Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain

The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms

(2015) Z. Li et al.   NEUROSCIENCE

RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on Chemoreceptors

(2015) Caroline Flegel et al.   PLoS One

Discovery and Characterization of 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a Potent and Selective Positive Allosteric Modulator of MrgX1

(2014) Wandong Wen et al.   ChemMedChem

Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice

(2014) Zhe Li et al.   PAIN

Calcium-Permeable Ion Channels in Pain Signaling

(2014) Emmanuel Bourinet et al.   PHYSIOLOGICAL REVIEWS

Evaluation of reward from pain relief

(2013) Edita Navratilova et al.   Annals of the New York Academy of Sciences

Effect of Mas-related gene (Mrg) receptors on hyperalgesia in rats with CFA-induced inflammation via direct and indirect mechanisms

(2013) Jianping Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Temporal changes in MrgC expression after spinal nerve injury

(2013) S.-Q. He et al.   NEUROSCIENCE

MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain

(2013) Shao-Qiu He et al.   PAIN

A Systematic Review: Current and Future Directions of Dorsal Root Ganglion Therapeutics to Treat Chronic Pain

(2013) Jason E. Pope et al.   PAIN MEDICINE

Mechanisms of Itch Evoked by  -Alanine

(2012) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

What Is Spontaneous Pain and Who Has It?

(2012) Gary J. Bennett   JOURNAL OF PAIN

A subpopulation of nociceptors specifically linked to itch

(2012) Liang Han et al.   NATURE NEUROSCIENCE

Distinct Mechanisms Underlying Pronociceptive Effects of Opioids

(2011) C. Heinl et al.   JOURNAL OF NEUROSCIENCE

BAM8-22 Peptide Produces Itch and Nociceptive Sensations in Humans Independent of Histamine Release

(2011) P. Sikand et al.   JOURNAL OF NEUROSCIENCE

Sensory Neuron-Specific Mas-Related Gene-X1 Receptors Resist Agonist-Promoted Endocytosis

(2010) H. J. Solinski et al.   MOLECULAR PHARMACOLOGY

A partial L5 spinal nerve ligation induces a limited prolongation of mechanical allodynia in rats: An efficient model for studying mechanisms of neuropathic pain

(2010) Yun Guan et al.   NEUROSCIENCE LETTERS

Mas-related G-protein-coupled receptors inhibit pathological pain in mice

(2010) Y. Guan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Unmasking the tonic-aversive state in neuropathic pain

(2009) Tamara King et al.   NATURE NEUROSCIENCE

Targeting voltage-gated calcium channels for neuropathic pain management

(2009) Danielle Perret et al.   Neurotherapeutics

Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats

(2008) Peiwen Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY