Review
Biochemistry & Molecular Biology
Fangyu An, Bai Sun, Ying Liu, Chunmei Wang, Xiaxia Wang, Jiayu Wang, Yongqi Liu, Chunlu Yan
Summary: miRNAs can regulate apoptosis, autophagy, and pyroptosis in KOA through various signaling pathways, with P2X7R and HMGB1 playing crucial roles. miR-140-5p and miR-107 can modulate the advancement of KOA chondrocytes by targeting distinct molecules involved in apoptosis, autophagy, and pyroptosis.
MOLECULAR GENETICS AND GENOMICS
(2023)
Review
Medicine, Research & Experimental
Sina Khodakarimi, Amir Zarebkohan, Houman Kahroba, Mohammadhassan Omrani, Tina Sepasi, Gisou Mohaddes, Hanieh Beyrampour-Basmenj, Ayyub Ebrahimi, Abbas Ebrahimi-Kalan
Summary: Autoimmune diseases are chronic injuries caused by specific auto-reactive reactions, with most of their etiology not well understood. Autophagy serves as a protective response to maintain homeostasis by recycling and discrediting cell compartments, playing a crucial role in controlling immune homeostasis.MicroRNAs, on the other hand, are endogenous non-coding small RNAs that play important roles in cell processes and immune system function, with dysregulated miRNAs implicated in the pathogenesis of autoimmune diseases and the regulation of autophagy.
Review
Cell Biology
Xinyuan Feng, Jiaying Xiao, Lunhao Bai
Summary: This article summarizes the role and mechanism of action of adiponectin in chondrocyte inflammation and death and the pathogenesis of osteoarthritis. It discusses the relationship between adiponectin and autophagy, inflammation, and osteoarthritis, as well as possible treatment methods. The article provides insights into the complex interrelationship between inflammation and metabolism in osteoarthritis and suggests potential future research on adiponectin as a target for treating the disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Zihao Li, Ziyu Huang, Lunhao Bai
Summary: Osteoarthritis is a common joint disease, where cartilage instability leads to cell death and inflammatory factor release, resulting in cartilage degradation. The P2X7 receptor plays a crucial role in cell death and inflammatory reactions, potentially serving as a therapeutic target for OA treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Yunfei Ding, Ruiqing Zhang, Boqing Li, Yunqiu Du, Jing Li, Xiaohan Tong, Yulong Wu, Xiaofei Ji, Ying Zhang
Summary: This study investigated the distribution, endocytosis, transport pathways, and cytotoxic effects of fluorescent polystyrene nanoplastics (PS-NPs) in mice and GES-1 cells. PS-NPs were found in various tissues and cells, and entry into GES-1 cells was reduced with inhibition of specific endocytosis pathways. The results highlight the potential threat of NP pollution to human health through cytotoxic effects in cells.
ENVIRONMENTAL POLLUTION
(2021)
Article
Immunology
Jinzhi Meng, Huawei Du, Haiyuan Lv, Jinfeng Lu, Jia Li, Jun Yao
Summary: This study identified PDK1 as a diagnostic marker for osteoarthritis and investigated its potential mechanisms for restoring autophagy and inhibiting chondrocyte apoptosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hao Tang, Kunpeng Qin, Anquan Wang, Shuang Li, Sheng Fang, Weilu Gao, Ming Lu, Wei Huang, Hui Zhang, Zongsheng Yin
Summary: This study found that DIM can inhibit chondrocyte apoptosis and ECM degradation induced by LPS by regulating the PI3K/AKT/mTOR-autophagy axis, thus delaying the progression of osteoarthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rendi Zhu, Yan Wang, Ziwei Ouyang, Wenjuan Hao, Fuli Zhou, Yi Lin, Yuanzhi Cheng, Renpeng Zhou, Wei Hu
Summary: In vivo articular cartilage degeneration is a key feature of osteoarthritis (OA), with chondrocyte death being a major factor. Various modes of cell death, such as apoptosis, ferroptosis, and autophagy, play important roles in OA chondrocyte death. There is currently insufficient understanding of OA pathogenesis and a lack of effective treatment methods. This review discusses the different forms of chondrocyte death, their associations, critical factors, and explores new approaches for regulating chondrocyte death in OA treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Yue Li, Bin Shen, Cunxian Lv, Xinyi Zhu, Qiqige Naren, Dong Xu, He Chen, Fengmiao Wu
Summary: This study investigates the protective effect of methyl gallate (MG) on the pathological process of osteoarthritis (OA). It was found that MG inhibits apoptosis and extracellular matrix degradation in chondrocytes through promoting autophagy and upregulating SIRT3 expression. MG could be a potential candidate for the treatment of OA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Jihang Dai, Yaxin Zhang, Deng Chen, Duoyun Chen, Xiaolei Li, Jingcheng Wang, Yu Sun
Summary: This study found that Glabridin can increase the expression of extracellular matrix related genes and significantly reduce oxidative stress levels, decreasing apoptosis of chondrocytes. In animal experiments, Glabridin was observed to alleviate the progression of osteoarthritis and protect chondrocytes from apoptosis.
Article
Pharmacology & Pharmacy
Bin He, Wenkan Zhang, Jiaming He
Summary: The study demonstrated that fraxinellone (FRA) isolated from the D. dasycarpus plant inhibited the proliferation and migration of osteosarcoma cells, induced cell apoptosis, and increased autophagy flux. The pro-apoptotic effect of FRA was achieved through excessive autophagy flux, providing new ideas for future osteosarcoma treatment and offering theoretical support for the anti-cancer mechanism of FRA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Haikang Zhou, Guoqing Li, Yang Wang, Rendong Jiang, Yicheng Li, Huhu Wang, Fei Wang, Hairong Ma, Li Cao
Summary: This study investigated the chondroprotective properties of NaB in inflammatory chondrocyte models and ACLT mouse models, revealing that NaB attenuated cartilage degradation by promoting autophagy to inhibit inflammation, oxidative stress, and apoptosis, thus reducing extracellular matrix degradation. The protective effects of NaB against OA were partially mediated by enhancing autophagy through the PI3K/Akt/mTOR pathway both in vitro and in vivo, suggesting NaB as a potential novel therapeutic approach for OA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Zhengyuan Wu, Xiaohan Zhang, Zhengtian Li, Zhenpei Wen, Yicai Lin
Summary: Lycopene exhibits significant chondrocyte-protective effects by reducing inflammation and chondrocyte degradation, promoting chondrocyte proliferation, inhibiting apoptosis, and decreasing ROS production. The mechanism involves induction of autophagy, inhibition of MAPK and PI3K/Akt/NF-kappa B axis, down-regulation of mTOR levels, and potential therapeutic implications for cartilage degeneration.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Elisabetta Di Bello, Veronica Sian, Giulio Bontempi, Clemens Zwergel, Rossella Fioravanti, Beatrice Noce, Carola Castiello, Stefano Tomassi, Davide Corinti, Daniela Passeri, Roberto Pellicciari, Ciro Mercurio, Mario Varasi, Lucia Altucci, Marco Tripodi, Raffaele Strippoli, Angela Nebbioso, Sergio Valente, Antonello Mai
Summary: After years of research, HDAC inhibitors have been developed and approved by FDA/Chinese FDA for the treatment of cancer and non-cancer diseases. A series of novel compounds have been discovered to be effective anticancer agents, demonstrating selective inhibition of HDACs and inducing cell death and differentiation. These compounds also modulate gene and protein expression related to apoptosis and show potent antiproliferative activity in various cancer cell lines.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Orthopedics
Jiajia Qian, Peiru Zhao, Qi Xu, Weiwei Yang, Ren Cai
Summary: This study evaluated the protective effect of swimming on knee osteoarthritis (KOA) mice and explored the underlying mechanism. The results showed that swimming could prevent cell death of chondrocytes via activation of the PI3K/AKT pathway and delay the progression of KOA.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)