Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions

Learned avoidance requires VTA KOR-mediated reductions in dopamine

(2020) Mykel A. Robble et al.   NEUROPHARMACOLOGY

Biased signaling by endogenous opioid peptides

(2020) Ivone Gomes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study

(2019) Diana Martinez et al.   NEUROPSYCHOPHARMACOLOGY

A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward

(2019) Kyle E. Parker et al.   CELL

A Survey of Molecular Imaging of Opioid Receptors

(2019) Paul Cumming et al.   MOLECULES

Kappa-opioid antagonists as stress resilience medications for the treatment of alcohol use disorders

(2018) Charles Chavkin   NEUROPSYCHOPHARMACOLOGY

Study characteristics influence the efficacy of substance abuse treatments: A meta-analysis of medications for alcohol use disorder

(2018) Elias M. Klemperer et al.   DRUG AND ALCOHOL DEPENDENCE

Diagnosis and Pharmacotherapy of Alcohol Use Disorder

(2018) Henry R. Kranzler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Naltrexone and nalmefene attenuate cocaine place preference in male mice

(2018) Kyle A. Windisch et al.   NEUROPHARMACOLOGY

In vivo detection of optically-evoked opioid peptide release

(2018) Ream Al-Hasani et al.   eLife

Characterization of a Multiple-Scan-Rate Voltammetric Waveform for Real-Time Detection of Met-Enkephalin

(2018) S. E. Calhoun et al.   ACS Chemical Neuroscience

Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain

(2018) Edita Navratilova et al.   PAIN

Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status

(2017) Joseph P Schacht et al.   NEUROPSYCHOPHARMACOLOGY

N-[18F]-FluoropropylJDTic for κ-opioid receptor PET imaging: Radiosynthesis, pre-clinical evaluation, and metabolic investigation in comparison with parent JDTic

(2017) Sébastien Schmitt et al.   NUCLEAR MEDICINE AND BIOLOGY

Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives

(2017) Juliana Perazzo et al.   Frontiers in Pharmacology

60 YEARS OF POMC: Melanocortin receptors: evolution of ligand selectivity for melanocortin peptides

(2016) Robert M Dores et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A Test in Context: Neprilysin

(2016) Antoni Bayes-Genis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C

(2015) Dhivya Kumar et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward

(2015) Ream Al-Hasani et al.   NEURON

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Multiple Scan Rate Voltammetry for Selective Quantification of Real-Time Enkephalin Dynamics

(2014) Andreas C. Schmidt et al.   ANALYTICAL CHEMISTRY

A mu–delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks

(2014) Eric Erbs et al.   Brain Structure & Function

Endothelin-converting enzyme 2 differentially regulates opioid receptor activity

(2014) A Gupta et al.   BRITISH JOURNAL OF PHARMACOLOGY

Opioid Receptor Function Is Regulated by Post-endocytic Peptide Processing

(2014) Achla Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptides in Seminal Fluid and Their Role in Infertility: A Potential Role for Opiorphin Inhibition of Neutral Endopeptidase Activity as a Clinically Relevant Modulator of Sperm Motility

(2014) Jayme S. Bosler et al.   Reproductive Sciences

Catechol-O-Methyltransferase Genotype Modulates Opioid Release in Decision Circuitry

(2013) Jennifer M. Mitchell et al.   CTS-Clinical and Translational Science

Extended-release naltrexone (XR-NTX) attenuates brain responses to alcohol cues in alcohol-dependent volunteers: A bold FMRI study

(2013) Scott E. Lukas et al.   NEUROIMAGE

The role of endogenous beta-endorphin and enkephalins in ethanol reward

(2013) Andy Tseng et al.   NEUROPHARMACOLOGY

GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding

(2013) I. Gomes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enkephalin Surges in Dorsal Neostriatum as a Signal to Eat

(2012) Alexandra G. DiFeliceantonio et al.   CURRENT BIOLOGY

The role of endogenous dynorphin in ethanol-induced state-dependent CPP

(2011) Khanh Nguyen et al.   BEHAVIOURAL BRAIN RESEARCH

Regulation of Neuropeptide Processing Enzymes by Catecholamines in Endocrine Cells

(2011) M. Helwig et al.   MOLECULAR PHARMACOLOGY

G Protein-Coupled Receptor Heteromerization: A Role in Allosteric Modulation of Ligand Binding

(2011) I. Gomes et al.   MOLECULAR PHARMACOLOGY

Quantitative Expression Profile of Distinct Functional Regions in the Adult Mouse Brain

(2011) Takeya Kasukawa et al.   PLoS One

Analysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins

(2010) Lloyd D. Fricker   Molecular BioSystems

Reward Processing by the Opioid System in the Brain

(2009) Julie Le Merrer et al.   PHYSIOLOGICAL REVIEWS

Opioid receptors in the gastrointestinal tract

(2009) Peter Holzer   REGULATORY PEPTIDES

Effect of Naltrexone and Ondansetron on Alcohol Cue–Induced Activation of the Ventral Striatum in Alcohol-Dependent People

(2008) Hugh Myrick et al.   ARCHIVES OF GENERAL PSYCHIATRY

The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin  -Opioid System

(2008) B. B. Land et al.   JOURNAL OF NEUROSCIENCE

 -Opioid Receptor Expression in the Ventral Tegmental Area Protects Against Elevated Alcohol Consumption

(2008) E. B. Margolis et al.   JOURNAL OF NEUROSCIENCE