Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP-Activated Protein Kinase

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes

(2013) Freyr Petursson et al.   ARTHRITIS RESEARCH & THERAPY

Role of PGC-1α signaling in skeletal muscle health and disease

(2012) Chounghun Kang et al.   Annals of the New York Academy of Sciences

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Effects of aging on articular cartilage homeostasis

(2012) Martin Lotz et al.   BONE

Mitochondria as sources and targets of damage in cellular aging

(2012) Mari Carmen Gomez-Cabrera et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Mechanical stress and ATP synthesis are coupled by mitochondrial oxidants in articular cartilage

(2012) Katherine J. Wolff et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mitochondrial electron transport and glycolysis are coupled in articular cartilage

(2012) J.A. Martin et al.   OSTEOARTHRITIS AND CARTILAGE

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

Aging and osteoarthritis

(2011) Richard F. Loeser   CURRENT OPINION IN RHEUMATOLOGY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Oxidative stress induces senescence in chondrocytes

(2011) Anita Brandl et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

The Extending Network of FOXO Transcriptional Target Genes

(2010) Kristan E. van der Vos et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells

(2010) David Álvarez-Guardia et al.   CARDIOVASCULAR RESEARCH

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism

(2010) D. Grahame Hardie   PROCEEDINGS OF THE NUTRITION SOCIETY

Caloric restriction: From soup to nuts

(2009) Stephen R. Spindler   AGEING RESEARCH REVIEWS

Mutual Dependence of Foxo3a and PGC-1α in the Induction of Oxidative Stress Genes

(2009) Yolanda Olmos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression

(2009) Jolene Bohensky et al.   PEDIATRIC NEPHROLOGY

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Autophagy: A New Phase in the Maturation of Growth Plate Chondrocytes Is Regulated by HIF, mTOR and AMP Kinase

(2008) Vickram Srinivas et al.   CELLS TISSUES ORGANS

AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism

(2008) C. A. Witczak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

AMP-Activated Protein Kinase-Regulated Activation of the PGC-1α Promoter in Skeletal Muscle Cells

(2008) Isabella Irrcher et al.   PLoS One

Proteomic analysis of human osteoarthritic chondrocytes reveals protein changes in stress and glycolysis

(2008) Cristina Ruiz-Romero et al.   PROTEOMICS

Deficiency of Insulin-Like Growth Factor 1 Reduces Sensitivity to Aging-Associated Cardiomyocyte Dysfunction

(2008) Qun Li et al.   REJUVENATION RESEARCH

AMP-activated protein kinase phosphorylates transcription factors of the CREB family

(2007) D. M. Thomson et al.   JOURNAL OF APPLIED PHYSIOLOGY