The Role of Autophagy in Osteoarthritis

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

Osteoarthritis year in review 2019: epidemiology and therapy

(2020) M. Kloppenburg et al.   OSTEOARTHRITIS AND CARTILAGE

Circulating microRNA let‑7e is decreased in knee osteoarthritis, accompanied by elevated apoptosis and reduced autophagy

(2020) Lei Feng et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression

(2020) Yeri Alice Rim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chondrocyte dedifferentiation and osteoarthritis (OA)

(2019) Edith Charlier et al.   BIOCHEMICAL PHARMACOLOGY

The role of sirtuin 1 and its activator, resveratrol in osteoarthritis

(2019) Zhenhan Deng et al.   BIOSCIENCE REPORTS

Sirtuins and FoxOs in osteoporosis and osteoarthritis

(2019) Maria Almeida et al.   BONE

Safety of Oral Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Osteoarthritis: What Does the Literature Say?

(2019) Cyrus Cooper et al.   DRUGS & AGING

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Modulated Autophagy by MicroRNAs in Osteoarthritis Chondrocytes

(2019) Yinghao Yu et al.   Biomed Research International

Loss of autophagy in chondrocytes causes severe growth retardation

(2019) Yoji Horigome et al.   Autophagy

Multi-pathway protective effects of microRNAs on human chondrocytes in an in vitro model of osteoarthritis

(2019) Rua Nader Al-Modawi et al.   Molecular Therapy-Nucleic Acids

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

(2019) Uxía Nogueira-Recalde et al.   EBioMedicine

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

(2019) Lian-Jiu Su et al.   Oxidative Medicine and Cellular Longevity

Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress

(2019) Vicente Roca-Agujetas et al.   Oxidative Medicine and Cellular Longevity

Inhibition of miR-20 promotes proliferation and autophagy in articular chondrocytes by PI3K/AKT/mTOR signaling pathway

(2018) Weidong He et al.   BIOMEDICINE & PHARMACOTHERAPY

Epidemiology of osteoarthritis

(2018) Ernest R. Vina et al.   CURRENT OPINION IN RHEUMATOLOGY

Targeting aging for disease modification in osteoarthritis

(2018) John A. Collins et al.   CURRENT OPINION IN RHEUMATOLOGY

miR-140-5p/miR-149 Affects Chondrocyte Proliferation, Apoptosis, and Autophagy by Targeting FUT1 in Osteoarthritis

(2018) Zi Wang et al.   INFLAMMATION

Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes

(2018) M.Y. Ansari et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis year in review 2017: clinical

(2018) A.E. Nelson   OSTEOARTHRITIS AND CARTILAGE

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

(2018) Tokio Matsuzaki et al.   Science Translational Medicine

Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor-1α Hydroxylase Inhibitors

(2018) Dheraj K. Taheem et al.   STEM CELLS

Reactive oxygen species, aging and articular cartilage homeostasis

(2018) Jesalyn A. Bolduc et al.   FREE RADICAL BIOLOGY AND MEDICINE

TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation

(2018) Gang Zheng et al.   Cell Death & Disease

Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives

(2018) C. Randall Harrell et al.   BIOMEDICINE & PHARMACOTHERAPY

Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy

(2018) Weiwei Zheng et al.   FASEB JOURNAL

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

(2018) Jun Ren et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of selective autophagy: the p62/SQSTM1 paradigm

(2017) Trond Lamark et al.   Essays in Biochemistry

Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP-Dependent Manner

(2017) Xiaomin Kang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

New insights into autophagosome–lysosome fusion

(2017) Shuhei Nakamura et al.   JOURNAL OF CELL SCIENCE

Local intra-articular injection of resveratrol delays cartilage degeneration in C57BL/6 mice by inducing autophagy via AMPK/mTOR pathway

(2017) Na Qin et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Isoimperatorin ameliorates osteoarthritis by downregulating the mammalian target of rapamycin C1 signaling pathway

(2017) Jiayao Ouyang et al.   Molecular Medicine Reports

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death

(2017) S. D'Adamo et al.   OSTEOARTHRITIS AND CARTILAGE

MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis

(2017) Stefania D’Adamo et al.   Oxidative Medicine and Cellular Longevity

Exercise-mediated modulation of autophagy in skeletal muscle

(2017) M. Martin-Rincon et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

(2017) Qian Tang et al.   Cell Death & Disease

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

(2017) Oscar Alvarez-Garcia et al.   Arthritis & Rheumatology

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis

(2016) SHIJU YAN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins

(2016) S. D'Adamo et al.   OSTEOARTHRITIS AND CARTILAGE

Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation

(2016) M. Ribeiro et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition of microRNA-449a prevents IL-1β-induced cartilage destruction via SIRT1

(2016) K.W. Park et al.   OSTEOARTHRITIS AND CARTILAGE

Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy

(2016) O. Alvarez-Garcia et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

(2015) Faezeh Vasheghani et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis

(2015) Thibault Bouderlique et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of HIF-1α and HIF-2α in osteoarthritis

(2015) Fang-Jie Zhang et al.   JOINT BONE SPINE

Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation

(2015) Karuna K Vuppalapati et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FGF signalling regulates bone growth through autophagy

(2015) Laura Cinque et al.   NATURE

Activate autophagy to prevent cartilage degeneration?

(2015) Caroline Barranco   Nature Reviews Rheumatology

Commentary on recent therapeutic guidelines for osteoarthritis

(2015) Maurizio Cutolo et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

(2015) Shuxi Qiao et al.   Nature Communications

Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells

(2015) Stefania Capasso et al.   Oncotarget

Autophagy Activation and Protection From Mitochondrial Dysfunction in Human Chondrocytes

(2015) Paloma López de Figueroa et al.   Arthritis & Rheumatology

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

(2014) Yue Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

Tougu Xiaotong capsule promotes chondrocyte autophagy by regulating the Atg12/LC3 conjugation systems

(2014) XIHAI LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

(2014) Koji Takayama et al.   ARTHRITIS RESEARCH & THERAPY

Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP-Activated Protein Kinase

(2014) Xianling Zhao et al.   Arthritis & Rheumatology

FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes

(2014) Yukio Akasaki et al.   Arthritis & Rheumatology

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

Boning up on autophagy

(2013) Irving M Shapiro et al.   Autophagy

Autophagy in Human Health and Disease

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Ubiquitination and selective autophagy

(2012) S Shaid et al.   CELL DEATH AND DIFFERENTIATION

Macro view of microRNA function in osteoarthritis

(2012) Shigeru Miyaki et al.   Nature Reviews Rheumatology

The interplay between autophagy and ROS in tumorigenesis

(2012) Sameera Kongara et al.   Frontiers in Oncology

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Osteoarthritis year 2010 in review: pathomechanisms

(2011) W.B. van den Berg   OSTEOARTHRITIS AND CARTILAGE

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

(2010) Kohichi Matsunaga et al.   JOURNAL OF CELL BIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Regulation of membrane biogenesis in autophagy via PI3P dynamics

(2010) Takeshi Noda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Eating to exit: autophagy-enabled senescence revealed

(2009) E. White et al.   GENES & DEVELOPMENT

Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression

(2009) Jolene Bohensky et al.   PEDIATRIC NEPHROLOGY