of the Interaction between CCR5 and Its Ligand Using Functional Reconstitution of CCR5 in Lipid Bilayers

(2010) Chie Yoshiura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From Polymer to Size-Defined Oligomers: A Highly Divergent and Stereocontrolled Construction of Chondroitin Sulfate A, C, D, E, K, L, and M Oligomers from a Single Precursor: Part 2

(2009) Jean-Claude Jacquinet et al.   CHEMISTRY-A EUROPEAN JOURNAL

Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12

(2009) Graeme O'Boyle et al.   FASEB JOURNAL

Organ-specific Heparan Sulfate Structural Phenotypes

(2009) Xiaofeng Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

(2009) Yutaka Kofuku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies

(2009) Sailaja Arungundram et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polypyrrole Oligosaccharide Array and Surface Plasmon Resonance Imaging for the Measurement of Glycosaminoglycan Binding Interactions

(2008) Emilie Mercey et al.   ANALYTICAL CHEMISTRY

Control of Chemokine-Guided Cell Migration by Ligand Sequestration

(2008) Bijan Boldajipour et al.   CELL

Sulfated oligosaccharides (heparin and fucoidan) binding and dimerization of stromal cell-derived factor-1 (SDF-1/CXCL 12) are coupled as evidenced by affinity CE-MS analysis

(2008) S. Fermas et al.   GLYCOBIOLOGY

Biological implications of glycosaminoglycan interactions with haemopoietic cytokines

(2008) Deirdre R Coombe   IMMUNOLOGY AND CELL BIOLOGY

Proteolytic processing of chemokines: Implications in physiological and pathological conditions

(2008) M WOLF et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mixture Synthesis and “Charge Tagging” Based Demixing: An Efficient Strategy for the Preparation of Heparan Sulfate Libraries

(2008) Anna Dilhas et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

The CXCL12γ Chemokine Displays Unprecedented Structural and Functional Properties that Make It a Paradigm of Chemoattractant Proteins

(2008) Patricia Rueda et al.   PLoS One

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling