Tissue chips to aid drug development and modeling for rare diseases

Animal disease models for drug screening: the elephant in the room?

(2016) Takashi Tsukamoto   DRUG DISCOVERY TODAY

Liver metastases: Microenvironments and ex-vivo models

(2016) Amanda M Clark et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The collaborative network approach: a new framework to accelerate Castleman's disease and other rare disease research

(2016) David C Fajgenbaum et al.   Lancet Haematology

Induced pluripotent stem cells from ALS patients for disease modeling

(2015) Jean-Philippe Richard et al.   BRAIN RESEARCH

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine

(2015) Muluneh M. Fashe et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

(2015) Jin-Young Kim et al.   JOURNAL OF BIOTECHNOLOGY

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

(2015) Mathieu Odijk et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

News Feature: Building benchtop human models

(2015) Amber Dance   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

(2015) Michael P. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioengineering approaches to guide stem cell-based organogenesis

(2014) Nikolche Gjorevski et al.   DEVELOPMENT

Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue

(2014) Kristin M Fabre et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening

(2014) Christopher Heylman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Calcium Transients Closely Reflect Prolonged Action Potentials in iPSC Models of Inherited Cardiac Arrhythmia

(2014) C. Ian Spencer et al.   Stem Cell Reports

Variation in diffusion of gases through PDMS due to plasma surface treatment and storage conditions

(2013) Dmitry A. Markov et al.   BIOMEDICAL MICRODEVICES

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture

(2013) Karl R. Koehler et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells

(2013) Yun Xia et al.   NATURE CELL BIOLOGY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline

(2013) Margaret L Sutherland et al.   Stem Cell Research & Therapy

A new platelet cryoprecipitate glue promoting bone formation after ectopic mesenchymal stromal cell-loaded biomaterial implantation in nude mice

(2013) Marina Trouillas et al.   Stem Cell Research & Therapy

Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels

(2012) Jack D. Wang et al.   ANNALS OF BIOMEDICAL ENGINEERING

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity—An Overview for Applied Toxicology

(2011) Tobias Christian Fuchs et al.   AAPS Journal

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

The potential investment impact of improved access to accelerated approval on the development of treatments for low prevalence rare diseases

(2011) Brigitta E Miyamoto et al.   Orphanet Journal of Rare Diseases

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Electrophysiological characterization of embryonic hippocampal neurons cultured in a 3D collagen hydrogel

(2009) Tao Xu et al.   BIOMATERIALS

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

A Combined Pharmacokinetic–Pharmacodynamic (PK–PD) Model for Tumor Growth in the Rat with UFT Administration

(2008) Jong Hwan Sung et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS