Article
Biochemistry & Molecular Biology
Sisi Huang, Kaiyue Wang, Dongyan Huang, Xin Su, Rongfu Yang, Congcong Shao, Juan Jiang, Jianhui Wu
Summary: This study found that lower doses of BPAF can promote dorsal prostatic hyperplasia in rats by interfering with multiple biomarkers in the NF-kappa B signaling pathway. These findings further confirm the toxic effect of BPAF on prostate health and provide important clues to the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kaiyue Wang, Dongyan Huang, Ping Zhou, Xin Su, Rongfu Yang, Congcong Shao, Aicui Ma, Jianhui Wu
Summary: BPA and BPAF can induce prostatic hyperplasia in rats and modulate the regulation of the NF-kB signaling pathway. In addition, combined exposure to BPA and BPAF can also increase proliferation and reduce apoptosis in human prostate cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jeong-Min Hong, Ji-Hong Moon, Young Min Oh, Sang-Youel Park
Summary: The activation of calcineurin and autophagy induced by prion peptide leads to neuroinflammation driven by NF-kappa B, suggesting that calcineurin and autophagy may be potential therapeutic targets for neurodegenerative diseases, including prion disease.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Immunology
Fatima Kanso, Alia Khalil, Hiba Noureddine, Yolla El-Makhour
Summary: NF kappa B-COX-PGs pathway mediates inflammation leading to chronic inflammation, requiring treatment. Anti-inflammatory drugs are effective but come with side effects, hence the need for new safer options like thiosemicarbazones derivatives.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Anna Eisenstein, Brandon K. Hilliard, Scott D. Pope, Cuiling Zhang, Pranali Taskar, Daniel A. Waizman, Kavita Israni-Winger, Hui Tian, Harding H. Luan, Andrew Wang
Summary: A study found that commonly used NSAIDs can induce the production of growth/differentiation factor 15 (GDF15) independently of their COX inhibition properties. This induction is dependent on the activation of nuclear factor erythroid 2-related factor 2 (NRF2) in myeloid cells and requires sensing by Cysteine 151 of the NRF2 chaperone, Kelch-like ECH-associated protein 1 (KEAP1). This discovery highlights a non-canonical NRF2-dependent mechanism for the anti-inflammatory activity of a certain subset of NSAIDs.
Review
Pathology
Lisa J. Schlein, Douglas H. Thamm
Summary: Spontaneous tumors in dogs share similarities with human cancers, making them an attractive model. There is evidence of NF-kB signaling aberration in canine cancers, suggesting that dogs may serve as a good model for studying human cancers with overactivation of NF-kB.
VETERINARY PATHOLOGY
(2022)
Article
Environmental Sciences
Qing-Yuan Zhong, Bing Lin, Yin-Ting Chen, Yin-Ping Huang, Wei-Peng Feng, Ying Wu, Gui-Hong Long, Yun-Nan Zou, Yu Liu, Bao-Qin Lin, Nian-Li Sang, Janis Ya-Xian Zhan
Summary: Male mice are more prone to skin tumor development induced by UV radiation compared to female mice, and they are more sensitive to UV irradiation, leading to greater oxidative stress and inflammatory damage.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Oncology
Hua Zhang, Xiaojin Zhao, Fajun Shang, Huan Sun, Xu Zheng, Jiabin Zhu
Summary: The study reveals that celastrol can effectively inhibit the proliferation of CRC cells by regulating the cell cycle and promoting cell apoptosis. In addition, celastrol also inhibits cell migration and invasion by regulating the expression of specific proteins, thus reducing the malignancy of CRC cells.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Asiya Kamber Zaidi, Puya Dehgani-Mobaraki
Summary: This article discusses the mechanism of action of Ivermectin against SARS-CoV-2 and its potential in preventing complications, summarizing the available literature on the drug over the years.
JOURNAL OF ANTIBIOTICS
(2022)
Article
Pharmacology & Pharmacy
Yasuhiro Yoshioka, Yuta Sugino, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda
Summary: The study demonstrates that dopamine attenuates the expression of proinflammatory cytokines in microglia through the formation of DA quinone in the central nervous system. This anti-inflammatory effect was observed in murine brain tissues under different experimental conditions, highlighting the potential therapeutic implications in neuroinflammatory diseases.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Fisheries
Tong Zhang, Jiejie Sun, Liyan Wang, Hongsheng Yao, Zhicheng Guo, Wei Wu, Yinan Li, Lingling Wang, Linsheng Song
Summary: CgBCL10, a homologue identified in Pacific oysters, plays a crucial role in regulating the expression of inflammatory cytokines by activating MAPK kinase, and nuclear translocation of NF-KB/Rel and AP-1 to defend against pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qian Lu, Chao Jiang, Jialong Hou, Hao Qian, Feifan Chu, Weiqi Zhang, Mengke Ye, Ziyi Chen, Jian Liu, Hanbing Yao, Jianfeng Zhang, Jiake Xu, Te Wang, Shunwu Fan, Qingqing Wang
Summary: The incidence of osteoporosis is increasing, especially in postmenopausal women. Patchouli alcohol (PA), a natural compound with anti-inflammatory effects, has shown inhibitory effects on osteoclasts and may be a potential treatment for osteoporosis in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Ya Gao, Boting Xi, Jiani Li, Zimeng Li, Jie Xu, Mingli Zhong, Qiongmei Xu, Yuanyu Lian, Riming Wei, Liping Wang, Houkang Cao, Ling Jin, Kefeng Zhang, Jianghui Dong
Summary: This study demonstrated that scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB signaling pathway, with the most significant effect observed at high doses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yin-Yuan Su, Yu-Ling Liu, Hsuan-Cheng Huang, Chen-Ching Lin
Summary: This study used an ensemble learning model to identify genes associated with the NF kappa B/TNF signaling pathway in cancer using transcriptome data from the TCGA database. The identified genes were found to be involved in adaptive immunity, anti-apoptosis, and cellular response to cytokine stimuli, and had detrimental effects on patient survival. This research provides valuable insights for the discovery of precise and targeted cancer therapeutics.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vivek Narayan, Kodihalli C. Ravindra, Chang Liao, Naveen Kaushal, Bradley A. Carlson, K. Sandeep Prabhu
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Pramod Kumar, Gajanand Sharma, Varun Gupta, Ramanpreet Kaur, Kanika Thakur, Ruchi Malik, Anil Kumar, Naveen Kaushal, Kaisar Raza
ACS CHEMICAL NEUROSCIENCE
(2018)
Article
Hematology
Pulkit Rastogi, Prashant Sharma, Neelam Varma, Dmitry Sukhachev, Naveen Kaushal, Ishwar Bihana, Man Updesh Singh Sachdeva, Shano Naseem, Pankaj Malhotra
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2018)
Article
Hematology
Pulkit Rastogi, Prashant Sharma, Neelam Varma, Dmitry Sukhachev, Naveen Kaushal, Ishwar Bihana, Man Updesh Singh Sachdeva, Shano Naseem, Pankaj Malhotra
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2018)
Article
Biochemistry & Molecular Biology
Rankaljeet Kaur, Preety Ghanghas, Pulkit Rastogi, Naveen Kaushal
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Immunology
Naveen Kaushal, Avinash K. Kudva, Andrew D. Patterson, Christopher Chiaro, Mary J. Kennett, Dhimant Desai, Shantu Amin, Bradley A. Carlson, Margherita T. Cantorna, K. Sandeep Prabhu
JOURNAL OF IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Ramanpreet Kaur, Shivani Thakur, Pulkit Rastogi, Naveen Kaushal
Article
Pharmacology & Pharmacy
Pramod Kumar, Gajanand Sharma, Varun Gupta, Ramanpreet Kaur, Kanika Thakur, Ruchi Malik, Anil Kumar, Naveen Kaushal, Om Prakash Katare, Kaisar Raza
Article
Toxicology
Mohita Sharma, Ramanpreet Kaur, Kuldeep Kaushik, Naveen Kaushal
TOXICOLOGY MECHANISMS AND METHODS
(2019)
Article
Cardiac & Cardiovascular Systems
Naveen Kaushal, Shallu Dhadwal, Parminder Kaur
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Roobee Garla, Nikita Sharma, Shamli, Naveen Kaushal, Mohan Lal Garg
Summary: Exposure to arsenic results in elevated accumulation of arsenic in liver and kidney tissues, leading to oxidative stress, impaired liver and kidney function, and histological abnormalities. Zinc supplementation can ameliorate these toxic effects by restoring the antioxidant defense system and improving liver and kidney function.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Preety Ghanghas, Monika Sharma, Dhimant Desai, Kaisar Raza, Aman Bhalla, Pramod Kumar, Dipika Narula, Shantu Amin, Sankar Nath Sanyal, Naveen Kaushal
Summary: The study revealed that Se-substituted SAHA (SelSA-1) has higher anti-carcinogenic potential and wider safety profiles in treating colorectal cancer, with better pharmacokinetic data and enhanced chemotherapeutic effects compared to the traditional HDAC inhibitor SAHA.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Cell Biology
Ramanpreet Kaur, Dhimant Desai, Shantu Amin, Kaisar Raza, Aman Bhalla, Pooja Yadav, Naveen Kaushal
Summary: This study demonstrates the translational applicability of a novel class of COX inhibitors containing Selenium for efficiently managing inflammatory disorders such as Ulcerative Colitis (UC). Selenocoxib-3 shows promising pharmacokinetics, therapeutic potential, and safety margins compared to its parent NSAID Celecoxib. It effectively resolves the symptoms of DSS-induced colitis and mitigates inflammation and colon damage.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Rajbinder K. Virk, Roobee Garla, Naveen Kaushal, Mohinder P. Bansal, Mohan L. Garg, Biraja P. Mohanty
Summary: Long term exposure to arsenic through consumption of contaminated groundwater is a global issue, but arsenic compounds are also emerging as potential chemotherapeutic drugs. Arsenic speciation studies have significantly contributed to our understanding of the biological behavior of arsenic in humans, but there are limitations and challenges in interpreting arsenic metabolism. Various technologies have identified hundreds of metabolic arsenic conjugates, but the relationship between these species and the metabolic pathway of arsenic remains unclear. New experimental methodologies have revealed novel biorelevant arsenic species, but there is still a need to focus on identifying and characterizing different types of arsenicals in a comprehensive manner.
Article
Multidisciplinary Sciences
Naveen Kaushal, Megha Gupta, Era Kulshreshtha
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)