The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment
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Title
The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment
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Journal
Acta Pharmaceutica Sinica B
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-02-11
DOI
10.1016/j.apsb.2021.02.008
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Note: Only part of the references are listed.- Across-site differences in the mechanism of alcohol-induced digestive tract carcinogenesis: an evaluation by mediation analysis
- (2020) Yuriko N. Koyanagi et al. CANCER RESEARCH
- Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms
- (2020) Michael R. Hodskinson et al. NATURE
- FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair
- (2020) Pablo Alcón et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Vitamin D Protects Against Alcohol-Induced Liver Cell Injury Within an NRF2-ALDH2 Feedback Loop
- (2019) Hong Zhang et al. MOLECULAR NUTRITION & FOOD RESEARCH
- β-Arrestins regulate stem cell-like phenotype and response to chemotherapy in bladder cancer.
- (2019) Georgios Kallifatidis et al. MOLECULAR CANCER THERAPEUTICS
- MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer
- (2019) Yueh-Shan Weng et al. Molecular Cancer
- A physiological concentration of luteolin induces phase II drug-metabolizing enzymes through the ERK1/2 signaling pathway in HepG2 cells
- (2019) Tomoya Kitakaze et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Acetaldehyde Suppresses the Display of HBV-MHC class I Complexes on HBV-Expressing Hepatocytes
- (2019) Murali Ganesan et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk
- (2019) Chen Suo et al. Journal of Thoracic Oncology
- ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA enriched extracellular vesicles
- (2019) Wonhyo Seo et al. JOURNAL OF HEPATOLOGY
- BRCA Mutation Carriers: Breast and Ovarian Cancer Screening Guidelines and Imaging Considerations
- (2019) Mai Elezaby et al. RADIOLOGY
- ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage
- (2019) Kaimi Li et al. NEOPLASIA
- Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence
- (2019) Michal Harel et al. CELL
- Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers
- (2019) Elizabeth C. Page et al. EUROPEAN UROLOGY
- Post-translational inhibition of YAP oncogene expression by 4-hydroxynonenal in bladder cancer cells
- (2019) Marie Angele Cucci et al. FREE RADICAL BIOLOGY AND MEDICINE
- Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase
- (2019) Zdenek Skrott et al. ONCOGENE
- Silencing transcription factor FOXM1 represses proliferation, migration, and invasion while inducing apoptosis of liver cancer stem cells by regulating the expression of ALDH2
- (2019) Lijian Chen et al. IUBMB LIFE
- The biological activity of bispecific trastuzumab/pertuzumab plant biosimilars may be drastically boosted by disulfiram increasing formaldehyde accumulation in cancer cells
- (2019) Tatiana V. Komarova et al. Scientific Reports
- Salivary Gland Function, Antioxidant Defence and Oxidative Damage in the Saliva of Patients with Breast Cancer: Does the BRCA1 Mutation Disturb the Salivary Redox Profile?
- (2019) Sawczuk et al. Cancers
- mTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression in silico
- (2019) Kashif Rafiq Zahid et al. Frontiers in Oncology
- Antioxidant Barrier, Redox Status, and Oxidative Damage to Biomolecules in Patients with Colorectal Cancer. Can Malondialdehyde and Catalase Be Markers of Colorectal Cancer Advancement?
- (2019) Zińczuk et al. Biomolecules
- Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium
- (2018) Tomotaka Ugai et al. CANCER SCIENCE
- Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion
- (2018) Recep Bayraktar et al. CLINICAL CANCER RESEARCH
- The effects of acetaldehyde exposure on histone modifications and chromatin structure in human lung bronchial epithelial cells
- (2018) Danqi Chen et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Targeting ALDH2 with disulfiram/copper reverses the resistance of cancer cells to microtubule inhibitors
- (2018) Nan-nan Wang et al. EXPERIMENTAL CELL RESEARCH
- Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer: a replication and mediation analysis
- (2018) Kuka Ishioka et al. Gastric Cancer
- Association of low-activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population-based cohort study
- (2018) Canqing Yu et al. INTERNATIONAL JOURNAL OF CANCER
- Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2: temperance reduces the risk
- (2018) Satoshi Abiko et al. JOURNAL OF GASTROENTEROLOGY
- Aldehyde-Induced DNA and Protein Adducts as Biomarker Tools for Alcohol Use Disorder
- (2018) Helen M. Heymann et al. TRENDS IN MOLECULAR MEDICINE
- Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
- (2018) Hadas Gibori et al. Nature Communications
- Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids
- (2018) Yanhang Gao et al. GUT
- Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells
- (2018) Juan I. Garaycoechea et al. NATURE
- Regulation of microRNA function in animals
- (2018) Luca F. R. Gebert et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients
- (2018) Xin Chen et al. CELLULAR ONCOLOGY
- The Influence of Prediagnosis Alcohol Consumption and the Polymorphisms of Ethanol-Metabolizing Genes on the Survival of Head and Neck Cancer Patients
- (2018) Wei-Ting Lee et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1
- (2018) Meryem Gülfem Öner et al. GASTROENTEROLOGY
- Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation
- (2018) Shanshan Zhong et al. JOURNAL OF CLINICAL INVESTIGATION
- Pro-apoptotic effects of lipid oxidation products: HNE at the crossroads of NF-κB pathway and anti-apoptotic Bcl-2
- (2017) Ahmet Can Timucin et al. FREE RADICAL BIOLOGY AND MEDICINE
- Impact of alcohol dehydrogenase-aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer
- (2017) Mehmet Ozgur Avinçsal et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice
- (2017) Guojun Hou et al. HEPATOLOGY
- Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
- (2017) Zdenek Skrott et al. NATURE
- VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
- (2017) Yao-Hui Gao et al. Nature Communications
- SIRT3: Oncogene and Tumor Suppressor in Cancer
- (2017) Margalida Torrens-Mas et al. Cancers
- Prognostic value of ALDH2 polymorphism for patients with oropharyngeal cancer in a Japanese population
- (2017) Hirotaka Shinomiya et al. PLoS One
- Carboxymethyl Dextran-Stabilized Polyethylenimine-Poly(epsilon-caprolactone) Nanoparticles-Mediated Modulation of MicroRNA-34a Expression via Small-Molecule Modulator for Hepatocellular Carcinoma Therapy
- (2016) Xiongwei Deng et al. ACS Applied Materials & Interfaces
- Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
- (2016) Wei Ge et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma
- (2016) J. Liu et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: gene–environment interaction
- (2016) Hiroyuki Masaoka et al. CARCINOGENESIS
- Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability
- (2016) Jian Chen et al. HEPATOLOGY
- Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer
- (2016) Y Yang et al. ONCOGENE
- Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1
- (2016) Bing Wu et al. Oncotarget
- Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway
- (2015) Cheng Shen et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis
- (2015) Shengfang Jin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study
- (2014) Angeline S. Andrew et al. BJU INTERNATIONAL
- Genetic polymorphisms of ADH1B, ADH1C and ALDH2, alcohol consumption, and the risk of gastric cancer: the Japan Public Health Center-based prospective study
- (2014) Akihisa Hidaka et al. CARCINOGENESIS
- The interplay between alcohol consumption, oral hygiene,ALDH2andADH1Bin the risk of head and neck cancer
- (2014) Sen-Tien Tsai et al. INTERNATIONAL JOURNAL OF CANCER
- Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy
- (2014) Aijun Sun et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population
- (2013) Yong Gao et al. HUMAN GENETICS
- Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: results from the treatment of early aggressive rheumatoid arthritis trial
- (2013) S Aslibekyan et al. PHARMACOGENOMICS JOURNAL
- Poly(ADP-ribose) polymerase inhibition prevents reactive oxygen species induced inhibition of aldehyde dehydrogenase2 activity
- (2012) Shu-jian Wei et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair
- (2012) N. Kotova et al. CARCINOGENESIS
- Differences in Susceptibility to Inactivation of Human Aldehyde Dehydrogenases by Lipid Peroxidation Byproducts
- (2012) Belem Yoval-Sánchez et al. CHEMICAL RESEARCH IN TOXICOLOGY
- SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates
- (2012) Luciana O. Almeida et al. FEBS Journal
- Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions
- (2012) Chen Wu et al. NATURE GENETICS
- Alcohol Metabolism in Human Cells Causes DNA Damage and Activates the Fanconi Anemia-Breast Cancer Susceptibility (FA-BRCA) DNA Damage Response Network
- (2011) Jessy Abraham et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC–EURGAST)
- (2011) Karen Balassiano et al. CANCER LETTERS
- Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
- (2011) E. J. Duell et al. CARCINOGENESIS
- SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity
- (2011) Zhongping Lu et al. EMBO REPORTS
- Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotype in the Korean population
- (2011) C. M. Shin et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: A case control study
- (2011) Takeshi Tomoda et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice
- (2011) Frédéric Langevin et al. NATURE
- Autoimmune Hepatitis Induced by Syngeneic Liver Cytosolic Proteins Biotransformed by Alcohol Metabolites
- (2010) Geoffrey M. Thiele et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population
- (2010) J. Y. Park et al. CARCINOGENESIS
- Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles
- (2010) F. Tanaka et al. GUT
- Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3
- (2010) Nataly Shulga et al. JOURNAL OF CELL SCIENCE
- The impact of miR-34a on protein output in hepatocellular carcinoma HepG2 cells
- (2010) Jun Cheng et al. PROTEOMICS
- A Novel Polymorphism rs1329149 of CYP2E1 and a Known Polymorphism rs671 of ALDH2 of Alcohol Metabolizing Enzymes Are Associated with Colorectal Cancer in a Southwestern Chinese Population
- (2009) H. Yang et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Inhibition of hepatic mitochondrial aldehyde dehydrogenase by carbon tetrachloride through JNK-mediated phosphorylation
- (2009) Kwan-Hoon Moon et al. FREE RADICAL BIOLOGY AND MEDICINE
- Functional Variants in ADH1B and ALDH2 Coupled With Alcohol and Smoking Synergistically Enhance Esophageal Cancer Risk
- (2009) Ri Cui et al. GASTROENTEROLOGY
- The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption
- (2009) Philip J Brooks et al. PLOS MEDICINE
- Ethanol intoxication increases hepatic N-lysyl protein acetylation
- (2008) Matthew J. Picklo BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans
- (2008) Sang-Yong Eom et al. CANCER CAUSES & CONTROL
- Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese
- (2008) Junya Kanda et al. CANCER SCIENCE
- Large-Scale Proteomics and Phosphoproteomics of Urinary Exosomes
- (2008) P. A. Gonzales et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde
- (2008) Naoki Kunugita et al. JOURNAL OF TOXICOLOGICAL SCIENCES
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