PTH receptor-1 signalling—mechanistic insights and therapeutic prospects

G Protein-coupled Receptor (GPCR) Signaling via Heterotrimeric G Proteins from Endosomes

(2015) Nikoleta G. Tsvetanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Abaloparatide, a Human Parathyroid Hormone-Related Peptide Analog, on Bone Mineral Density in Postmenopausal Women with Osteoporosis

(2015) Benjamin Z. Leder et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Renal Control of Calcium, Phosphate, and Magnesium Homeostasis

(2014) J. Blaine et al.   Clinical Journal of the American Society of Nephrology

Investigational parathyroid hormone receptor analogs for the treatment of osteoporosis

(2014) Stergios A Polyzos et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Use of parathyroid hormone in hypoparathyroidism

(2014) N. E. Cusano et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Drug-Target Residence Time-A Case for G Protein-Coupled Receptors

(2014) Dong Guo et al.   MEDICINAL RESEARCH REVIEWS

Minireview: More Than Just a Hammer: Ligand “Bias” and Pharmaceutical Discovery

(2014) Louis M. Luttrell   MOLECULAR ENDOCRINOLOGY

Backbone modification of a polypeptide drug alters duration of action in vivo

(2014) Ross W Cheloha et al.   NATURE BIOTECHNOLOGY

Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase

(2014) Alexandre Gidon et al.   Nature Chemical Biology

Endosomal generation of cAMP in GPCR signaling

(2014) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis

(2014) Nikoleta G Tsvetanova et al.   Nature Chemical Biology

Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias

(2014) Kim Vietz Andreassen et al.   PLoS One

Biased ligands at G-protein-coupled receptors: promise and progress

(2014) Jonathan D. Violin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

cAMP signaling microdomains and their observation by optical methods

(2014) Davide Calebiro et al.   Frontiers in Cellular Neuroscience

Recent developments in biased agonism

(2013) James W Wisler et al.   CURRENT OPINION IN CELL BIOLOGY

Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin

(2013) Timothy N. Feinstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comparison of parathyroid hormone-related protein (1-36) and parathyroid hormone (1-34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study

(2013) Mara J Horwitz et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Structure of class B GPCR corticotropin-releasing factor receptor 1

(2013) Kaspar Hollenstein et al.   NATURE

Structure of the human glucagon class B G-protein-coupled receptor

(2013) Fai Yiu Siu et al.   NATURE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Identification of Six Novel PTH1R Mutations in Families with a History of Primary Failure of Tooth Eruption

(2013) Lotte Risom et al.   PLoS One

Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH

(2013) A. Maeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical GPCR signaling arising from a PTH receptor–arrestin–Gβγ complex

(2013) Vanessa L. Wehbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the structure of class B GPCRs

(2013) Kaspar Hollenstein et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Efficacy and safety of recombinant human parathyroid hormone (1–84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study

(2013) Michael Mannstadt et al.   Lancet Diabetes & Endocrinology

β-Arrestin-biased signaling of PTH analogs of the type 1 parathyroid hormone receptor

(2012) Miranda M.C. van der Lee et al.   CELLULAR SIGNALLING

Non-canonical signaling of the PTH receptor

(2012) Jean-Pierre Vilardaga et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Parathyroid Hormone Receptorsome and the Potential for Therapeutic Intervention

(2011) M. J. Mahon   CURRENT DRUG TARGETS

Synthetic Human Parathyroid Hormone 1-34 Replacement Therapy: A Randomized Crossover Trial Comparing PumpVersusInjections in the Treatment of Chronic Hypoparathyroidism

(2011) Karen K. Winer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Our choice from the recent literature

(2011)   Nature Physics

Emerging therapeutic opportunities for skeletal restoration

(2011) Masanobu Kawai et al.   NATURE REVIEWS DRUG DISCOVERY

Parathyroid hormone analogues in the treatment of osteoporosis

(2011) Marius E. Kraenzlin et al.   Nature Reviews Endocrinology

Regulation of G Protein-Coupled Receptor Function by Na+/H+ Exchange Regulatory Factors

(2011) J. A. Ardura et al.   PHARMACOLOGICAL REVIEWS

Deletion and Point Mutations of PTHLH Cause Brachydactyly Type E

(2010) Eva Klopocki et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm

(2010) Jean-Pierre Vilardaga et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice

(2010) Ramiro E. Toribio et al.   FASEB JOURNAL

Na/H Exchanger Regulatory Factors Control Parathyroid Hormone Receptor Signaling by Facilitating Differential Activation of Gα Protein Subunits

(2010) Bin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation in vivo of a potent parathyroid hormone antagonist: [Nle8,18, D-Trp12, Tyr34]bPTH(7-34)NH2

(2010) Rivka Dresner-Pollak et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Parathyroid Hormone-Related Protein for the Treatment of Postmenopausal Osteoporosis: Defining the Maximal Tolerable Dose

(2010) Mara J. Horwitz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

(2009) George S. Baillie   FEBS Journal

Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides

(2009) Augen A. Pioszak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperparathyroidism

(2009) William D Fraser   LANCET

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A  -Arrestin-Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation

(2009) D. Gesty-Palmer et al.   Science Translational Medicine

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

PTHR1 mutations associated with Ollier disease result in receptor loss of function

(2008) Alain Couvineau et al.   HUMAN MOLECULAR GENETICS

Hypoparathyroidism

(2008) Dolores Shoback   NEW ENGLAND JOURNAL OF MEDICINE

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation

(2008) M. Okazaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein

(2008) D. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular recognition of parathyroid hormone by its G protein-coupled receptor

(2008) Augen A. Pioszak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety of parathyroid hormone for the treatment of osteoporosis

(2008) Paul D. Miller   Current Osteoporosis Reports

The cell biology of parathyroid hormone in osteoblasts

(2008) Stavroula Kousteni et al.   Current Osteoporosis Reports

Altered Selectivity of Parathyroid Hormone (PTH) and PTH-Related Protein (PTHrP) for Distinct Conformations of the PTH/PTHrP Receptor

(2007) Thomas Dean et al.   MOLECULAR ENDOCRINOLOGY