PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway

The role of TOR in autophagy regulation from yeast to plants and mammals

(2014) Sandra Díaz-Troya et al.   Autophagy

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

(2010) P. Isakson et al.   BLOOD

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Autophagy Is a Critical Mechanism for the Induction of the Antileukemic Effects of Arsenic Trioxide

(2010) Dennis J. Goussetis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia

(2009) F. C. Guibal et al.   BLOOD

Leukemic transformation by the APL fusion protein PRKAR1A-RAR  critically depends on recruitment of RXR 

(2009) J. J. Qiu et al.   BLOOD

Activation of the Unfolded Protein Response Is Associated with Favorable Prognosis in Acute Myeloid Leukemia

(2009) J. A. Schardt et al.   CLINICAL CANCER RESEARCH

Autophagy: Regulation and role in disease

(2009) Alfred J. Meijer et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Regulation of PERK Signaling and Leukemic Cell Survival by a Novel Cytosolic Isoform of the UPR Regulator GRP78/BiP

(2009) Min Ni et al.   PLoS One

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

(2008) Rihab Nasr et al.   NATURE MEDICINE