Off the beaten path: Novel mRNA-nanoformulations for therapeutic vaccination against HIV

Polylactide-Based Reactive Micelles as a Robust Platform for mRNA Delivery

(2020) Céline Lacroix et al.   PHARMACEUTICAL RESEARCH

Synthesis of low immunogenicity RNA with high-temperature in vitro transcription

(2020) Monica Z. Wu et al.   RNA

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

(2020) Abishek Wadhwa et al.   Pharmaceutics

Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection

(2020) Cynthia L. Gay et al.   Scientific Reports

The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook

(2020) Hager Mohamed et al.   Journal of Immunology Research

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Characterization of HIV-1 nucleoside-modified mRNA vaccines in rabbits and rhesus macaques

(2019) Norbert Pardi et al.   Molecular Therapy-Nucleic Acids

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

(2019) R. Alexander Wesselhoeft et al.   MOLECULAR CELL

Structural topology defines protective CD8+ T cell epitopes in the HIV proteome

(2019) Gaurav D. Gaiha et al.   SCIENCE

A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA

(2019) Markus Baiersdörfer et al.   Molecular Therapy-Nucleic Acids

HIV “shock and kill” therapy: In need of revision

(2019) Erik Abner et al.   ANTIVIRAL RESEARCH

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

(2019) Anna K. Blakney et al.   GENE THERAPY

iHIVARNA phase IIa, a randomized, placebo-controlled, double-blinded trial to evaluate the safety and immunogenicity of iHIVARNA-01 in chronically HIV-infected patients under stable combined antiretroviral therapy

(2019) Wesley de Jong et al.   Trials

HIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomised phase 2 trial

(2019) Vincent Vieillard et al.   npj Vaccines

HIV Rebound Is Predominantly Fueled by Genetically Identical Viral Expansions from Diverse Reservoirs

(2019) Marie-Angélique De Scheerder et al.   Cell Host & Microbe

DNA priming and gp120 boosting induces HIV-specific antibodies in a randomized clinical trial

(2019) Nadine G. Rouphael et al.   JOURNAL OF CLINICAL INVESTIGATION

Three decades of messenger RNA vaccine development

(2019) Rein Verbeke et al.   Nano Today

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial

(2019) Giuseppe Pantaleo et al.   Lancet HIV

Immunogenicity of AGS-004 Dendritic Cell Therapy in Patients Treated During Acute HIV Infection

(2018) Cynthia L. Gay et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

The proton sponge hypothesis: Fable or fact?

(2018) Lotte M.P. Vermeulen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Cyclodextrins: structure, physicochemical properties and pharmaceutical applications

(2018) Phatsawee Jansook et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties

(2018) Bo Lou et al.   JOURNAL OF CONTROLLED RELEASE

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

(2018) Norbert Pardi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alnylam prepares to land first RNAi drug approval

(2018) Chris Morrison   NATURE REVIEWS DRUG DISCOVERY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

An origin of the immunogenicity of in vitro transcribed RNA

(2018) Xin Mu et al.   NUCLEIC ACIDS RESEARCH

Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment

(2018) Henk-Jan van den Ham et al.   PLoS One

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

Therapeutic vaccination for HIV

(2018) Kathryn E. Stephenson   Current Opinion in HIV and AIDS

Poly(β-amino ester)-co -poly(caprolactone) Terpolymers as Nonviral Vectors for mRNA Delivery In Vitro and In Vivo

(2018) Umberto Capasso Palmiero et al.   Advanced Healthcare Materials

Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection

(2018) Torben Knuschke et al.   Frontiers in Immunology

Immune Modulation by Human Secreted RNases at the Extracellular Space

(2018) Lu Lu et al.   Frontiers in Immunology

Functional Invariant Natural Killer T Cells Secreting Cytokines Are Associated With Non-Progressive Human Immunodeficiency Virus-1 Infection but Not With Suppressive Anti-Retroviral Treatment

(2018) Dharmendra Singh et al.   Frontiers in Immunology

mRNA polyplexes with post-conjugated GALA peptides efficiently target, transfect and activate antigen presenting cells

(2018) Bo Lou et al.   BIOCONJUGATE CHEMISTRY

Identification of novel HIV-1-derived HLA-E-binding peptides

(2018) Zara Hannoun et al.   IMMUNOLOGY LETTERS

3′ end additions by T7 RNA polymerase are RNA self-templated, distributive and diverse in character—RNA-Seq analyses

(2018) Yasaman Gholamalipour et al.   NUCLEIC ACIDS RESEARCH

mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice

(2018) Ole A. W. Haabeth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overcoming immunogenicity issues of HIV p24 antigen by the use of innovative nanostructured lipid carriers as delivery systems: evidences in mice and non-human primates

(2018) Emilie Bayon et al.   npj Vaccines

Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions

(2018) Tatiana M. Garcia-Bates et al.   JOURNAL OF VIROLOGY

Using Dendritic Cell-Based Immunotherapy to Treat HIV: How Can This Strategy be Improved?

(2018) Laís Teodoro da Silva et al.   Frontiers in Immunology

Poly(lactic acid) nanoparticles and cell-penetrating peptide potentiate mRNA-based vaccine expression in dendritic cells triggering their activation

(2018) Anne-Line Coolen et al.   BIOMATERIALS

New challenges in therapeutic vaccines against HIV infection

(2017) Lorna Leal et al.   Expert Review of Vaccines

Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

(2017) S Guan et al.   GENE THERAPY

Improvement of In Vivo Expression of Genes Delivered by Self-Amplifying RNA Using Vaccinia Virus Immune Evasion Proteins

(2017) Tim Beissert et al.   HUMAN GENE THERAPY

RNA sensors of the innate immune system and their detection of pathogens

(2017) Nanhua Chen et al.   IUBMB LIFE

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA

(2017) Rein Verbeke et al.   JOURNAL OF CONTROLLED RELEASE

Fibroblast-adapted human CMV vaccines elicit predominantly conventional CD8 T cell responses in humans

(2017) Susan E. Murray et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design

(2017) Timothy Pepini et al.   JOURNAL OF IMMUNOLOGY

Sequential Vacc-4x and romidepsin during combination antiretroviral therapy (cART): Immune responses to Vacc-4x regions on p24 and changes in HIV reservoirs

(2017) G. Tapia et al.   JOURNAL OF INFECTION

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

(2017) Colin J. McKinlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivering the right message: Challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics—An innate immune system standpoint

(2017) Yasmin Granot et al.   SEMINARS IN IMMUNOLOGY

Type I Interferons Modulate CD8 + T Cell Immunity to mRNA Vaccines

(2017) Ans De Beuckelaer et al.   TRENDS IN MOLECULAR MEDICINE

Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects

(2017) Gemma Hancock et al.   Journal of the International AIDS Society

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

(2017) Vimal K. Udhayakumar et al.   Advanced Healthcare Materials

A thermostable messenger RNA based vaccine against rabies

(2017) Lothar Stitz et al.   PLoS Neglected Tropical Diseases

Nutrient and Metabolic Sensing in T Cell Responses

(2017) Jun Wei et al.   Frontiers in Immunology

Hybrid inorganic-organic capsules for efficient intracellular delivery of novel siRNAs against influenza A (H1N1) virus infection

(2017) Alexander S. Timin et al.   Scientific Reports

Balance between activation and regulation of HIV-specific CD8+ T-cell response after modified vaccinia Ankara B therapeutic vaccination

(2016) Norma Rallón et al.   AIDS

Preclinical evaluation of an mRNA HIV vaccine combining rationally selected antigenic sequences and adjuvant signals (HTI-TriMix)

(2016) Alberto C. Guardo et al.   AIDS

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Evading innate immunity in nonviral mRNA delivery: don’t shoot the messenger

(2016) Joke Devoldere et al.   DRUG DISCOVERY TODAY

Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef

(2016) Rajesh T. Gandhi et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Dendritic Cell Immunotherapy for HIV-1 Infection Using Autologous HIV-1 RNA

(2016) Jeffrey M. Jacobson et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs

(2016) Liang Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways

(2016) Man Li et al.   JOURNAL OF CONTROLLED RELEASE

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

A Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimera Vaccines in Cytomegalovirus–Seronegative Men

(2016) Stuart P. Adler et al.   JOURNAL OF INFECTIOUS DISEASES

Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection

(2016) Beatrice Ondondo et al.   MOLECULAR THERAPY

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

(2016) S. G. Hansen et al.   SCIENCE

Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

(2016) Katrijn Broos et al.   Molecular Therapy-Nucleic Acids

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

(2015) Ulrich Lächelt et al.   CHEMICAL REVIEWS

Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA

(2015) Mengnan Zhao et al.   DRUG DELIVERY

A review of the developments of characteristics of PEI derivatives for gene delivery applications

(2015) Shahrouz Taranejoo et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

(2015) Beatriz Mothe et al.   Journal of Translational Medicine

HIV-1 Reservoir Dynamics after Vaccination and Antiretroviral Therapy Interruption Are Associated with Dendritic Cell Vaccine-Induced T Cell Responses

(2015) Cristina Andrés et al.   JOURNAL OF VIROLOGY

Origin of Rebound Plasma HIV Includes Cells with Identical Proviruses That Are Transcriptionally Active before Stopping of Antiretroviral Therapy

(2015) Mary F. Kearney et al.   JOURNAL OF VIROLOGY

A Phase I Randomized Therapeutic MVA-B Vaccination Improves the Magnitude and Quality of the T Cell Immune Responses in HIV-1-Infected Subjects on HAART

(2015) Carmen Elena Gómez et al.   PLoS One

DC immunotherapy in HIV-1 infection induces a major blood transcriptome shift

(2015) Anna L. de Goede et al.   VACCINE

mRNA delivery using non-viral PCL nanoparticles

(2015) Ilaria E. Palamà et al.   Biomaterials Science

Nanocoating for biomolecule delivery using layer-by-layer self-assembly

(2015) M. Keeney et al.   Journal of Materials Chemistry B

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells

(2015) S. Van Lint et al.   Cancer Immunology Research

Effect of therapeutic intensification followed by HIV DNA prime and rAd5 boost vaccination on HIV-specific immunity and HIV reservoir (EraMune 02): a multicentre randomised clinical trial

(2015) Chad J Achenbach et al.   Lancet HIV

Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral load

(2014) Yves Lévy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Self-replicating alphavirus RNA vaccines

(2014) Karl Ljungberg et al.   Expert Review of Vaccines

Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery

(2014) Helen O. McCarthy et al.   JOURNAL OF CONTROLLED RELEASE

Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion

(2014) W. M. Bogers et al.   JOURNAL OF INFECTIOUS DISEASES

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

Intracellular delivery of nanomaterials: How to catch endosomal escape in the act

(2014) Thomas F. Martens et al.   Nano Today

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

HIV-1 Conserved Elements p24CE DNA Vaccine Induces Humoral Immune Responses with Broad Epitope Recognition in Macaques

(2014) Viraj Kulkarni et al.   PLoS One

Intranasal Administration of a Therapeutic HIV Vaccine (Vacc-4x) Induces Dose-Dependent Systemic and Mucosal Immune Responses in a Randomized Controlled Trial

(2014) Kristin Brekke et al.   PLoS One

Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses

(2014) Núria Climent et al.   VACCINE

Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis

(2013) Zia ur Rehman et al.   ACS Nano

Characterization of Conformation and Interaction of Gene Delivery Vector Polyethylenimine with Phospholipid Bilayer at Different Protonation State

(2013) Chandan Kumar Choudhury et al.   BIOMACROMOLECULES

Impact of Autologous Dendritic Cell–Based Immunotherapy (AGS-004) on B- and T-Cell Subset Changes and Immune Activation in HIV-Infected Patients Receiving Antiretroviral Therapy

(2013) Mohammad-Ali Jenabian et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

(2013) Martin A Maier et al.   MOLECULAR THERAPY

A Dendritic Cell-Based Vaccine Elicits T Cell Responses Associated with Control of HIV-1 Replication

(2013) F. Garcia et al.   Science Translational Medicine

Nanoparticle vaccines

(2013) Liang Zhao et al.   VACCINE

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Transfection efficiency boost of cholesterol-containing lipoplexes

(2012) Daniela Pozzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control

(2012) Z. M. Ndhlovu et al.   BLOOD

Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

(2012) S. Van Lint et al.   CANCER RESEARCH

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study)

(2012) A. Duerr et al.   JOURNAL OF INFECTIOUS DISEASES

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection

(2012) F J Ibarrondo et al.   Mucosal Immunology

Tailoring layer-by-layer capsules for biomedical applications

(2012) Marie-Luce De Temmerman et al.   Nanomedicine

Lipoplexes carrying mRNA encoding Gag protein modulate dendritic cells to stimulate HIV-specific immune responses

(2012) Winni De Haes et al.   Nanomedicine

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients

(2011) Ellen Van Gulck et al.   AIDS

A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption

(2011) Sabine D. Allard et al.   CLINICAL IMMUNOLOGY

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

(2011) M Diken et al.   GENE THERAPY

Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways

(2011) Jenny K.W. Lam et al.   JOURNAL OF CONTROLLED RELEASE

Definition of the viral targets of protective HIV-1-specific T cell responses

(2011) Beatriz Mothe et al.   Journal of Translational Medicine

Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study

(2011) Glenda E Gray et al.   LANCET INFECTIOUS DISEASES

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Challenges in dendritic cells-based therapeutic vaccination in HIV-1 infection

(2011) Felipe García et al.   VACCINE

LAH4 enhances CD8+ T cell immunity of protein/peptide-based vaccines

(2011) Tong Tong Zhang et al.   VACCINE

Elite controllers as a model of functional cure

(2011) Brigitte Autran et al.   Current Opinion in HIV and AIDS

Role of Dendritic Cells in HIV-Immunotherapy

(2010) Ellen Van Gulck et al.   CURRENT HIV RESEARCH

Polyelectrolyte Capsules-containing HIV-1 p24 and Poly I:C Modulate Dendritic Cells to Stimulate HIV-1-specific Immune Responses

(2010) Winni De Haes et al.   MOLECULAR THERAPY

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

(2010) Susanne M Rittig et al.   MOLECULAR THERAPY

Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy

(2009) Jean-Pierre Routy et al.   CLINICAL IMMUNOLOGY

Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels

(2009) G. Galli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating the elite: mechanisms of control in HIV-1 infection

(2009) Karen A. O’Connell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Viral fitness implications of variation within an immunodominant CD8+ T-cell epitope of HIV-1

(2009) N.M. Christie et al.   VIROLOGY

Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control

(2008) A. L. Ferre et al.   BLOOD

An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses

(2008) Alexandre Harari et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of the Polymer Nature on the Structural Organization of Lipid/Polymer Particle Assemblies

(2008) Julie Thevenot et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Cationic Liposomes Formulated with Synthetic Mycobacterial Cordfactor (CAF01): A Versatile Adjuvant for Vaccines with Different Immunological Requirements

(2008) Else Marie Agger et al.   PLoS One

Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells

(2008) Hendrik Streeck et al.   PLOS MEDICINE