Complement Has Brains—Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?

Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis

(2020) Giuseppina Arbore et al.   Cellular & Molecular Immunology

Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons

(2020) Gabriel M. S. Janach et al.   Journal of Neuroinflammation

Bypassing the blood-brain barrier

(2020) Justin Rustenhoven et al.   SCIENCE

Social Safety Theory: A Biologically Based Evolutionary Perspective on Life Stress, Health, and Behavior

(2020) George M. Slavich   Annual Review of Clinical Psychology

Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells

(2020) Martin Kolev et al.   IMMUNITY

Complement and human T cell metabolism: Location, location, location

(2020) Erin E. West et al.   IMMUNOLOGICAL REVIEWS

Integrins meet complement: The evolutionary tip of an iceberg orchestrating metabolism and immunity

(2020) Nicolas S Merle et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

(2020) Emanuela Pasciuto et al.   CELL

PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

(2020) Luis Eduardo Alves Damasceno et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection

(2020) Stina L. Urban et al.   NATURE IMMUNOLOGY

Complement's favourite organelle—Mitochondria?

(2020) Jubayer Rahman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice

(2020) Ryan J. Worthen et al.   Journal of Neuroinflammation

Innate immune-responses and their role in driving autoimmunity

(2019) Elias Toubi et al.   AUTOIMMUNITY REVIEWS

Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases

(2019) Nabil Karnib et al.   NEUROPSYCHOPHARMACOLOGY

The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells

(2019) Esperanza Perucha et al.   Nature Communications

Physical principles of retroviral integration in the human genome

(2019) D. Michieletto et al.   Nature Communications

Why Study the History of Neuroscience?

(2019) Richard E. Brown   Frontiers in Behavioral Neuroscience

The Promoter Regions of Intellectual Disability-Associated Genes Are Uniquely Enriched in LTR Sequences of the MER41 Primate-Specific Endogenous Retrovirus: An Evolutionary Connection Between Immunity and Cognition

(2019) Serge Nataf et al.   Frontiers in Genetics

Complement in Motion: The Evolution of CD46 from a Complement Regulator to an Orchestrator of Normal Cell Physiology

(2019) M. Kathryn Liszewski et al.   JOURNAL OF IMMUNOLOGY

Interaction of neurotransmitters and neurochemicals with lymphocytes

(2019) Daniel Kerage et al.   JOURNAL OF NEUROIMMUNOLOGY

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses

(2019) Charise Garber et al.   NATURE NEUROSCIENCE

Dynamic Metabolic State of Tissue Resident CD8 T Cells

(2019) Špela Konjar et al.   Frontiers in Immunology

Role of the Immune System in the Development of the Central Nervous System

(2019) Keiko Morimoto et al.   Frontiers in Neuroscience

Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

(2019) Ke-qi Fan et al.   CELL

Complement dysregulation in the central nervous system during development and disease

(2019) John D. Lee et al.   SEMINARS IN IMMUNOLOGY

The CNS Immune Landscape from the Viewpoint of a T Cell

(2019) Sarah Mundt et al.   TRENDS IN NEUROSCIENCES

Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype

(2019) Björn Laffer et al.   Frontiers in Cellular Neuroscience

Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory

(2019) Miguel Ribeiro et al.   Science Immunology

IL-17a promotes sociability in mouse models of neurodevelopmental disorders

(2019) Michael Douglas Reed et al.   NATURE

Complement and the Regulation of T Cell Responses

(2018) Erin E. West et al.   Annual Review of Immunology

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

Complement component 3a receptor deficiency attenuates chronic stress-induced monocyte infiltration and depressive-like behavior

(2018) Amanda Crider et al.   BRAIN BEHAVIOR AND IMMUNITY

Understanding Subset Diversity in T Cell Memory

(2018) Stephen C. Jameson et al.   IMMUNITY

Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts

(2018) Brenda Raud et al.   IMMUNOLOGICAL REVIEWS

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

(2018) Kumar Vijay   INTERNATIONAL IMMUNOPHARMACOLOGY

New tricks for an ancient system: Physiological and pathological roles of complement in the CNS

(2018) Andrea J. Tenner et al.   MOLECULAR IMMUNOLOGY

C1q restrains autoimmunity and viral infection by regulating CD8+T cell metabolism

(2018) Guang Sheng Ling et al.   SCIENCE

Complement in stem cells and development

(2018) Owen A. Hawksworth et al.   SEMINARS IN IMMUNOLOGY

Complement involvement in bone homeostasis and bone disorders

(2018) Yvonne Mödinger et al.   SEMINARS IN IMMUNOLOGY

Introduction to complement in health and disease: novel aspects and insights

(2018) B. Paul Morgan et al.   Seminars in Immunopathology

Brain Energy and Oxygen Metabolism: Emerging Role in Normal Function and Disease

(2018) Michelle E. Watts et al.   Frontiers in Molecular Neuroscience

LFA-1 in T Cell Migration and Differentiation

(2018) Brandon L. Walling et al.   Frontiers in Immunology

Complement in the Initiation and Evolution of Rheumatoid Arthritis

(2018) V. Michael Holers et al.   Frontiers in Immunology

Intracellular C3 Protects Human Airway Epithelial Cells from Stress-Associated Cell Death

(2018) Hrishikesh S Kulkarni et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Complement and Bacterial Infections: From Molecular Mechanisms to Therapeutic Applications

(2018) Dani A.C. Heesterbeek et al.   Journal of Innate Immunity

CNS infection and immune privilege

(2018) John V. Forrester et al.   NATURE REVIEWS NEUROSCIENCE

Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism

(2018) Giuseppina Arbore et al.   Nature Communications

Astrocyte glycogen and lactate: New insights into learning and memory mechanisms

(2017) Cristina M. Alberini et al.   GLIA

Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer

(2017) Rehman Ata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation and pathogenic manipulation of the sensors of the innate immune system

(2017) Charlotte Odendall et al.   MICROBES AND INFECTION

C1q as an autocrine and paracrine regulator of cellular functions

(2017) Berhane Ghebrehiwet et al.   MOLECULAR IMMUNOLOGY

Intracellular complement − the complosome − in immune cell regulation

(2017) Giuseppina Arbore et al.   MOLECULAR IMMUNOLOGY

IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses

(2017) Changchun Chen et al.   NATURE

How and why do T cells and their derived cytokines affect the injured and healthy brain?

(2017) Anthony J. Filiano et al.   NATURE REVIEWS NEUROSCIENCE

Brain interference: Revisiting the role of IFNγ in the central nervous system

(2017) S. Monteiro et al.   PROGRESS IN NEUROBIOLOGY

Host and Viral Modulation of RIG-I-Mediated Antiviral Immunity

(2017) Yiliu Liu et al.   Frontiers in Immunology

Keeping It All Going—Complement Meets Metabolism

(2017) Martin Kolev et al.   Frontiers in Immunology

Interferon-Related Depression: A Primer on Mechanisms, Treatment, and Prevention of a Common Clinical Problem

(2016) Ekta Franscina Pinto et al.   Current Neuropharmacology

Complement-Mediated Regulation of Metabolism and Basic Cellular Processes

(2016) Christoph Hess et al.   IMMUNITY

Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

(2016) Karin Steinbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LFA-1/ICAM-1 Ligation in Human T Cells Promotes Th1 Polarization through a GSK3β Signaling–Dependent Notch Pathway

(2016) Navin K. Verma et al.   JOURNAL OF IMMUNOLOGY

Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury

(2016) Rodney M. Ritzel et al.   JOURNAL OF IMMUNOLOGY

Interferon gamma protects neonatal neural stem/progenitor cells during measles virus infection of the brain

(2016) Kristen N. Fantetti et al.   Journal of Neuroinflammation

Balancing the immune response in the brain: IL-10 and its regulation

(2016) Diogo Lobo-Silva et al.   Journal of Neuroinflammation

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

Multifaceted interactions between adaptive immunity and the central nervous system

(2016) J. Kipnis   SCIENCE

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

(2016) Mulki Angela et al.   Nature Communications

Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling

(2016) Fabia Filipello et al.   Oncotarget

mTOR regulates neuroprotective effect of immunized CD4+Foxp3+ T cells in optic nerve ischemia

(2016) Guochun Chen et al.   Scientific Reports

Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

(2016) Yuki Murakami et al.   Scientific Reports

Loss of T cells influences sex differences in behavior and brain structure

(2015) Kelly C. Rilett et al.   BRAIN BEHAVIOR AND IMMUNITY

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

(2015) Martin Kolev et al.   IMMUNITY

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

(2015) James T. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphocytes from Chronically Stressed Mice Confer Antidepressant-Like Effects to Naive Mice

(2015) R. A. Brachman et al.   JOURNAL OF NEUROSCIENCE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Effects of psychotropic drugs on inflammation: consequence or mediator of therapeutic effects in psychiatric treatment?

(2015) David Baumeister et al.   PSYCHOPHARMACOLOGY

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

(2015) Liana Fasching et al.   Cell Reports

Involvement of Adult Hippocampal Neurogenesis in Learning and Forgetting

(2015) Suk-yu Yau et al.   NEURAL PLASTICITY

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Human C3 Deficiency Associated with Impairments in Dendritic Cell Differentiation, Memory B Cells, and Regulatory T Cells

(2014) A. Ghannam et al.   JOURNAL OF IMMUNOLOGY

Complement activation in patients with neuromyelitis optica

(2014) Petra Nytrova et al.   JOURNAL OF NEUROIMMUNOLOGY

The role of the globular heads of the C1q receptor in HPV-16 E2-induced human cervical squamous carcinoma cell apoptosis via a mitochondria-dependent pathway

(2014) Zheng-lin Chen et al.   Journal of Translational Medicine

The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery

(2014) Johan Dahl et al.   PSYCHONEUROENDOCRINOLOGY

IFN-γ differentially modulates memory-related processes under basal and chronic stressor conditions

(2014) Darcy Litteljohn et al.   Frontiers in Cellular Neuroscience

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire

(2013) Ali Radjavi et al.   BRAIN BEHAVIOR AND IMMUNITY

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

CD46: The ‘multitasker’ of complement proteins

(2013) Hidekazu Yamamoto et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interleukin-10 regulates progenitor differentiation and modulates neurogenesis in adult brain

(2013) F. J. Perez-Asensio et al.   JOURNAL OF CELL SCIENCE

C5a Receptor Signaling Prevents Folate Deficiency-Induced Neural Tube Defects in Mice

(2013) K. J. Denny et al.   JOURNAL OF IMMUNOLOGY

Evidence for Polygenic Adaptation to Pathogens in the Human Genome

(2013) Josephine T. Daub et al.   MOLECULAR BIOLOGY AND EVOLUTION

Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation

(2013) Arije Ghannam et al.   MOLECULAR IMMUNOLOGY

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Neuronal Synapse Formation Induced by Microglia and Interleukin 10

(2013) So-Hee Lim et al.   PLoS One

Serotonergic Chemosensory Neurons Modify the C. elegans Immune Response by Regulating G-Protein Signaling in Epithelial Cells

(2013) Alexandra Anderson et al.   PLoS Pathogens

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

(2013) L Rattazzi et al.   Translational Psychiatry

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

(2012) L. M. Wakim et al.   JOURNAL OF IMMUNOLOGY

The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases

(2012) Je-Min Choi et al.   MOLECULES AND CELLS

The CD46-Jagged1 interaction is critical for human TH1 immunity

(2012) Gaëlle Le Friec et al.   NATURE IMMUNOLOGY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Interferon modulates central nervous system function

(2011) Cruz Reyes-Vázquez et al.   BRAIN RESEARCH

Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration

(2011) Carlos Carmona-Fontaine et al.   DEVELOPMENTAL CELL

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression

(2011) M. E. Benoit et al.   JOURNAL OF NEUROSCIENCE

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Correction: Signatures of Environmental Genetic Adaptation Pinpoint Pathogens as the Main Selective Pressure through Human Evolution

(2011) Matteo Fumagalli et al.   PLoS Genetics

Synapse elimination during development and disease: immune molecules take centre stage

(2010) Dorothy P. Schafer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Amygdala Activity, Fear, and Anxiety: Modulation by Stress

(2010) Kerry J. Ressler   BIOLOGICAL PSYCHIATRY

LFA-1–specific therapy prolongs allograft survival in rhesus macaques

(2010) Idelberto R. Badell et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LFA-1 Contributes to Signal I of T-Cell Activation and to the Production of Th1 Cytokines

(2010) Georg Varga et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interferon-gamma (+874) T/A genotypes and risk of IFN-alpha-induced depression

(2010) G. Oxenkrug et al.   JOURNAL OF NEURAL TRANSMISSION

Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells

(2010) John Cardone et al.   NATURE IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

(2010) L. M. Wakim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-gamma deficiency modifies the effects of a chronic stressor in mice: Implications for psychological pathology

(2009) Darcy Litteljohn et al.   BRAIN BEHAVIOR AND IMMUNITY

Conditioning Protects C. elegans from Lethal Effects of Enteropathogenic E. coli by Activating Genes that Regulate Lifespan and Innate Immunity

(2009) Akwasi Anyanful et al.   Cell Host & Microbe

Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus

(2009) Susanne A. Wolf et al.   FASEB JOURNAL

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

Genome-wide Analysis of Histone Methylation Reveals Chromatin State-Based Regulation of Gene Transcription and Function of Memory CD8+ T Cells

(2009) Yasuto Araki et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Presenilin/ -Secretase Cleaves CD46 in Response to Neisseria Infection

(2009) N. J. Weyand et al.   JOURNAL OF IMMUNOLOGY

CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis

(2009) S. A. Wolf et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

A Polymorphism in npr-1 Is a Behavioral Determinant of Pathogen Susceptibility in C. elegans

(2009) K. C. Reddy et al.   SCIENCE

Vaccination as a Novel Approach for Treating Depressive Behavior

(2008) Gil M. Lewitus et al.   BIOLOGICAL PSYCHIATRY

Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis

(2008) P. N. Lalli et al.   BLOOD

Neurotransmitters activate T-cells and elicit crucial functions via neurotransmitter receptors

(2008) Mia Levite   CURRENT OPINION IN PHARMACOLOGY

IFN-γ enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer’s disease

(2008) Rona Baron et al.   FASEB JOURNAL

Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells

(2008) Michael G. Strainic et al.   IMMUNITY

Expression of complement components coincides with early patterning and organogenesis in Xenopus laevis

(2008) Valerie A. Mclin et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Immune system dysregulation in adolescent major depressive disorder

(2008) Vilma Gabbay et al.   JOURNAL OF AFFECTIVE DISORDERS

Role of Th1 and Th17 cells in organ-specific autoimmunity

(2008) Valérie Dardalhon et al.   JOURNAL OF AUTOIMMUNITY

IL-10 modulates depressive-like behavior

(2008) Ana Raquel Mesquita et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Evidence for a cytokine model of cognitive function

(2008) J. McAfoose et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Age-Dependent Spatial Memory Loss Can Be Partially Restored by Immune Activation

(2008) N. Ron-Harel et al.   REJUVENATION RESEARCH

A detailed examination of cytokine abnormalities in Major Depressive Disorder

(2007) N.M. Simon et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A hormone map of human immune cells showing the presence of adrenocorticotropic hormone, triiodothyronine and endorphin in immunophenotyped white blood cells

(2007) Éva Pállinger et al.   IMMUNOLOGY