Exosomes, the message transporters in vascular calcification

Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways

(2018) Neal X. Chen et al.   KIDNEY INTERNATIONAL

Comparison of coronary artery calcification, carotid intima-media thickness and ankle-brachial index for predicting 10-year incident cardiovascular events in the general population

(2017) Marie Henrike Geisel et al.   EUROPEAN HEART JOURNAL

Quantitative changes in the protein and miRNA cargo of plasma exosome-like vesicles after exposure to ionizing radiation

(2017) Ramesh Yentrapalli et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Roles of platelet-derived growth factor in vascular calcification

(2017) Liu Ouyang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A novel role of cellular interactions in vascular calcification

(2017) Adham Sameer A. Bardeesi et al.   Journal of Translational Medicine

Ghrelin improves vascular autophagy in rats with vascular calcification

(2017) Mingming Xu et al.   LIFE SCIENCES

Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury

(2017) Chunxiao Wang et al.   MOLECULAR THERAPY

Extracellular vesicles in coronary artery disease

(2017) Chantal M. Boulanger et al.   Nature Reviews Cardiology

NPC-EXs Alleviate Endothelial Oxidative Stress and Dysfunction through the miR-210 Downstream Nox2 and VEGFR2 Pathways

(2017) Hua Liu et al.   Oxidative Medicine and Cellular Longevity

BRAFV600inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells

(2017) Taral R. Lunavat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study

(2017) A. Neradova et al.   BMC Nephrology

Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis

(2017) Min Gong et al.   Oncotarget

Autophagy regulates UBC9 levels during viral-mediated tumorigenesis

(2017) Domenico Mattoscio et al.   PLoS Pathogens

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

(2017) Sara Pinto et al.   Frontiers in Neuroscience

MicroRNA-32 promotes calcification in vascular smooth muscle cells: Implications as a novel marker for coronary artery calcification

(2017) Jianghua Liu et al.   PLoS One

Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells

(2017) Ying-Da Chen et al.   Scientific Reports

Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway

(2017) Pranjali Dalvi et al.   Scientific Reports

Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β ProductionHighlights

(2016) Nicolle Ceneri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Characterisation of matrix vesicles in skeletal and soft tissue mineralisation

(2016) L. Cui et al.   BONE

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway

(2016) Jianbing Hao et al.   CELL AND TISSUE RESEARCH

Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-β1/Smad3

(2016) Chunli Liang et al.   CELL BIOCHEMISTRY AND FUNCTION

Inhibiting post-translational core fucosylation prevents vascular calcification in the model of uremia

(2016) Xinyu Wen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation

(2016) A. N. Kapustin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques

(2016) Joshua D. Hutcheson et al.   NATURE MATERIALS

Apocynin attenuates angiotensin II-induced vascular smooth muscle cells osteogenic switching via suppressing extracellular signal-regulated kinase 1/2

(2016) Weijing Feng et al.   Oncotarget

The Role of AGE/RAGE Signaling in Diabetes-Mediated Vascular Calcification

(2016) Amber M. Kay et al.   Journal of Diabetes Research

New Insights into Regulatory T Cells: Exosome- and Non-Coding RNA-Mediated Regulation of Homeostasis and Resident Treg Cells

(2016) Peiyao Li et al.   Frontiers in Immunology

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

(2016) Weijia Sun et al.   Cell Discovery

HMGB1 Induces Secretion of Matrix Vesicles by Macrophages to Enhance Ectopic Mineralization

(2016) Qiang Chen et al.   PLoS One

Matrix vesicles: Are they anchored exosomes?

(2015) Irving M. Shapiro et al.   BONE

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors

(2015) G. Pironti et al.   CIRCULATION

Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

(2015) A. N. Kapustin et al.   CIRCULATION RESEARCH

Exosomes: Nanosized Cellular Messages

(2015) Y. Tintut et al.   CIRCULATION RESEARCH

Targeting local vascular and systemic consequences of inflammation on vascular and cardiac valve calcification

(2015) Lucie Hénaut et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles

(2015) Nicolas Jaé et al.   FEBS LETTERS

Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression

(2015) Yazhou Cui et al.   FEBS LETTERS

7-Ketocholesterol-induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress

(2015) Ryo Sudo et al.   GENES TO CELLS

MicroRNAs 29b, 133b, and 211 Regulate Vascular Smooth Muscle Calcification Mediated by High Phosphorus

(2015) S. Panizo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Runx2/miR-3960/miR-2861 Positive Feedback Loop Is Responsible for Osteogenic Transdifferentiation of Vascular Smooth Muscle Cells

(2015) Zhu-Ying Xia et al.   Biomed Research International

Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling

(2015) Dmitry A. Chistiakov et al.   Biomed Research International

Differential miRNA Expression in Cells and Matrix Vesicles in Vascular Smooth Muscle Cells from Rats with Kidney Disease

(2015) Praneet Chaturvedi et al.   PLoS One

Has Our Understanding of Calcification in Human Coronary Atherosclerosis Progressed?

(2014) Fumiyuki Otsuka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

miRNA-221 and miRNA-222 synergistically function to promote vascular calcification

(2014) N. C. W. Mackenzie et al.   CELL BIOCHEMISTRY AND FUNCTION

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

(2014) Isobel S. Okoye et al.   IMMUNITY

Secretion of small/microRNAs including miR-638 into extracellular spaces by sphingomyelin phosphodiesterase 3

(2014) SHIORI KUBOTA et al.   ONCOLOGY REPORTS

Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

(2014) Ji-Feng Xu et al.   PLoS One

Advanced glycation end products accelerate rat vascular calcification through RAGE/oxidative stress

(2013) Qin Wei et al.   BMC Cardiovascular Disorders

Vascular Calcification: An Update on Mechanisms and Challenges in Treatment

(2013) Meiting Wu et al.   CALCIFIED TISSUE INTERNATIONAL

The effects of rhBMP-2 and Treg/Th17 
functional disequilibrium in uremic patients 
with cardiovascular complication after 
maintenance hemodialysis

(2013) Chen Danyan et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Extracellular MicroRNAs in Urologic Malignancies: Chances and Challenges

(2013) Xiaoyi Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Body Fluid Exosomes Promote Secretion of Inflammatory Cytokines in Monocytic Cells via Toll-like Receptor Signaling

(2013) Niko P. Bretz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release

(2013) Xiao-Yan Dai et al.   KIDNEY INTERNATIONAL

Decreased MicroRNA Is Involved in the Vascular Remodeling Abnormalities in Chronic Kidney Disease (CKD)

(2013) Neal X. Chen et al.   PLoS One

Ceramide Mediates Ox-LDL-Induced Human Vascular Smooth Muscle Cell Calcification via p38 Mitogen-Activated Protein Kinase Signaling

(2013) Lizhen Liao et al.   PLoS One

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Bone Morphogenetic Protein‐2 Decreases MicroRNA‐30b and MicroRNA‐30c to Promote Vascular Smooth Muscle Cell Calcification

(2013) Joshua A. F. Balderman et al.   Journal of the American Heart Association

MicroRNA in Diabetic Nephropathy: Renin Angiotensin, AGE/RAGE, and Oxidative Stress Pathway

(2013) Shinji Hagiwara et al.   Journal of Diabetes Research

Macrophages play a unique role in the plaque calcification by enhancing the osteogenic signals exerted by vascular smooth muscle cells

(2012) Koji Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

(2012) N. Ismail et al.   BLOOD

MicroRNA-204 regulates vascular smooth muscle cell calcification in vitro and in vivo

(2012) R.-R. Cui et al.   CARDIOVASCULAR RESEARCH

Rare, Nonsynonymous Variant in the Smooth Muscle-Specific Isoform of Myosin Heavy Chain, MYH11 , R247C, Alters Force Generation in the Aorta and Phenotype of Smooth Muscle Cells

(2012) Shao-Qing Kuang et al.   CIRCULATION RESEARCH

Phosphate Binders in CKD: Bad News or Good News?

(2012) T. B. Drueke et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effects of Phosphate Binders in Moderate CKD

(2012) G. A. Block et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNAs that target Ca2+ transporters are involved in vascular smooth muscle cell calcification

(2012) Ting Gui et al.   LABORATORY INVESTIGATION

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

Inorganic Phosphate Accelerates the Migration of Vascular Smooth Muscle Cells: Evidence for the Involvement of miR-223

(2012) Ashraf Yusuf Rangrez et al.   PLoS One

Treg/Th17 Functional Disequilibrium in Chinese Uremia on Hemodialysis: A Link between Calcification and Cardiovascular Disease

(2012) Danyan Chen et al.   RENAL FAILURE

Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated Neuronal dysfunction

(2012) G Hu et al.   Cell Death & Disease

miR-125b Regulates Calcification of Vascular Smooth Muscle Cells

(2011) Claudia Goettsch et al.   AMERICAN JOURNAL OF PATHOLOGY

Calcium Regulates Key Components of Vascular Smooth Muscle Cell–Derived Matrix Vesicles to Enhance Mineralization

(2011) Alexander N. Kapustin et al.   CIRCULATION RESEARCH

Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice

(2011) Tsutomu Matsubara et al.   HEPATOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner

(2010) Kartik Balachandran et al.   AMERICAN JOURNAL OF PATHOLOGY

Statins moderate coronary stenoses but not coronary calcification: Results from meta-analyses

(2010) Michael Y. Henein et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Reduced Expression of Perlecan in the Aorta of Secondary Hyperparathyroidism Model Rats with Medial Calcification

(2010) Maki Shibata et al.   RENAL FAILURE

Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling

(2008) Chang Hyun Byon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway

(2008) Youssef H. Zeidan et al.   JOURNAL OF CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE