The Role of Organelles in Intestinal Function, Physiology, and Disease

Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn’s disease recurrence

(2020) Sevana Khaloian et al.   GUT

Regulation of intestinal lipid metabolism: current concepts and relevance to disease

(2020) Chih-Wei Ko et al.   Nature Reviews Gastroenterology & Hepatology

Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation

(2020) Antonin Levy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cell atlas of the adult Drosophila midgut

(2020) Ruei-Jiun Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisome Elevation Induces Stem Cell Differentiation and Intestinal Epithelial Repair

(2020) Gang Du et al.   DEVELOPMENTAL CELL

An intestinal zinc sensor regulates food intake and developmental growth

(2020) Siamak Redhai et al.   NATURE

Essential role for autophagy protein ATG7 in the maintenance of intestinal stem cell integrity

(2020) Coralie Trentesaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Grasp55−/− mice display impaired fat absorption and resistance to high-fat diet-induced obesity

(2020) Jiyoon Kim et al.   Nature Communications

Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

(2020) Yanan Sun et al.   eLife

Autophagosome biogenesis and human health

(2020) Tsuyoshi Kawabata et al.   Cell Discovery

Ageing, metabolism and the intestine

(2020) Maja C Funk et al.   EMBO REPORTS

Lipoic acid rejuvenates aged intestinal stem cells by preventing age‐associated endosome reduction

(2020) Gang Du et al.   EMBO REPORTS

Mitochondria regulate intestinal stem cell proliferation and epithelial homeostasis through FOXO

(2020) Fan Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Folding the Mitochondrial UPR into the Integrated Stress Response

(2020) Nadine S. Anderson et al.   TRENDS IN CELL BIOLOGY

The actin nucleator Cobl organises the terminal web of enterocytes

(2020) Anne J. Beer et al.   Scientific Reports

A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein

(2020) Meredith H. Wilson et al.   PLoS Genetics

Dietary cholesterol and apolipoprotein A-I are trafficked in endosomes and lysosomes in the live zebrafish intestine

(2019) Jessica P Otis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling

(2019) Chiwei Xu et al.   Cell Reports

Diet Induced Obesity Alters Intestinal Cytoplasmic Lipid Droplet Morphology and Proteome in the Postprandial Response to Dietary Fat

(2019) Theresa D’Aquila et al.   Frontiers in Physiology

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

(2019) Joep Grootjans et al.   SCIENCE

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

(2019) Emily J. Jones et al.   Disease Models & Mechanisms

Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity

(2019) Prasanna V. Ramachandran et al.   DEVELOPMENTAL CELL

The C. elegans intestine: organogenesis, digestion, and physiology

(2019) Ivan Dimov et al.   CELL AND TISSUE RESEARCH

A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane

(2019) Aurélien Bidaud-Meynard et al.   DEVELOPMENT

An SH3PX1-Dependent Endocytosis-Autophagy Network Restrains Intestinal Stem Cell Proliferation by Counteracting EGFR-ERK Signaling

(2019) Peng Zhang et al.   DEVELOPMENTAL CELL

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

(2019) Anaïs Larabi et al.   Autophagy

Recycling endosomes in mature epithelia restrain tumorigenic signaling

(2019) Luca D'Agostino et al.   CANCER RESEARCH

Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain

(2019) Zhe Cao et al.   Nature Communications

Intestinal lipid droplets as novel mediators of host–pathogen interaction in Drosophila

(2019) Sneh Harsh et al.   Biology Open

Lipid droplet biogenesis

(2019) Catherine L Jackson   CURRENT OPINION IN CELL BIOLOGY

Regulation of cargo export and sorting at the trans‐Golgi network

(2019) Rosaria Di Martino et al.   FEBS LETTERS

A critical role of VMP1 in lipoprotein secretion

(2019) Hideaki Morishita et al.   eLife

Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways

(2019) Bing Huang et al.   CELL

Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut

(2019) Jieun Park et al.   DEVELOPMENTAL CELL

Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine

(2019) Yalong Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

(2019) Steve Cornick et al.   Nature Communications

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

(2019) Evandro F. Fang et al.   Nature Communications

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

(2019) Laura Novellasdemunt et al.   EMBO JOURNAL

Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism

(2019) Aude D. Bouagnon et al.   PLOS BIOLOGY

High fat diet induces microbiota-dependent silencing of enteroendocrine cells

(2019) Lihua Ye et al.   eLife

ER Stress and the UPR in Shaping Intestinal Tissue Homeostasis and Immunity

(2019) Olivia I. Coleman et al.   Frontiers in Immunology

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

(2018) Paul K. Ziegler et al.   CELL

The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism

(2018) Layla Kamareddine et al.   Cell Metabolism

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway

(2018) Kenyi Saito-Diaz et al.   DEVELOPMENTAL CELL

Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease

(2018) Kerstin Schneeberger et al.   Disease Models & Mechanisms

The Function of ATPase Copper Transporter ATP7B in Intestine

(2018) Hannah Pierson et al.   GASTROENTEROLOGY

The enigmatic endosome – sorting the ins and outs of endocytic trafficking

(2018) Naava Naslavsky et al.   JOURNAL OF CELL SCIENCE

A novel requirement for ubiquitin-conjugating enzyme UBC-13 in retrograde recycling of MIG-14/Wntless and Wnt signaling

(2018) Junbing Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content

(2018) Jaakko Mattila et al.   DEVELOPMENTAL CELL

Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy

(2018) Francesca Di Cara et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy maintains stem cells and intestinal homeostasis in Drosophila

(2018) Péter Nagy et al.   Scientific Reports

Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster

(2018) Irene Miguel-Aliaga et al.   GENETICS

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

An alternative mode of epithelial polarity in the Drosophila midgut

(2018) Jia Chen et al.   PLOS BIOLOGY

The VPS34 PI3K negatively regulates RAB-5 during endosome maturation

(2017) Fiona Law et al.   JOURNAL OF CELL SCIENCE

Using primary murine intestinal enteroids to study dietary TAG absorption, lipoprotein synthesis, and the role of apoC-III in the intestine

(2017) Javeed Jattan et al.   JOURNAL OF LIPID RESEARCH

NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model

(2017) Hyun Yang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

(2017) John C. Schell et al.   NATURE CELL BIOLOGY

Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease

(2017) Georg F. Vogel et al.   TRAFFIC

Mitochondrial gene polymorphism is associated with gut microbial communities in mice

(2017) Misa Hirose et al.   Scientific Reports

Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration

(2017) Jumpei Asano et al.   Cell Reports

Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila

(2017) Jung-Kun Wen et al.   eLife

Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer

(2016) Lucie Brisson et al.   CANCER CELL

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

(2016) Carmen Dominguez-Brauer et al.   Cell Stem Cell

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis inCaenorhabditis elegans

(2016) Haarin Chun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

Plasticity of the brush border — the yin and yang of intestinal homeostasis

(2016) Delphine Delacour et al.   Nature Reviews Gastroenterology & Hepatology

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane

(2016) Zeina Soayfane et al.   Nutrition & Metabolism

Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells

(2016) J F van Lidth de Jeude et al.   ONCOGENE

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

Mitochondrial function controls intestinal epithelial stemness and proliferation

(2016) Emanuel Berger et al.   Nature Communications

RAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling Endosomes

(2016) Peixiang Wang et al.   PLoS Genetics

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

(2016) Wakana Ohashi et al.   PLoS Genetics

Recycling endosomes

(2015) James R Goldenring   CURRENT OPINION IN CELL BIOLOGY

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking

(2015) Kerstin Schneeberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

(2015) A. Folick et al.   SCIENCE

Myo5b knockout mice as a model of microvillus inclusion disease

(2015) Fernando Cartón-García et al.   Scientific Reports

PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

(2015) Lifen Wang et al.   PLoS Genetics

Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine

(2015) Daniel N. Frank et al.   PLoS One

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Sara endosomes and the asymmetric division of intestinal stem cells

(2014) C. Montagne et al.   DEVELOPMENT

TLR sorting by Rab11 endosomes maintains intestinal epithelial‐microbial homeostasis

(2014) Shiyan Yu et al.   EMBO JOURNAL

Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease

(2014) Caroline L. Wiegerinck et al.   GASTROENTEROLOGY

Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease

(2014) Byron C. Knowles et al.   JOURNAL OF CLINICAL INVESTIGATION

Trafficking to the Apical and Basolateral Membranes in Polarized Epithelial Cells

(2014) E. H. Stoops et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Secretory cargo sorting at the trans-Golgi network

(2014) Christine Kienzle et al.   TRENDS IN CELL BIOLOGY

An ER Protein Functionally Couples Neutral Lipid Metabolism on Lipid Droplets to Membrane Lipid Synthesis in the ER

(2014) Daniel F. Markgraf et al.   Cell Reports

Rab11a is required for apical protein localisation in the intestine

(2014) T. Sobajima et al.   Biology Open

Atg9 Interacts with dTRAF2/TRAF6 to Regulate Oxidative Stress-Induced JNK Activation and Autophagy Induction

(2013) Hong-Wen Tang et al.   DEVELOPMENTAL CELL

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Peroxisomes take shape

(2013) Jennifer J. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Negative feedback by IRE1  optimizes mucin production in goblet cells

(2013) A. Tsuru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosome-Related Organelles in Intestinal Cells Are a Zinc Storage Site in C. elegans

(2012) Hyun Cheol Roh et al.   Cell Metabolism

The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium

(2012) Alexander Jaschke et al.   HUMAN MOLECULAR GENETICS

RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate

(2012) A. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins

(2011) Céline Revenu et al.   MOLECULAR BIOLOGY OF THE CELL

Peroxisome proliferator-activated receptor-  coactivator 1-  (PGC1 ) is a metabolic regulator of intestinal epithelial cell fate

(2011) I. D'Errico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the Switch in Early-to-Late Endosome Transition

(2010) Dmitry Poteryaev et al.   CELL

A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER

(2010) Shahzad Siddiqi et al.   JOURNAL OF LIPID RESEARCH

TBC-2 Regulates RAB-5/RAB-7-mediated Endosomal Trafficking in Caenorhabditis elegans

(2010) Laëtitia Chotard et al.   MOLECULAR BIOLOGY OF THE CELL

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

(2010) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila

(2009) Donna Denton et al.   CURRENT BIOLOGY

Sec24C is required for docking the prechylomicron transport vesicle with the Golgi

(2009) Shahzad Siddiqi et al.   JOURNAL OF LIPID RESEARCH

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

IRE1β Inhibits Chylomicron Production by Selectively Degrading MTP mRNA

(2008) Jahangir Iqbal et al.   Cell Metabolism

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE

MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity

(2008) Thomas Müller et al.   NATURE GENETICS

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA