Selective Incorporation of Fluorine in Pyrazoles

Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2and electron-deficient alkynes

(2015) Pavel K Mykhailiuk   Beilstein Journal of Organic Chemistry

“On water” synthesis of N-unsubstituted pyrazoles: semicarbazide hydrochloride as an alternative to hydrazine for preparation of pyrazole-3-carboxylate derivatives and 3,5-disubstituted pyrazoles

(2015) Violeta Marković et al.   GREEN CHEMISTRY

Synthesis and charge density determination of 4,4-difluoro-3,5-diphenyl-4H-pyrazole and a hydrate derivative

(2015) LeAnn Walton et al.   JOURNAL OF FLUORINE CHEMISTRY

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

(2015) Hélène Munier-Lehmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes

(2015) Pavel K. Mykhailiuk   ORGANIC & BIOMOLECULAR CHEMISTRY

Green synthesis and pharmacological screening of polyhydroquinoline derivatives bearing a fluorinated 5-aryloxypyrazole nucleus

(2015) Sharad C. Karad et al.   RSC Advances

Multigram Synthesis of Fluoroalkyl-Substituted Pyrazole-4-carboxylic Acids

(2014) Rustam T. Iminov et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2Generated in situ: Optimized Synthesis of Tris(trifluoromethyl)pyrazole

(2014) Evgeniy Y. Slobodyanyuk et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

One-Pot Synthesis of 1,4-Disubstituted Pyrazoles from Arylglycines via Copper-Catalyzed Sydnone–Alkyne Cycloaddition Reaction

(2014) Simon Specklin et al.   JOURNAL OF ORGANIC CHEMISTRY

Design, Synthesis and Fungicidal Activities of Some Novel Pyrazole Derivatives

(2014) Xue-Ru Liu et al.   MOLECULES

A New Synthesis and Process Development of Bis(fluoroalkyl)pyrazoles As Novel Agrophores

(2014) Florence Giornal et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of Fluorinated and Nonfluorinated Tebufenpyrad Analogues for the Study of Anti-angiogenesis MOA

(2014) Raquel Román et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Direct Noncatalytic Electrophilic Trifluoroacetylation of Electron-Rich Pyrazoles

(2014) Pavel Mykhailiuk et al.   SYNTHESIS-STUTTGART

One-pot to fused pyrazoles by a double cyclization of o-alkynylaldehydes with ketones and hydrazine under metal-free condition

(2014) Jinxia Qiao et al.   TETRAHEDRON

A concise approach to CF3-containing furan-3-ones, (bis)pyrazoles from novel fluorinated building blocks based on 2,3-butanedione

(2014) Denis N. Bazhin et al.   TETRAHEDRON LETTERS

Efficacy of Fall- and Spring-Applied Pyroxasulfone For Herbicide-Resistant Weeds in Field Pea

(2014) Breanne D. Tidemann et al.   WEED TECHNOLOGY

Thermally robust and porous noncovalent organic framework with high affinity for fluorocarbons and CFCs

(2014) Teng-Hao Chen et al.   Nature Communications

Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles

(2013) Feng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

A New Life for an Old Reagent: Fluoroalkyl Amino Reagents as Efficient Tools for the Synthesis of Diversely Fluorinated Pyrazoles

(2013) Sergiy Pazenok et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Direct Electrophilic Acylation of N-Substituted Pyrazoles by Anhydrides of Carboxylic Acids

(2013) Ilya Taydakov et al.   SYNTHESIS-STUTTGART

Synthesis of pyrazoles with fluorinated side-chain by cyclization of fluoroalkylated triketides

(2013) Willi Desens et al.   TETRAHEDRON

Direct Electrophilic N-Trifluoromethylation of Azoles by a Hypervalent Iodine Reagent

(2012) Katrin Niedermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preparation and Chemistry of 3/5-Halogenopyrazoles

(2012) Yves L. Janin   CHEMICAL REVIEWS

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

(2012) Florence Giornal et al.   JOURNAL OF FLUORINE CHEMISTRY

A General and Regioselective Synthesis of 5-Trifluoromethyl-pyrazoles

(2012) Robert S. Foster et al.   ORGANIC LETTERS

Effect of bixafen on senescence and yield formation of wheat

(2012) C.A. Berdugo et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Syntheses of 2-(trifluoromethyl)-1,3-dicarbonyl compounds through direct trifluoromethylation with CF3I and their application to fluorinated pyrazoles syntheses

(2012) Yuhki Ohtsuka et al.   TETRAHEDRON

From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles

(2011) Santos Fustero et al.   CHEMICAL REVIEWS

Synthesis of 3-Amino-4-fluoropyrazoles

(2011) Riccardo Surmont et al.   JOURNAL OF ORGANIC CHEMISTRY

“Reported, but Still Unknown.” A Closer Look into 3,4-Bis- and 3,4,5-Tris(trifluoromethyl)pyrazoles

(2011) Igor I. Gerus et al.   JOURNAL OF ORGANIC CHEMISTRY

Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block

(2011) Lucilla Levi et al.   MOLECULES

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

A Novel Synthesis of Fluorinated Pyrazoles via Gold(I)-Catalyzed Tandem Aminofluorination of Alkynes in the Presence of Selectfluor

(2011) Jianqiang Qian et al.   ORGANIC LETTERS

Efficient Synthesis of Pyrazoles: Oxidative CC/NN Bond-Formation Cascade

(2010) Julia J. Neumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and anti-microbial activity of some new fluorinated 1H-pyrazoles

(2010) Dun-Jia Wang et al.   JOURNAL OF FLUORINE CHEMISTRY

New Synthesis of Fluorinated Pyrazoles

(2010) Riccardo Surmont et al.   ORGANIC LETTERS

Microwave-mediated pyrazole fluorinations using selectfluor®

(2009) Joseph C. Sloop et al.   HETEROATOM CHEMISTRY

Trifluoromethylation of various aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide

(2009) Tatsuhito Kino et al.   JOURNAL OF FLUORINE CHEMISTRY

Recent Advances in the Synthesis of Pyrazoles. A Review

(2009) Santos Fustero et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Reaction of 3-(polyfluoroacyl)chromones with hydrazines: new regioselective synthesis of RF-containing pyrazoles

(2009) V. Ya. Sosnovskikh et al.   RUSSIAN CHEMICAL BULLETIN

Microwave-assisted aliphatic fluorine–chlorine exchange using triethylamine trihydrofluoride (TREAT-HF)

(2009) Jennifer M. Kremsner et al.   TETRAHEDRON LETTERS

Molecular Imaging with PET

(2008) Simon M. Ametamey et al.   CHEMICAL REVIEWS

Improved Regioselectivity in Pyrazole Formation through the Use of Fluorinated Alcohols as Solvents: Synthesis and Biological Activity of Fluorinated Tebufenpyrad Analogs

(2008) Santos Fustero et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Synthesis of 1,3,5-Tri- and 1,3,4,5-Tetrasubstituted Pyrazoles fromN-Arylhydrazones and Nitroolefins

(2008) Xiaohu Deng et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of New Fluorinated Tebufenpyrad Analogs with Acaricidal Activity Through Regioselective Pyrazole Formation

(2008) Santos Fustero et al.   JOURNAL OF ORGANIC CHEMISTRY

Base-Mediated Reaction of Hydrazones and Nitroolefins with a Reversed Regioselectivity:  A Novel Synthesis of 1,3,4-Trisubstituted Pyrazoles

(2008) Xiaohu Deng et al.   ORGANIC LETTERS

N-Arylation of nitrogen heterocycles with 2,4-difluoroiodobenzene

(2008) Rukkiat Jitchati et al.   TETRAHEDRON

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS