Self-replicating alphavirus RNA vaccines

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9

(2014) R. E. Rigby et al.   EMBO JOURNAL

Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines

(2014) Raquel P Deering et al.   Expert Opinion on Drug Delivery

Nonmucosal Alphavirus Vaccination Stimulates a Mucosal Inductive Environment in the Peripheral Draining Lymph Node

(2014) J. M. Thompson et al.   JOURNAL OF IMMUNOLOGY

Chikungunya Vaccine Candidate Is Highly Attenuated and Protects Nonhuman Primates Against Telemetrically Monitored Disease Following a Single Dose

(2014) C. J. Roy et al.   JOURNAL OF INFECTIOUS DISEASES

Prime-Boost Immunization Strategies against Chikungunya Virus

(2014) D. Hallengard et al.   JOURNAL OF VIROLOGY

An Alphavirus-Based Adjuvant Enhances Serum and Mucosal Antibodies, T Cells, and Protective Immunity to Influenza Virus in Neonatal Mice

(2014) S. M. Khalil et al.   JOURNAL OF VIROLOGY

Kinetic and Phenotypic Analysis of CD8+ T Cell Responses after Priming with Alphavirus Replicons and Homologous or Heterologous Booster Immunizations

(2014) M. L. Knudsen et al.   JOURNAL OF VIROLOGY

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

Toward a Human Vaccines Project

(2014) Wayne C Koff et al.   NATURE IMMUNOLOGY

A tetravalent alphavirus-vector based dengue vaccine provides effective immunity in an early life mouse model

(2014) Syed Muaz Khalil et al.   VACCINE

Reverse vaccinology in the 21st century: improvements over the original design

(2013) Claudio Donati et al.   Annals of the New York Academy of Sciences

Innate immunity

(2013) Jules Hoffmann et al.   CURRENT OPINION IN IMMUNOLOGY

Synthetic DNA vaccine strategies against persistent viral infections

(2013) Daniel O Villarreal et al.   Expert Review of Vaccines

Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Protects Nonhuman Primates from Intramuscular and Aerosol Challenge with Ebolavirus

(2013) A. S. Herbert et al.   JOURNAL OF VIROLOGY

An Alphavirus Vector-Based Tetravalent Dengue Vaccine Induces a Rapid and Protective Immune Response in Macaques That Differs Qualitatively from Immunity Induced by Live Virus Infection

(2013) L. J. White et al.   JOURNAL OF VIROLOGY

Novel Attenuated Chikungunya Vaccine Candidates Elicit Protective Immunity in C57BL/6 mice

(2013) D. Hallengard et al.   JOURNAL OF VIROLOGY

Alphavirus-based Vaccines Encoding Nonstructural Proteins of Hepatitis C Virus Induce Robust and Protective T-cell Responses

(2013) Peng Peng Ip et al.   MOLECULAR THERAPY

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

(2013) Shuzhao Li et al.   NATURE IMMUNOLOGY

The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon

(2013) Maria L. Knudsen et al.   PLoS One

A Vaccinia Virus Recombinant Transcribing an Alphavirus Replicon and Expressing Alphavirus Structural Proteins Leads to Packaging of Alphavirus Infectious Single Cycle Particles

(2013) Juana M. Sánchez-Puig et al.   PLoS One

Accelerating Next-Generation Vaccine Development for Global Disease Prevention

(2013) W. C. Koff et al.   SCIENCE

Systems biological approaches to measure and understand vaccine immunity in humans

(2013) Shuzhao Li et al.   SEMINARS IN IMMUNOLOGY

RNA: The new revolution in nucleic acid vaccines

(2013) Andrew J. Geall et al.   SEMINARS IN IMMUNOLOGY

A mucosal adjuvant for the inactivated poliovirus vaccine

(2013) Benjamin P. Steil et al.   VACCINE

Development and evaluation of a replicon particle vaccine expressing the E2 glycoprotein of bovine viral diarrhea virus (BVDV) in cattle

(2013) John Dustin Loy et al.   Virology Journal

DNA vaccines

(2013) Cevayir Coban et al.   Human Vaccines & Immunotherapeutics

A novel, disruptive vaccination technology

(2013) Karl-Josef Kallen et al.   Human Vaccines & Immunotherapeutics

Role of Humoral versus Cellular Responses Induced by a Protective Dengue Vaccine Candidate

(2013) Raphaël M. Zellweger et al.   PLoS Pathogens

Rapidly produced SAM® vaccine against H7N9 influenza is immunogenic in mice

(2013) Armin Hekele et al.   Emerging Microbes & Infections

Lack of Interference with Immunogenicity of a Chimeric Alphavirus Replicon Particle-Based Influenza Vaccine by Preexisting Antivector Immunity

(2012) Yasushi Uematsu et al.   Clinical and Vaccine Immunology

Phase I Safety and Immunogenicity Evaluations of an Alphavirus Replicon HIV-1 Subtype CgagVaccine in Healthy HIV-1-Uninfected Adults

(2012) M. Wecker et al.   Clinical and Vaccine Immunology

Viperin restricts chikungunya virus replication and pathology

(2012) Terk-Shin Teng et al.   JOURNAL OF CLINICAL INVESTIGATION

Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect

(2012) Mariola Fotin-Mleczek et al.   JOURNAL OF GENE MEDICINE

Attenuation of Chikungunya Virus Vaccine Strain 181/Clone 25 Is Determined by Two Amino Acid Substitutions in the E2 Envelope Glycoprotein

(2012) R. Gorchakov et al.   JOURNAL OF VIROLOGY

Superior Induction of T Cell Responses to Conserved HIV-1 Regions by Electroporated Alphavirus Replicon DNA Compared to That with Conventional Plasmid DNA Vaccine

(2012) Maria L. Knudsen et al.   JOURNAL OF VIROLOGY

Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

(2012) S. Jensen et al.   JOURNAL OF VIROLOGY

Immunotherapeutic Synergy Between Anti-CD137 mAb and Intratumoral Administration of a Cytopathic Semliki Forest Virus Encoding IL-12

(2012) José I Quetglas et al.   MOLECULAR THERAPY

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

(2012) Benjamin Petsch et al.   NATURE BIOTECHNOLOGY

Structural vaccinology starts to deliver

(2012) Philip R. Dormitzer et al.   NATURE REVIEWS MICROBIOLOGY

Intradermal Electroporation of Naked Replicon RNA Elicits Strong Immune Responses

(2012) Daniel X. Johansson et al.   PLoS One

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses

(2012) D. R. Burton et al.   SCIENCE

Novel Recombinant Alphaviral and Adenoviral Vectors for Cancer Immunotherapy

(2012) Takuya Osada et al.   SEMINARS IN ONCOLOGY

Infected dendritic cells are sufficient to mediate the adjuvant activity generated by Venezuelan equine encephalitis virus replicon particles

(2012) Daniel R. Tonkin et al.   VACCINE

Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine

(2012) Ryan L. Vander Veen et al.   VACCINE

US Military contributions to the global response to pandemic chikungunya

(2012) Charles H. Hoke et al.   VACCINE

Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: Eastern equine and western equine encephalitis

(2012) Ronald B. Reisler et al.   VACCINE

RNA-based vaccines

(2012) Jeffrey B. Ulmer et al.   VACCINE

Comprehensive evaluation of the adenovirus/alphavirus-replicon chimeric vector-based vaccine rAdV-SFV-E2 against classical swine fever

(2012) Yuan Sun et al.   VACCINE

A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostate-specific membrane antigen (PSMA) in subjects with prostate cancer

(2012) Susan F. Slovin et al.   VACCINE

Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor

(2011) Deborah A. Grosenbaugh et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Tumor vaccination using messenger RNA: prospects of a future therapy

(2011) Sebastian Kreiter et al.   CURRENT OPINION IN IMMUNOLOGY

Electroporation delivery of DNA vaccines: prospects for success

(2011) Niranjan Y Sardesai et al.   CURRENT OPINION IN IMMUNOLOGY

mRNA vaccination as a safe approach for specific protection from type I allergy

(2011) Richard Weiss et al.   Expert Review of Vaccines

A Semliki Forest virus vector engineered to express IFNα induces efficient elimination of established tumors

(2011) J I Quetglas et al.   GENE THERAPY

Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells

(2011) Tatsuya Saitoh et al.   IMMUNITY

dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity

(2011) Yaming Wang et al.   IMMUNOLOGICAL REVIEWS

Enhancement of the immunogenicity of DNA replicon vaccine ofClostridium botulinumneurotoxin serotype A byGM-CSFgene adjuvant

(2011) Na Li et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

(2011) Marina Caskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Viperin, a key player in the antiviral response

(2011) Sandy Mattijssen et al.   MICROBES AND INFECTION

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

A novel alphavirus replicon-vectored vaccine delivered by adenovirus induces sterile immunity against classical swine fever

(2011) Yuan Sun et al.   VACCINE

Role of innate signalling pathways in the immunogenicity of alphaviral replicon-based vaccines

(2011) Tanja I Näslund et al.   Virology Journal

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Replicon particle vaccine protects swine against influenza

(2010) B. Bosworth et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques

(2010) Maximillian Rosario et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunologic Basis of Vaccine Vectors

(2010) Margaret A. Liu   IMMUNITY

DNA vaccines: an historical perspective and view to the future

(2010) Margaret A. Liu   IMMUNOLOGICAL REVIEWS

Exposing Viruses: RNA Patterns Sensed by RIG-I-like Receptors

(2010) Jan Rehwinkel   JOURNAL OF CLINICAL IMMUNOLOGY

An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer

(2010) Michael A. Morse et al.   JOURNAL OF CLINICAL INVESTIGATION

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

(2010) Mariola Fotin-Mleczek et al.   JOURNAL OF IMMUNOTHERAPY

Successful Vaccination Strategies That Protect Aged Mice from Lethal Challenge from Influenza Virus and Heterologous Severe Acute Respiratory Syndrome Coronavirus

(2010) T. Sheahan et al.   JOURNAL OF VIROLOGY

A Chimeric Alphavirus Replicon Particle Vaccine Expressing the Hemagglutinin and Fusion Proteins Protects Juvenile and Infant Rhesus Macaques from Measles

(2010) C.-H. Pan et al.   JOURNAL OF VIROLOGY

Antibody-Mediated Protection against Mucosal Simian-Human Immunodeficiency Virus Challenge of Macaques Immunized with Alphavirus Replicon Particles and Boosted with Trimeric Envelope Glycoprotein in MF59 Adjuvant

(2010) S. W. Barnett et al.   JOURNAL OF VIROLOGY

Heterologous Prime-Boost Immunizations with a Virosomal and an Alphavirus Replicon Vaccine

(2010) Mateusz Walczak et al.   MOLECULAR PHARMACEUTICS

Alphavirus Replicon Particles Expressing TRP-2 Provide Potent Therapeutic Effect on Melanoma through Activation of Humoral and Cellular Immunity

(2010) Francesca Avogadri et al.   PLoS One

Induction of neutralizing antibodies to Hendra and Nipah glycoproteins using a Venezuelan equine encephalitis virus in vivo expression system

(2010) Gabriel N. Defang et al.   VACCINE

Alphavirus replicon-based enhancement of mucosal and systemic immunity is linked to the innate response generated by primary immunization

(2010) Daniel R. Tonkin et al.   VACCINE

Alphavirus replicon-based adjuvants enhance the immunogenicity and effectiveness of Fluzone® in rhesus macaques

(2010) Timothy D. Carroll et al.   VACCINE

Enhanced immunity against classical swine fever in pigs induced by prime-boost immunization using an alphavirus replicon-vectored DNA vaccine and a recombinant adenovirus

(2010) Yuan Sun et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Vaccination with DNA Plasmids Expressing Gn Coupled to C3d or Alphavirus Replicons Expressing Gn Protects Mice against Rift Valley Fever Virus

(2010) Nitin Bhardwaj et al.   PLoS Neglected Tropical Diseases

Recombinant Sindbis Virus Vectors Designed To Express Protective Antigen of Bacillus anthracis Protect Animals from Anthrax and Display Synergy with Ciprofloxacin

(2009) J. M. Thomas et al.   Clinical and Vaccine Immunology

An alphavirus replicon-derived candidate vaccine against Rift Valley fever virus

(2009) M. T. HEISE et al.   EPIDEMIOLOGY AND INFECTION

DNA vaccines for biodefense

(2009) Lesley C Dupuy et al.   Expert Review of Vaccines

Vaccination with recombinant Semliki Forest virus particles expressing translation initiation factor 3 of Brucella abortus induces protective immunity in BALB/c mice

(2009) Alex Cabrera et al.   IMMUNOBIOLOGY

Innate recognition of viruses

(2009) Sandra Diebold   IMMUNOLOGY LETTERS

Immunize and disappear—Safety-optimized mRNA vaccination with a panel of 29 allergens

(2009) Elisabeth Roesler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Alphavirus-Adjuvanted Norovirus-Like Particle Vaccines: Heterologous, Humoral, and Mucosal Immune Responses Protect against Murine Norovirus Challenge

(2009) A. D. LoBue et al.   JOURNAL OF VIROLOGY

Sindbis Virus-Based Measles DNA Vaccines Protect Cotton Rats against Respiratory Measles: Relevance of Antibodies, Mucosal and Systemic Antibody-Secreting Cells, Memory B Cells, and Th1-Type Cytokines as Correlates of Immunity

(2009) M. F. Pasetti et al.   JOURNAL OF VIROLOGY

Acute Infection with Venezuelan Equine Encephalitis Virus Replicon Particles Catalyzes a Systemic Antiviral State and Protects from Lethal Virus Challenge

(2009) J. L. Konopka et al.   JOURNAL OF VIROLOGY

Sterile Protection against Plasmodium knowlesi in Rhesus Monkeys from a Malaria Vaccine: Comparison of Heterologous Prime Boost Strategies

(2009) George Jiang et al.   PLoS One

Molecular smallpox vaccine delivered by alphavirus replicons elicits protective immunity in mice and non-human primates

(2009) Jay W. Hooper et al.   VACCINE

Randomized, double-blind, Phase 1 trial of an alphavirus replicon vaccine for cytomegalovirus in CMV seronegative adult volunteers

(2009) David I. Bernstein et al.   VACCINE

Prime-boost immunization using alphavirus replicon and adenovirus vectored vaccines induces enhanced immune responses against classical swine fever virus in mice

(2009) He-Ping Zhao et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Prostate Stem Cell Antigen Vaccination Induces a Long-term Protective Immune Response against Prostate Cancer in the Absence of Autoimmunity

(2008) M. de la Luz Garcia-Hernandez et al.   CANCER RESEARCH

Dose-Dependent Protection against or Exacerbation of Disease by a Polylactide Glycolide Microparticle-Adsorbed, Alphavirus-Based Measles Virus DNA Vaccine in Rhesus Macaques

(2008) C.-H. Pan et al.   Clinical and Vaccine Immunology

Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines

(2008) S S Diebold et al.   GENE THERAPY

Induction of Broad CD4+ and CD8+ T-Cell Responses and Cross- Neutralizing Antibodies against Hepatitis C Virus by Vaccination with Th1-Adjuvanted Polypeptides Followed by Defective Alphaviral Particles Expressing Envelope Glycoproteins gpE1 and gpE2 and Nonstructural Proteins 3, 4, and 5

(2008) Y. Lin et al.   JOURNAL OF VIROLOGY

An Alphavirus Replicon-Based Human Metapneumovirus Vaccine Is Immunogenic and Protective in Mice and Cotton Rats

(2008) H. Mok et al.   JOURNAL OF VIROLOGY

Comparison of multiple vaccine vectors in a single heterologous prime-boost trial

(2008) Brice Barefoot et al.   VACCINE

A sindbis virus replicon-based DNA vaccine encoding the rabies virus glycoprotein elicits immune responses and complete protection in mice from lethal challenge

(2008) Sonal Saxena et al.   VACCINE

Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen

(2008) Joseph M. Thompson et al.   VACCINE

Augmentation of alphavirus vector-induced human papilloma virus-specific immune and anti-tumour responses by co-expression of interleukin-12

(2008) Annelies Riezebos-Brilman et al.   VACCINE