Pyrazoles as Key Scaffolds for the Development of Fluorine-18-Labeled Radiotracers for Positron Emission Tomography (PET)
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pyrazoles as Key Scaffolds for the Development of Fluorine-18-Labeled Radiotracers for Positron Emission Tomography (PET)
Authors
Keywords
-
Journal
MOLECULES
Volume 25, Issue 7, Pages 1722
Publisher
MDPI AG
Online
2020-04-10
DOI
10.3390/molecules25071722
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Evaluation of the novel TSPO radiotracer 2-(7-butyl-2-(4-(2-([ 18 F]fluoroethoxy)phenyl)-5-methylpyrazolo[1,5- a ]pyrimidin-3-yl)- N , N -diethylacetamide in a preclinical model of neuroinflammation
- (2018) Dewei Tang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Current progress on antioxidants incorporating the pyrazole core
- (2018) Vera L.M. Silva et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Prolonged hematopoietic and myeloid cellular response in patients after an acute coronary syndrome measured with 18F-DPA-714 PET/CT
- (2018) Simone L. Verweij et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Preclinical Evaluation of a Novel TSPO PET Ligand 2-(7-Butyl-2-(4-(2-[18F]Fluoroethoxy)phenyl)-5-Methylpyrazolo[1,5-a]Pyrimidin-3-yl)-N,N-Diethylacetamide (18F-VUIIS1018A) to Image Glioma
- (2018) Dewei Tang et al. MOLECULAR IMAGING AND BIOLOGY
- Development of two fluorine-18 labeled PET radioligands targeting PDE10A and in vivo PET evaluation in nonhuman primates
- (2018) Vladimir Stepanov et al. NUCLEAR MEDICINE AND BIOLOGY
- Pharmacology of Adenosine Receptors: The State of the Art
- (2018) Pier Andrea Borea et al. PHYSIOLOGICAL REVIEWS
- Novel potential pyrazolopyrimidine based translocator protein ligands for the evaluation of neuroinflammation with PET
- (2018) Young-Do Kwon et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- [18F]F-DPA for the detection of activated microglia in a mouse model of Alzheimer's disease
- (2018) Thomas Keller et al. NUCLEAR MEDICINE AND BIOLOGY
- Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist
- (2018) Chun-Ping Chang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety
- (2018) Mohammed S. Abdel-Maksoud et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET
- (2018) Marloes H. J. Hagens et al. Journal of Neuroinflammation
- PET/CT-guided interventions: Indications, advantages, disadvantages and the state of the art
- (2017) Roberto Luigi Cazzato et al. MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
- [18F]DPA-714 PET Imaging Reveals Global Neuroinflammation in Zika Virus-Infected Mice
- (2017) Kyle Kuszpit et al. MOLECULAR IMAGING AND BIOLOGY
- Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats
- (2017) Thomas Keller et al. MOLECULAR IMAGING AND BIOLOGY
- Synthesis of Chromone-Related Pyrazole Compounds
- (2017) Clementina Santos et al. MOLECULES
- Review: biologically active pyrazole derivatives
- (2017) Anam Ansari et al. NEW JOURNAL OF CHEMISTRY
- Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor
- (2017) Artem Lebedev et al. PLoS One
- [18F]JNJ42259152 binding to phosphodiesterase 10A, a key regulator of medium spiny neuron excitability, is altered in the presence of cyclic AMP
- (2016) Maarten Ooms et al. JOURNAL OF NEUROCHEMISTRY
- Preclinical Evaluation and Quantification of 18 F-Fluoroethyl and 18 F-Fluoropropyl Analogs of SCH442416 as Radioligands for PET Imaging of the Adenosine A 2A Receptor in Rat Brain
- (2016) Shivashankar Khanapur et al. JOURNAL OF NUCLEAR MEDICINE
- Synthesis of 3-(2-nitrovinyl)-4H-chromones: useful scaffolds for the construction of biologically relevant 3-(pyrazol-5-yl)chromones
- (2016) Raquel G. Soengas et al. TETRAHEDRON
- Recent advances in bioactive pyrazoles
- (2015) Ş.Güniz Küçükgüzel et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Novel Pyrazolo[1,5-a]pyrimidines as Translocator Protein 18 kDa (TSPO) Ligands: Synthesis, in Vitro Biological Evaluation, [18F]-Labeling, and in Vivo Neuroinflammation PET Images
- (2015) Annelaure Damont et al. JOURNAL OF MEDICINAL CHEMISTRY
- Dose-Finding Quantitative 18F-FDG PET Imaging Study with the Oral Pan-AKT Inhibitor GSK2141795 in Patients with Gynecologic Malignancies
- (2015) H. Gungor et al. JOURNAL OF NUCLEAR MEDICINE
- Evaluation of PET Imaging Performance of the TSPO Radioligand [18F]DPA-714 in Mouse and Rat Models of Cancer and Inflammation
- (2015) Jinzi Zheng et al. MOLECULAR IMAGING AND BIOLOGY
- [18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain
- (2014) S. Lavisse et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- [18F]DPA-C5yne, a novel fluorine-18-labelled analogue of DPA-714: radiosynthesis and preliminary evaluation as a radiotracer for imaging neuroinflammation with PET
- (2014) Vincent Médran-Navarrete et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Development of [18F]-Labeled Pyrazolo[4,3-e]-1,2,4- triazolo[1,5-c]pyrimidine (SCH442416) Analogs for the Imaging of Cerebral Adenosine A2A Receptors with Positron Emission Tomography
- (2014) Shivashankar Khanapur et al. JOURNAL OF MEDICINAL CHEMISTRY
- 1,2-Diazole prevents cisplatin-induced nephrotoxicity in experimental rats
- (2014) Venugopal Vinod Prabhu et al. Pharmacological Reports
- [18F]DPA-714 as a biomarker for positron emission tomography imaging of rheumatoid arthritis in an animal model
- (2014) Géraldine Pottier et al. ARTHRITIS RESEARCH & THERAPY
- Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis
- (2014) Yoony YJ Gent et al. ARTHRITIS RESEARCH & THERAPY
- Synthesis and in vitro evaluation of [18F]BMS-754807: A potential PET ligand for IGF-1R
- (2013) Vattoly J. Majo et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pyrazole containing natural products: Synthetic preview and biological significance
- (2013) Vinod Kumar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The potential of carbon-11 and fluorine-18 chemistry: illustration through the development of positron emission tomography radioligands targeting the translocator protein 18 kDa
- (2013) Annelaure Damont et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Synthesis and Structure–Activity Relationships of 5,6,7-Substituted Pyrazolopyrimidines: Discovery of a Novel TSPO PET Ligand for Cancer Imaging
- (2013) Dewei Tang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Quantification of 18F-JNJ-42259152, a Novel Phosphodiesterase 10A PET Tracer: Kinetic Modeling and Test-Retest Study in Human Brain
- (2013) K. Van Laere et al. JOURNAL OF NUCLEAR MEDICINE
- Pyrazole Derivatives as Antitumor, Anti-Inflammatory and Antibacterial Agents
- (2013) Jia-Jia Liu et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Synthesis, biological evaluation of novel 4,5-dihydro-2H-pyrazole 2-hydroxyphenyl derivatives as BRAF inhibitors
- (2012) Jia-Jia Liu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging
- (2012) Koen Van Laere et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- An efficient copper-catalyzed formation of highly substituted pyrazoles using molecular oxygen as the oxidant
- (2012) Mamta Suri et al. GREEN CHEMISTRY
- Quantitative Preclinical Imaging of TSPO Expression in Glioma Using N,N-Diethyl-2-(2-(4-(2-18F-Fluoroethoxy)Phenyl)-5,7-Dimethylpyrazolo[1,5-a]Pyrimidin-3-yl)Acetamide
- (2012) D. Tang et al. JOURNAL OF NUCLEAR MEDICINE
- Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in the aortic wall of experimental abdominal aneurysms
- (2012) Laure Sarda-Mantel et al. JOURNAL OF VASCULAR SURGERY
- Fluorinated COX-2 Inhibitors as Agents in PET Imaging of Inflammation and Cancer
- (2011) M. J. Uddin et al. Cancer Prevention Research
- The State of the Art of Pyrazole Derivatives as Monoamine Oxidase Inhibitors and Antidepressant/Anticonvulsant Agents
- (2011) D. Secci et al. CURRENT MEDICINAL CHEMISTRY
- Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging
- (2011) José-Ignacio Andrés et al. JOURNAL OF MEDICINAL CHEMISTRY
- Radiopharmaceutical chemistry for positron emission tomography
- (2010) Zibo Li et al. ADVANCED DRUG DELIVERY REVIEWS
- Preclinical Evaluation of 18F-JNJ41510417 as a Radioligand for PET Imaging of Phosphodiesterase-10A in the Brain
- (2010) S. Celen et al. JOURNAL OF NUCLEAR MEDICINE
- Design of Targeted Cardiovascular Molecular Imaging Probes
- (2010) C. J. Anderson et al. JOURNAL OF NUCLEAR MEDICINE
- Reduced PBR/TSPO Expression After Minocycline Treatment in a Rat Model of Focal Cerebral Ischemia: A PET Study Using [18F]DPA-714
- (2010) Abraham Martín et al. MOLECULAR IMAGING AND BIOLOGY
- Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation
- (2010) Zhude Tu et al. NUCLEAR MEDICINE AND BIOLOGY
- Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation
- (2009) F. Chauveau et al. JOURNAL OF NUCLEAR MEDICINE
- [11C]-DPA-713 and [18F]-DPA-714 as New PET Tracers for TSPO: A Comparison with [11C]-(R)-PK11195 in a Rat Model of Herpes Encephalitis
- (2009) Janine Doorduin et al. MOLECULAR IMAGING AND BIOLOGY
- The role of positron emission tomography imaging of β-amyloid in patients with Alzheimerʼs disease
- (2009) Kun-Lin Xiong et al. NUCLEAR MEDICINE COMMUNICATIONS
- The psychiatric side-effects of rimonabant
- (2009) Fabrício A. Moreira et al. REVISTA BRASILEIRA DE PSIQUIATRIA
- Radiosynthesis and Biodistribution in Mice of a 18F-Labeled Analog of O-1302 for Use in Cerebral CB1 Cannabinoid Receptor Imaging
- (2008) Yumiko Nojiri et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- The role of clinical imaging in oncological drug development
- (2008) P S MURPHY et al. BRITISH JOURNAL OF RADIOLOGY
- Synthesis, Radiofluorination, and In Vitro Evaluation of Pyrazolo[1,5-a]pyridine-Based Dopamine D4Receptor Ligands: Discovery of an Inverse Agonist Radioligand for PET
- (2008) Olaf Prante et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Biological Evaluation of Substituted [18F]Imidazo[1,2-a]pyridines and [18F]Pyrazolo[1,5-a]pyrimidines for the Study of the Peripheral Benzodiazepine Receptor Using Positron Emission Tomography
- (2008) Christopher J. R. Fookes et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis of (E)- and (Z)-3(5)-(2-hydroxyphenyl)-4-styrylpyrazoles
- (2008) Vera L. M. Silva et al. MONATSHEFTE FUR CHEMIE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now