4.8 Article

Synthesis of Pyrazoles from 1,3-Diols via Hydrogen Transfer Catalysis

Journal

ORGANIC LETTERS
Volume 17, Issue 6, Pages 1405-1408

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00266

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1,3-Diols engage in ruthenium-catalyzed hydrogen transfer in the presence of alkyl hydrazines to provide 1,4-disubstituted pyrazoles. Regioselective synthesis of unsymmetrical pyrazoles from beta-hydroxy ketones is also described.

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