Journal
TETRAHEDRON LETTERS
Volume 55, Issue 18, Pages 2986-2990Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.03.125
Keywords
Pyrazoles; Multicomponent reaction; Michael addition; Cu catalyst and Ullmann cross-coupling reaction
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An efficient synthesis of unsymmetrically substituted 1,3-pyrazole derivatives has been developed via three-component coupling reaction involving 3-(dimethylamino)-1-phenylprop-2-en-1-one, hydrazine, and aryl halides in one pot process exhibiting high regioselectivity. The pyrazole synthesis proceeds via a sequential series of reactions such as Michael addition, heterocyclization, dehydration, and Ullmann cross-coupling. (C) 2014 Elsevier Ltd. All rights reserved.
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