TRIMming p53’s anticancer activity

Whole-genome cartography of p53 response elements ranked on transactivation potential

(2015) Toma Tebaldi et al.   BMC GENOMICS

ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase

(2015) Huibin Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM25 has a dual function in the p53/Mdm2 circuit

(2015) P Zhang et al.   ONCOGENE

TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin

(2015) Yasushi Masuda et al.   Nature Communications

TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

(2015) Yu Chen et al.   Oncotarget

TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma

(2015) Mariano Francesco Caratozzolo et al.   Oncotarget

KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells

(2014) J. B. Addison et al.   CANCER RESEARCH

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

(2014) Zhicheng Zhou et al.   GASTROENTEROLOGY

TRIM24 Is a p53-Induced E3-Ubiquitin Ligase That Undergoes ATM-Mediated Phosphorylation and Autodegradation during DNA Damage

(2014) A. K. Jain et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes

(2014) Che-Pei Kung et al.   MOLECULAR CANCER RESEARCH

Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization

(2014) B. Ashok Reddy et al.   MOLECULAR CELL

Down-regulation of Tripartite-motif containing 22 expression in breast cancer is associated with a lack of p53-mediated induction

(2013) Yang Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ataxia-Telangiectasia Group D Complementing Gene (ATDC) Promotes Lung Cancer Cell Proliferation by Activating NF-κB Pathway

(2013) Zhong-Ping Tang et al.   PLoS One

TRIM24 Overexpression Is Common in Locally Advanced Head and Neck Squamous Cell Carcinoma and Correlates with Aggressive Malignant Phenotypes

(2013) Zhibin Cui et al.   PLoS One

MOZ increases p53 acetylation and premature senescence through its complex formation with PML

(2013) S. Rokudai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Roles of PML Isoforms

(2013) Sébastien Nisole et al.   Frontiers in Oncology

TRIM28, a new molecular marker predicting metastasis and survival in early-stage non-small cell lung cancer

(2012) Lei Liu et al.   Cancer Epidemiology

Ubiquitylation of p53 by the APC/C inhibitor Trim39

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM29 negatively regulates p53 via inhibition of Tip60

(2011) Takuya Sho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The transcription-independent mitochondrial p53 program is a major contributor to Nutlin-induced apoptosis in tumor cells

(2011) Angelina V. Vaseva et al.   CELL CYCLE

Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2

(2011) Hae Mi Joo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Modulation of TRIM5  Activity in Human Cells by Alternatively Spliced TRIM5 Isoforms

(2011) E. Battivelli et al.   JOURNAL OF VIROLOGY

Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase

(2011) Alex C. Faesen et al.   MOLECULAR CELL

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma

(2011) B. Herquel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions

(2010) Z. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

TRIM24 links a non-canonical histone signature to breast cancer

(2010) Wen-Wei Tsai et al.   NATURE

AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation

(2010) Q Li et al.   ONCOGENE

SUMO E3 ligase activity of TRIM proteins

(2010) Y Chu et al.   ONCOGENE

Oncogenic Function of ATDC in Pancreatic Cancer through Wnt Pathway Activation and β-Catenin Stabilization

(2009) Lidong Wang et al.   CANCER CELL

Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53

(2009) S. Haupt et al.   CANCER RESEARCH

Regulation of p53 - insights into a complex process

(2009) Karen A Boehme et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Dynamic movements of Ro52 cytoplasmic bodies along microtubules

(2009) Makoto Tanaka et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Trim24 targets endogenous p53 for degradation

(2009) Kendra Allton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tripartite Motif Protein 32 Facilitates Cell Growth and Migration via Degradation of Abl-Interactor 2

(2008) S. Kano et al.   CANCER RESEARCH

New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors

(2008) Stefanie Wittmann et al.   GENES CHROMOSOMES & CANCER

Novel Breast Cancer Metastasis-Associated Proteins

(2008) Jiapei Ho et al.   JOURNAL OF PROTEOME RESEARCH

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PML enhances the regulation of p53 by CK1 in response to DNA damage

(2008) O Alsheich-Bartok et al.   ONCOGENE