Innate immune receptor clustering and its role in immune regulation

Imaging of the immune system – towards a subcellular and molecular understanding

(2020) Lai Wen et al.   JOURNAL OF CELL SCIENCE

Lipid Rafts: Controversies Resolved, Mysteries Remain

(2020) Ilya Levental et al.   TRENDS IN CELL BIOLOGY

Simultaneous Nanoscale Imaging of Chemical and Architectural Heterogeneity on Yeast Cell Wall Particles

(2020) Wenqian Li et al.   LANGMUIR

Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers

(2020) Toon Verheyen et al.   NUCLEIC ACIDS RESEARCH

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

(2020) Rémi Veneziano et al.   Nature Nanotechnology

Macrophage activation on “phagocytic synapse” arrays: Spacing of nanoclustered ligands directs TLR1/2 signaling with an intrinsic limit

(2020) Miao Li et al.   Science Advances

How does T cell receptor clustering impact on signal transduction?

(2019) Jesse Goyette et al.   JOURNAL OF CELL SCIENCE

Cholesterol depletion by MβCD enhances cell membrane tension, its variations and reduces integrity

(2019) Arikta Biswas et al.   BIOPHYSICAL JOURNAL

Programming Structured DNA Assemblies to Probe Biophysical Processes

(2019) Eike-Christian Wamhoff et al.   Annual Review of Biophysics

TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion

(2019) Naveen Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The plasma membrane as a mechanochemical transducer

(2019) Anabel-Lise Le Roux et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages

(2019) Yanxian Feng et al.   Nature Communications

Innate Immune Recognition: An Issue More Complex Than Expected

(2019) Klara Kubelkova et al.   Frontiers in Cellular and Infection Microbiology

Tracking Single Molecules in Biomembranes: Is Seeing Always Believing?

(2019) Yanqi Yu et al.   ACS Nano

Geometrical reorganization of Dectin-1 and TLR2 on single phagosomes alters their synergistic immune signaling

(2019) Wenqian Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement

(2018) Spencer A. Freeman et al.   CELL

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

(2018) Haogang Cai et al.   Nature Nanotechnology

Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility

(2018) Zhongwen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-Type Lectin-Like Receptors As Emerging Orchestrators of Sterile Inflammation Represent Potential Therapeutic Targets

(2018) Elise Chiffoleau   Frontiers in Immunology

Combining Adhesive Nanostructured Surfaces and Costimulatory Signals to Increase T Cell Activation

(2018) Judith Guasch et al.   NANO LETTERS

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

(2018) Ying Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages

(2017) Filipa B. Lopes et al.   JOURNAL OF CELL BIOLOGY

Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through FcαRI–TLR Cross-Talk

(2017) Ivo S. Hansen et al.   JOURNAL OF IMMUNOLOGY

The FcεRI signaling cascade and integrin trafficking converge at patterned ligand surfaces

(2017) Devin L. Wakefield et al.   MOLECULAR BIOLOGY OF THE CELL

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biased signalling is an essential feature of TLR4 in glioma cells

(2016) Marie-Theres Zeuner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis

(2016) Spencer A. Freeman et al.   CELL

Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells

(2016) Mickaël M. Ménager et al.   CELL

Functional crosstalk between membrane lipids and TLR biology

(2016) Marielle S Köberlin et al.   CURRENT OPINION IN CELL BIOLOGY

Cortical actin and the plasma membrane: inextricably intertwined

(2016) Darius V Köster et al.   CURRENT OPINION IN CELL BIOLOGY

The Continuing Mystery of Lipid Rafts

(2016) Ilya Levental et al.   JOURNAL OF MOLECULAR BIOLOGY

Raft-based interactions of gangliosides with a GPI-anchored receptor

(2016) Naoko Komura et al.   Nature Chemical Biology

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Role of lipid microdomains in TLR-mediated signalling

(2015) Jean-Marie Ruysschaert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

With or without rafts? Alternative views on cell membranes

(2015) Eva Sevcsik et al.   BIOESSAYS

C-type lectins in immunity: recent developments

(2015) Ivy M Dambuza et al.   CURRENT OPINION IN IMMUNOLOGY

Functions of cholera toxin B-subunit as a raft cross-linker

(2015) Charles A. Day et al.   Essays in Biochemistry

Live Cell Plasma Membranes Do Not Exhibit a Miscibility Phase Transition over a Wide Range of Temperatures

(2015) Il-Hyung Lee et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Nanoscale optomechanical actuators for controlling mechanotransduction in living cells

(2015) Zheng Liu et al.   NATURE METHODS

The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck

(2015) Kyung-Ho Roh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Control of B Cell Activation and Immunological Synapse Formation

(2015) Elina Kuokkanen et al.   TRAFFIC

GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane

(2015) Eva Sevcsik et al.   Nature Communications

CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway

(2015) Juin-Hua Huang et al.   PLoS Pathogens

Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling

(2014) Agnieszka Płóciennikowska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Actin Cytoskeleton Reorganization by Syk Regulates Fcγ Receptor Responsiveness by Increasing Its Lateral Mobility and Clustering

(2014) Valentin Jaumouillé et al.   DEVELOPMENTAL CELL

The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse

(2014) Kathryn Lagrue et al.   IMMUNOLOGICAL REVIEWS

Phagocytosis: receptors, signal integration, and the cytoskeleton

(2014) Spencer A. Freeman et al.   IMMUNOLOGICAL REVIEWS

Differential Activation of Human TLR4 by Escherichia coli and Shigella flexneri 2a Lipopolysaccharide: Combined Effects of Lipid A Acylation State and TLR4 Polymorphisms on Signaling

(2014) P. Rallabhandi et al.   JOURNAL OF IMMUNOLOGY

Spatial control of membrane receptor function using ligand nanocalipers

(2014) Alan Shaw et al.   NATURE METHODS

Actin Dynamics, Architecture, and Mechanics in Cell Motility

(2014) Laurent Blanchoin et al.   PHYSIOLOGICAL REVIEWS

Atomic Force Microscopy in Microbiology: New Structural and Functional Insights into the Microbial Cell Surface

(2014) Y. F. Dufrene   mBio

Clustering of Pattern Recognition Receptors for Fungal Detection

(2014) Makoto Inoue et al.   PLoS Pathogens

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Interaction of membrane/lipid rafts with the cytoskeleton: Impact on signaling and function

(2013) Brian P. Head et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Distinct Stages of Stimulated FcεRI Receptor Clustering and Immobilization Are Identified through Superresolution Imaging

(2013) Sarah A. Shelby et al.   BIOPHYSICAL JOURNAL

Fluorescent Probes for Lipid Rafts: From Model Membranes to Living Cells

(2013) Andrey S. Klymchenko et al.   CHEMISTRY & BIOLOGY

Gelsolin: The tail of a molecular gymnast

(2013) Shalini Nag et al.   Cytoskeleton

Modulation of T cell signaling by the actin cytoskeleton

(2013) Y. Yu et al.   JOURNAL OF CELL SCIENCE

TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors

(2013) Jeroen van Bergenhenegouwen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fine Tuning and Efficient T Cell Activation with Stimulatory aCD3 Nanoarrays

(2013) Jovana Matic et al.   NANO LETTERS

T Cell Activation is Determined by the Number of Presented Antigens

(2013) Janosch Deeg et al.   NANO LETTERS

Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts

(2013) J. F. Frisz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor Signaling Clusters in the Immune Synapse

(2012) Michael L. Dustin et al.   Annual Review of Biophysics

The lipid raft hypothesis revisited - New insights on raft composition and function from super-resolution fluorescence microscopy

(2012) Dylan M. Owen et al.   BIOESSAYS

Super-resolution characterization of TCR-dependent signaling clusters

(2012) Eilon Sherman et al.   IMMUNOLOGICAL REVIEWS

Quantitative Nanoscale Analysis of IgE-FcεRI Clustering and Coupling to Early Signaling Proteins

(2012) Sarah L. Veatch et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Characterization of Differential Toll-like Receptor Responses below the Optical Diffraction Limit

(2012) Jesse S. Aaron et al.   Small

Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution

(2012) Dylan M. Owen et al.   Nature Communications

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice

(2011) Y. Liu et al.   BLOOD

Toll-like receptors

(2011) Eva Marie Y. Moresco et al.   CURRENT BIOLOGY

Signaling clusters in the cell membrane

(2011) Niña C Hartman et al.   CURRENT OPINION IN CELL BIOLOGY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Location, Location, Location: Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?

(2011) Martha Triantafilou et al.   MEDIATORS OF INFLAMMATION

Super-resolution microscopy reveals cell wall dynamics and peptidoglycan architecture in ovococcal bacteria

(2011) Richard Wheeler et al.   MOLECULAR MICROBIOLOGY

The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity

(2011) J E Bakema et al.   Mucosal Immunology

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac

(2010) A. Y. Pollitt et al.   BLOOD

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Evaluation of the cytotoxicity of β-cyclodextrin derivatives: Evidence for the role of cholesterol extraction

(2010) T. Kiss et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets

(2010) Ronald S. Flannagan et al.   JOURNAL OF CELL BIOLOGY

Signalling complexes and clusters: functional advantages and methodological hurdles

(2010) M. Cebecauer et al.   JOURNAL OF CELL SCIENCE

Cutting Edge: Critical Role of Intracellular Osteopontin in Antifungal Innate Immune Responses

(2010) M. Inoue et al.   JOURNAL OF IMMUNOLOGY

Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes

(2010) Scott B Halstead et al.   LANCET INFECTIOUS DISEASES

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Super-Resolution Fluorescence Microscopy

(2009) Bo Huang et al.   Annual Review of Biochemistry

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

A nanometer scale optical view on the compartmentalization of cell membranes

(2009) Thomas S. van Zanten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Activated Dectin-1 Localizes to Lipid Raft Microdomains for Signaling and Activation of Phagocytosis and Cytokine Production in Dendritic Cells

(2009) Shengli Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of Fc RIIa (CD32a) with Lipid Rafts Regulates Ligand Binding Activity

(2009) S. Bournazos et al.   JOURNAL OF IMMUNOLOGY

Formation of a Mast Cell Synapse: Fc RI Membrane Dynamics upon Binding Mobile or Immobilized Ligands on Surfaces

(2009) A. Carroll-Portillo et al.   JOURNAL OF IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages

(2008) Gerben Ferwerda et al.   CELLULAR MICROBIOLOGY

The Pattern Recognition Receptor Dectin-1: From Fungi to Mycobacteria

(2008) J. Schorey et al.   CURRENT DRUG TARGETS

Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers

(2008) Hao Yuan Kueh et al.   JOURNAL OF CELL BIOLOGY

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE

The development of allergic inflammation

(2008) Stephen J. Galli et al.   NATURE

Micropatterning of costimulatory ligands enhances CD4+ T cell function

(2008) K. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Resolution Cell Surface Dynamics of Germinating Aspergillus fumigatus Conidia

(2007) Etienne Dague et al.   BIOPHYSICAL JOURNAL