Caveolae and lipid sorting: Shaping the cellular response to stress

Membrane Curvature and Tension Control the Formation and Collapse of Caveolar Superstructures

(2019) Gonen Golani et al.   DEVELOPMENTAL CELL

Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

(2019) Melissa Dewulf et al.   Nature Communications

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

(2019) Kerrie-Ann McMahon et al.   Nature Communications

Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration

(2019) Joseph H.R. Hetmanski et al.   DEVELOPMENTAL CELL

Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis

(2019) Punit Bhattachan et al.   FASEB JOURNAL

A variable undecad repeat domain in cavin1 regulates caveola formation and stability

(2018) Vikas A Tillu et al.   EMBO REPORTS

Modulation of caveolae by insulin/IGF‐1 signaling regulates aging of Caenorhabditis elegans

(2018) Noa Roitenberg et al.   EMBO REPORTS

Cell-free formation and interactome analysis of caveolae

(2018) WooRam Jung et al.   JOURNAL OF CELL BIOLOGY

Caveolae: Structure, Function, and Relationship to Disease

(2018) Robert G. Parton   Annual Review of Cell and Developmental Biology

Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane

(2017) Takashi Hirama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

EHD2 restrains dynamics of caveolae by an ATP-dependent, membrane-bound, open conformation

(2017) Maria Hoernke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the activation mechanism of dynamin-like EHD ATPases

(2017) Arthur Alves Melo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis

(2017) Takashi Hirama et al.   Nature Communications

Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination

(2017) Eric Seemann et al.   eLife

Curcumin attenuates high glucose-induced podocyte apoptosis by regulating functional connections between caveolin-1 phosphorylation and ROS

(2016) Li-na Sun et al.   ACTA PHARMACOLOGICA SINICA

Caveolae are involved in mechanotransduction during pulmonary hypertension

(2016) Guillaume Gilbert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Impact of Simulated Weightlessness on Endothelium-Dependent Angiogenesis and the Role of Caveolae/Caveolin-1

(2016) Fei Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells

(2016) Jason Tran et al.   PLoS One

Model for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs

(2016) Miriam Stoeber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo

(2016) Hong Yang et al.   Oncotarget

Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy

(2015) Yin Shi et al.   Autophagy

Hypergravity-induced enrichment of β1 integrin on the cell membranes of osteoblast-like cells via caveolae-dependent endocytosis

(2015) Shuai Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modular Detection of GFP-Labeled Proteins for Rapid Screening by Electron Microscopy in Cells and Organisms

(2015) Nicholas Ariotti et al.   DEVELOPMENTAL CELL

The Importance of Caveolin-1 as Key-Regulator of Three-Dimensional Growth in Thyroid Cancer Cells Cultured under Real and Simulated Microgravity Conditions

(2015) Stefan Riwaldt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osmotic Stress Reduces Ca2+Signals through Deformation of Caveolae

(2015) Yuanjian Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Characterization of Caveolin-induced Membrane Curvature

(2015) Nicholas Ariotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolae protect endothelial cells from membrane rupture during increased cardiac output

(2015) Jade P.X. Cheng et al.   JOURNAL OF CELL BIOLOGY

The caveolin–cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle

(2015) Harriet P. Lo et al.   JOURNAL OF CELL BIOLOGY

Cavin family proteins and the assembly of caveolae

(2015) O. Kovtun et al.   JOURNAL OF CELL SCIENCE

Membrane curvature at a glance

(2015) H. T. McMahon et al.   JOURNAL OF CELL SCIENCE

Complementary probes reveal that phosphatidylserine is required for the proper transbilayer distribution of cholesterol

(2015) M. Maekawa et al.   JOURNAL OF CELL SCIENCE

Caveolae regulate vasoconstriction of conduit arteries to angiotensin II in hindlimb unweighted rats

(2015) Zhongchao Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation

(2015) Vikas A. Tillu et al.   MOLECULAR BIOLOGY OF THE CELL

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy

(2015) Valerie Uytterhoeven et al.   NEURON

Endocytic sites mature by continuous bending and remodeling of the clathrin coat

(2015) O. Avinoam et al.   SCIENCE

Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

(2015) Y. Zhou et al.   SCIENCE

Dynamic caveolae exclude bulk membrane proteins and are required for sorting of excess glycosphingolipids

(2015) Elena Shvets et al.   Nature Communications

Evolution of cubic membranes as antioxidant defence system

(2015) Y. Deng et al.   Interface Focus

Oxidative Stress Induces Caveolin 1 Degradation and Impairs Caveolae Functions in Skeletal Muscle Cells

(2015) Alexis Mougeolle et al.   PLoS One

Effect of Receptor Dimerization on Membrane Lipid Raft Structure Continuously Quantified on Single Cells by Camera Based Fluorescence Correlation Spectroscopy

(2015) Heng Huang et al.   PLoS One

Caveolin-1 mediates chemoresistance in breast cancer stem cells via β-catenin/ABCG2 signaling pathway

(2014) Zhiyu Wang et al.   CARCINOGENESIS

Structural Insights into the Organization of the Cavin Membrane Coat Complex

(2014) Oleksiy Kovtun et al.   DEVELOPMENTAL CELL

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

(2014) Francesco Paneni et al.   EUROPEAN HEART JOURNAL

Oxidative Stress-induced Inhibition of Sirt1 by Caveolin-1 Promotes p53-dependent Premature Senescence and Stimulates the Secretion of Interleukin 6 (IL-6)

(2014) Daniela Volonte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling

(2014) Nicholas Ariotti et al.   JOURNAL OF CELL BIOLOGY

Lipid Organization of the Plasma Membrane

(2014) Helgi I. Ingólfsson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Caveolin-1 Provides Palliation for Adverse Hepatic Reactions in Hypercholesterolemic Rabbits

(2014) Ya-Hui Chen et al.   PLoS One

The Adaptive Remodeling of Endothelial Glycocalyx in Response to Fluid Shear Stress

(2014) Ye Zeng et al.   PLoS One

Nitroglycerin Tolerance in Caveolin-1 Deficient Mice

(2014) Mao Mao et al.   PLoS One

BIN1/M-Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin

(2014) Laura Picas et al.   Nature Communications

Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis

(2014) Natasha Chaudhary et al.   PLOS BIOLOGY

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

(2014) Yann Gambin et al.   eLife

Role of caveolae in shear stress-mediated endothelium-dependent dilation in coronary arteries

(2013) Qiang Chai et al.   CARDIOVASCULAR RESEARCH

AMP-dependent Kinase Inhibits Oxidative Stress-induced Caveolin-1 Phosphorylation and Endocytosis by Suppressing the Dissociation between c-Abl and Prdx1 Proteins in Endothelial Cells

(2013) Kimio Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated Endothelial Nitric Oxide Synthase Activation by Translocation and Phosphorylation Determines Flow-Induced Nitric Oxide Production in Resistance Vessels

(2013) Xavier F. Figueroa et al.   JOURNAL OF VASCULAR RESEARCH

Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

(2013) Daniela Volonte et al.   MOLECULAR BIOLOGY OF THE CELL

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Composition and Ultrastructure of the Caveolar Coat Complex

(2013) Alexander Ludwig et al.   PLOS BIOLOGY

Constitutive Formation of Caveolae in a Bacterium

(2012) Piers J. Walser et al.   CELL

Caveolae

(2012) Asier Echarri et al.   CURRENT BIOLOGY

Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin

(2012) Miriam Stoeber et al.   EMBO JOURNAL

Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes

(2012) Ji Hee Yun et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins

(2012) Kwang-jin Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation

(2012) Bharat Joshi et al.   JOURNAL OF CELL BIOLOGY

Molecular simulation of rapid translocation of cholesterol, diacylglycerol, and ceramide in model raft and nonraft membranes

(2012) W. F. Drew Bennett et al.   JOURNAL OF LIPID RESEARCH

Treatment with n-3 polyunsaturated fatty acids reverses endothelial dysfunction and oxidative stress in experimental menopause

(2012) Gianluca Gortan Cappellari et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization

(2012) Björn Morén et al.   MOLECULAR BIOLOGY OF THE CELL

The oyster genome reveals stress adaptation and complexity of shell formation

(2012) Guofan Zhang et al.   NATURE

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

(2012) F.-Xabier Contreras et al.   NATURE

Cholesterol Depletion in Adipocytes Causes Caveolae Collapse Concomitant with Proteosomal Degradation of Cavin-2 in a Switch-Like Fashion

(2012) Michael R. Breen et al.   PLoS One

Sub-resolution lipid domains exist in the plasma membrane and regulate protein diffusion and distribution

(2012) Dylan M. Owen et al.   Nature Communications

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Cytokine production and inflammation drive autophagy in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Caveolin-1 Deficiency Causes Cholesterol-Dependent Mitochondrial Dysfunction and Apoptotic Susceptibility

(2011) Marta Bosch et al.   CURRENT BIOLOGY

Polymerase I and Transcript Release Factor (PTRF)/Cavin-1 Is a Novel Regulator of Stress-induced Premature Senescence

(2011) Daniela Volonte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Inflammatory Response in Caveolin-1-deficient Mice withPseudomonas aeruginosaInfection Is Mediated by STAT3 Protein and Nuclear Factor κB (NF-κB)

(2011) Kefei Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

(2011) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

Visualization of flow-induced ATP release and triggering of Ca2+ waves at caveolae in vascular endothelial cells

(2011) K. Yamamoto et al.   JOURNAL OF CELL SCIENCE

Caveolae respond to cell stretch and contribute to stretch-induced signaling

(2011) O. L. Gervasio et al.   JOURNAL OF CELL SCIENCE

Redistribution of caveolae during mitosis

(2011) E. Boucrot et al.   JOURNAL OF CELL SCIENCE

Curvature-Driven Lipid Sorting in Biomembranes

(2011) A. Callan-Jones et al.   Cold Spring Harbor Perspectives in Biology

A novel role for caveolin-1 in regulating endothelial nitric oxide synthase activation in response to H2O2 and shear stress

(2010) Jing Tian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Lung Cancer Cell Migration and Invasion by Reactive Oxygen Species and Caveolin-1

(2010) Sudjit Luanpitpong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring the caves: cavins, caveolins and caveolae

(2010) Carsten G. Hansen et al.   TRENDS IN CELL BIOLOGY

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Sorting of Lipids and Proteins in Membrane Curvature Gradients

(2009) A. Tian et al.   BIOPHYSICAL JOURNAL

Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence

(2009) Daniela Volonte et al.   EMBO REPORTS

Docosapentaenoic acid (DPA) is a critical determinant of cubic membrane formation in amoeba Chaos mitochondria

(2009) Yuru Deng et al.   FASEB JOURNAL

Measurement of the membrane curvature preference of phospholipids reveals only weak coupling between lipid shape and leaflet curvature

(2009) Marzuk M. Kamal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique

(2009) A. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curvature-driven lipid sorting needs proximity to a demixing point and is aided by proteins

(2009) B. Sorre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis of Caveolae: Stepwise Assembly of Large Caveolin and Cavin Complexes

(2009) Arnold Hayer et al.   TRAFFIC

Deletion of Caveolin-1 Protects against Oxidative Lung InjuryviaUp-Regulation of Heme Oxygenase-1

(2008) Yang Jin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress

(2008) Tatyana Milovanova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion

(2008) B. Joshi et al.   CANCER RESEARCH

Increased abundance of cytoplasmic and nuclear caveolin 1 in human diploid fibroblasts in H2O2-induced premature senescence and interplay with p38αMAPK

(2008) Aline Chrétien et al.   FEBS LETTERS

Caveolin-1: A tumor-promoting role in human cancer

(2008) Maria Shatz et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Cholesterol Substitution Increases the Structural Heterogeneity of Caveolae

(2008) Maurice Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolin-1 Expression Is Required for the Development of Pulmonary Emphysema through Activation of the ATM-p53-p21 Pathway

(2008) Daniela Volonte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionary analysis and molecular dissection of caveola biogenesis

(2008) M. Kirkham et al.   JOURNAL OF CELL SCIENCE

The role of fatty acids and caveolin-1 in tumor necrosis factor α–induced endothelial cell activation

(2008) Lei Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Phosphorylation of caveolin-1 is anti-apoptotic and promotes cell attachment during oxidative stress of kidney cells

(2008) Christine J. Percy et al.   PATHOLOGY

High-Resolution 3D Quantitative Analysis of Caveolar Ultrastructure and Caveola–Cytoskeleton Interactions

(2008) Tobias Richter et al.   TRAFFIC

Physiological hydrostatic pressure protects endothelial monolayer integrity

(2007) K. Müller-Marschhausen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall

(2007) Sebastian Albinsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY