Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease

GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents

(2014) Jianping Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Role of β Cell Glucagon-like Peptide-1 Signaling in Glucose Regulation and Response to Diabetes Drugs

(2014) Eric P. Smith et al.   Cell Metabolism

GLP-1 Secretion Is Increased by Inflammatory Stimuli in an IL-6-Dependent Manner, Leading to Hyperinsulinemia and Blood Glucose Lowering

(2014) F. Kahles et al.   DIABETES

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

(2014) Charles Pyke et al.   ENDOCRINOLOGY

Novel Gut-Based Pharmacology of Metformin in Patients with Type 2 Diabetes Mellitus

(2014) Antonella Napolitano et al.   PLoS One

Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose

(2013) Melissa A. Burmeister et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hindbrain GLP-1 receptor-mediated suppression of food intake requires a PI3K-dependent decrease in phosphorylation of membrane-bound Akt

(2013) Laura E. Rupprecht et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy

(2013) Adam P. Chambers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats

(2013) Joram D. Mul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

Glucagon-Induced Acetylation of Foxa2 Regulates Hepatic Lipid Metabolism

(2013) Ferdinand von Meyenn et al.   Cell Metabolism

Effects of Sitagliptin and Metformin Treatment on Incretin Hormone and Insulin Secretory Responses to Oral and "Isoglycemic" Intravenous Glucose

(2013) I. Vardarli et al.   DIABETES

Contribution of Endogenous Glucagon-Like Peptide 1 to Glucose Metabolism After Roux-en-Y Gastric Bypass

(2013) M. Shah et al.   DIABETES

Exaggerated Glucagon-Like Peptide 1 Response Is Important for Improved β-Cell Function and Glucose Tolerance After Roux-en-Y Gastric Bypass in Patients With Type 2 Diabetes

(2013) Nils B. Jørgensen et al.   DIABETES

Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls

(2013) D. J. Drucker   DIABETES

Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model

(2013) P. Richards et al.   DIABETES

Long-Term Effects of Bariatric Surgery on Meal Disposal and  -Cell Function in Diabetic and Nondiabetic Patients

(2013) S. Camastra et al.   DIABETES

Tolbutamide Controls Glucagon Release From Mouse Islets Differently Than Glucose: Involvement of KATP Channels From Both  -Cells and  -Cells

(2013) R. Cheng-Xue et al.   DIABETES

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

(2013) K. M. Habegger et al.   DIABETES

Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency

(2013) H. E. Wilson-Perez et al.   DIABETES

GLP-1 Action and Glucose Tolerance in Subjects With Remission of Type 2 Diabetes After Gastric Bypass Surgery

(2013) A. Jimenez et al.   DIABETES CARE

Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies

(2013) S. Calanna et al.   DIABETOLOGIA

Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety

(2013) Carolyn F Deacon et al.   EXPERT OPINION ON PHARMACOTHERAPY

Blockade of Glucagon-like Peptide 1 Receptor Corrects Postprandial Hypoglycemia After Gastric Bypass

(2013) Marzieh Salehi et al.   GASTROENTEROLOGY

Improved Glycemic Control Enhances the Incretin Effect in Patients With Type 2 Diabetes

(2013) Zhibo An et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: Mechanisms of Diabetes Remission and Role of Gut Hormones

(2013) M. Nannipieri et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic α-Cell Hyperplasia: Facts and Myths

(2013) Run Yu   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Emerging combinatorial hormone therapies for the treatment of obesity and T2DM

(2013) Sharon A. Sadry et al.   Nature Reviews Endocrinology

Fast pouch emptying, delayed small intestinal transit, and exaggerated gut hormone responses after Roux-en-Y gastric bypass

(2013) C. Dirksen et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Small human islets comprised of moreβ-cells with higher insulin content than large islets

(2013) Bilal Farhat et al.   Islets

Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials

(2013) V. L. Gloy et al.   BMJ-British Medical Journal

Transformation of postingestive glucose responses after deletion of sweet taste receptor subunits or gastric bypass surgery

(2012) Maartje C. P. Geraedts et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation

(2012) Maarten R. Soeters et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Differential effects of oxyntomodulin and GLP-1 on glucose metabolism

(2012) Xiaobing Du et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose metabolism is altered after loss of L cells and α-cells but not influenced by loss of K cells

(2012) J Pedersen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Drug-Drug Interactions with Glucagon-Like Peptide-1 Receptor Agonists

(2012) Kathryn M Hurren et al.   ANNALS OF PHARMACOTHERAPY

Alterations in energy balance following exenatide administration

(2012) David P. Bradley et al.   Applied Physiology Nutrition and Metabolism

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents

(2012) Jonathan W. Day et al.   BIOPOLYMERS

In Situ Electrophysiological Examination of Pancreatic   Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion

(2012) Y.-C. Huang et al.   DIABETES

Ectopic Expression of GIP in Pancreatic  -Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides

(2012) A. Fukami et al.   DIABETES

Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia

(2012) T. M. Tan et al.   DIABETES

Liver-Specific Disruption of the Murine Glucagon Receptor Produces  -Cell Hyperplasia: Evidence for a Circulating  -Cell Growth Factor

(2012) C. Longuet et al.   DIABETES

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

(2012) G. da Silva Xavier et al.   DIABETOLOGIA

Direct effect of GLP-1 infusion on endogenous glucose production in humans

(2012) M. Seghieri et al.   DIABETOLOGIA

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

(2012) P. Marchetti et al.   DIABETOLOGIA

Suppression of Food Intake by Glucagon-Like Peptide-1 Receptor Agonists: Relative Potencies and Role of Dipeptidyl Peptidase-4

(2012) Lene Jessen et al.   ENDOCRINOLOGY

Minireview: The Role of the Autonomic Nervous System in Mediating the Glucagon Response to Hypoglycemia

(2012) Gerald J. Taborsky et al.   ENDOCRINOLOGY

GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic MaleApoE−/−Mice

(2012) Naim Panjwani et al.   ENDOCRINOLOGY

Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner

(2012) S Zhao et al.   INTERNATIONAL JOURNAL OF OBESITY

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vagal Afferents Mediate Early Satiation and Prevent Flavour Avoidance Learning in Response to Intraperitoneally Infused Exendin-4

(2012) M. A. Labouesse et al.   JOURNAL OF NEUROENDOCRINOLOGY

Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study

(2012) John B Buse et al.   LANCET

Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver

(2012) Clinton M. Hasenour et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

Preproglucagon (PPG) neurons innervate neurochemicallyidentified autonomic neurons in the mouse brainstem

(2012) I.J. Llewellyn-Smith et al.   NEUROSCIENCE

Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes

(2012) Philip R. Schauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

GLP-1 Response to a Mixed Meal: What Happens 10 Years after Roux-en-Y Gastric Bypass (RYGB)?

(2012) Moahad S. Dar et al.   OBESITY SURGERY

Changes in Gastrointestinal Hormone Responses, Insulin Sensitivity, and Beta-Cell Function Within 2 Weeks After Gastric Bypass in Non-diabetic Subjects

(2012) S. H. Jacobsen et al.   OBESITY SURGERY

Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization

(2012) Gina M. Whitaker et al.   PLoS One

A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents

(2012) Jian Luo et al.   PLoS One

The Anorectic Effect of GLP-1 in Rats Is Nutrient Dependent

(2012) Darleen Sandoval et al.   PLoS One

Paracrine and autocrine interactions in the human islet: More than meets the eye

(2012) Alejandro Caicedo   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The role of the Wnt signaling pathway in incretin hormone production and function

(2012) Yu-ting A. Chiang et al.   Frontiers in Physiology

Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice

(2011) Melissa A. Burmeister et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1

(2011) Matthew R. Hayes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion

(2011) HE Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of calcium in pancreatic α- and β-cells in health and disease

(2011) Patrik Rorsman et al.   CELL CALCIUM

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation

(2011) Matthew R. Hayes et al.   Cell Metabolism

Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas

(2011) Rayner Rodriguez-Diaz et al.   Cell Metabolism

Glucagonoma and the glucagonoma syndrome - cumulative experience with an elusive endocrine tumour

(2011) Roy Eldor et al.   CLINICAL ENDOCRINOLOGY

CCK Stimulation of GLP-1 Neurons Involves α 1 -Adrenoceptor–Mediated Increase in Glutamatergic Synaptic Inputs

(2011) Kazunari Hisadome et al.   DIABETES

Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians

(2011) M. S. Thearle et al.   DIABETES

Hepatic Glucagon Action Is Essential for Exercise-Induced Reversal of Mouse Fatty Liver

(2011) Eric D. Berglund et al.   DIABETES

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity

(2011) J. W. M. Creemers et al.   DIABETES

GIP Does Not Potentiate the Antidiabetic Effects of GLP-1 in Hyperglycemic Patients With Type 2 Diabetes

(2011) N. Mentis et al.   DIABETES

Gastric Bypass Surgery Enhances Glucagon-Like Peptide 1-Stimulated Postprandial Insulin Secretion in Humans

(2011) M. Salehi et al.   DIABETES

Metabolic impact of glucagon deficiency

(2011) Y. Hayashi   DIABETES OBESITY & METABOLISM

Early milestones in glucagon research

(2011) P. J. Lefèbvre   DIABETES OBESITY & METABOLISM

The role of dysregulated glucagon secretion in type 2 diabetes

(2011) D. D'Alessio   DIABETES OBESITY & METABOLISM

Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion

(2011) Y. Gosmain et al.   DIABETES OBESITY & METABOLISM

Physiologic action of glucagon on liver glucose metabolism

(2011) C. J. Ramnanan et al.   DIABETES OBESITY & METABOLISM

Brain glucose sensing and neural regulation of insulin and glucagon secretion

(2011) B. Thorens   DIABETES OBESITY & METABOLISM

GLP-1 receptor agonists today

(2011) Michel Marre et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Absence of the Glucagon-Like Peptide-1 Receptor Does Not Affect the Metabolic Phenotype of Mice with Liver-Specific Gsα Deficiency

(2011) Min Chen et al.   ENDOCRINOLOGY

Physiological and Pharmacological Mechanisms through which the DPP-4 Inhibitor Sitagliptin Regulates Glycemia in Mice

(2011) Aurélie Waget et al.   ENDOCRINOLOGY

Minireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes

(2011) Philip E. Cryer   ENDOCRINOLOGY

Diabetes remission after bariatric surgery: is it just the incretins?

(2011) B Laferrère   INTERNATIONAL JOURNAL OF OBESITY

Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice

(2011) Michael M. Scott et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis

(2011) Safina Ali et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice

(2011) Benjamin J. Lamont et al.   JOURNAL OF CLINICAL INVESTIGATION

Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?

(2011) N M Whalley et al.   JOURNAL OF ENDOCRINOLOGY

Hyperphagia and Increased Fat Accumulation in Two Models of Chronic CNS Glucagon-Like Peptide-1 Loss of Function

(2011) J. G. Barrera et al.   JOURNAL OF NEUROSCIENCE

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

(2011) Gianluca Svegliati-Baroni et al.   LIVER INTERNATIONAL

Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers

(2011) Craig Dorrell et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

(2011) Rayner Rodriguez-Diaz et al.   NATURE MEDICINE

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

GLP-1 and energy balance: an integrated model of short-term and long-term control

(2011) Jason G. Barrera et al.   Nature Reviews Endocrinology

The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide

(2011) Scott E. Kanoski et al.   NEUROPHARMACOLOGY

Preproglucagon neurons project widely to autonomic control areas in the mouse brain

(2011) I.J. Llewellyn-Smith et al.   NEUROSCIENCE

Impact of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Bypass on HbA1c Blood Level and Pharmacological Treatment of Type 2 Diabetes Mellitus in Severe or Morbidly Obese Patients. Results of a Multicenter Prospective Study at 1 Year

(2011) David Nocca et al.   OBESITY SURGERY

How neural mediation of anticipatory and compensatory insulin release helps us tolerate food

(2011) Karen L. Teff   PHYSIOLOGY & BEHAVIOR

A Whole-Body Model for Glycogen Regulation Reveals a Critical Role for Substrate Cycling in Maintaining Blood Glucose Homeostasis

(2011) Ke Xu et al.   PLoS Computational Biology

Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor

(2010) Wei Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia

(2010) Wanling Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exenatide reduces food intake and activates the enteric nervous system of the gastrointestinal tract and the dorsal vagal complex of the hindbrain in the rat by a GLP-1 receptor

(2010) Martha C. Washington et al.   BRAIN RESEARCH

The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4

(2010) RJ Mann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bariatric surgery reduces mortality in Swedish men

(2010) R. Marsk et al.   BRITISH JOURNAL OF SURGERY

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

(2010) Yang Z. De Marinis et al.   Cell Metabolism

Insulin Reciprocally Regulates Glucagon Secretion in Humans

(2010) B. A. Cooperberg et al.   DIABETES

The Glucagonostatic and Insulinotropic Effects of Glucagon-Like Peptide 1 Contribute Equally to Its Glucose-Lowering Action

(2010) K. J. Hare et al.   DIABETES

Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius

(2010) Kazunari Hisadome et al.   DIABETES

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in  -Cells Inhibits Glucagon Secretion From Human Islets

(2010) R. Ramracheya et al.   DIABETES

Effect of Endogenous GLP-1 on Insulin Secretion in Type 2 Diabetes

(2010) M. Salehi et al.   DIABETES

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?

(2010) M. A. Nauck et al.   DIABETOLOGIA

Metabolism and Excretion of the Once-Daily Human Glucagon-Like Peptide-1 Analog Liraglutide in Healthy Male Subjects and Its In Vitro Degradation by Dipeptidyl Peptidase IV and Neutral Endopeptidase

(2010) M. Malm-Erjefalt et al.   DRUG METABOLISM AND DISPOSITION

Molecular mechanisms underlying nutrient-stimulated incretin secretion

(2010) Helen E. Parker et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Pancreatic Islet α-Cells and Promotes Insulin Secretion

(2010) Yukihiro Fujita et al.   GASTROENTEROLOGY

Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway

(2010) Nitika Arora Gupta et al.   HEPATOLOGY

Glucose Suppression of Glucagon Secretion

(2010) Sylvain J. Le Marchand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous GLP-1 Regulates Postprandial Glycemia in Humans: Relative Contributions of Insulin, Glucagon, and Gastric Emptying

(2010) Mathias Nicolaus et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase

(2010) Shani Ben-Shlomo et al.   JOURNAL OF HEPATOLOGY

Hepatic-Portal Vein Infusions of Glucagon-Like Peptide-1 Reduce Meal Size and Increase c-Fos Expression in the Nucleus Tractus Solitarii, Area Postrema and Central Nucleus of the Amygdala in Rats

(2010) I. Baumgartner et al.   JOURNAL OF NEUROENDOCRINOLOGY

Glucagon Deficiency Reduces Hepatic Glucose Production and Improves Glucose Tolerance In Adult Mice

(2010) Aidan S. Hancock et al.   MOLECULAR ENDOCRINOLOGY

The metabolic actions of glucagon revisited

(2010) Kirk M. Habegger et al.   Nature Reviews Endocrinology

Cephalic phase responses and appetite

(2010) Paul AM Smeets et al.   NUTRITION REVIEWS

Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition

(2010) Donald J. Steiner et al.   Islets

Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of β-cell regeneration

(2010) German Kilimnik et al.   Islets

Pancreatic β-cell overexpression of the glucagon receptor gene results in enhanced β-cell function and mass

(2009) Richard W. Gelling et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats

(2009) Tohru Hira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Stimulation of incretin secretion by dietary lipid: is it dose dependent?

(2009) Stephanie M. Yoder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of central administration of glucagon on feed intake and endocrine responses in sheep

(2009) Yohei KUROSE et al.   ANIMAL SCIENCE JOURNAL

Improvement in Glucose Metabolism After Bariatric Surgery: Comparison of Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy

(2009) Ralph Peterli et al.   ANNALS OF SURGERY

Immune challenge and satiety-related activation of both distinct and overlapping neuronal populations in the brainstem indicate parallel pathways for viscerosensory signaling

(2009) Ronald PA Gaykema et al.   BRAIN RESEARCH

Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide

(2009) Lisbeth V. Jacobsen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Bile Acids Have the Gall to Function as Hormones

(2009) Thomas Quad de Aguiar Vallim et al.   Cell Metabolism

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

(2009) Dan Kawamori et al.   Cell Metabolism

Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivo

(2009) Ian R. Kelsall et al.   CELLULAR SIGNALLING

New insights into the role of cAMP in the production and function of the incretin hormone glucagon-like peptide-1 (GLP-1)

(2009) Zhiwen Yu et al.   CELLULAR SIGNALLING

Differences in the Central Anorectic Effects of Glucagon-Like Peptide-1 and Exendin-4 in Rats

(2009) Jason G. Barrera et al.   DIABETES

TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

(2009) D. T. Villareal et al.   DIABETES

Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

(2009) A. Pocai et al.   DIABETES

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men

(2009) K. Pilgaard et al.   DIABETOLOGIA

Hormonal and Metabolic Mechanisms of Diabetes Remission after Gastrointestinal Surgery

(2009) Joshua P. Thaler et al.   ENDOCRINOLOGY

Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study

(2009) T. O. Kilpelainen et al.   HUMAN MOLECULAR GENETICS

Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass

(2009) J Korner et al.   INTERNATIONAL JOURNAL OF OBESITY

GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells

(2009) Julie Quoyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous Glucagon-Like Peptide-1 Slows Gastric Emptying in Healthy Subjects, Attenuating Postprandial Glycemia

(2009) Adam M. Deane et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hepatic energy state is regulated by glucagon receptor signaling in mice

(2009) Eric D. Berglund et al.   JOURNAL OF CLINICAL INVESTIGATION

GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis

(2009) Hong Lan et al.   JOURNAL OF ENDOCRINOLOGY

Direct Control of Peripheral Lipid Deposition by CNS GLP-1 Receptor Signaling Is Mediated by the Sympathetic Nervous System and Blunted in Diet-Induced Obesity

(2009) R. Nogueiras et al.   JOURNAL OF NEUROSCIENCE

Relationship among Brain and Blood Glucose Levels and Spontaneous and Glucoprivic Feeding

(2009) A. A. Dunn-Meynell et al.   JOURNAL OF NEUROSCIENCE

Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study

(2009) Arne Astrup et al.   LANCET

Mice Deficient for Glucagon Gene-Derived Peptides Display Normoglycemia and Hyperplasia of Islet α-Cells But Not of Intestinal L-Cells

(2009) Yoshitaka Hayashi et al.   MOLECULAR ENDOCRINOLOGY

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

(2009) Jonathan W Day et al.   Nature Chemical Biology

Incretin-based therapies for type 2 diabetes mellitus

(2009) Julie A. Lovshin et al.   Nature Reviews Endocrinology

Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat

(2009) v. bucinskaite et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Metabolic/Bariatric Surgery Worldwide 2008

(2009) Henry Buchwald et al.   OBESITY SURGERY

The effects of GLP-1 infusion in the hepatic portal region on food intake

(2009) Dong-Hoon Kim et al.   REGULATORY PEPTIDES

Exenatide can reduce glucose independent of islet hormones or gastric emptying

(2008) Viorica Ionut et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes

(2008) Safina Ali et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nutrient-driven incretin secretion into intestinal lymph is different between diabetic Goto-Kakizaki rats and Wistar rats

(2008) Tammy L. Kindel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Glutamate Is a Positive Autocrine Signal for Glucagon Release

(2008) Over Cabrera et al.   Cell Metabolism

The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

(2008) Christine Longuet et al.   Cell Metabolism

Glucagon receptors

(2008) F. Authier et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ventromedial Hypothalamic Glucokinase Is an Important Mediator of the Counterregulatory Response to Insulin-Induced Hypoglycemia

(2008) B. E. Levin et al.   DIABETES

Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing

(2008) C. Knauf et al.   DIABETES

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake

(2008) D. A. Sandoval et al.   DIABETES

Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

(2008) P. V. Højberg et al.   DIABETOLOGIA

Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

(2008) P. V. Højberg et al.   DIABETOLOGIA

Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts

(2008) A. Wojtusciszyn et al.   DIABETOLOGIA

Cross Talk between the Insulin and Wnt Signaling Pathways: Evidence from Intestinal Endocrine L Cells

(2008) Fenghua Yi et al.   ENDOCRINOLOGY

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

(2008) Zhi-Liang Chu et al.   ENDOCRINOLOGY

Brain Glucagon-Like Peptide 1 Signaling Controls the Onset of High-Fat Diet-Induced Insulin Resistance and Reduces Energy Expenditure

(2008) Claude Knauf et al.   ENDOCRINOLOGY

The Glucagon-Like Peptide-1 Receptor Regulates Endogenous Glucose Production and Muscle Glucose Uptake Independent of Its Incretin Action

(2008) Julio E. Ayala et al.   ENDOCRINOLOGY

Intrameal Hepatic Portal and Intraperitoneal Infusions of Glucagon-Like Peptide-1 Reduce Spontaneous Meal Size in the Rat via Different Mechanisms

(2008) Elisabeth B. Rüttimann et al.   ENDOCRINOLOGY

Dorsal Hindbrain 5′-Adenosine Monophosphate-Activated Protein Kinase as an Intracellular Mediator of Energy Balance

(2008) Matthew R. Hayes et al.   ENDOCRINOLOGY

Glucagon Receptor Signaling Is Essential for Control of Murine Hepatocyte Survival

(2008) Elaine M. Sinclair et al.   GASTROENTEROLOGY

Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation

(2008) Zhengyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei

(2008) Miyuki Tauchi et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Regulation of Islet Hormone Release and Gastric Emptying by Endogenous Glucagon-Like Peptide 1 after Glucose Ingestion

(2008) Marzieh Salehi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Long-Term Effects of Roux-en-Y Gastric Bypass Surgery on Plasma Glucagon-Like Peptide-1 and Islet Function in Morbidly Obese Subjects

(2008) Josep Vidal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mechanisms underlying proglucagon gene expression

(2008) Tianru Jin   JOURNAL OF ENDOCRINOLOGY

Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas

(2008) Ditte Tornehave et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study

(2008) Daniel J Drucker et al.   LANCET

Effects of Gastric Bypass and Gastric Banding on Glucose Kinetics and Gut Hormone Release

(2008) Frédérique Rodieux et al.   Obesity

Interleukin-6 regulates pancreatic  -cell mass expansion

(2008) H. Ellingsgaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic   cells

(2008) N. Sonoda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is secretion of glucagon-like peptide-1 reduced in type 2 diabetes mellitus?

(2008) Juris J Meier et al.   Nature clinical practice. Endocrinology & metabolism

Divergent Leptin Signaling in Proglucagon Neurons of the Nucleus of the Solitary Tract in Mice and Rats

(2007) Lihong Huo et al.   ENDOCRINOLOGY