Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer’s Disease and Parkinson’s Disease Treatment (2011–2020)

Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer’s disease

(2020) Sarfaraz Shaikh et al.   BIOORGANIC CHEMISTRY

Deoxofluorination of (Hetero)aromatic Acids

(2020) Serhii Trofymchuk et al.   JOURNAL OF ORGANIC CHEMISTRY

Multicomponent Pyrazole Synthesis from Alkynes, Nitriles, and Titanium Imido Complexes via Oxidatively Induced N–N Bond Coupling

(2020) Adam J. Pearce et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids

(2020) Eirini Chainoglou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pyrazoles as Key Scaffolds for the Development of Fluorine-18-Labeled Radiotracers for Positron Emission Tomography (PET)

(2020) Pedro M. O. Gomes et al.   MOLECULES

C H functionalization of (hetero)arenes: Direct selanylation mediated by Selectfluor

(2020) Andrei L. Belladona et al.   TETRAHEDRON LETTERS

Primary Vinyl Ethers as Acetylene Surrogate: A Flexible Tool for Deuterium-Labeled Pyrazole Synthesis

(2020) Maria S. Ledovskaya et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

TEMPO-Mediated C–H Amination of Benzoxazoles with N-Heterocycles

(2020) Jian Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Access to α-Pyrazole and α-Triazole Derivatives of Ketones from Oxidative Heteroarylation of Silyl Enolethers

(2020) Sandeep Dhanju et al.   ORGANIC LETTERS

Domino C-H Sulfonylation and Pyrazole Annulation for Fully Substituted Pyrazole Synthesis in Water Using Hydrophilic Enaminones

(2019) Yanhui Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

Apixaban: A Clinical Pharmacokinetic and Pharmacodynamic Review

(2019) Wonkyung Byon et al.   CLINICAL PHARMACOKINETICS

Synthesis of N-Arylpyrazoles by Palladium-Catalyzed Coupling of Aryl Triflates with Pyrazole Derivatives

(2019) Shunsuke Onodera et al.   JOURNAL OF ORGANIC CHEMISTRY

Silver-Mediated [3 + 2] Cycloaddition of Alkynes and N-Isocyanoiminotriphenylphosphorane: Access to Monosubstituted Pyrazoles

(2019) Fanhua Yi et al.   ORGANIC LETTERS

l-(−)-Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles

(2019) Qifan Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Acute Rodent Tolerability, Toxicity, and Radiation Dosimetry Estimates of the S1P1-Specific Radioligand [11C]CS1P1

(2019) Hui Liu et al.   MOLECULAR IMAGING AND BIOLOGY

Pyrrolo[3,4-c]pyrazole Synthesis via Copper(Ι) Chloride-Catalyzed Oxidative Coupling of Hydrazones to Maleimides

(2019) Jia-Nan Zhu et al.   ORGANIC LETTERS

Facile One-Pot Transformation of Primary Alcohols into 3-Aryl- and 3-Alkyl-isoxazoles and -pyrazoles

(2019) Eiji Kobayashi et al.   SYNTHESIS-STUTTGART

Development of pyrazole and spiropyrazoline analogs as multifunctional agents for treatment of Alzheimer’s disease

(2019) Gopichand Gutti et al.   BIOORGANIC CHEMISTRY

A Monophosphine Ligand Derived from Anthracene Photodimer: Synthetic Applications for Palladium-Catalyzed Coupling Reactions

(2019) Xin Wang et al.   ORGANIC LETTERS

Exploiting Synergistic Catalysis for an Ambient Temperature Photocycloaddition to Pyrazoles

(2019) Christopher P. Lakeland et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents

(2019) Holger Rosenbrock et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

HBF4/ACN: A simple and efficient protocol for the synthesis of pyrazoles under ambient reaction conditions

(2019) Roktopol Hazarika et al.   SYNTHETIC COMMUNICATIONS

Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

(2018) Valentina Gandin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

(2018) Khalid Karrouchi et al.   MOLECULES

Phosphine-Free [3+2] Cycloaddition of Propargylamines with Dialkyl Azodicarboxylates: An Efficient Access to Pyrazole Backbone

(2018) Jie Liu et al.   SYNTHESIS-STUTTGART

Some pyrazoles derivatives: Potent carbonic anhydrase, α-glycosidase, and cholinesterase enzymes inhibitors

(2018) Fikret Turkan et al.   ARCHIV DER PHARMAZIE

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

(2018) Masha G. Savelieff et al.   CHEMICAL REVIEWS

Recent Updates In Curcumin Pyrazole and Isoxazole Derivatives: Synthesis and Biological Application

(2018) Satyendra Mishra et al.   CHEMISTRY & BIODIVERSITY

Efficient Copper-Catalyzed Synthesis of Substituted Pyrazoles at Room Temperature

(2018) Haifeng Wang et al.   SYNLETT

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

(2017) Jos Prickaerts et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Decrease of Amyloid-β Levels by Curcumin Derivative via Modulation of Amyloid-β Protein Precursor Trafficking

(2017) Rina Kotani et al.   JOURNAL OF ALZHEIMERS DISEASE

PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8

(2017) Michiaki Okuda et al.   JOURNAL OF ALZHEIMERS DISEASE

Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration

(2017) Nikolay T. Tzvetkov et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease

(2017) Snahel Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium-Catalyzed Tandem C–H Fluoromethylation/Cyclization of N-Alkylhydrazones with CBr3F: Access to 4-Fluoropyrazoles

(2017) Alexis Prieto et al.   JOURNAL OF ORGANIC CHEMISTRY

Fluoroalkyl Amino Reagents for the Introduction of the Fluoro(trifluoromethoxy)methyl Group onto Arenes and Heterocycles

(2017) Etienne Schmitt et al.   ORGANIC LETTERS

Copper-Mediated Domino Cyclization/Trifluoromethylation/Deprotection with TMSCF3: Synthesis of 4-(Trifluoromethyl)pyrazoles

(2017) Quande Wang et al.   ORGANIC LETTERS

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

(2017) Claire E. Le Pichon et al.   Science Translational Medicine

Identification of a New Series of Potent Adenosine A2A Receptor Antagonists Based on 4-Amino-5-carbonitrile Pyrimidine Template for the Treatment of Parkinson’s Disease

(2016) Zhaohui Yang et al.   ACS Chemical Neuroscience

Design and synthesis of curcumin derivatives as tau and amyloid β dual aggregation inhibitors

(2016) Michiaki Okuda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

First-in-human study assessing safety, tolerability and pharmacokinetics of BI 409306, a selective phosphodiesterase 9A inhibitor, in healthy males

(2016) Viktoria Moschetti et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

(2016) Paula Ruiz-Castillo et al.   CHEMICAL REVIEWS

A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns

(2016) Etienne Schmitt et al.   CHEMISTRY-A EUROPEAN JOURNAL

The therapeutic voyage of pyrazole and its analogs: A review

(2016) Mohemmed Faraz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases

(2016) Peng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Radical Addition of Hydrazones by α-Bromo Ketones To Prepare 1,3,5-Trisubstituted Pyrazoles via Visible Light Catalysis

(2016) Xiu-Wei Fan et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible-Light Photocatalytic Aerobic Annulation for the Green Synthesis of Pyrazoles

(2016) Ya Ding et al.   ORGANIC LETTERS

Synthesis of Aminopyrazoles from Isoxazoles: Comparison of Preparative Methods by in situ NMR Analysis

(2016) David Mitchell et al.   SYNTHESIS-STUTTGART

Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies

(2015) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

In Situ Generation of Difluoromethyl Diazomethane for [3+2] Cycloadditions with Alkynes

(2015) Pavel K. Mykhailiuk   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates

(2015) Andreas A. Deeg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson’s disease

(2015) Flavia Niccolini et al.   BRAIN

Selective Incorporation of Fluorine in Pyrazoles

(2015) Joseph C. Sloop et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate

(2015) Junfeng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)

(2015) Snahel Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Pyrazoles from 1,3-Diols via Hydrogen Transfer Catalysis

(2015) Daniel C. Schmitt et al.   ORGANIC LETTERS

I2–TBHP-Catalyzed Oxidative Cross-Coupling of N-Sulfonyl Hydrazones and Isocyanides to 5-Aminopyrazoles

(2015) Gopal Chandru Senadi et al.   ORGANIC LETTERS

nBu3P-Catalyzed Desulfonylative [3 + 2] Cycloadditions of Allylic Carbonates with Arylazosulfones to Pyrazole Derivatives

(2015) Qi Zhang et al.   ORGANIC LETTERS

Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses

(2015) Oksana Lockridge   PHARMACOLOGY & THERAPEUTICS

Gold-catalyzed stereoselective 1,4-conjugate addition of pyrazoles to propiolates and their hydrogenation to β-pyrazolyl acid esters

(2015) Guanglin Luo et al.   TETRAHEDRON LETTERS

Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein

(2015) Nuzhat Ahsan et al.   Scientific Reports

Optimization of 6-Heterocyclic-2-(1H-pyrazol-1-yl)-N-(pyridin-2-yl)pyrimidin-4-amine as Potent Adenosine A2A Receptor Antagonists for the Treatment of Parkinson’s Disease

(2014) Jiyue Zheng et al.   ACS Chemical Neuroscience

Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent

(2014) Guojing Ji et al.   CHEMICAL COMMUNICATIONS

CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson’s disease mice

(2014) Richard L. Jayaraj et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A Multicenter, Double-Blind, Placebo-Controlled Trial of the PDE9A Inhibitor, PF-04447943, in Alzheimer’s Disease

(2014) Elias Schwam et al.   Current Alzheimer Research

Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer’s Disease: A Translational Overview

(2014) P.R.A. Heckman et al.   CURRENT PHARMACEUTICAL DESIGN

Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

(2014) Snahel Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

I2-Mediated Oxidative C–N Bond Formation for Metal-Free One-Pot Synthesis of Di-, Tri-, and Tetrasubstituted Pyrazoles from α,β-Unsaturated Aldehydes/Ketones and Hydrazines

(2014) Xinting Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Preparation of 3,5-Disubstituted Pyrazoles and Isoxazoles from Terminal Alkynes, Aldehydes, Hydrazines, and Hydroxylamine

(2014) Ryo Harigae et al.   JOURNAL OF ORGANIC CHEMISTRY

One-Pot Synthesis of 1,4-Disubstituted Pyrazoles from Arylglycines via Copper-Catalyzed Sydnone–Alkyne Cycloaddition Reaction

(2014) Simon Specklin et al.   JOURNAL OF ORGANIC CHEMISTRY

Levodopa-induced dyskinesias are associated with transient down-regulation of cAMP and cGMP in the caudate-putamen of hemiparkinsonian rats: Reduced synthesis or increased catabolism?

(2014) Giuseppe Sancesario et al.   NEUROCHEMISTRY INTERNATIONAL

Rhodium-Catalyzed Addition–Cyclization of Hydrazines with Alkynes: Pyrazole Synthesis via Unexpected C–N Bond Cleavage

(2014) Deng Yuan Li et al.   ORGANIC LETTERS

One-Pot Oxidation and Rearrangement of Propargylamines and in Situ Pyrazole Synthesis

(2014) Jinshan Chen et al.   ORGANIC LETTERS

An efficient regioselective copper catalyzed multi-component synthesis of 1,3-disubstituted pyrazoles

(2014) Akula Raghunadh et al.   TETRAHEDRON LETTERS

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles

(2013) Feng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice

(2013) Junfang Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Replacement of amide with bioisosteres led to a new series of potent adenosine A2A receptor antagonists

(2013) Zhaohui Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Highly Regioselective Organocatalyzed Synthesis of Pyrazoles from Diazoacetates and Carbonyl Compounds

(2013) Lei Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pyrazole containing natural products: Synthetic preview and biological significance

(2013) Vinod Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

(2013) Christine D. Pozniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of 5-Lipoxygenase in Proteotoxicity and Alzheimer's Disease

(2013) E. Valera et al.   JOURNAL OF NEUROSCIENCE

Cyclocondensation of Arylhydrazines with 1,3-Bis(het)arylmonothio-1,3-diketones and 1,3-Bis(het)aryl-3-(methylthio)-2-propenones: Synthesis of 1-Aryl-3,5-bis(het)arylpyrazoles with Complementary Regioselectivity

(2013) S. Vijay Kumar et al.   JOURNAL OF ORGANIC CHEMISTRY

One-Pot Three-Component Approach to the Synthesis of Polyfunctional Pyrazoles

(2013) Guolin Zhang et al.   ORGANIC LETTERS

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Facile One-Pot Synthesis of 3,5-Disubstituted 1H-Pyrazoles from Propargylic Alcohols via Propargyl Hydrazides

(2013) Chada Raji Reddy et al.   SYNTHESIS-STUTTGART

Tau oligomers and tau toxicity in neurodegenerative disease

(2012) Sarah M. Ward et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases

(2012) L. Pisani et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

(2012) Florence Giornal et al.   JOURNAL OF FLUORINE CHEMISTRY

Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders

(2012) Patrick R. Verhoest et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer’s Disease

(2012) Ling Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fe-Catalyzed One-Pot Synthesis of 1,3-Di- and 1,3,5-Trisubstituted Pyrazoles from Hydrazones and Vicinal Diols

(2012) Niranjan Panda et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Tri- and Tetrasubstituted Pyrazoles via Ru(II) Catalysis: Intramolecular Aerobic Oxidative C–N Coupling

(2012) Jiantao Hu et al.   ORGANIC LETTERS

Efficient one-pot synthesis of substituted pyrazoles

(2012) Meng Tang et al.   TETRAHEDRON

Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A

(2012) Junfeng Li et al.   MedChemComm

Approaches towards the synthesis of 5-aminopyrazoles

(2011) Ranjana Aggarwal et al.   Beilstein Journal of Organic Chemistry

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease

(2011) M Cuadrado-Tejedor et al.   BRITISH JOURNAL OF PHARMACOLOGY

From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles

(2011) Santos Fustero et al.   CHEMICAL REVIEWS

Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives

(2011) Daniel Silva et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Challenges associated with curcumin therapy in Alzheimer disease

(2011) Abdenour Belkacemi et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

(2011) Arundhati Sengupta Ghosh et al.   JOURNAL OF CELL BIOLOGY

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of β-Sheet Ligands Against Aβ42-Induced Toxicity

(2011) Katrin Hochdörffer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Synthesis of Polysubstituted Aluminoisoxazoles and Pyrazoles by a Metalative Cyclization

(2011) Olivier Jackowski et al.   ORGANIC LETTERS

Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson's disease

(2011) Marie Therese Armentero et al.   PHARMACOLOGY & THERAPEUTICS

A simple and efficient synthesis of pyrazoles in water

(2011) Jun Wen et al.   TETRAHEDRON

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib

(2010) Dhimant Desai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Coordination Versatility of Pyrazole-Based Ligands towards High-Nuclearity Transition-Metal and Rare-Earth Clusters

(2010) Marta Viciano-Chumillas et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

(2010) Viktor Lakics et al.   NEUROPHARMACOLOGY

Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†† Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

(2009) Patrick R. Verhoest et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-  Load in an Alzheimer's Disease Mouse Model

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology

(2009) M. Polydoro et al.   JOURNAL OF NEUROSCIENCE

Phosphodiesterase inhibition in heart failure

(2008) Matthew Movsesian et al.   HEART FAILURE REVIEWS

A broadly neuroprotective derivative of curcumin

(2008) Yuanbin Liu et al.   JOURNAL OF NEUROCHEMISTRY

Curcumin-Derived Pyrazoles and Isoxazoles: Swiss Army Knives or Blunt Tools for Alzheimer's Disease?

(2007) Rajeshwar Narlawar et al.   ChemMedChem