Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis

SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis

(2017) Renea P. Jablonski et al.   FASEB JOURNAL

Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling

(2017) Robert D. Guzy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteasome Structure and Assembly

(2017) Lauren Budenholzer et al.   JOURNAL OF MOLECULAR BIOLOGY

Transforming growth factor beta 1 increases collagen content, and stimulates procollagen I and tissue inhibitor of metalloproteinase-1 production of dental pulp cells: Role of MEK/ERK and activin receptor-like kinase-5/Smad signaling

(2017) Po-Shuen Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system

(2017) Piotr Bragoszewski et al.   Open Biology

Alveolar Epithelial Disintegrity in Pulmonary Fibrosis

(2016) Tejaswini Kulkarni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TCF11/Nrf1-Mediated Induction of Proteasome Expression Prevents Cytotoxicity by Rotenone

(2016) Franziska Sotzny et al.   ANTIOXIDANTS & REDOX SIGNALING

On the linkage between the ubiquitin-proteasome system and the mitochondria

(2016) Gilad Lehmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic advances in idiopathic pulmonary fibrosis

(2016) E. Fraser et al.   CLINICAL MEDICINE

E3 Ubiquitin Ligases as Molecular Targets in Human Oral Cancers

(2016) Kazuma Masumoto et al.   CURRENT CANCER DRUG TARGETS

Therapeutic targets in fibrotic pathways

(2016) Travis Lear et al.   CYTOKINE

Fibroblast growth factors and pulmonary fibrosis: it's more complex than it sounds

(2016) Kevin K Kim et al.   JOURNAL OF PATHOLOGY

Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis

(2016) Meredith L. Sosulski et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?

(2016) Adam J. Byrne et al.   TRENDS IN MOLECULAR MEDICINE

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

(2016) Kaname Akamata et al.   Oncotarget

Erratum: Erratum: Sustained PI3K Activation exacerbates BLM-induced Lung Fibrosis via activation of pro-inflammatory and pro-fibrotic pathways

(2016) Julia Barbara Kral et al.   Scientific Reports

TRIB2 and the ubiquitin proteasome system in cancer

(2015) M. Salome et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The interplay between autophagy and the ubiquitin–proteasome system in cardiac proteotoxicity

(2015) Changhua Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

mTORC1 signaling activates NRF1 to increase cellular proteasome levels

(2015) Yinan Zhang et al.   CELL CYCLE

Identification of minimum Rpn4-responsive elements in genes related to proteasome functions

(2015) Ryohei Shirozu et al.   FEBS LETTERS

Targeting ubiquitination for cancer therapies

(2015) John Kenneth Morrow et al.   Future Medicinal Chemistry

The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis

(2015) Seok-Jo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission

(2015) Jinjin Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

(2015) Nagalingam R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer

(2015) R. F. Shearer et al.   MOLECULAR CANCER RESEARCH

RBR E3 ubiquitin ligases: new structures, new insights, new questions

(2014) Donald E. Spratt et al.   BIOCHEMICAL JOURNAL

Proteasome assembly

(2014) Zhu Chao Gu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proteasomes Associated with the Blm10 Activator Protein Antagonize Mitochondrial Fission through Degradation of the Fission Protein Dnm1

(2014) Krisztina Tar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

(2014) Marta Bueno et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Perilous journey: a tour of the ubiquitin–proteasome system

(2014) Gary Kleiger et al.   TRENDS IN CELL BIOLOGY

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

Pathogenesis of Idiopathic Pulmonary Fibrosis

(2013) Paul J. Wolters et al.   Annual Review of Pathology-Mechanisms of Disease

Mitochondrial genome function and maternal inheritance

(2013) John F. Allen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis

(2013) Norihiko Sakai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impaired Assembly and Post-translational Regulation of 26S Proteasome in Human End-Stage Heart Failure

(2013) Sharlene M. Day et al.   Circulation-Heart Failure

Targeting the ubiquitin–proteasome system for cancer therapy

(2013) Min Shen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Regulation of TGF-  family signalling by ubiquitination and deubiquitination

(2013) T. Imamura et al.   JOURNAL OF BIOCHEMISTRY

Proteomic remodeling of proteasome in right heart failure

(2013) Delphine Fessart et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of caveolin-1 in fibrotic diseases

(2013) David Gvaramia et al.   MATRIX BIOLOGY

Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer’s disease

(2013) Liang Hong et al.   NEUROLOGICAL RESEARCH

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

(2013) Y. Ihara et al.   Cold Spring Harbor Perspectives in Medicine

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

(2013) Hari B Kamadurai et al.   eLife

Proteasome inhibition attenuates heart failure during the late stages of pressure overload through alterations in collagen expression

(2012) Yuedong Ma et al.   BIOCHEMICAL PHARMACOLOGY

Mechanisms of Protein Misfolding in Conformational Lung Diseases

(2012) N. G. McElvaney et al.   CURRENT MOLECULAR MEDICINE

New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis

(2012) Isis E Fernandez et al.   LANCET

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1

(2012) S. W. Manka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological Alteration of FoxO3a Activity Promotes Idiopathic Pulmonary Fibrosis Fibroblast Proliferation on Type I Collagen Matrix

(2011) Richard Seonghun Nho et al.   AMERICAN JOURNAL OF PATHOLOGY

Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3

(2011) Liu-Ya Tang et al.   EMBO JOURNAL

Alveolar Epithelial Cells Undergo Epithelial-to-Mesenchymal Transition in Response to Endoplasmic Reticulum Stress

(2011) Harikrishna Tanjore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β1signalling

(2011) Gökhan M Mutlu et al.   THORAX

The dynamic state of protein turnover: It's about time

(2011) Izumi V. Hinkson et al.   TRENDS IN CELL BIOLOGY

Ubiquitin–Proteasome System and mitochondria — Reciprocity

(2010) Nurit Livnat-Levanon et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

(2010) Senthil K. Radhakrishnan et al.   MOLECULAR CELL

How is the balance between protein synthesis and degradation achieved?

(2010) Stephen Rothman   Theoretical Biology and Medical Modelling

Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts

(2010) Laurence Goffin et al.   ARTHRITIS RESEARCH & THERAPY

Genetic Defects in Surfactant Protein A2 Are Associated with Pulmonary Fibrosis and Lung Cancer

(2008) Yongyu Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial Protein Quality Control by the Proteasome Involves Ubiquitination and the Protease Omi

(2008) Susanne Radke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin–Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion

(2008) Mickael M.J. Cohen et al.   MOLECULAR BIOLOGY OF THE CELL

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One