How and why do T cells and their derived cytokines affect the injured and healthy brain?

Human endogenous retroviruses in neurologic disease

(2016) Tove Christensen   APMIS

Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination

(2016) Shengfeng Huang et al.   CELL

Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment

(2016) Thomas Blank et al.   IMMUNITY

Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury

(2016) Sachin P. Gadani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals

(2016) Sarah M. Clark et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

Multifaceted interactions between adaptive immunity and the central nervous system

(2016) J. Kipnis   SCIENCE

Sickness Behavior in Honey Bees

(2016) Nadia Kazlauskas et al.   Frontiers in Physiology

Immune deficiency influences juvenile social behavior and maternal behavior.

(2015) Kayla M. Quinnies et al.   BEHAVIORAL NEUROSCIENCE

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation

(2015) Paula Korhonen et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-33 ameliorates ischemic brain injury in experimental stroke through promoting Th2 response and suppressing Th17 response

(2015) Yi Luo et al.   BRAIN RESEARCH

The impact of gut microbiota on brain and behaviour

(2015) Timothy G. Dinan et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

(2015) James T. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis

(2015) Matilda Degn et al.   Multiple Sclerosis Journal

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

(2015) Sachin P. Gadani et al.   NEURON

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

(2015) Liana Fasching et al.   Cell Reports

Why Do We Feel Sick When Infected—Can Altruism Play a Role?

(2015) Keren Shakhar et al.   PLOS BIOLOGY

Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis

(2015) Matilda Degn et al.   Multiple Sclerosis Journal

Opposing Roles of Interferon-Gamma on Cells of the Central Nervous System in Autoimmune Neuroinflammation

(2015) Payton A. Ottum et al.   Frontiers in Immunology

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Regulatory T Cells in Central Nervous System Injury: A Double-Edged Sword

(2014) James T. Walsh et al.   JOURNAL OF IMMUNOLOGY

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis

(2014) A Masi et al.   MOLECULAR PSYCHIATRY

Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance

(2014) Alexandre Fort et al.   NATURE GENETICS

The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery

(2014) Johan Dahl et al.   PSYCHONEUROENDOCRINOLOGY

Antigen-specific immune reactions to ischemic stroke

(2014) Xabier Urra et al.   Frontiers in Cellular Neuroscience

Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire

(2013) Ali Radjavi et al.   BRAIN BEHAVIOR AND IMMUNITY

The immunologic profile of adoptively transferred lymphocytes influences stroke outcome of recipients

(2013) Dannielle Zierath et al.   JOURNAL OF NEUROIMMUNOLOGY

Immune cell subtyping in the cerebrospinal fluid of patients with neurological diseases

(2013) M. C. Kowarik et al.   JOURNAL OF NEUROLOGY

Dynamics of the meningeal CD4+ T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice

(2013) A Radjavi et al.   MOLECULAR PSYCHIATRY

Two-Photon Microscopy Imaging of thy1GFP-M Transgenic Mice: A Novel Animal Model to Investigate Brain Dendritic Cell Subsets In Vivo

(2013) Claudia Laperchia et al.   PLoS One

Brain Hyperconnectivity in Children with Autism and its Links to Social Deficits

(2013) Kaustubh Supekar et al.   Cell Reports

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

(2013) L Rattazzi et al.   Translational Psychiatry

Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature

(2012) C. Kleinschnitz et al.   BLOOD

In the company of cowbirds, Molothrus ater ater: Robust patterns of sociability predict reproductive performance.

(2012) Gregory M. Kohn et al.   JOURNAL OF COMPARATIVE PSYCHOLOGY

Brain-Derived Antigens in Lymphoid Tissue of Patients with Acute Stroke

(2012) A. M. Planas et al.   JOURNAL OF IMMUNOLOGY

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

(2011) Ping Jun Zhu et al.   CELL

Sick ants become unsociable

(2011) N. BOS et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Aberrant Immune Responses in a Mouse with Behavioral Disorders

(2011) Yong Heo et al.   PLoS One

Autoimmune Responses to the Brain After Stroke Are Associated With Worse Outcome

(2011) Kyra J. Becker et al.   STROKE

Regulatory T cells in CNS injury: the simple, the complex and the confused

(2011) James T. Walsh et al.   TRENDS IN MOLECULAR MEDICINE

Change in Human Social Behavior in Response to a Common Vaccine

(2010) Chris Reiber et al.   ANNALS OF EPIDEMIOLOGY

Interferon gamma licensing of human dendritic cells in T-helper-independent CD8+ alloimmunity

(2010) R. Lemoine et al.   BLOOD

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Meningeal Mast Cells Affect Early T Cell Central Nervous System Infiltration and Blood-Brain Barrier Integrity through TNF: A Role for Neutrophil Recruitment?

(2010) B. A. Sayed et al.   JOURNAL OF IMMUNOLOGY

Inhibitory role for GABA in autoimmune inflammation

(2010) R. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Transgenic models for cytokine-induced neurological disease

(2009) Iain L. Campbell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An Autistic Endophenotype Results in Complex Immune Dysfunction in Healthy Siblings of Autistic Children

(2009) Marina Saresella et al.   BIOLOGICAL PSYCHIATRY

Cytokine, Sickness Behavior, and Depression

(2009) Robert Dantzer   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

CD4-Positive T Lymphocytes Provide a Neuroimmunological Link in the Control of Adult Hippocampal Neurogenesis

(2009) S. A. Wolf et al.   JOURNAL OF IMMUNOLOGY

Elevated immune response in the brain of autistic patients

(2009) Xiaohong Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Human-Specific Modulation of Transcriptional Activity Provided by Endogenous Retroviral Insertions

(2009) E. Gogvadze et al.   JOURNAL OF VIROLOGY

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Origin and evolution of the adaptive immune system: genetic events and selective pressures

(2009) Martin F. Flajnik et al.   NATURE REVIEWS GENETICS

CNS Immune Responses Following Experimental Stroke

(2009) Dannielle Zierath et al.   Neurocritical Care

Recombinant T Cell Receptor Ligand Treats Experimental Stroke

(2009) Sandhya Subramanian et al.   STROKE

Adaptive immunity affects learning behavior in mice

(2008) Anna Brynskikh et al.   BRAIN BEHAVIOR AND IMMUNITY

Induction of Immunologic Tolerance to Myelin Basic Protein Prevents Central Nervous System Autoimmunity and Improves Outcome After Stroke

(2008) J. Michael Gee et al.   STROKE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology