Identifying Receptors for Neuropeptides and Peptide Hormones: Challenges and Recent Progress

A G protein–coupled receptor mediates neuropeptide-induced oocyte maturation in the jellyfish Clytia

(2020) Gonzalo Quiroga Artigas et al.   PLOS BIOLOGY

GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents

(2020) Gina L.C. Yosten et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism and site of action of big dynorphin on ASIC1a

(2020) Christian B. Borg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions

(2020) Lloyd D. Fricker et al.   MOLECULAR PHARMACOLOGY

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides

(2020) Max Meyrath et al.   Nature Communications

Repertoires of G protein-coupled receptors for Ciona-specific neuropeptides

(2019) Akira Shiraishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding to carboxypeptidase M mediates protective effects of fibrinopeptide Bβ(15-42)

(2019) Inga Sörensen-Zender et al.   Translational Research

Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3)

(2019) Dmitry I. Osmakov et al.   Biomolecules

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

(2019) Simon R. Foster et al.   CELL

TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths

(2019) Nicole Maloney Belle et al.   Nature Communications

Accurate annotation of human protein-coding small open reading frames

(2019) Thomas F. Martinez et al.   Nature Chemical Biology

Molecular and Physiological Characterization of a Receptor for d-Amino Acid-Containing Neuropeptides

(2018) James W. Checco et al.   ACS Chemical Biology

Functional Peptidomics: Stimulus- and Time-of-Day-Specific Peptide Release in the Mammalian Circadian Clock

(2018) Norman Atkins et al.   ACS Chemical Neuroscience

The G protein-coupled receptors deorphanization landscape

(2018) Céline Laschet et al.   BIOCHEMICAL PHARMACOLOGY

Dual signaling of Wamide myoinhibitory peptides through a peptide-gated channel and a GPCR in Platynereis

(2018) Axel Schmidt et al.   FASEB JOURNAL

Genome-scale identification of cellular pathways required for cell surface recognition

(2018) Sumana Sharma et al.   GENOME RESEARCH

The long and the short of it – a perspective on peptidergic regulation of circuits and behaviour

(2018) Gáspár Jékely et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry

(2018) Vivian Hook et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Leukocyte differentiation by histidine-rich glycoprotein/stanniocalcin-2 complex regulates murine glioma growth through modulation of anti-tumor immunity

(2018) Francis P Roche et al.   MOLECULAR CANCER THERAPEUTICS

Orphan neuropeptides and receptors: Novel therapeutic targets

(2018) Lloyd D. Fricker et al.   PHARMACOLOGY & THERAPEUTICS

HATRIC-based identification of receptors for orphan ligands

(2018) Nadine Sobotzki et al.   Nature Communications

Identifying neuropeptide GPCRs in the mud crab, Scylla paramamosain, by combinatorial bioinformatics analysis

(2018) Chenchang Bao et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems

(2018) Tomonori Tamura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein–Coupled Receptors

(2018) Frederike M. Müskens et al.   MOLECULAR PHARMACOLOGY

Approaches to identify extracellular receptor–ligand interactions

(2018) Laura Wood et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Toll like receptors TLR1/2, TLR6 and MUC5B as binding interaction partners with cytostatic proline rich polypeptide 1 in human chondrosarcoma

(2017) Karina Galoian et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Classification and function of small open reading frames

(2017) Juan-Pablo Couso et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain

(2017) Zhe Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions

(2017) Bing Yang et al.   Nature Communications

An ancient FMRFamide-related peptide–receptor pair induces defence behaviour in a brachiopod larva

(2017) Daniel Thiel et al.   Open Biology

Conservation of Three-Dimensional Helix-Loop-Helix Structure through the Vertebrate Lineage Reopens the Cold Case of Gonadotropin-Releasing Hormone-Associated Peptide

(2017) Daniela I. Pérez Sirkin et al.   Frontiers in Endocrinology

Biotin-transfer from a trifunctional crosslinker for identification of cell surface receptors of soluble protein ligands

(2017) Tammy-Lynn Tremblay et al.   Scientific Reports

Single Cell Peptide Heterogeneity of Rat Islets of Langerhans

(2016) Erik T. Jansson et al.   ACS Chemical Biology

Adropin acts in brain to inhibit water drinking: potential interaction with the orphan G protein-coupled receptor, GPR19

(2016) Lauren M. Stein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173

(2016) Lauren M. Stein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells

(2016) Mollisa M. Elrick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A Whole Proteome Inventory of Background Photocrosslinker Binding

(2016) Philipp Kleiner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles

(2016) Debbie L. Hay et al.   Annual Review of Pharmacology and Toxicology

60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth

(2016) Andrew B Bicknell   JOURNAL OF MOLECULAR ENDOCRINOLOGY

60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides

(2016) Niamh X Cawley et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Identification of Putative Receptors for the Novel Adipokine CTRP3 Using Ligand-Receptor Capture Technology

(2016) Ying Li et al.   PLoS One

Serum stimulation of CCR7 chemotaxis due to coagulation factor XIIa-dependent production of high-molecular-weight kininogen domain 5

(2016) Manish P. Ponda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN

(2016) Ivone Gomes et al.   Science Signaling

Analytic framework for peptidomics applied to large-scale neuropeptide identification

(2016) Anna Secher et al.   Nature Communications

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN

(2016) Ivone Gomes et al.   Science Signaling

PTH receptor-1 signalling—mechanistic insights and therapeutic prospects

(2015) Ross W. Cheloha et al.   Nature Reviews Endocrinology

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease

(2015) Darleen A. Sandoval et al.   PHYSIOLOGICAL REVIEWS

Peptidomics for the discovery and characterization of neuropeptides and hormones

(2015) Elena V. Romanova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing

(2015) Andres Garelli et al.   Nature Communications

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Large-Scale Combinatorial Deorphanization of Platynereis Neuropeptide GPCRs

(2015) Philipp Bauknecht et al.   Cell Reports

Identification and quantification of neuropeptides in naïve mouse spinal cord using mass spectrometry reveals [des-Ser1]-cerebellin as a novel modulator of nociception

(2014) Jie Su et al.   JOURNAL OF NEUROCHEMISTRY

Neuropeptides as Targets for the Development of Anticonvulsant Drugs

(2014) Elke Clynen et al.   MOLECULAR NEUROBIOLOGY

ProSAAS-Derived Peptides Are Differentially Processed and Sorted in Mouse Brain and AtT-20 Cells

(2014) Jonathan H. Wardman et al.   PLoS One

Brain galanin system genes interact with life stresses in depression-related phenotypes

(2014) G. Juhasz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors

(2014) A. Pauli et al.   SCIENCE

A Peptide Hormone and Its Receptor Protein Kinase Regulate Plant Cell Expansion

(2014) M. Haruta et al.   SCIENCE

Modulation of Circadian Glucocorticoid Oscillation via Adrenal Opioid-CXCR7 Signaling Alters Emotional Behavior

(2013) Yuichi Ikeda et al.   CELL

Evidence for an interaction between proinsulin C-peptide and GPR146

(2013) Gina L C Yosten et al.   JOURNAL OF ENDOCRINOLOGY

GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding

(2013) I. Gomes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global view of the evolution and diversity of metazoan neuropeptide signaling

(2013) G. Jekely   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107

(2012) Gina L. C. Yosten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Human Cathepsin V Protease Participates in Production of Enkephalin and NPY Neuropeptide Neurotransmitters

(2012) Lydiane Funkelstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters

(2012) Weiya Douglas Lu et al.   JOURNAL OF NEUROCHEMISTRY

Direct identification of ligand-receptor interactions on living cells and tissues

(2012) Andreas P Frei et al.   NATURE BIOTECHNOLOGY

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

PEAKS DB:De NovoSequencing Assisted Database Search for Sensitive and Accurate Peptide Identification

(2011) Jing Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Cerebellin1 is a novel orexigenic peptide

(2010) J. V. Gardiner et al.   DIABETES OBESITY & METABOLISM

Mas-related G-protein-coupled receptors inhibit pathological pain in mice

(2010) Y. Guan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MIPs are ancestral ligands for the sex peptide receptor

(2010) Y.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Receptor guanylyl cyclases in Inka cells targeted by eclosion hormone

(2009) J.-C. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice

(2009) E. Szentirmai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulinostatic activity of cerebellin — Evidence from in vivo and in vitro studies in rats

(2009) Mathias Z. Strowski et al.   REGULATORY PEPTIDES

Peptidomics ofCpefat/fatmouse brain regions: implications for neuropeptide processing

(2008) Xin Zhang et al.   JOURNAL OF NEUROCHEMISTRY

The Tissue-Specific Processing of Pro-Opiomelanocortin

(2008) A. B. Bicknell   JOURNAL OF NEUROENDOCRINOLOGY

Photocrosslinkers illuminate interactions in living cells

(2008) Yoshihito Tanaka et al.   Molecular BioSystems

CART peptides: regulators of body weight, reward and other functions

(2008) G. Rogge et al.   NATURE REVIEWS NEUROSCIENCE

Mass spectrometry-based discovery of circadian peptides

(2008) N. G. Hatcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA