Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells

(2017) Ardiyanto Liaunardy-Jopeace et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase

(2017) Catherine B. Carbone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells

(2017) En Cai et al.   SCIENCE

Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells

(2017) Ardiyanto Liaunardy-Jopeace et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes

(2017) Matthew B Stone et al.   eLife

The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering

(2017) Bing-Mae Chen et al.   Frontiers in Immunology

Molecular Occupancy of Nanodot Arrays

(2016) Haogang Cai et al.   ACS Nano

Initiation of T cell signaling by CD45 segregation at 'close contacts'

(2016) Veronica T Chang et al.   NATURE IMMUNOLOGY

Size-dependent protein segregation at membrane interfaces

(2016) Eva M. Schmid et al.   Nature Physics

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

(2016) Sophie V. Pageon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designing chimeric antigen receptors to effectively and safely target tumors

(2015) Michael C Jensen et al.   CURRENT OPINION IN IMMUNOLOGY

In vitro membrane reconstitution of the T-cell receptor proximal signaling network

(2014) Enfu Hui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nanoscale Ligand Spacing Influences Receptor Triggering in T Cells and NK Cells

(2013) Derfogail Delcassian et al.   NANO LETTERS

Fine Tuning and Efficient T Cell Activation with Stimulatory aCD3 Nanoarrays

(2013) Jovana Matic et al.   NANO LETTERS

T Cell Activation is Determined by the Number of Presented Antigens

(2013) Janosch Deeg et al.   NANO LETTERS

Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments

(2013) Helena Gradišar et al.   Nature Chemical Biology

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

(2012) Etienne Gagnon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

(2012) John R. James et al.   NATURE

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

(2011) Eilon Sherman et al.   IMMUNITY

Supported Membranes Embedded with Fixed Arrays of Gold Nanoparticles

(2011) Theobald Lohmüller et al.   NANO LETTERS

Transforming binding affinities from three dimensions to two with application to cadherin clustering

(2011) Yinghao Wu et al.   NATURE

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

(2011) B. N. Manz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Role of Ubiquitin and TSG101 Protein in Formation and Function of the Central Supramolecular Activation Cluster

(2010) Santosha Vardhana et al.   IMMUNITY

Probing Cellular Traction Forces by Micropillar Arrays: Contribution of Substrate Warping to Pillar Deflection

(2010) Ingmar Schoen et al.   NANO LETTERS

Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function

(2009) Christopher J. Bettinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Human Immunodeficiency Virus Type 1 Envelope gp120-Induced Partial T-Cell Receptor Signaling Creates an F-Actin-Depleted Zone in the Virological Synapse

(2009) G. Vasiliver-Shamis et al.   JOURNAL OF VIROLOGY

Robust Pattern Transfer of Nanoimprinted Features for Sub-5-nm Fabrication

(2009) Mark Schvartzman et al.   NANO LETTERS