Biophysical Challenges to Axonal Transport: Motor-Cargo Deficiencies and Neurodegeneration

Tau Aggregates: Toxic, Inert, or Protective Species?

(2017) Alexis Bretteville et al.   JOURNAL OF ALZHEIMERS DISEASE

Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo

(2013) Shermali Gunawardena et al.   HUMAN MOLECULAR GENETICS

Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport

(2013) Yanmin Chen et al.   JOURNAL OF CELL BIOLOGY

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Amyloid-  Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3  in Primary Cultured Hippocampal Neurons

(2013) H. Decker et al.   JOURNAL OF NEUROSCIENCE

Long-distance retrograde neurotrophic factor signalling in neurons

(2013) Anthony W. Harrington et al.   NATURE REVIEWS NEUROSCIENCE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Tau phosphorylation affects its axonal transport and degradation

(2013) Teresa Rodríguez-Martín et al.   NEUROBIOLOGY OF AGING

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

(2013) Wendy Noble et al.   Frontiers in Neurology

Neurotrophin Signaling via Long-Distance Axonal Transport

(2012) Praveen D. Chowdary et al.   Annual Review of Physical Chemistry

Bidirectional intracellular transport: utility and mechanism: Figure 1

(2012) Amber L. Jolly et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Enhanced  -secretase processing alters APP axonal transport and leads to axonal defects

(2012) E. M. Rodrigues et al.   HUMAN MOLECULAR GENETICS

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila

(2012) Gerald F. Reis et al.   MOLECULAR BIOLOGY OF THE CELL

Motor transport of self-assembled cargos in crowded environments

(2012) L. Conway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles

(2012) L. Szpankowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular crowding creates traffic jams of kinesin motors on microtubules

(2012) C. Leduc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal transport and neurodegenerative disease: Can we see the elephant?

(2012) Lawrence S.B. Goldstein   PROGRESS IN NEUROBIOLOGY

Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold

(2012) N. D. Derr et al.   SCIENCE

Endogenous GSK-3/Shaggy Regulates Bidirectional Axonal Transport of the Amyloid Precursor Protein

(2012) Carole Weaver et al.   TRAFFIC

Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer’s disease: implications for axoplasmic transport

(2011) Marina Morel et al.   ACTA NEUROPATHOLOGICA

Exome Sequencing Identifies a DYNC1H1 Mutation in a Large Pedigree with Dominant Axonal Charcot-Marie-Tooth Disease

(2011) Michael N. Weedon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Stable Kinesin and Dynein Assemblies Drive the Axonal Transport of Mammalian Prion Protein Vesicles

(2011) Sandra E. Encalada et al.   CELL

Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2

(2011) C Crimella et al.   CLINICAL GENETICS

Force–velocity relationship for multiple kinesin motors pulling a magnetic bead

(2011) Todd L. Fallesen et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport

(2011) Julie Y. Yi et al.   JOURNAL OF CELL BIOLOGY

KLP6: a newly identified kinesin that regulates the morphology and transport of mitochondria in neuronal cells

(2011) K. Tanaka et al.   JOURNAL OF CELL SCIENCE

Soluble tau Species, Not Neurofibrillary Aggregates, Disrupt Neural System Integration in a tau Transgenic Model

(2011) Leora M. Fox et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Translocation Selectivity of the Kinesins that Mediate Neuronal Organelle Transport

(2011) Chun-fang Huang et al.   TRAFFIC

Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells

(2011) Silke Brunholz et al.   EXPERIMENTAL BRAIN RESEARCH

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Motor Coordination via a Tug-of-War Mechanism Drives Bidirectional Vesicle Transport

(2010) Adam G. Hendricks et al.   CURRENT BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glycogen synthase kinase-3β and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons

(2010) M. Morel et al.   NEUROSCIENCE

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Paclitaxel induces axonal microtubules polar reconfiguration and impaired organelle transport: implications for the pathogenesis of paclitaxel-induced polyneuropathy

(2009) Or A. Shemesh et al.   ACTA NEUROPATHOLOGICA

Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking†

(2009) Andreas Weihofen et al.   BIOCHEMISTRY

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Anterograde Transport of TrkB in Axons Is Mediated by Direct Interaction with Slp1 and Rab27

(2009) Nariko Arimura et al.   DEVELOPMENTAL CELL

Kinesin velocity increases with the number of motors pulling against viscoelastic drag

(2009) Jason Gagliano et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

The PINK1/Parkin pathway: a mitochondrial quality control system?

(2009) Alexander J. Whitworth et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Opposite-polarity motors activate one another to trigger cargo transport in live cells

(2009) Shabeen Ally et al.   JOURNAL OF CELL BIOLOGY

Traffic control: regulation of kinesin motors

(2009) Kristen J. Verhey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons

(2009) C. Sinadinos et al.   NEUROBIOLOGY OF DISEASE

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes

(2009) V. Soppina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntingtin as an essential integrator of intracellular vesicular trafficking

(2009) Juliane P. Caviston et al.   TRENDS IN CELL BIOLOGY

Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets

(2008) George T. Shubeita et al.   CELL

Nerve injury signaling

(2008) Namiko Abe et al.   CURRENT OPINION IN NEUROBIOLOGY

Axonal transport and the delivery of pre-synaptic components

(2008) Ann YN Goldstein et al.   CURRENT OPINION IN NEUROBIOLOGY

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

Mechanisms of neurodegeneration in Huntington’s disease

(2008) Joana M. Gil et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular motors: A traffic cop within?

(2008) M. A. Welte et al.   HFSP Journal

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

(2008) Nichole E. LaPointe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Herpesvirus Interactions with the Host Cytoskeleton

(2008) M. G. Lyman et al.   JOURNAL OF VIROLOGY

Axcaliber: A method for measuring axon diameter distribution from diffusion MRI

(2008) Yaniv Assaf et al.   MAGNETIC RESONANCE IN MEDICINE

The role of microtubule movement in bidirectional organelle transport

(2008) I. M. Kulic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

(2008) M. Saotome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Tau-Induced Traffic Jams Reflect Organelles Accumulation at Points of Microtubule Polar Mismatching

(2008) Or A. Shemesh et al.   TRAFFIC

Identification of an Axonal Kinesin-3 Motor for Fast Anterograde Vesicle Transport that Facilitates Retrograde Transport of Neuropeptides

(2007) Rosemarie V. Barkus et al.   MOLECULAR BIOLOGY OF THE CELL