Review
Plant Sciences
Shazia Parveen, Foziya Altaf, Sumira Farooq, Mohammad Lateef Lone, Aehsan ul Haq, Inayatullah Tahir
Summary: Flower senescence is a complex process involving cytological, physiological, and molecular changes, similar to programmed cell death. Ethylene plays a crucial role in ethylene-dependent petal senescence, triggering various changes such as wilting, oxidative stress, protein and nucleic acid degradation, and autophagy. Despite advances in understanding the mechanism and regulation of petal senescence, there are still knowledge gaps that require critical evaluation of the available literature. A deeper understanding of ethylene-dependent senescence can lead to improved regulation of senescence timing and site, resulting in optimized crop yields, enhanced product quality, and extended longevity.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Wenfei Yu, Zhuxun Li, Wenjing Wu, Dandan Zhao, Chuanzhu Yan, Pengfei Lin
Summary: This study investigated the mechanisms underlying telbivudine-induced myopathy and found that it is associated with mitochondrial toxicity and impaired energy metabolism. This provides evidence supporting the common mechanism of NAs causing neuromyopathy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Biochemistry & Molecular Biology
Yue Hu, Yumin Luo, Yangmin Zheng
Summary: Cerebrovascular disease is a prevalent and complex condition that poses a serious threat to human life and health. Current research has shown that oxidative stress and autophagy are important pathophysiological activities in cerebrovascular diseases, with some studies exploring their crosstalk. However, more detailed studies are needed to determine the specific mechanisms.
Article
Engineering, Environmental
Seham M. Hamed, N. Hozzein, Samy Selim, Hussein S. Mohamed, Hamada AbdElgawad
Summary: This study demonstrated that cyanobacteria Nostoc muscorum showed efficient accumulation and degradation of organophosphorus pesticide PY compared to Ana-baena laxa. PY inhibited cell growth, reduced chlorophyll a content and photosynthesis related enzymes activities in both species, but the effects were less pronounced in N. muscorum.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Qing Li, Yi Wang, Shu-Jie Yang, Yu Liu, Xiang Ma, Lu Liu, Si-Hong Li, Dong Niu, Xing Duan
Summary: Maternal diabetes has negative effects on oocyte quality, but melatonin supplementation can protect oocytes from these damages and improve oocyte quality in assisted reproductive technologies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Oncology
Zachary D. Prudowsky, Jason T. Yustein
Summary: Osteosarcoma is the most common bone malignancy of childhood. Standard chemotherapy regimens work well for many patients, but there are minimal options for patients with progressive or resistant disease. A better understanding of therapy resistance is necessary to improve current treatments and design new strategies for future treatment options.
Review
Biochemistry & Molecular Biology
Diana Salnikova, Varvara Orekhova, Andrey Grechko, Antonina Starodubova, Evgeny Bezsonov, Tatyana Popkova, Alexander Orekhov
Summary: Altered mitochondrial function plays a crucial role in the initiation and progression of atherosclerosis, leading to changes in cellular metabolism, respiration, and increased production of reactive oxygen species. Mitochondrial dysfunction is associated with vascular disease and chronic inflammation, and targeted approaches to reduce oxidative stress and inflammation show promise in atherosclerosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Chongshan Dai, Subhajit Das Gupta, Zhanhui Wang, Haiyang Jiang, Tony Velkov, Jianzhong Shen
Summary: In this review, the authors summarized the current knowledge and challenges related to T-2 toxin-induced cardiotoxicity, and discussed potential treatment approaches. The cardiotoxicity caused by T-2 toxin involves various cellular pathways and mechanisms, including oxidative stress, mitochondrial dysfunction, and inflammatory responses. Antioxidant supplementation, induction of autophagy, and blockade of inflammatory signaling may provide protective effects against T-2 toxin-induced cardiac toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Medicine, Research & Experimental
Dan Ni, Zhongcheng Mo, Guanghui Yi
Summary: Cardiovascular and cerebrovascular diseases caused by atherosclerosis are major health threats, with autophagy playing a key role in plaque development. Further research is needed to understand the mechanisms involved.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yongteng Zhao, Xueting Song, Peng Zhao, Tao Li, Jun-Wei Xu, Xuya Yu
Summary: The study found that melatonin significantly promoted lipid accumulation in Monoraphidium sp. QLY-1 under salinity stress by upregulating lipogenesis-related genes, reducing oxidative stress, and promoting autophagic activity. Furthermore, the combination of melatonin and the autophagy activator rapamycin further increased lipid content, suggesting a valuable strategy for enhancing lipid production in microalgae.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Review
Cell Biology
Anna Maria Fratta Pasini, Chiara Stranieri, Fabiana Busti, Edoardo Giuseppe Di Leo, Domenico Girelli, Luciano Cominacini
Summary: Cardiovascular diseases (CVDs) are the leading cause of disease burden and death globally. Ferroptosis, characterized by altered iron metabolism and increased lipid peroxidation, has been found to play a key role in the pathogenesis of CVDs such as ischemic heart disease and cardiomyopathies. This article reviews the molecular mechanism of ferroptosis and its involvement in ischemic heart disease and cardiomyopathies, and suggests that understanding the regulation of ferroptosis in vascular and cardiac cells may lead to new strategies for preventing and treating CVDs.
Review
Cardiac & Cardiovascular Systems
Z. L. Zeng, Qing Yuan, Xuyu Zu, Jianghua Liu
Summary: Vascular calcification is a growing burden in aging societies worldwide, and effective therapies are still lacking. Recent advances in understanding the role of mitochondria in maintaining vascular physiology have opened up promising avenues for treatment. This review discusses the relationship between mitochondrial dysfunction and vascular calcification, as well as the challenges and prerequisites for therapeutic applications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Yuvraj Anandrao Jagtap, Prashant Kumar, Sumit Kinger, Ankur Rakesh Dubey, Akash Choudhary, Ravi Kumar Gutti, Sarika Singh, Hem Chandra Jha, Krishna Mohan Poluri, Amit Mishra
Summary: Disturbance in mitochondrial functions is a defining characteristic of neurodegenerative diseases, such as Parkinson's, ALS, and Alzheimer's. Misfolded proteins play a role in the impairment of mitochondrial pathways, exacerbating disease progression. However, the impact of mitochondrial dysfunction on other organelles and cellular processes remains understudied. Investigating the interplay between mitochondria and neurodegeneration can provide valuable insights for targeted therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Plant Sciences
Anket Sharma, Dhriti Kapoor, Shristy Gautam, Marco Landi, Nidhi Kandhol, Fabrizio Araniti, Muthusamy Ramakrishnan, Lakkakula Satish, Vijay Pratap Singh, Priyanka Sharma, Renu Bhardwaj, Durgesh Kumar Tripathi, Bingsong Zheng
Summary: Different forms of heavy metals in the earth crust are primitive and related to the origin of plant life. However, human activities have led to a significant increase in heavy metal use and contamination, negatively impacting plant growth and yield. Exogenous application of phytohormones has been found to positively regulate heavy metal toxicity and enhance plant growth and productivity.
PHYSIOLOGIA PLANTARUM
(2022)
Review
Cardiac & Cardiovascular Systems
Yunqing Hua, Jing Zhang, Qianqian Liu, Jing Su, Yun Zhao, Guobin Zheng, Zhihui Yang, Danping Zhuo, Chuanrui Ma, Guanwei Fan
Summary: This paper reviews the role of endothelial cells in the pathogenesis of atherosclerosis and explores the molecular mechanisms involved in atherosclerosis development. Endothelial cell dysfunction initiates the development of atherosclerosis, and autophagic flux plays an important role in maintaining normal blood vessel walls.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Neurosciences
Vicente Roca-Agujetas, Elisabet Barbero-Camps, Cristina de Dios, Petar Podlesniy, Xenia Abadin, Albert Morales, Montserrat Mari, Ramon Trullas, Anna Colell
Summary: Accumulation of intracellular cholesterol hinders the clearance of defective mitochondria, suggesting restoration of cholesterol homeostasis and mitochondrial scavenging of ROS as potential therapeutic targets for Alzheimer's disease.
MOLECULAR NEURODEGENERATION
(2021)
Editorial Material
Biochemistry & Molecular Biology
Montserrat Mari, Anna Colell
Article
Medicine, General & Internal
Neus Martinez-Bosch, Helena Cristobal, Mar Iglesias, Meritxell Gironella, Luis Barranco, Laura Visa, Domenico Calafato, Silvia Jimenez-Parrado, Julie Earl, Alfredo Carrato, Noemi Manero-Ruperez, Mireia Moreno, Albert Morales, Carmen Guerra, Pilar Navarro, Pablo Garcia de Frutos
Summary: This study explores the use of sAXL as a biomarker for pancreatic ductal adenocarcinoma (PDAC). The research shows that AXL is increased in PDAC tissues and plasma sAXL concentrations are elevated in PDAC patients. Higher levels of AXL are associated with lower overall survival. sAXL performs better than CA19-9 in discriminating between PDAC and chronic pancreatitis (CP). The combination of sAXL and CA19-9 improves the diagnostic value.
Review
Oncology
Blanca Cucarull, Anna Tutusaus, Patricia Rider, Tania Hernaez-Alsina, Carlos Cuno, Pablo Garcia de Frutos, Anna Colell, Montserrat Mari, Albert Morales
Summary: Hepatocellular carcinoma (HCC) is the most common form of liver cancer with poor prognosis and increasing incidence. Recent advances in systemic treatment options, including tyrosine kinase inhibitors, antiangiogenic antibodies, and immune checkpoint inhibitors, have provided hope for HCC patients. Understanding the specific molecular mechanisms that influence tumor growth and immune control in HCC is crucial for physician decision-making and developing effective treatments.
Article
Neurosciences
Cristina de Dios, Xenia Abadin, Vicente Roca-Agujetas, Marina Jimenez-Martinez, Albert Morales, Ramon Trullas, Montserrat Mari, Anna Colell
Summary: The sustained activation of inflammasomes in Alzheimer's disease (AD) is not well understood. This study examines whether cholesterol-mediated changes can regulate the inflammasome pathway. It was found that cholesterol levels affect the inflammasome-mediated immune response in microglia and neuronal cells differently, and cholesterol modulation may be a potential therapeutic target for AD treatment.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Health Care Sciences & Services
Helena Cristobal, Cristina Enjuanes, Montserrat Batlle, Marta Tajes, Begona Campos, Josep Francesch, Pedro Moliner, Marta Farrero, Rut Andrea, Jose Tomas Ortiz-Perez, Albert Morales, Manel Sabate, Josep Comin-Colet, Pablo Garcia de Frutos
Summary: Heart failure (HF) is classified based on left ventricular ejection fraction (EF) into HF with reduced, mildly reduced, and preserved EF. Biomarkers may differ depending on EF type. This study analyzed the levels of soluble form of the AXL receptor tyrosine kinase (sAXL) in HF patients with reduced and preserved EF. The results showed that sAXL levels were a reliable predictor for all-cause and cardiovascular mortality only in the HFpEF cohort.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Carlos Cuno-Gomiz, Estefania de Gregorio, Anna Tutusaus, Patricia Rider, Nuria Andres-Sanchez, Anna Colell, Albert Morales, Montserrat Mari
Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common liver condition today. In its more advanced form, called metabolic dysfunction-associated steatohepatitis (MASH), adult men are more often affected than women, though this difference vanishes after menopause. Various factors contribute to MASH, including a specific immune cell type called NKT cells, which has not been deeply researched yet. To explore the role of NKT cells in steatohepatitis, we used male and female mice with or without NKT cells (CD1d-/- mice), feeding them a high-fat diet that induces steatohepatitis. Our findings revealed that female mice had less severe steatohepatitis compared to males. Interestingly, we observed a protective role of NKT cells during steatohepatitis, as male mice without these cells had more damage, inflammation, and fibrosis than those with NKT cells. However, in females, even though those lacking NKT cells showed more liver damage and immune alterations, NKT did not seem to play a major role in early steatohepatitis progression. Notably, females had much fewer NKT cells in their livers compared to males, possibly explaining this difference. In conclusion, NKT cells seem to slow down steatohepatitis progression, especially in male mice. In females, their impact on early steatohepatitis advance appears more limited.
BIOLOGY OF SEX DIFFERENCES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Anna Tutusaus, Blanca Cucarull, Patricia Rider, Carlos Cuno, Pablo Garcia de Frutos, Loreto Boix, Montserrat Mari, Albert Morales
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Sturla M. Groendal, Anna Tutusaus, Pablo Garcia de Frutos, Magnus Blo, Linn Hodneland, Gro Gausdal, Akil Jackson, James B. Lorens, Albert Morales, Montserrat Mari
JOURNAL OF HEPATOLOGY
(2022)