A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

Vaccination with gag, vif, and nef Gene Fragments Affords Partial Control of Viral Replication after Mucosal Challenge with SIVmac239

(2014) M. A. Martins et al.   JOURNAL OF VIROLOGY

Safety and efficacy of the peptide-based therapeutic vaccine for HIV-1, Vacc-4×: a phase 2 randomised, double-blind, placebo-controlled trial

(2014) Richard B Pollard et al.   LANCET INFECTIOUS DISEASES

Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques

(2014) Viraj Kulkarni et al.   PLoS One

DNA/long peptide vaccination against conserved regions of SIV induces partial protection against SIVmac251 challenge

(2013) Gerrit Koopman et al.   AIDS

The p40 Subunit of Interleukin (IL)-12 Promotes Stabilization and Export of the p35 Subunit

(2013) Rashmi Jalah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccine-Induced Gag-Specific T Cells Are Associated With Reduced Viremia After HIV-1 Infection

(2013) Holly Janes et al.   JOURNAL OF INFECTIOUS DISEASES

Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire

(2013) Joseph P. Casazza et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative Capacity

(2013) M. Rolland et al.   JOURNAL OF VIROLOGY

Mechanism of HIV-1 Neutralization by Antibodies Targeting a Membrane-Proximal Region of gp41

(2013) J. Chen et al.   JOURNAL OF VIROLOGY

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

Association of HLA-DRB1–restricted CD4+ T cell responses with HIV immune control

(2013) Srinika Ranasinghe et al.   NATURE MEDICINE

Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine

(2013) Scott M. Hammer et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIV-1 p24gag Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice

(2013) Viraj Kulkarni et al.   PLoS One

Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design

(2013) Pratima Kunwar et al.   PLoS One

Fitness Costs of Mutations at the HIV-1 Capsid Hexamerization Interface

(2013) Siriphan Manocheewa et al.   PLoS One

DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge

(2013) V. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms

(2013) S. G. Hansen et al.   SCIENCE

Boosters of a therapeutic HIV-1 vaccine induce divergent T cell responses related to regulatory mechanisms

(2013) Andreas Lind et al.   VACCINE

Extreme Genetic Fragility of the HIV-1 Capsid

(2013) Suzannah J. Rihn et al.   PLoS Pathogens

Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted Within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines

(2012) Ingrid Karlsson et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes

(2012) D. Y. Chen et al.   BLOOD

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals

(2012) S. C. Zhang et al.   JOURNAL OF IMMUNOLOGY

Antiviral Inhibitory Capacity of CD8+ T cells Predicts the Rate of CD4+ T-Cell Decline in HIV-1 Infection

(2012) Hongbing Yang et al.   JOURNAL OF INFECTIOUS DISEASES

Vaccine-induced CD8+ T cells control AIDS virus replication

(2012) Philip A. Mudd et al.   NATURE

CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control

(2012) Beatriz Mothe et al.   PLoS One

HIV-1: From escapism to conservatism

(2011) Tomáš Hanke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune-mediated attenuation of HIV-1

(2011) Denis R Chopera et al.   Future Virology

Definition of the viral targets of protective HIV-1-specific T cell responses

(2011) Beatriz Mothe et al.   Journal of Translational Medicine

HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome

(2011) S. Ranasinghe et al.   JOURNAL OF VIROLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial

(2011) Morgane Rolland et al.   NATURE MEDICINE

Increased Breadth and Depth of Cytotoxic T Lymphocytes Responses against HIV-1-B Nef by Inclusion of Epitope Variant Sequences

(2011) Morgane Rolland et al.   PLoS One

Preclinical evaluation of HIV-1 therapeutic ex vivo dendritic cell vaccines expressing consensus Gag antigens and conserved Gag epitopes

(2011) Liguo Niu et al.   VACCINE

Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02)

(2011) Felipe García et al.   VACCINE

Increasing CTL Targeting of Conserved Sequences During Early HIV-1 Infection Is Correlated to Decreasing Viremia

(2010) Otto O. Yang et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

AIDS Clinical Trials Group 5197: A Placebo‐Controlled Trial of Immunization of HIV‐1–Infected Persons with a Replication‐Deficient Adenovirus Type 5 Vaccine Expressing the HIV‐1 Core Protein

(2010) Robert T. Schooley et al.   JOURNAL OF INFECTIOUS DISEASES

Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype

(2010) W. L. Dinges et al.   JOURNAL OF VIROLOGY

Early Selection in Gag by Protective HLA Alleles Contributes to Reduced HIV-1 Replication Capacity That May Be Largely Compensated for in Chronic Infection

(2010) M. A. Brockman et al.   JOURNAL OF VIROLOGY

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

(2010) Dan H Barouch et al.   NATURE MEDICINE

Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization

(2010) Vainav Patel et al.   VACCINE

Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques

(2010) Viraj Kulkarni et al.   VACCINE

Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452)

(2009) Brigitte Autran et al.   AIDS

Two MHC Class I Molecules Associated with Elite Control of Immunodeficiency Virus Replication, Mamu-B*08 and HLA-B*2705, Bind Peptides with Sequence Similarity

(2009) J. T. Loffredo et al.   JOURNAL OF IMMUNOLOGY

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins

(2009) Zabrina L. Brumme et al.   PLoS One

Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response

(2009) Ryan M. Troyer et al.   PLoS Pathogens

HLA class I supertypes: a revised and updated classification

(2008) John Sidney et al.   BMC IMMUNOLOGY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Coping with Viral Diversity in HIV Vaccine Design: A Response to Nickle et al.

(2008) Will Fischer et al.   PLoS Computational Biology