Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review
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Title
Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review
Authors
Keywords
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Journal
MOLECULES
Volume 23, Issue 1, Pages 134
Publisher
MDPI AG
Online
2018-01-15
DOI
10.3390/molecules23010134
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- Design, synthesis, characterization and anti-inflammatory evaluation of novel pyrazole amalgamated flavones
- (2013) Hemant V. Chavan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues
- (2013) Jonathan M. Large et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel pyrazole integrated 1,3,4-oxadiazoles: Synthesis, characterization and antimicrobial evaluation
- (2013) Srikantamurthy Ningaiah et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis, anticancer activity and DNA-binding properties of novel 4-pyrazolyl-1,8-naphthalimide derivatives
- (2013) Shenghui Li et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2)
- (2013) Yong Xu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation
- (2013) Hardik H. Jardosh et al. CHINESE CHEMICAL LETTERS
- Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents
- (2013) Fatma A. Ragab et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Novel chiral ferrocenylpyrazolo[1,5-a][1,4]diazepin-4-one derivatives – Synthesis, characterization and inhibition against lung cancer cells
- (2013) Shi-Li Shen et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, biological evaluation and molecular docking studies of pyrazole derivatives coupling with a thiourea moiety as novel CDKs inhibitors
- (2013) Jian Sun et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of pyrazole as C-terminus of selective BACE1 inhibitors
- (2013) Yiquan Zou et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, biological evaluation and molecular modeling study of 5-trifluoromethyl-Δ2-pyrazoline and isomeric 5/3-trifluoromethylpyrazole derivatives as anti-inflammatory agents
- (2013) Ranjana Aggarwal et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, diversity-oriented synthesis and structure activity relationship studies of quinolinyl heterocycles as antimycobacterial agents
- (2013) Venkatesham Rachakonda et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, hypoglycemic activity and molecular modeling studies of pyrazole-3-carbohydrazides designed by a CoMFA model
- (2013) Eduardo Hernández-Vázquez et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Development of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors
- (2013) Ganesh Samala et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design and stereoselective synthesis of novel isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents
- (2013) Song-Lin Zhu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazoles
- (2013) Wedad M. Al-Adiwish et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents
- (2013) A.M. Vijesh et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole
- (2013) Marta E. López-Viseras et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells
- (2013) Vassilios Bavetsias et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Hepatitis C Virus NS3-4A Protease Inhibitors with Improved Barrier to Resistance and Favorable Liver Distribution
- (2013) Benoît Moreau et al. JOURNAL OF MEDICINAL CHEMISTRY
- Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure
- (2013) David A. Griffith et al. JOURNAL OF MEDICINAL CHEMISTRY
- Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting InhA in Mycobacterium tuberculosis
- (2013) Pravin S. Shirude et al. JOURNAL OF MEDICINAL CHEMISTRY
- Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform
- (2013) Bimbisar Desai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch
- (2013) Gary Probst et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
- (2013) Anthony A. Estrada et al. JOURNAL OF MEDICINAL CHEMISTRY
- A facile access to 1,3,4-trisubstituted pyrazoles via 1,3-dipolar cycloaddition of 3-arylsydnones with α,β-unsaturated ketones
- (2013) Fei Chen et al. MONATSHEFTE FUR CHEMIE
- Synthesis and insecticidal activities of novel pyrazole oxime ether derivatives with different substituted pyridyl rings
- (2013) Cuirong Fu et al. PEST MANAGEMENT SCIENCE
- Synthesis, characterization and anti-proliferative activity of Cd(II) complexes with NNN type pyrazole-based ligand and pseudohalide ligands as coligand
- (2013) Cigdem Hopa et al. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
- Copper on iron promoted one-pot synthesis of β-aminoenones and 3,5-disubstituted pyrazoles
- (2013) Szabolcs Kovács et al. TETRAHEDRON
- Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes
- (2013) Narihiro Toda et al. ACS Medicinal Chemistry Letters
- Aminopyrazole–Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies
- (2013) Ming Yu et al. ACS Medicinal Chemistry Letters
- Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1H-azoles as New Class of Antitubercular and Antimicrobial Agents
- (2013) Namrata Anand et al. ACS Medicinal Chemistry Letters
- Copper triflate-mediated synthesis of 1,3,5-triarylpyrazoles in [bmim][PF6] ionic liquid and evaluation of their anticancer activities
- (2013) V. Kameshwara Rao et al. RSC Advances
- Synthesis, characterization, antimicrobial, anticancer, and antituberculosis activity of some new pyrazole, isoxazole, pyrimidine and benzodiazepine derivatives containing thiochromeno and benzothiepino moieties
- (2013) Pandaram Palanisamy et al. RSC Advances
- Novel Pyrazole and Indazole Derivatives: Synthesis and Evaluation of Their Anti-Proliferative and Anti-Angiogenic Activities
- (2012) Evangelia Tzanetou et al. ARCHIV DER PHARMAZIE
- Synthesis and Antimalarial Activity of Substituted Pyrazole Derivatives
- (2012) José Domínguez et al. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
- Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists
- (2012) Satoshi Yamamoto et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
- (2012) Tomohiro Yoshida et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and biological validation of novel pyrazole derivatives with anticancer activity guided by 3D-QSAR analysis
- (2012) Ines Vujasinović et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors
- (2012) Ke-Ming Qiu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase
- (2012) M. Emilia Di Francesco et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2
- (2012) Magda A.-A. El-Sayed et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Structure–activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia
- (2012) Nobuhiko Fushimi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives
- (2012) Ravindra B. Pathak et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents
- (2012) Xi Li et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives
- (2012) Xiao-Guang Bai et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors
- (2012) Lavinia Baciu-Atudosie et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis of pyrazole peptidomimetics and their inhibition against A549 lung cancer cells
- (2012) Ying-Rui Liu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- 4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators
- (2012) Hermogenes N. Jimenez et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives
- (2012) Sharad N. Shelke et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents
- (2012) Ahmed Kamal et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor
- (2012) Kentaro Futatsugi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and insecticidal evaluation of novel N-pyridylpyrazolecarboxamides containing cyano substituent in the ortho-position
- (2012) Mingzhen Mao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and anti-TMV activity of novel N-(3-alkyl-1H-pyrazol-4-yl)-3-alkyl-4-substituted-1H-pyrazole-5-carboxamides
- (2012) Da Qiang Zhang et al. CHINESE CHEMICAL LETTERS
- Synthesis of ferrocenyl pyrazole-containing chiral aminoethanol derivatives and their inhibition against A549 and H322 lung cancer cells
- (2012) Shi-Li Shen et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of novel pyrazolo[3,4-d]pyrimidine derivatives as potential anti-breast cancer agents
- (2012) Mohammed K. Abd El Hamid et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, antitumor, cytotoxic and antioxidant evaluation of some new pyrazolotriazines attached to antipyrine moiety
- (2012) M.A. Metwally et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents
- (2012) Pushpan Puthiyapurayil et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA)
- (2012) Ming-Xia Song et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates
- (2012) Paola Hernández et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Insecticidal Activity of Novel Pyrazole Derivatives Containing α-Hydroxymethyl-N-benzyl Carboxamide, α-Chloromethyl-N-benzyl Carboxamide, and 4,5-Dihydrooxazole Moieties
- (2012) Hongjian Song et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Synthesis, characterization, and in vitro biological studies of some novel pyran fused pyrimidone derivatives
- (2012) Prashant T. Mistry et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Discovery of a Novel Glucagon Receptor Antagonist N-[(4-{(1S)-1-[3-(3, 5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the Treatment of Type II Diabetes
- (2012) Yusheng Xiong et al. JOURNAL OF MEDICINAL CHEMISTRY
- N-[5-(5-Fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate
- (2012) Riccardo Zanaletti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia
- (2012) Vassilios Bavetsias et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)
- (2012) Riccardo Zanaletti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer
- (2012) J. Jean Cui et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors
- (2012) Emily J. Hanan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Non-nucleoside Inhibitors of the Measles Virus RNA-Dependent RNA Polymerase: Synthesis, Structure–Activity Relationships, and Pharmacokinetics
- (2012) J. Maina Ndungu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and antitubercular activity of novel pyrazole–quinazolinone hybrid analogs
- (2012) Unnat Pandit et al. MEDICINAL CHEMISTRY RESEARCH
- Coumarinyl pyrazole derivatives of INH: promising antimycobacterial agents
- (2012) Prashant Aragade et al. MEDICINAL CHEMISTRY RESEARCH
- Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives
- (2012) Zhibing Wu et al. MOLECULES
- Synthesis and Bioactivity of Pyrazole Acyl Thiourea Derivatives
- (2012) Jian Wu et al. MOLECULES
- 4-(1H-Pyrazol-1-yl) Benzenesulfonamide Derivatives: Identifying New Active Antileishmanial Structures for Use against a Neglected Disease
- (2012) Roberta Marra et al. MOLECULES
- Reaction of pregnenolone with cyanoacetylhydrazine: Novel synthesis of hydrazide–hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations
- (2012) Rafat M. Mohareb et al. STEROIDS
- Heterocyclizations of pregnenolone: Novel synthesis of thiosemicarbazone, thiophene, thiazole, thieno[2,3-b]pyridine derivatives and their cytotoxicity evaluations
- (2012) Rafat M. Mohareb et al. STEROIDS
- Syntheses of 2-(trifluoromethyl)-1,3-dicarbonyl compounds through direct trifluoromethylation with CF3I and their application to fluorinated pyrazoles syntheses
- (2012) Yuhki Ohtsuka et al. TETRAHEDRON
- One-pot synthesis and antiproliferative evaluation of pyrazolo[3,4-d]pyrimidine derivatives
- (2012) Yu-Ying Huang et al. TETRAHEDRON
- ‘One-pot’ synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates via lithium tert-butoxide-mediated sterically hindered Claisen condensation and Knorr reaction
- (2012) Jian-An Jiang et al. TETRAHEDRON
- Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
- (2012) Junwon Kim et al. ACS Medicinal Chemistry Letters
- Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor
- (2012) Bryan K. Chan et al. ACS Medicinal Chemistry Letters
- Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study
- (2011) Magda A.-A. El-Sayed et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamides
- (2011) Kentaro Rikimaru et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis of novel pyrazolo[1,5- a ]pyrazin-4(5 H )-one derivatives and their inhibition against growth of A549 and H322 lung cancer cells
- (2011) Liang-Wen Zheng et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives
- (2011) Maurício S. dos Santos et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2′ region
- (2011) Michael S. Malamas et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of novel antitubercular 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues
- (2011) Mohamed Jawed Ahsan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and biological evaluation of some novel N-aryl-1,4-dihydropyridines as potential antitubercular agents
- (2011) Amit R. Trivedi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors
- (2011) Cheng Hua Jin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis, antitubercular evaluation and 3D-QSAR study of N-phenyl-3-(4-fluorophenyl)-4-substituted pyrazole derivatives
- (2011) R.C. Khunt et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles
- (2011) Santos Fustero et al. CHEMICAL REVIEWS
- Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity
- (2011) Alessandro Balbi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives
- (2011) Datong Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives
- (2011) A.M. Vijesh et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and biological evaluation of some 4-functionalized-pyrazoles as antimicrobial agents
- (2011) Pawan K. Sharma et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives
- (2011) Daniel Silva et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- N-Aryl-2-phenyl-2,3-dihydro-imidazo[1,2-b]pyrazole-1-carboxamides 7-substituted strongly inhibiting both fMLP-OMe- and IL-8-induced human neutrophil chemotaxis
- (2011) Chiara Brullo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and biological evaluation of pyrazole derivatives as potential multi-kinase inhibitors in hepatocellular carcinoma
- (2011) Elena Strocchi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of pyrazolo[3,4-b]pyridines under microwave irradiation in multi-component reactions and their antitumor and antimicrobial activities – Part 1
- (2011) M.A. El-borai et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents
- (2011) Li-Li Xu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and antitumor evaluation of some new 1,3,4-oxadiazole-based heterocycles
- (2011) Samir Bondock et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and antiviral activity of novel pyrazole amides containing α-aminophosphonate moiety
- (2011) Lintao Wu et al. JOURNAL OF HETEROCYCLIC CHEMISTRY
- Platinum(II) and palladium(II) complexes with (N,N′) and (C,N,N′)− ligands derived from pyrazole as anticancer and antimalarial agents: Synthesis, characterization and in vitro activities
- (2011) Josefina Quirante et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Novel Orally Active Antimalarial Thiazoles
- (2011) Diego González Cabrera et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and antileishmanial activity of new 1-aryl-1H-pyrazole-4-carboximidamides derivatives
- (2011) Maurício S. dos Santos et al. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
- Synthesis and antiviral activity of new 3-methyl-1,5-diphenyl-1H-pyrazole derivatives
- (2011) Atif S. Tantawy et al. MEDICINAL CHEMISTRY RESEARCH
- Synthesis and anti-inflammatory activity of some pyrazole derivatives
- (2011) Samir M. El-Moghazy et al. MEDICINAL CHEMISTRY RESEARCH
- Synthesis and anti-tubercular evaluation of some novel pyrazolo[3,4-d]pyrimidine derivatives
- (2011) Amit R. Trivedi et al. MEDICINAL CHEMISTRY RESEARCH
- Synthesis, characterization and antimicrobial activity of novel ethyl 1-(N-substituted)-5-phenyl-1H-pyrazole-4-carboxylate derivatives
- (2011) B. Chandrakantha et al. MEDICINAL CHEMISTRY RESEARCH
- Synthesis and antimicrobial activities of some isoxazolyl thiazolyl pyrazoles
- (2011) Satbir Mor et al. MEDICINAL CHEMISTRY RESEARCH
- Design, synthesis and insecticidal activities of novel pyrazole amides containing hydrazone substructures
- (2011) Jian Wu et al. PEST MANAGEMENT SCIENCE
- Synthesis, characterization and antibacterial activity of some new pyrazole based Schiff bases
- (2011) Shridhar Malladi et al. Arabian Journal of Chemistry
- Microwave-assisted synthesis, characterization and biological activity of novel pyrazole derivatives
- (2011) Theivendren Panneer Selvam et al. Journal of Saudi Chemical Society
- Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents
- (2010) Babasaheb P. Bandgar et al. BIOORGANIC & MEDICINAL CHEMISTRY
- 1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPARγ partial agonists
- (2010) Jiwon Choi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: Aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif
- (2010) Dai-Shi Su et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes
- (2010) Robert P. Brigance et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- N-Heterocyclic derived M1 positive allosteric modulators
- (2010) Scott D. Kuduk et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells
- (2010) Liang-Wen Zheng et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies
- (2010) Morshed A. Chowdhury et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core
- (2010) Dong-Ming Shen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Non-oxime pyrazole based inhibitors of B-Raf kinase
- (2010) Bradley J. Newhouse et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel Anti-inflammatory Agents Based on Pyrazole Based Dimeric Compounds; Design, Synthesis, Docking and in Vivo Activity
- (2010) Ashish Kumar Tewari et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Synthesis and biological evaluation of some pyrazolylpyrazolines as anti-inflammatory–antimicrobial agents
- (2010) Pawan K. Sharma et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline
- (2010) K.S. Girisha et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of new pyrazole derivatives and their anticancer evaluation
- (2010) George Mihai Nitulescu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Herbicidal Activity of NovelN-(2,2,2)-Trifluoroethylpyrazole Derivatives
- (2010) Hong-Ju Ma et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Design, Synthesis and Insecticidal Activity of Novel Phenylpyrazoles Containing a 2,2,2-Trichloro-1-alkoxyethyl Moiety
- (2010) Qiqi Zhao et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Synthesis, anti-HSV-1, and cytotoxic activities of some new pyrazole- and isoxazole-based heterocycles
- (2010) Kamal M. Dawood et al. MEDICINAL CHEMISTRY RESEARCH
- Synthesis and antimicrobial screening of N-(1-methyl-1H-pyrazole-4-carbonyl)-thiourea derivatives
- (2010) George M. Nitulescu et al. MEDICINAL CHEMISTRY RESEARCH
- A Modular Sydnone Cycloaddition/Suzuki−Miyaura Cross-Coupling Strategy to Unsymmetrical 3,5-Bis(hetero)aromatic Pyrazoles
- (2010) Thierry Delaunay et al. ORGANIC LETTERS
- Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells
- (2009) Liang-Wen Zheng et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones
- (2009) Daniele Castagnolo et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and discovery of pyrazole-5-carbohydrazide N-glycosides as inducer of autophagy in A549 lung cancer cells
- (2009) Song Lian et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Pyrazole NNRTIs 1: Design and initial optimisation of a novel template
- (2009) Charles E. Mowbray et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors
- (2009) Paul S. Humphries et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pyrazole NNRTIs 4: Selection of UK-453,061 (lersivirine) as a Development Candidate
- (2009) Charles E. Mowbray et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells
- (2009) Xiao-Ling Ding et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase
- (2009) Shyama Sidique et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and antiviral activity of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) against peste des petits ruminant virus (PPRV)
- (2009) Kuppusamy Sujatha et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives
- (2009) A. Padmaja et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1 H )-pyrazole derivatives
- (2009) Franco Chimenti et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and antimicrobial activities of novel 1,5-diaryl pyrazoles
- (2009) R. Venkat Ragavan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- New pyrazoles incorporating pyrazolylpyrazole moiety: Synthesis, anti-HCV and antitumor activity
- (2009) Sayed M. Riyadh et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Biological Activity of New (E)-α-(Methoxyimino)benzeneacetate Derivatives Containing a Substituted Pyrazole Ring†
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- Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus
- (2009) Jason M. Uslaner et al. NEUROPHARMACOLOGY
- New one-pot synthesis of pyrazole-5-carboxylates by 1,3-dipole cycloadditions of ethyl diazoacetate with α-methylene carbonyl compounds
- (2009) Antimo Gioiello et al. TETRAHEDRON LETTERS
- 1,3-Dipolar cycloaddition of diazoacetate compounds to terminal alkynes promoted by Zn(OTf)2: an efficient way to the preparation of pyrazoles
- (2009) Sheng He et al. TETRAHEDRON LETTERS
- Synthesis and antibacterial activity of some new derivatives of pyrazole
- (2009) Mohammad Rahimizadeh et al. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
- Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives
- (2008) Aymn E. Rashad et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis of new 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines: A search for novel nitric oxide donor anti-inflammatory agents
- (2008) Morshed Alam Chowdhury et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis
- (2008) Daniele Castagnolo et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and exploration of novel curcumin analogues as anti-malarial agents
- (2008) Satyendra Mishra et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group
- (2008) Guiping Ouyang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and discovery of autophagy inducers for A549 and H460 lung cancer cells, novel 1-(2′-hydroxy-3′-aroxypropyl)-3-aryl-1H-pyrazole-5-carbohydrazide derivatives
- (2008) Chuan-Dong Fan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors
- (2008) Li-Fan Zeng et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators
- (2008) Colleen M. Niswender et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy
- (2008) Adrian Hall et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and in vitro antimycobacterial activity of 3-substituted 5-hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-1-(isonicotinoyl) pyrazoles
- (2008) Pedro E. Almeida da Silva et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Synthesis and Antiviral Activities of Pyrazole Derivatives Containing an Oxime Moiety
- (2008) Guiping Ouyang et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Synthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents
- (2008) Adnan A. Bekhit et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- 5-tert-Butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide Derivatives as Novel Potent Inhibitors ofMycobacterium tuberculosisPantothenate Synthetase: Initiating a Quest for New Antitubercular Drugs
- (2008) Subash Velaparthi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of New Fluorinated Tebufenpyrad Analogs with Acaricidal Activity Through Regioselective Pyrazole Formation
- (2008) Santos Fustero et al. JOURNAL OF ORGANIC CHEMISTRY
- Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]- triazolo[1,5-c]pyrimidine Derivatives
- (2008) Nada Abunada et al. MOLECULES
- A pyrazole derivative of curcumin enhances memory
- (2008) Pamela Maher et al. NEUROBIOLOGY OF AGING
- Base-Mediated Reaction of Hydrazones and Nitroolefins with a Reversed Regioselectivity: A Novel Synthesis of 1,3,4-Trisubstituted Pyrazoles
- (2008) Xiaohu Deng et al. ORGANIC LETTERS
- Straightforward and Regiospecific Synthesis of Pyrazole-5-carboxylates from Unsymmetrical Enaminodiketones
- (2008) Marcos Martins et al. SYNLETT
- Synthesis of pyrazole-3-carboxylates and pyrazole-1,5-dicarboxylates by one-pot cyclization of hydrazone dianions with diethyl oxalate
- (2008) Tung T. Dang et al. TETRAHEDRON
- A novel synthesis of 1,3,5-trisubstituted pyrazoles through a spiro-pyrazoline intermediate via a tandem 1,3-dipolar cycloaddition/elimination
- (2008) Sureshbabu Dadiboyena et al. TETRAHEDRON LETTERS
- Cost-Utility Analysis of Rimonabant in the Treatment of Obesity
- (2008) Christian Hampp et al. VALUE IN HEALTH
- Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives
- (2007) Ahmad M. Farag et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents
- (2007) Adnan A. Bekhit et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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