Immune Modulation by Human Secreted RNases at the Extracellular Space

RNase 7 Strongly Promotes TLR9-Mediated DNA Sensing by Human Plasmacytoid Dendritic Cells

(2018) Verena Kopfnagel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population

(2018) Gora Diop et al.   MALARIA JOURNAL

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNase 7 but not psoriasin nor sPLA2-IIA associates with Mycobacterium tuberculosis during airway epithelial cell infection

(2018) Flor Torres-Juarez et al.   Pathogens and Disease

Differential Expression of Six Rnase2 and Three Rnase3 Paralogs Identified in Blunt Snout Bream in Response to Aeromonas hydrophila Infection

(2018) Ruijing Geng et al.   Genes

Elevated Systemic Levels of Eosinophil, Neutrophil, and Mast Cell Granular Proteins in Strongyloides Stercoralis Infection that Diminish following Treatment

(2018) Anuradha Rajamanickam et al.   Frontiers in Immunology

Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities

(2017) Ayush Attery et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Hyaluronic acid modification of RNase A and its intracellular delivery using lipid-like nanoparticles

(2017) Xiaoying Wang et al.   JOURNAL OF CONTROLLED RELEASE

Antitumor Macrophage Response to Bacillus pumilus Ribonuclease (Binase)

(2017) Anna Makeeva et al.   MEDIATORS OF INFLAMMATION

In Vivo Cleavage Map Illuminates the Central Role of RNase E in Coding and Non-coding RNA Pathways

(2017) Yanjie Chao et al.   MOLECULAR CELL

The CDI toxin of Yersinia kristensenii is a novel bacterial member of the RNase A superfamily

(2017) Gaëlle Batot et al.   NUCLEIC ACIDS RESEARCH

Introducing the new bacterial branch of the RNase A superfamily

(2017) Bonnie J. Cuthbert et al.   RNA Biology

Toxins of Prokaryotic Toxin-Antitoxin Systems with Sequence-Specific Endoribonuclease Activity

(2017) Hisako Masuda et al.   Toxins

The evolutionary history of plant T2/S-type ribonucleases

(2017) Karolis Ramanauskas et al.   PeerJ

Differential processing of small RNAs during endoplasmic reticulum stress

(2017) Mikhail V. Mesitov et al.   Scientific Reports

The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement

(2016) G. Prats-Ejarque et al.   BIOCHEMICAL JOURNAL

Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases

(2016) Sydney P. Thomas et al.   BIOCHEMISTRY

Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells

(2016) Kevin A. Goncalves et al.   CELL

Extracellular Ribonucleic Acids (RNA) Enter the Stage in Cardiovascular Disease

(2016) Alma Zernecke et al.   CIRCULATION RESEARCH

Structural basis of substrate specificity in porcine RNase 4

(2016) Shutian Liang et al.   FEBS Journal

RNase 7 in Cutaneous Defense

(2016) Franziska Rademacher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense

(2016) Brian Becknell et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Th17 Cells Lack HIV-Inhibitory RNases and Are Highly Permissive to Productive HIV Infection

(2016) Aaron Christensen-Quick et al.   JOURNAL OF VIROLOGY

Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract

(2016) Tad E. Eichler et al.   KIDNEY INTERNATIONAL

Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components

(2016) Martijn J.C. van Herwijnen et al.   MOLECULAR & CELLULAR PROTEOMICS

tRNA is a new target for cleavage by a MazF toxin

(2016) Jason M. Schifano et al.   NUCLEIC ACIDS RESEARCH

Molecular basis for the autonomous promotion of cell proliferation by angiogenin

(2016) Trish T. Hoang et al.   NUCLEIC ACIDS RESEARCH

RNA biology of angiogenin: Current state and perspectives

(2016) Shawn M. Lyons et al.   RNA Biology

DJ-1 Is Upregulated in Oral Squamous Cell Carcinoma and Promotes Oral Cancer Cell Proliferation and Invasion

(2016) Shuaimei Xu et al.   Journal of Cancer

Exploring the mechanisms of action of human secretory RNase 3 and RNase 7 againstCandida albicans

(2016) Vivian A. Salazar et al.   MicrobiologyOpen

Solution structure and base specificity of cytotoxic RC-RNase 2 from Rana catesbeiana

(2015) Chun-Hua Hsu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner

(2015) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Schistosoma mansoni T2 ribonuclease omega-1 modulates inflammasome-dependent IL-1β secretion in macrophages

(2015) Brian J. Ferguson et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense

(2015) Helene Rosenberg   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome secretion by eosinophils: A possible role in asthma pathogenesis

(2015) Carla Mazzeo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil-associated Ribonuclease 11 Is a Macrophage Chemoattractant

(2015) Kelsey J. Yamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basal Cells Contribute to Innate Immunity of the Airway Epithelium through Production of the Antimicrobial Protein RNase 7

(2015) Gimano D. Amatngalim et al.   JOURNAL OF IMMUNOLOGY

Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract

(2015) Brian Becknell et al.   KIDNEY INTERNATIONAL

Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct

(2015) Rong Xu et al.   METHODS

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers

(2015) Shozo Honda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Humanized Anti-CD22-Onconase Antibody-Drug Conjugate Mediates Highly Potent Destruction of Targeted Tumor Cells

(2015) Tobias Weber et al.   Journal of Immunology Research

Bovine seminal ribonuclease triggers Beclin1-mediated autophagic cell death in pancreatic cancer cells

(2014) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein post-translational modification in host defense: the antimicrobial mechanism of action of human eosinophil cationic protein native forms

(2014) Vivian A. Salazar et al.   FEBS Journal

tRNA fragments in human health and disease

(2014) Paul Anderson et al.   FEBS LETTERS

Bovine Brain Ribonuclease Is the Functional Homolog of Human Ribonuclease 1

(2014) Chelcie H. Eller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eosinophil Granule Proteins: Form and Function

(2014) K. Ravi Acharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Evolution of Ribonuclease Inhibitor: Insights from Birds and Reptiles

(2014) Jo E. Lomax et al.   JOURNAL OF MOLECULAR BIOLOGY

Plasma Autoantibodies against Heat Shock Protein 70, Enolase 1 and Ribonuclease/Angiogenin Inhibitor 1 as Potential Biomarkers for Cholangiocarcinoma

(2014) Rucksak Rucksaken et al.   PLoS One

RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-α in cardiac ischaemia/reperfusion injury

(2014) Hector Cabrera-Fuentes et al.   THROMBOSIS AND HAEMOSTASIS

Identification of Novel Synovial Fluid Biomarkers Associated with Meniscal Pathology

(2014) Brandon Roller et al.   Journal of Knee Surgery

PI3K, ERK, p38 MAPK and integrins regulate CCR3-mediated secretion of mouse and human eosinophil-associated RNases

(2013) R. Shamri et al.   ALLERGY

Two Human Host Defense Ribonucleases against Mycobacteria, the Eosinophil Cationic Protein (RNase 3) and RNase 7

(2013) David Pulido et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prenatal human skin expresses the antimicrobial peptide RNase 7

(2013) Christopher Schuster et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

tRNA modifications: Necessary for correct tRNA-derived fragments during the recovery from stress?

(2013) Zeljko Durdevic et al.   BIOESSAYS

Eosinophil-derived neurotoxin levels at 3 months post-respiratory syncytial virus bronchiolitis are a predictive biomarker of recurrent wheezing

(2013) Chang-Keun Kim et al.   BIOMARKERS

Activated mouse eosinophils protect against lethal respiratory virus infection

(2013) C. M. Percopo et al.   BLOOD

Role of Extracellular RNA in Atherosclerotic Plaque Formation in Mice

(2013) Sakine Simsekyilmaz et al.   CIRCULATION

Multiple bursts of pancreatic ribonuclease gene duplication in insect-eating bats

(2013) Huihui Xu et al.   GENE

The Expansion and Functional Diversification of the Mammalian Ribonuclease A Superfamily Epitomizes the Efficiency of Multigene Families at Generating Biological Novelty

(2013) Stephen M. Goo et al.   Genome Biology and Evolution

Ribonuclease/angiogenin inhibitor 1 regulates stress-induced subcellular localization of angiogenin to control growth and survival

(2013) E. Pizzo et al.   JOURNAL OF CELL SCIENCE

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

(2013) Marco Prunotto et al.   Journal of Proteomics

Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract

(2013) John David Spencer et al.   KIDNEY INTERNATIONAL

An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract

(2013) John D. Spencer et al.   KIDNEY INTERNATIONAL

Heterogeneity in Neutrophil Microparticles Reveals Distinct Proteome and Functional Properties

(2013) Jesmond Dalli et al.   MOLECULAR & CELLULAR PROTEOMICS

Differential protein profiling of renal cell carcinoma urinary exosomes

(2013) F. Raimondo et al.   Molecular BioSystems

Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis

(2013) F. Acquati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimicrobial Action and Cell Agglutination by the Eosinophil Cationic Protein Are Modulated by the Cell Wall Lipopolysaccharide Structure

(2012) David Pulido et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nucleotide binding architecture for secreted cytotoxic endoribonucleases

(2012) Ester Boix et al.   BIOCHIMIE

Structural determinants of the eosinophil cationic protein antimicrobial activity

(2012) Ester Boix et al.   BIOLOGICAL CHEMISTRY

Genetic diversity of human RNase 8

(2012) Calvin C Chan et al.   BMC GENOMICS

Onconase downregulates microRNA expression through targeting microRNA precursors

(2012) Meng Qiao et al.   CELL RESEARCH

Eosinophils in infection and intestinal immunity

(2012) Simon P. Hogan et al.   CURRENT OPINION IN GASTROENTEROLOGY

The skin surface as antimicrobial barrier: present concepts and future outlooks

(2012) Jürgen Harder et al.   EXPERIMENTAL DERMATOLOGY

CCL11 elicits secretion of RNases from mouse eosinophils and their cell-free granules

(2012) Revital Shamri et al.   FASEB JOURNAL

The mammalian secreted RNases: Mechanisms of action in host defence

(2012) Sandeep K Gupta et al.   Innate Immunity

An insertion in loop L7 of human eosinophil-derived neurotoxin is crucial for its antiviral activity

(2012) Deepa Sikriwal et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin Modulates the Inflammatory Granulocyte Response to Streptococci via Phosphatidylinositol 3-Kinase

(2012) Sybille Kenzel et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial RNases in Cutaneous Defense

(2012) Maren Simanski et al.   Journal of Innate Immunity

Identification and Functional Characterization of tRNA-derived RNA Fragments (tRFs) in Respiratory Syncytial Virus Infection

(2012) Qingrong Wang et al.   MOLECULAR THERAPY

Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs

(2012) Zhihua Li et al.   NUCLEIC ACIDS RESEARCH

Structure and activity of the only human RNase T2

(2012) Andrea Thorn et al.   NUCLEIC ACIDS RESEARCH

Double Domain Swapping in Bovine Seminal RNase: Formation of Distinct N- and C-swapped Tetramers and Multimers with Increasing Biological Activities

(2012) Giovanni Gotte et al.   PLoS One

Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of   chemokines and RNases

(2012) F. Cocchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons

(2012) Nethaji Thiyagarajan et al.   Nature Communications

Exploring New Biological Functions of Amyloids: Bacteria Cell Agglutination Mediated by Host Protein Aggregation

(2012) Marc Torrent et al.   PLoS Pathogens

A Novel Cationic Ribonuclease with Antimicrobial Activity from Rana dybowskii

(2011) Fengyun Tao et al.   BIOCHEMICAL GENETICS

Bovine Pancreatic Ribonuclease: Fifty Years of the First Enzymatic Reaction Mechanism

(2011) Claudi M. Cuchillo et al.   BIOCHEMISTRY

Role of unique basic residues in cytotoxic, antibacterial and antiparasitic activities of human eosinophil cationic protein

(2011) Anubha Singh et al.   BIOLOGICAL CHEMISTRY

Protecting the boundary: the sentinel role of host defense peptides in the skin

(2011) Jamie J. Bernard et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Polymorphisms in the RNASE3 Gene Are Associated with Susceptibility to Cerebral Malaria in Ghanaian Children

(2011) Bright Adu et al.   PLoS One

Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT)

(2011) Zhen Wang et al.   PROTEOMICS

The Structural Biology of Toll-like Receptors

(2011) Istvan Botos et al.   STRUCTURE

A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish

(2010) Elio Pizzo et al.   BIOCHEMICAL JOURNAL

TNF-α Mediates Eosinophil Cationic Protein-induced Apoptosis in BEAS-2B Cells

(2010) Kun-Che Chang et al.   BMC CELL BIOLOGY

Eosinophils in innate immunity: an evolving story

(2010) Revital Shamri et al.   CELL AND TISSUE RESEARCH

Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens

(2010) Oliver T. Burton et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The eight human “canonical” ribonucleases: Molecular diversity, catalytic properties, and special biological actions of the enzyme proteins

(2010) Salvatore Sorrentino   FEBS LETTERS

Characterisation of the anti-microbial activity of bovine milk ribonuclease4 and ribonuclease5 (angiogenin)

(2010) Paul Harris et al.   INTERNATIONAL DAIRY JOURNAL

Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly

(2010) Mohamed M. Emara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Expression and Secretion of Antimicrobial Peptides in Atopic Dermatitis and after Superficial Skin Injury

(2010) Jürgen Harder et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin Commensals Amplify the Innate Immune Response to Pathogens by Activation of Distinct Signaling Pathways

(2010) Ines Wanke et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Proteomics Analysis of Bladder Cancer Exosomes

(2010) Joanne L. Welton et al.   MOLECULAR & CELLULAR PROTEOMICS

Angiogenin Levels and ANG Genotypes: Dysregulation in Amyotrophic Lateral Sclerosis

(2010) Russell Lewis McLaughlin et al.   PLoS One

Collaborative Non-Self Recognition System in S-RNase-Based Self-Incompatibility

(2010) K.-i. Kubo et al.   SCIENCE

Expression and localisation of vascular ribonucleases in endothelial cells

(2010) Sara Dadkhahi et al.   THROMBOSIS AND HAEMOSTASIS

T2 Family ribonucleases: ancient enzymes with diverse roles

(2010) Natalie Luhtala et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human ribonuclease 9, a member of ribonuclease A superfamily, specifically expressed in epididymis, is a novel sperm-binding protein

(2009) Gui-Zhi Cheng et al.   ASIAN JOURNAL OF ANDROLOGY

Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7

(2009) Marc Torrent et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Human hair follicle epithelium has an antimicrobial defence system that includes the inducible antimicrobial peptide psoriasin (S100A7) and RNase 7

(2009) K. Reithmayer et al.   BRITISH JOURNAL OF DERMATOLOGY

Stressing Out over tRNA Cleavage

(2009) Debrah M. Thompson et al.   CELL

Functional extracellular eosinophil granules: novel implications in eosinophil immunobiology

(2009) Josiane S Neves et al.   CURRENT OPINION IN IMMUNOLOGY

Schistosoma mansoniegg antigens induce Treg that participate in diabetes prevention in NOD mice

(2009) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ribonucleases as potential modalities in anticancer therapy

(2009) Wojciech Ardelt et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization of the angiogenic activity of zebrafish ribonucleases

(2009) Daria M. Monti et al.   FEBS Journal

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

The Coding ECP 434(G>C) Gene Polymorphism Determines the Cytotoxicity of ECP but Has Minor Effects on Fibroblast-Mediated Gel Contraction and No Effect on RNase Activity

(2009) J. Rubin et al.   JOURNAL OF IMMUNOLOGY

Eosinophil Ribonucleases and Their Cutaneous Lesion-Forming Activity

(2009) D. A. Plager et al.   JOURNAL OF IMMUNOLOGY

Constitutive Expression of the Antimicrobial Peptide RNase 7 Is Associated withStaphylococcus aureusInfection of the Skin

(2009) Philipp Zanger et al.   JOURNAL OF INFECTIOUS DISEASES

Antimicrobial RNases of Human Skin

(2009) Michael Zasloff   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Degradation by Stratum Corneum Proteases Prevents Endogenous RNase Inhibitor from Blocking Antimicrobial Activities of RNase 5 and RNase 7

(2009) Arby Abtin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Human mast cells synthesize and release angiogenin, a member of the ribonuclease A (RNase A) superfamily

(2009) Marianna Kulka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection

(2009) Marco Henneke et al.   NATURE GENETICS

RNase 7 Contributes to the Cutaneous Defense against Enterococcus faecium

(2009) Bente Köten et al.   PLoS One

Role of catalytic and non-catalytic subsite residues in ribonuclease activity of human eosinophil-derived neurotoxin

(2008) Deepa Sikriwal et al.   BIOLOGICAL CHEMISTRY

Intracellular Routing of Cytotoxic Pancreatic-Type Ribonucleases

(2008) Antoni Benito et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Antibody-Targeted RNase Fusion Proteins (ImmunoRNases) for Cancer Therapy

(2008) Jurgen Krauss et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Ribonucleases with angiogenic and bactericidal activities from the Atlantic salmon

(2008) Elio Pizzo et al.   FEBS Journal

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

(2008) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNase A ribonucleases and host defense: an evolving story

(2008) Helene F. Rosenberg   JOURNAL OF LEUKOCYTE BIOLOGY

tRNA cleavage is a conserved response to oxidative stress in eukaryotes

(2008) D. M. Thompson et al.   RNA