Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease

Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy

(2017) Qiang Feng et al.   JOURNAL OF CELL SCIENCE

Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease

(2017) Georg F. Vogel et al.   TRAFFIC

Mechanisms of Cell Polarity–Controlled Epithelial Homeostasis and Immunity in the Intestine

(2017) Leon J. Klunder et al.   Cold Spring Harbor Perspectives in Biology

Identification of intestinal ion transport defects in microvillus inclusion disease

(2016) Dmitri V. Kravtsov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The role of enterocyte defects in the pathogenesis of congenital diarrheal disorders

(2016) Arend W. Overeem et al.   Disease Models & Mechanisms

Control of apico–basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7

(2016) Ivar Noordstra et al.   JOURNAL OF CELL SCIENCE

The zebrafish goosepimples/myosin Vb mutant exhibits cellular attributes of human microvillus inclusion disease

(2016) Jaydeep Sidhaye et al.   MECHANISMS OF DEVELOPMENT

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease

(2015) Grégoire Michaux et al.   BIOLOGY OF THE CELL

Microtubule Minus-End-Targeting Proteins

(2015) Anna Akhmanova et al.   CURRENT BIOLOGY

Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3

(2015) Georg F. Vogel et al.   JOURNAL OF CELL BIOLOGY

Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes

(2015) B. C. Knowles et al.   JOURNAL OF CELL SCIENCE

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking

(2015) Kerstin Schneeberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells

(2015) Mika Toya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myo5b knockout mice as a model of microvillus inclusion disease

(2015) Fernando Cartón-García et al.   Scientific Reports

Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment

(2014) Dmitri Kravtsov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TLR sorting by Rab11 endosomes maintains intestinal epithelial‐microbial homeostasis

(2014) Shiyan Yu et al.   EMBO JOURNAL

Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease

(2014) Caroline L. Wiegerinck et al.   GASTROENTEROLOGY

Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays

(2014) Kelli L VanDussen et al.   GUT

Shaping the intestinal brush border

(2014) Scott W. Crawley et al.   JOURNAL OF CELL BIOLOGY

Myosin Vb and Rab11a regulate phosphorylation of ezrin in enterocytes

(2014) H. S. Dhekne et al.   JOURNAL OF CELL SCIENCE

Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease

(2014) Byron C. Knowles et al.   JOURNAL OF CLINICAL INVESTIGATION

Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location-Specific Function

(2014) Sabine Middendorp et al.   STEM CELLS

Rab11a is required for apical protein localisation in the intestine

(2014) T. Sobajima et al.   Biology Open

Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells

(2013) Elmer Antileo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Myosin-V Opposes Microtubule-Based Cargo Transport and Drives Directional Motility on Cortical Actin

(2013) Lukas C. Kapitein et al.   CURRENT BIOLOGY

Cdc42 Coordinates Proliferation, Polarity, Migration, and Differentiation of Small Intestinal Epithelial Cells in Mice

(2013) Jaime Melendez et al.   GASTROENTEROLOGY

An Overview and Online Registry of Microvillus Inclusion Disease Patients and theirMYO5BMutations

(2013) K. Joeri van der Velde et al.   HUMAN MUTATION

Molecular Motors and Apical CFTR Traffic in Epithelia

(2013) Dmitri Kravtsov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TTC7A mutations disrupt intestinal epithelial apicobasal polarity

(2013) Amélie E. Bigorgne et al.   JOURNAL OF CLINICAL INVESTIGATION

Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium

(2013) Raphael Rapetti-Mauss et al.   JOURNAL OF PHYSIOLOGY-LONDON

Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis

(2013) C Moon et al.   Mucosal Immunology

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due toSTXBP2/MUNC18-2mutations

(2013) Polina Stepensky et al.   PEDIATRIC BLOOD & CANCER

Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost

(2013) A. Fatehullah et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Generation of BAC Transgenic Epithelial Organoids

(2013) Gerald Schwank et al.   PLoS One

Microvillus Inclusion Disease: Loss of Myosin Vb Disrupts Intracellular Traffic and Cell Polarity

(2013) Cornelia E. Thoeni et al.   TRAFFIC

Tethering the assembly of SNARE complexes

(2013) WanJin Hong et al.   TRENDS IN CELL BIOLOGY

Myosin VI is required for maintenance of brush border structure, composition, and membrane trafficking functions in the intestinal epithelial cell

(2012) Peter S. Hegan et al.   Cytoskeleton

Myosin-1A Targets to Microvilli Using Multiple Membrane Binding Motifs in the Tail Homology 1 (TH1) Domain

(2012) Jessica N. Mazerik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells

(2012) Raghuvir Viswanatha et al.   JOURNAL OF CELL BIOLOGY

Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

(2012) Ryotaro Sakamori et al.   JOURNAL OF CLINICAL INVESTIGATION

Rap2A links intestinal cell polarity to brush border formation

(2012) Martijn Gloerich et al.   NATURE CELL BIOLOGY

Structure and dynamics of a primordial catalytic fold generated by in vitro evolution

(2012) Fa-An Chao et al.   Nature Chemical Biology

Tight Junction Pore and Leak Pathways: A Dynamic Duo

(2011) Le Shen et al.   Annual Review of Physiology

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Rab11 Is a Useful Tool for the Diagnosis of Microvillous Inclusion Disease

(2011) Geoffrey Talmon et al.   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Functional Characterization of Mutations in the Myosin Vb Gene Associated With Microvillus Inclusion Disease

(2011) Agata M Szperl et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins

(2011) Céline Revenu et al.   MOLECULAR BIOLOGY OF THE CELL

Severe Hypernatremic Dehydration and Metabolic Acidosis due to Neonatal Intestinal Microvillus Inclusion Disease

(2011) Shaneela Shahid et al.   Neonatology

Ezrin-mediated apical integrity is required for intestinal homeostasis

(2011) J. B. Casaletto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization

(2011) J. T. Roland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light Microscopic Diagnosis of Microvillus Inclusion Disease on Colorectal Specimens Using CD10

(2010) Scott A. Koepsell et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Congenital intractable diarrhea of infancy in Iraqi Jews

(2010) Rachel Straussberg et al.   CLINICAL GENETICS

Loss-of-function of MYO5B is the main cause of microvillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell model

(2010) Frank M. Ruemmele et al.   HUMAN MUTATION

A molecular network for de novo generation of the apical surface and lumen

(2010) David M. Bryant et al.   NATURE CELL BIOLOGY

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of the Actin Remodeler Eps8 Causes Intestinal Defects and Improved Metabolic Status in Mice

(2010) Arianna Tocchetti et al.   PLoS One

Recycling endosomes in apical plasma membrane domain formation and epithelial cell polarity

(2010) Magdalena R. Golachowska et al.   TRENDS IN CELL BIOLOGY

Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex

(2009) Jean Paul ten Klooster et al.   DEVELOPMENTAL CELL

Endocytosis and Recycling of Tight Junction Proteins in Inflammation

(2009) Markus Utech et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Apical trafficking in epithelial cells: signals, clusters and motors

(2009) O. A. Weisz et al.   JOURNAL OF CELL SCIENCE

Lipid raft organization and function in the small intestinal brush border

(2009) E. M. Danielsen et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Plastin 1 Binds to Keratin and Is Required for Terminal Web Assembly in the Intestinal Epithelium

(2009) Eva-Maria S. Grimm-Günter et al.   MOLECULAR BIOLOGY OF THE CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Multi-layered regulation of intestinal antimicrobial defense

(2008) S. Mukherjee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells

(2008) F. A. Wald et al.   JOURNAL OF CELL SCIENCE

Proteomic changes during intestinal cell maturation in vivo

(2008) Jinsook Chang et al.   Journal of Proteomics

MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity

(2008) Thomas Müller et al.   NATURE GENETICS