Osteoarthritis In Vitro Models: Applications and Implications in Development of Intra-Articular Drug Delivery Systems

Models of Osteoarthritis: Relevance and New Insights

(2020) Hasmik Jasmine Samvelyan et al.   CALCIFIED TISSUE INTERNATIONAL

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

(2020) Emine Alarçin et al.   DRUG DEVELOPMENT RESEARCH

Etoricoxib-loaded bio-adhesive hybridized polylactic acid-based nanoparticles as an intra-articular injection for the treatment of osteoarthritis

(2020) Alaa H. Salama et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Osteoarthritis year in review 2019: epidemiology and therapy

(2020) M. Kloppenburg et al.   OSTEOARTHRITIS AND CARTILAGE

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

(2020) Sharon L. Kolasinski et al.   Arthritis & Rheumatology

Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound

(2020) Chung-Hwan Chen et al.   International Journal of Nanomedicine

A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis

(2020) Jae Hyun Jung et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model

(2020) Masanori Tsubosaka et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A novel diclofenac-hydrogel conjugate system for intraarticular sustained release: Development of 2-pyridylamino-substituted 1-phenylethanol (PAPE) and its derivatives as tunable traceless linkers

(2020) Toshio Kawanami et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Biomaterial strategies for improved intra‐articular drug delivery

(2020) Lina María Mancipe Castro et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Thermoresponsive, hollow, degradable core-shell nanoparticles for intra-articular delivery of anti-inflammatory peptide

(2020) Marcus Deloney et al.   JOURNAL OF CONTROLLED RELEASE

Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

(2020) Tian Jin et al.   JOURNAL OF NANOBIOTECHNOLOGY

Anti-Inflammatory and Chondroprotective Effects of Vanillic Acid and Epimedin C in Human Osteoarthritic Chondrocytes

(2020) Reihane Ziadlou et al.   Biomolecules

Dextran sulfate-triamcinolone acetonide conjugate nanoparticles for targeted treatment of osteoarthritis

(2020) Peng She et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Combination of Hyaluronic Acid and PLGA Particles as Hybrid Systems for Viscosupplementation in Osteoarthritis

(2019) Ana Henriques Mota et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Attenuation of osteoarthritis progression in mice following intra-articular administration of simvastatin-conjugated gelatin hydrogel

(2019) Toshikazu Tanaka et al.   Journal of Tissue Engineering and Regenerative Medicine

Liposome-encapsulated fish oil protein-tagged gold nanoparticles for intra-articular therapy in osteoarthritis

(2019) Amrita Sarkar et al.   Nanomedicine

Chitosan-based composite bilayer scaffold as an in vitro osteochondral defect regeneration model

(2019) Ariane E. Erickson et al.   BIOMEDICAL MICRODEVICES

Intra-articular targeting of nanomaterials for the treatment of osteoarthritis

(2019) Shannon Brown et al.   Acta Biomaterialia

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Mimicking the Articular Joint with In Vitro Models

(2019) Susanna Piluso et al.   TRENDS IN BIOTECHNOLOGY

pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis

(2019) L. Zerrillo et al.   JOURNAL OF CONTROLLED RELEASE

Establishing outcome measures in early knee osteoarthritis

(2019) Carolyn A. Emery et al.   Nature Reviews Rheumatology

Adenosine-Functionalized Biodegradable PLA-b-PEG Nanoparticles Ameliorate Osteoarthritis in Rats

(2019) Xiuling Liu et al.   Scientific Reports

Multi-pathway protective effects of microRNAs on human chondrocytes in an in vitro model of osteoarthritis

(2019) Rua Nader Al-Modawi et al.   Molecular Therapy-Nucleic Acids

Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model

(2019) Paola Occhetta et al.   Nature Biomedical Engineering

Regulation of Inflammatory Response in Human Osteoarthritic Chondrocytes by Novel Herbal Small Molecules

(2019) Ziadlou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thermoresponsive Hyalomer intra-articular hydrogels improve monoiodoacetate-induced osteoarthritis in rats

(2019) Amira Sayed Hanafy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Sustained low-dose dexamethasone delivery via a PLGA microsphere-embedded agarose implant for enhanced osteochondral repair

(2019) Robert M. Stefani et al.   Acta Biomaterialia

Understanding osteoarthritis pathogenesis

(2019) Anusha Ratneswaran et al.   CURRENT OPINION IN RHEUMATOLOGY

Osteoarthritis

(2019) Benjamin Abramoff et al.   MEDICAL CLINICS OF NORTH AMERICA

Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs

(2019) Zixuan Lin et al.   Frontiers in Bioengineering and Biotechnology

Intra-articular drug delivery systems for joint diseases

(2018) Muhammad Farooq Rai et al.   CURRENT OPINION IN PHARMACOLOGY

Intra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis

(2018) Wenshuai Fan et al.   DRUG DELIVERY

Recent advances in intra-articular drug delivery systems for osteoarthritis therapy

(2018) Pierre Maudens et al.   DRUG DISCOVERY TODAY

Sustained intra-articular release of celecoxib in an equine repeated LPS synovitis model

(2018) Stefan M. Cokelaere et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Novel Ex Vivo Human Osteochondral Explant Model of Knee and Spine Osteoarthritis Enables Assessment of Inflammatory and Drug Treatment Responses

(2018) Jeroen Geurts et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nanocrystals of a potent p38 MAPK inhibitor embedded in microparticles: Therapeutic effects in inflammatory and mechanistic murine models of osteoarthritis

(2018) Pierre Maudens et al.   JOURNAL OF CONTROLLED RELEASE

Chondrocyte affinity peptide modified PAMAM conjugate as a nanoplatform for targeting and retention in cartilage

(2018) Qing Hu et al.   Nanomedicine

Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy

(2018) Pierre Maudens et al.   Nanoscale

Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)

(2018) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Nanocrystal-Polymer Particles: Extended Delivery Carriers for Osteoarthritis Treatment

(2018) Pierre Maudens et al.   Small

Bioactive Scaffolds for Regeneration of Cartilage and Subchondral Bone Interface

(2018) Cuijun Deng et al.   Theranostics

Intra-articular TSG-6 delivery from heparin-based microparticles reduces cartilage damage in a rat model of osteoarthritis

(2018) Liane E. Tellier et al.   Biomaterials Science

Intra-Articular Delivery of Quercetin Using Thermosensitive Hydrogel Attenuate Cartilage Degradation in an Osteoarthritis Rat Model

(2018) Sze-Wing Mok et al.   Cartilage

Models of osteoarthritis: the good, the bad and the promising

(2018) P.J. Cope et al.   OSTEOARTHRITIS AND CARTILAGE

The Use of Platelet-Rich Plasma in Symptomatic Knee Osteoarthritis

(2018) Taylor Southworth et al.   Journal of Knee Surgery

Knee osteoarthritis: pathophysiology and current treatment modalities

(2018) Juan C Mora et al.   Journal of Pain Research

Development, characterization and in vitro evaluation of biodegradable rhein-loaded microparticles for treatment of osteoarthritis

(2017) Carolina Gómez-Gaete et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Delivery of anti-inflammatory peptides from hollow PEGylated poly(NIPAM) nanoparticles reduces inflammation in an ex vivo osteoarthritis model

(2017) James McMasters et al.   JOURNAL OF CONTROLLED RELEASE

Single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis

(2017) Norio Goto et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

In situ handheld three-dimensional bioprinting for cartilage regeneration

(2017) Claudia Di Bella et al.   Journal of Tissue Engineering and Regenerative Medicine

Hyaluronic Acid Hydrogel Functionalized with Self-Assembled Micelles of Amphiphilic PEGylated Kartogenin for the Treatment of Osteoarthritis

(2017) Mi-Lan Kang et al.   TISSUE ENGINEERING PART A

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

(2017) Di Chen et al.   Bone Research

Pharmacokinetic Profile of Intra-articular Fluticasone Propionate Microparticles in Beagle Dog Knees

(2017) Alan Getgood et al.   Cartilage

Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial

(2017) Laszlo Hangody et al.   Cartilage

Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis

(2016) Mi-Lan Kang et al.   Acta Biomaterialia

Osteoarthritis: Models for appropriate care across the disease continuum

(2016) Kelli D. Allen et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Injectable long acting chitosan/tripolyphosphate microspheres for the intra-articular delivery of lornoxicam: Optimization and in vivo evaluation

(2016) Hend Abd-Allah et al.   CARBOHYDRATE POLYMERS

Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice

(2016) Julie Pradal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Synthesis, characterizations,in vitroandin vivoevaluation of Etoricoxib-loaded Poly (Caprolactone) microparticles – a potential Intra-articular drug delivery system for the treatment of Osteoarthritis

(2016) P. Arunkumar et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Celecoxib-loaded PEA microspheres as an auto regulatory drug-delivery system after intra-articular injection

(2016) Maarten Janssen et al.   JOURNAL OF CONTROLLED RELEASE

Controlled release of anti-inflammatory peptides from reducible thermosensitive nanoparticles suppresses cartilage inflammation

(2016) Jenny B. Lin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

Comparative pain reduction of oral non-steroidal anti-inflammatory drugs and opioids for knee osteoarthritis: systematic analytic review

(2016) S.R. Smith et al.   OSTEOARTHRITIS AND CARTILAGE

Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term

(2016) A.G. Bajpayee et al.   OSTEOARTHRITIS AND CARTILAGE

In vitro models for the study of osteoarthritis

(2016) Craig I. Johnson et al.   VETERINARY JOURNAL

Phytantriol-Based In Situ Liquid Crystals with Long-Term Release for Intra-articular Administration

(2015) Yulin Chen et al.   AAPS PHARMSCITECH

Sustained intra-articular release of celecoxib from in situ forming gels made of acetyl-capped PCLA-PEG-PCLA triblock copolymers in horses

(2015) Audrey Petit et al.   BIOMATERIALS

Targets, models and challenges in osteoarthritis research

(2015) S. Thysen et al.   Disease Models & Mechanisms

Intra-articular bioactivity of a p38 MAPK inhibitor and development of an extended-release system

(2015) Julie Pradal et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Sustained efficacy of a single intra-articular dose of FX006 in a rat model of repeated localized knee arthritis

(2015) A. Kumar et al.   OSTEOARTHRITIS AND CARTILAGE

Direct chemotherapeutic dual drug delivery through intra-articular injection for synergistic enhancement of rheumatoid arthritis treatment

(2015) A Reum Son et al.   Scientific Reports

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration

(2014) Mi Lan Kang et al.   BIOMATERIALS

Long-term sustained-releasedin situgels of a water-insoluble drug amphotericin B for mycotic arthritis intra-articular administration: preparation,in vitroandin vivoevaluation

(2014) Guo Shan-Bin et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

In vitroandin vivoevaluation of doxycycline-chondroitin sulfate/PCLmicrospheres for intraarticular treatment of osteoarthritis

(2014) Ozlem Aydin et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

The individual and socioeconomic impact of osteoarthritis

(2014) David J. Hunter et al.   Nature Reviews Rheumatology

A systematic review of recommendations and guidelines for the management of osteoarthritis: The Chronic Osteoarthritis Management Initiative of the U.S. Bone and Joint Initiative

(2013) Amanda E. Nelson et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Intra-articular delivery of liposomal celecoxib–hyaluronate combination for the treatment of osteoarthritis in rabbit model

(2012) Ji Dong et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Redifferentiation of dedifferentiated human articular chondrocytes: comparison of 2D and 3D cultures

(2012) M.M.J. Caron et al.   OSTEOARTHRITIS AND CARTILAGE

Physical Therapy in Persons With Osteoarthritis

(2012) Rachel Brakke et al.   PM&R

Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: Establishment and characterization of a long-term cartilage-synovium coculture

(2011) Michiel Beekhuizen et al.   ARTHRITIS AND RHEUMATISM

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences