TRIM proteins in lung cancer: Mechanisms, biomarkers and therapeutic targets

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Overexpression of tripartite motif containing 26 inhibits non‐small cell lung cancer cell growth by suppressing PI3K/AKT signaling

(2020) Jia‐Li Tao et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Tripartite motif containing 35 contributes to the proliferation, migration, and invasion of lung cancer cells in vitro and in vivo

(2020) Jingtao Zhang et al.   BIOSCIENCE REPORTS

Tripartite motif protein 25 is associated with epirubicin resistance in hepatocellular carcinoma cells via regulating PTEN/AKT pathway

(2020) Peng Yuan et al.   CELL BIOLOGY INTERNATIONAL

E3 ubiquitin ligase TRIM7 negatively regulates NF-kappa B signaling pathway by degrading p65 in lung cancer

(2020) Jiangbo Jin et al.   CELLULAR SIGNALLING

Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway

(2020) Hui Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TRIM2 directly deubiquitinates and stabilizes Snail1 protein, mediating proliferation and metastasis of lung adenocarcinoma

(2020) Zhaoxian Lin et al.   Cancer Cell International

TRIM59 knockdown blocks cisplatin resistance in A549/DDP cells through regulating PTEN/AKT/HK2

(2020) Rong He et al.   GENE

Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression

(2020) Manman Liang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

LPLUNC1 stabilises PHB1 by counteracting TRIM21-mediated ubiquitination to inhibit NF-κB activity in nasopharyngeal carcinoma

(2019) Heran Wang et al.   ONCOGENE

TRIM44 activates the AKT/mTOR signal pathway to induce melanoma progression by stabilizing TLR4

(2019) Chuan-Yuan Wei et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Epigenetics in Human Obesity and Type 2 Diabetes

(2019) Charlotte Ling et al.   Cell Metabolism

Knockdown of tripartite motif 59 (TRIM59) inhibits proliferation in cholangiocarcinoma via the PI3K/AKT/mTOR signalling pathway

(2019) Hao Shen et al.   GENE

Emerging therapies for non-small cell lung cancer

(2019) Chao Zhang et al.   Journal of Hematology & Oncology

Emerging therapies for small cell lung cancer

(2019) Sen Yang et al.   Journal of Hematology & Oncology

TRIM69 inhibits cataractogenesis by negatively regulating p53

(2019) Xianfang Rong et al.   Redox Biology

TRIM11 promotes proliferation and glycolysis of breast cancer cells via targeting AKT/GLUT1 pathway

(2019) WenBo Song et al.   OncoTargets and Therapy

Knockdown of TRIM65 inhibits autophagy and cisplatin resistance in A549/DDP cells by regulating miR-138-5p/ATG7

(2019) Xufeng Pan et al.   Cell Death & Disease

Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53

(2019) Yajie Chen et al.   Cell Death & Disease

TRIM27 promotes the development of esophagus cancer via regulating PTEN/AKT signaling pathway

(2019) Liang Ma et al.   Cancer Cell International

Elevated TRIM23 expression predicts cisplatin resistance in lung adenocarcinoma

(2019) Youwei Zhang et al.   CANCER SCIENCE

TRIM45 Suppresses the Development of Non-small Cell Lung Cancer

(2019) Xiyang Peng et al.   CURRENT MOLECULAR MEDICINE

TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells

(2019) Ling Xu et al.   GENE

Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis

(2018) Pengbo Guo et al.   EXPERIMENTAL CELL RESEARCH

MID1–PP2A complex functions as new insights in human lung adenocarcinoma

(2018) Lin Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

KAP1 inhibits the Raf-MEK-ERK pathway to promote tumorigenesis in A549 lung cancer cells

(2018) Guo-Jin Wu et al.   MOLECULAR CARCINOGENESIS

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

(2018) Lara N. Gechijian et al.   Nature Chemical Biology

Knockdown of TRIM66 inhibits malignant behavior and epithelial-mesenchymal transition in non-small cell lung cancer

(2018) Huan-yu Dai et al.   PATHOLOGY RESEARCH AND PRACTICE

TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1

(2018) Tianyu Han et al.   Autophagy

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

An ATM/TRIM37/NEMO axis counteracts genotoxicity by activating nuclear-to-cytoplasmic NF-κB signaling

(2018) Geyan Wu et al.   CANCER RESEARCH

Tripartite motif-containing 37 (TRIM37) promotes the aggressiveness of non-small-cell lung cancer cells by activating the NF-κB pathway

(2018) Yun Li et al.   JOURNAL OF PATHOLOGY

TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway

(2018) Weihong Yang et al.   Cell Death & Disease

Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis

(2018) Willy Roque et al.   CONNECTIVE TISSUE RESEARCH

An TRIM59-CDK6 axis regulates growth and metastasis of lung cancer

(2018) Biao Geng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Expression and the potential functions of TRIM32 in lung cancer tumorigenesis

(2018) Hongmei Yin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TRIM37 targets AKT in the growth of lung cancer cells

(2018) Shumin Dong et al.   OncoTargets and Therapy

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment

(2017) Ya-Ting Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

NEMO–IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS–STING Pathway

(2017) Run Fang et al.   JOURNAL OF IMMUNOLOGY

Lung cancer: current therapies and new targeted treatments

(2017) Fred R Hirsch et al.   LANCET

Trim13 Potentiates Toll-Like Receptor 2–Mediated Nuclear Factor κ B Activation via K29-Linked Polyubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6

(2017) Bin Huang et al.   MOLECULAR PHARMACOLOGY

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination

(2017) Jindong Zhang et al.   Cell Death & Disease

TRIM24 promotes the aggression of gastric cancer via the Wnt/β-catenin signaling pathway

(2017) Ziling Fang et al.   Oncology Letters

TRIM47 overexpression is a poor prognostic factor and contributes to carcinogenesis in non-small cell lung carcinoma

(2017) Yudong Han et al.   Oncotarget

E3 ubiquitin ligase tripartite motif-containing 71 promotes the proliferation of non-small cell lung cancer through the inhibitor of kappaB-α/nuclear factor kappaB pathway

(2017) Hongjiu Ren et al.   Oncotarget

TRIM22 confers poor prognosis and promotes epithelial-mesenchymal transition through regulation of AKT/GSK3β/β-catenin signaling in non-small cell lung cancer

(2017) Li Liu et al.   Oncotarget

TRIM23 mediates virus-induced autophagy via activation of TBK1

(2017) Konstantin M. J. Sparrer et al.   Nature Microbiology

TRIM14 is a Putative Tumor Suppressor and Regulator of Innate Immune Response in Non-Small Cell Lung Cancer

(2017) Josephine Hai et al.   Scientific Reports

TRIM65 negatively regulates p53 through ubiquitination

(2016) Yang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer

(2016) Anna C. Groner et al.   CANCER CELL

A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer

(2016) A. Diaz-Lagares et al.   CLINICAL CANCER RESEARCH

TRIM11 overexpression promotes proliferation, migration and invasion of lung cancer cells

(2016) Xiaolin Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TRIMming p53’s anticancer activity

(2016) S Elabd et al.   ONCOGENE

Overexpression of TRIM25 in Lung Cancer Regulates Tumor Cell Progression

(2016) Ying Qin et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Knockdown of TRIM65 inhibits lung cancer cell proliferation, migration and invasion: A therapeutic target in human lung cancer

(2016) Xiao-Lin Wang et al.   Oncotarget

TRIM44 promotes proliferation and metastasis in non‑small cell lung cancer via mTOR signaling pathway

(2016) Ying Xing et al.   Oncotarget

Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma

(2016) Koichiro Kajiura et al.   Oncotarget

Tripartite motif 16 inhibits epithelial–mesenchymal transition and metastasis by down-regulating sonic hedgehog pathway in non-small cell lung cancer cells

(2015) Xiongwei Huo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

(2015) James Bennett et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

(2015) Wylie S. Palmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

TRIM25 has a dual function in the p53/Mdm2 circuit

(2015) P Zhang et al.   ONCOGENE

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

(2015) Yanai Zhan et al.   Epigenetics & Chromatin

Tripartite motif-containing 29 as a novel biomarker in non-small cell lung cancer

(2015) XIAOMING SONG et al.   Oncology Letters

The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling

(2015) Atanu Chakraborty et al.   Nature Communications

TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins

(2015) Weihua Zhan et al.   PLoS One

Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

(2014) Claudia Fumarola et al.   BIOCHEMICAL PHARMACOLOGY

PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation ofMMP2

(2014) Hong-Yi Kuo et al.   CELL CYCLE

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-κB activation

(2014) Dhanendra Tomar et al.   CELLULAR SIGNALLING

Molecular Pathways: Translational Potential of Deubiquitinases as Drug Targets

(2014) P. D'Arcy et al.   CLINICAL CANCER RESEARCH

InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins

(2014) Gijs A. Versteeg et al.   CYTOKINE & GROWTH FACTOR REVIEWS

TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

(2014) Zhicheng Zhou et al.   GASTROENTEROLOGY

Trim44 facilitates the migration and invasion of human lung cancer cells via the NF-κB signaling pathway

(2014) Qingquan Luo et al.   International Journal of Clinical Oncology

Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation

(2014) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Loss of the novel tumour suppressor and polarity geneTrim62(Dear1) synergizes with oncogenic Ras in invasive lung cancer

(2014) Alfonso Quintás-Cardama et al.   JOURNAL OF PATHOLOGY

TRIM22 can activate the noncanonical NF-κB pathway by affecting IKKα

(2014) Hui Qiu et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization

(2014) B. Ashok Reddy et al.   MOLECULAR CELL

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway

(2014) L-H Zhang et al.   ONCOGENE

The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway

(2014) T Sato et al.   ONCOGENE

TRIM31 is downregulated in non-small cell lung cancer and serves as a potential tumor suppressor

(2014) Hui Li et al.   TUMOR BIOLOGY

TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination

(2014) J. Yan et al.   Journal of Molecular Cell Biology

The TRIM-NHL Protein LIN-41 Controls the Onset of Developmental Plasticity in Caenorhabditis elegans

(2014) Cristina Tocchini et al.   PLoS Genetics

Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung

(2014) Annika Stjernström et al.   Cancer Medicine

The PML isoform IV is a negative regulator of nuclear EGFR’s transcriptional activity in lung cancer

(2013) Hong-Yi Kuo et al.   CARCINOGENESIS

New insights on the function of SCF ubiquitin E3 ligases in the lung

(2013) Nathaniel M. Weathington et al.   CELLULAR SIGNALLING

TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response

(2013) Z. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM22 inhibits the TRAF6-stimulated NF-κB pathway by targeting TAB2 for degradation

(2013) Hui Qiu et al.   VIROLOGICA SINICA

TRIM8 modulates p53 activity to dictate cell cycle arrest

(2012) Mariano Francesco Caratozzolo et al.   CELL CYCLE

Ubiquitination and Proteolysis in Acute Lung Injury

(2012) István Vadász et al.   CHEST

Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models

(2012) J. M. Spoerke et al.   CLINICAL CANCER RESEARCH

Clarifying the Spectrum of Driver Oncogene Mutations in Biomarker-Verified Squamous Carcinoma of Lung: Lack of EGFR/KRAS and Presence of PIK3CA/AKT1 Mutations

(2012) N. Rekhtman et al.   CLINICAL CANCER RESEARCH

KAP1/TRIM28: An inhibitor of IRF5 function in inflammatory macrophages

(2012) H.L. Eames et al.   IMMUNOBIOLOGY

Tripartite Motif Containing 28 (Trim28) Can Regulate Cell Proliferation by Bridging HDAC1/E2F Interactions

(2012) Lu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E3 Ubiquitin Ligase Tripartite Motif 38 Negatively Regulates TLR-Mediated Immune Responses by Proteasomal Degradation of TNF Receptor-Associated Factor 6 in Macrophages

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Developmental regulation of MURF E3 ubiquitin ligases in skeletal muscle

(2012) Sue Perera et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Significance of TRIM29 and β-catenin expression in non-small-cell lung cancer

(2012) Zhi-Yi Zhou et al.   Journal of the Chinese Medical Association

Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase

(2012) Marianna Scrima et al.   PLoS One

Nucleo-Cytoplasmic Trafficking of TRIM8, a Novel Oncogene, Is Involved in Positive Regulation of TNF Induced NF-κB Pathway

(2012) Dhanendra Tomar et al.   PLoS One

Ubiquitylation of p53 by the APC/C inhibitor Trim39

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

(2012) Akshay A. D'Cruz et al.   PROTEIN SCIENCE

TRIM59, a novel multiple cancer biomarker for immunohistochemical detection of tumorigenesis

(2012) Vida Khatamianfar et al.   BMJ Open

PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway

(2011) Ying Huang et al.   Autophagy

TRIM29 negatively regulates p53 via inhibition of Tip60

(2011) Takuya Sho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells

(2011) Dhanendra Tomar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)

(2011) Meiju Ji et al.   BMC CANCER

TRIM40 promotes neddylation of IKK  and is downregulated in gastrointestinal cancers

(2011) K. Noguchi et al.   CARCINOGENESIS

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

(2011) Taro Kawai et al.   EMBO Molecular Medicine

Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2

(2011) Hae Mi Joo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα

(2011) K B Grandinetti et al.   ONCOGENE

Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination

(2011) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions

(2010) Z. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

Downregulation of active IKKβ by Ro52-mediated autophagy

(2010) Motoko Niida et al.   MOLECULAR IMMUNOLOGY

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

(2010) K.-i. Arimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Identification of TRIM23 as a Cofactor Involved in the Regulation of NF- B by Human Cytomegalovirus

(2009) E. Poole et al.   JOURNAL OF VIROLOGY

Trim24 targets endogenous p53 for degradation

(2009) Kendra Allton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology