Non-caveolar caveolins – duties outside the caves

Lipid droplets, bioenergetic fluxes, and metabolic flexibility

(2020) Marta Bosch et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity

(2019) Laura Rangel et al.   Scientific Reports

EHD2 regulates adipocyte function and is enriched at cell surface-associated lipid droplets in primary human adipocytes

(2019) Björn Morén et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

(2019) Kerrie-Ann McMahon et al.   Nature Communications

Super-resolution modularity analysis shows polyhedral caveolin-1 oligomers combine to form scaffolds and caveolae

(2019) Ismail M. Khater et al.   Scientific Reports

Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis

(2019) Punit Bhattachan et al.   FASEB JOURNAL

A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

(2018) Kirill Bersuker et al.   DEVELOPMENTAL CELL

Endosome maturation factors Rabenosyn‐5/VPS45 and caveolin‐1 regulate ciliary membrane and polycystin‐2 homeostasis

(2018) Noémie Scheidel et al.   EMBO JOURNAL

Modulation of caveolae by insulin/IGF‐1 signaling regulates aging of Caenorhabditis elegans

(2018) Noa Roitenberg et al.   EMBO REPORTS

Cell-free formation and interactome analysis of caveolae

(2018) WooRam Jung et al.   JOURNAL OF CELL BIOLOGY

Super Resolution Network Analysis Defines the Molecular Architecture of Caveolae and Caveolin-1 Scaffolds

(2018) Ismail M. Khater et al.   Scientific Reports

Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress

(2018) Roberto Bravo-Sagua et al.   CELL DEATH AND DIFFERENTIATION

Caveolae: Structure, Function, and Relationship to Disease

(2018) Robert G. Parton   Annual Review of Cell and Developmental Biology

Interplay between Membrane Curvature and Cholesterol: Role of Palmitoylated Caveolin-1

(2018) Anjali Krishna et al.   BIOPHYSICAL JOURNAL

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

(2018) Yunxiao Zhang et al.   CELL

Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin–stimulated, cAMP-mediated lipolysis

(2017) Andrew Kuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER

(2017) Muthukumar Kannan et al.   JOURNAL OF LIPID RESEARCH

Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia

(2017) Adam Kassan et al.   JOURNAL OF NEUROPHYSIOLOGY

The phospho–caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration

(2017) Fanrui Meng et al.   MOLECULAR BIOLOGY OF THE CELL

A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal

(2017) Courtney A. Copeland et al.   MOLECULAR BIOLOGY OF THE CELL

Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology

(2017) Monia Barnat et al.   NEURON

KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling

(2017) Kenneth B. Schou et al.   Nature Communications

Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination

(2017) Eric Seemann et al.   eLife

Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration

(2017) Xiaoying Luo et al.   Redox Biology

Caveolin1 protects against diet induced hepatic lipid accumulation in mice

(2017) Meng Li et al.   PLoS One

Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

(2016) A. Schonle et al.   BLOOD

The Allostery Model of TCR Regulation

(2016) Wolfgang W. A. Schamel et al.   JOURNAL OF IMMUNOLOGY

Caveolae: One Function or Many?

(2016) Jade P.X. Cheng et al.   TRENDS IN CELL BIOLOGY

Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

(2016) Aleix Sala-Vila et al.   Scientific Reports

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy

(2015) Yin Shi et al.   Autophagy

Caveolae - mechanosensitive membrane invaginations linked to actin filaments

(2015) A. Echarri et al.   JOURNAL OF CELL SCIENCE

Cavin family proteins and the assembly of caveolae

(2015) O. Kovtun et al.   JOURNAL OF CELL SCIENCE

Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function

(2015) Junji Egawa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tagging Strategies Strongly Affect the Fate of Overexpressed Caveolin-1

(2015) Bing Han et al.   TRAFFIC

Dynamic caveolae exclude bulk membrane proteins and are required for sorting of excess glycosphingolipids

(2015) Elena Shvets et al.   Nature Communications

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Galectin-3 Overrides PTRF/Cavin-1 Reduction of PC3 Prostate Cancer Cell Migration

(2015) Fanrui Meng et al.   PLoS One

Interactions of caveolin-1 scaffolding and intramembrane regions containing a CRAC motif with cholesterol in lipid bilayers

(2014) Guanhua Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Fertilization-induced K63-linked ubiquitylation mediates clearance of maternal membrane proteins

(2014) M. Sato et al.   DEVELOPMENT

Pleiotropic Effects of Cavin-1 Deficiency on Lipid Metabolism

(2014) Shi-Ying Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites

(2014) Albert Pol et al.   JOURNAL OF CELL BIOLOGY

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling

(2014) Nicholas Ariotti et al.   JOURNAL OF CELL BIOLOGY

Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia

(2014) Hideo Hagihara et al.   Molecular Brain

Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis

(2014) Natasha Chaudhary et al.   PLOS BIOLOGY

Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes

(2013) Christoph Meyer et al.   Cell Communication and Signaling

Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response

(2013) Benjamin R. Myers et al.   DEVELOPMENTAL CELL

Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo

(2013) Eugenia Trushina et al.   HUMAN MOLECULAR GENETICS

Ubiquitination of the N-terminal Region of Caveolin-1 Regulates Endosomal Sorting by the VCP/p97 AAA-ATPase

(2013) Philipp Kirchner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolin-1 Interacts with Derlin-1 and Promotes Ubiquitination and Degradation of Cyclooxygenase-2 via Collaboration with p97 Complex

(2013) Shu-Fen Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer

(2013) H Moon et al.   ONCOGENE

Overexpression of Caveolin-1 Is Sufficient to Phenocopy the Behavior of a Disease-Associated Mutant

(2013) Caroline A. Hanson et al.   TRAFFIC

Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae

(2013) Carsten Gram Hansen et al.   Nature Communications

Caveolin-1 Is Necessary for Hepatic Oxidative Lipid Metabolism: Evidence for Crosstalk between Caveolin-1 and Bile Acid Signaling

(2013) Manuel A. Fernández-Rojo et al.   Cell Reports

Constitutive Formation of Caveolae in a Bacterium

(2012) Piers J. Walser et al.   CELL

Altered Mitochondrial Function and Metabolic Inflexibility Associated with Loss of Caveolin-1

(2012) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin

(2012) Miriam Stoeber et al.   EMBO JOURNAL

Mitochondria-localized caveolin in adaptation to cellular stress and injury

(2012) Heidi N. Fridolfsson et al.   FASEB JOURNAL

Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation

(2012) Bharat Joshi et al.   JOURNAL OF CELL BIOLOGY

EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization

(2012) Björn Morén et al.   MOLECULAR BIOLOGY OF THE CELL

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Caveolin-1 Deficiency Causes Cholesterol-Dependent Mitochondrial Dysfunction and Apoptotic Susceptibility

(2011) Marta Bosch et al.   CURRENT BIOLOGY

Distinct Roles of Endothelial and Adipocyte Caveolin-1 in Macrophage Infiltration and Adipose Tissue Metabolic Activity

(2011) N. Briand et al.   DIABETES

Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells

(2011) Lynne A. Lapierre et al.   EXPERIMENTAL CELL RESEARCH

Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration

(2011) Manuel Alejandro Fernández-Rojo et al.   HEPATOLOGY

Neuron-targeted Caveolin-1 Protein Enhances Signaling and Promotes Arborization of Primary Neurons

(2011) Brian P. Head et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

(2011) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis

(2011) C. G. Hansen et al.   JOURNAL OF CELL SCIENCE

Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting

(2011) Y. Senju et al.   JOURNAL OF CELL SCIENCE

Redistribution of caveolae during mitosis

(2011) E. Boucrot et al.   JOURNAL OF CELL SCIENCE

Caveolin-1 Orchestrates TCR Synaptic Polarity, Signal Specificity, and Function in CD8 T Cells

(2011) T. Tomassian et al.   JOURNAL OF IMMUNOLOGY

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

(2011) Danilo Ritz et al.   NATURE CELL BIOLOGY

Endocytosis Regulates Cell Soma Translocation and the Distribution of Adhesion Proteins in Migrating Neurons

(2011) Jennifer C. Shieh et al.   PLoS One

Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes

(2011) Y. Uchida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Cholesterol: A Connection Between Caveolin, Metabolism, and Disease

(2011) Marta Bosch et al.   TRAFFIC

Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes

(2011) Paul F. Pilch et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Schizophrenia risk gene CAV1 is both pro-psychotic and required for atypical antipsychotic drug actions in vivo

(2011) J A Allen et al.   Translational Psychiatry

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation

(2010) Stephanos Pavlides et al.   CELL CYCLE

Lipid transport and signaling inCaenorhabditis elegans

(2010) Robyn Branicky et al.   DEVELOPMENTAL DYNAMICS

Caveolin-1 Protects against Sepsis by Modulating Inflammatory Response, Alleviating Bacterial Burden, and Suppressing Thymocyte Apoptosis

(2010) Hong Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Revisiting caveolin trafficking: the end of the caveosome: Figure 1.

(2010) Robert G. Parton et al.   JOURNAL OF CELL BIOLOGY

Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation

(2010) Arnold Hayer et al.   JOURNAL OF CELL BIOLOGY

Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectin-binding pathogens

(2010) C. Hoffmann et al.   JOURNAL OF CELL SCIENCE

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington’s disease

(2010) Daniel Del Toro et al.   JOURNAL OF NEUROCHEMISTRY

Loss of Caveolin-1 Accelerates Neurodegeneration and Aging

(2010) Brian P. Head et al.   PLoS One

Fatal Cardiac Arrhythmia and Long-QT Syndrome in a New Form of Congenital Generalized Lipodystrophy with Muscle Rippling (CGL4) Due to PTRF-CAVIN Mutations

(2010) Anna Rajab et al.   PLoS Genetics

GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells

(2009) A. Prinetti et al.   GLYCOBIOLOGY

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

(2009) Michele Bastiani et al.   JOURNAL OF CELL BIOLOGY

Liver X receptor in cholesterol metabolism

(2009) Chunyan Zhao et al.   JOURNAL OF ENDOCRINOLOGY

Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects

(2009) Cédric M. Blouin et al.   JOURNAL OF LIPID RESEARCH

Regulation of Group I Metabotropic Glutamate Receptor Trafficking and Signaling by the Caveolar/Lipid Raft Pathway

(2009) A. Francesconi et al.   JOURNAL OF NEUROSCIENCE

Caveolin-2 Is Required for Apical Lipid Trafficking and Suppresses Basolateral Recycling Defects in the Intestine of Caenorhabditis elegans

(2009) Scott Parker et al.   MOLECULAR BIOLOGY OF THE CELL

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis

(2009) Renata Sano et al.   MOLECULAR CELL

A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique

(2009) A. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrophobic and Basic Domains Target Proteins to Lipid Droplets

(2009) Mercedes Ingelmo-Torres et al.   TRAFFIC

Biogenesis of Caveolae: Stepwise Assembly of Large Caveolin and Cavin Complexes

(2009) Arnold Hayer et al.   TRAFFIC

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Role of caveolin-1 in the regulation of lipoprotein metabolism

(2008) Philippe G. Frank et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulated association of caveolins to lipid droplets during differentiation of 3T3-L1 adipocytes

(2008) Cédric M. Blouin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

(2008) Michelle M. Hill et al.   CELL

A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types

(2008) Myriam Heiman et al.   CELL

Deletion of Cavin/PTRF Causes Global Loss of Caveolae, Dyslipidemia, and Glucose Intolerance

(2008) Libin Liu et al.   Cell Metabolism

Rab11 is required for synchronous secretion of chondroitin proteoglycans after fertilization in Caenorhabditis elegans

(2008) M. Sato et al.   JOURNAL OF CELL SCIENCE

Evolutionary analysis and molecular dissection of caveola biogenesis

(2008) M. Kirkham et al.   JOURNAL OF CELL SCIENCE

Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

(2008) T. Walsh et al.   SCIENCE

Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice

(2007) L GIOIOSA   BEHAVIOURAL BRAIN RESEARCH