Article
Engineering, Biomedical
Rapeepat Sangsuwan, Jasper H. N. Yik, Matthew Owen, Gang -Yu Liu, Dominik R. Haudenschild, Jamal S. Lewis
Summary: This study demonstrates the potential of using poly(lactic-co-glycolic acid) microparticles encapsulating flavopiridol as a strategy for sustained delivery of small molecule drugs to the knee joint. The microparticles showed good injectability, sustained release behavior, and reduced the severity of post-traumatic osteoarthritis in a rat model.
ACTA BIOMATERIALIA
(2022)
Article
Biotechnology & Applied Microbiology
Kaamini M. Dhanabalan, Ameya A. Dravid, Smriti Agarwal, Ramanath K. Sharath, Ashok Kumar Padmanabhan, Rachit Agarwal
Summary: Trauma to the knee joint can lead to cartilage degeneration and bone erosion, causing osteoarthritis. Current treatments focus on symptom relief. Modulating autophagy and targeting senescence pathways show potential as treatment strategies. A study found that rapamycin-loaded microparticles can effectively mitigate cartilage damage and inflammation, potentially preventing the progression of post-traumatic osteoarthritis.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Dongyang Zhou, Fengjin Zhou, Shihao Sheng, Yan Wei, Xiao Chen, Jiacan Su
Summary: Osteoarthritis (OA) is characterized by progressive cartilage degeneration. Drug delivery via intra-articular administration (IA) can be restricted by various challenges. Nanodrug delivery systems, such as liposomes, micelles, and nanoparticles (NPs), have shown great potential to overcome these challenges and improve OA treatment.
DRUG DISCOVERY TODAY
(2023)
Article
Pharmacology & Pharmacy
Niranjan G. Kotla, Jean-Baptiste Langlois, Andreas Fisch, Ina Kramer, Christine Halleux
Summary: This study reports the formulation and characterization of surface modified PLGA microparticles that can interact with synovial fluid glycosaminoglycans to reduce local inflammatory response in the knee joint. The microparticles showed preferential adhesion with anionic glycosaminoglycans and released the model drug triamcinolone acetonide over a period of 10 weeks. The surface modification did not affect cell viability or inflammatory response in vitro. These findings suggest that surface-modified PLGA microparticles have potential as long-acting injectables.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Weikang Zhang, Xiaohang Zheng, Yuhang Gong, Ting Jiang, Jianxin Qiu, Xinhui Wu, Fangying Lu, Zhangfu Wang, Zhenghua Hong
Summary: The use of the ERK inhibitor VX-11e has been found to inhibit chondrocyte necroptosis and slow down the progression of osteoarthritis. VX-11e protects articular cartilage and subchondral bone by regulating the RIP1/RIP3/MLKL and MAPK signaling pathways.
BIOORGANIC CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Yifeng Cao, Yifeng Ma, Yi Tao, Weifeng Lin, Ping Wang
Summary: OA is a common joint disease, and current clinical treatments are limited to pain relief and anti-inflammation, emphasizing the need to develop disease-modifying drugs for more efficient treatment. Intra-articular injection delivers drugs directly to the joints, increasing drug concentration and reducing side effects, calling for proper design of drug delivery systems to prolong retention time and improve targeting.
Review
Biochemistry & Molecular Biology
Eriko Toyoda, Miki Maehara, Masahiko Watanabe, Masato Sato
Summary: Osteoarthritis (OA) of the knee is a disease that significantly decreases the quality of life due to joint deformation and pain caused by degeneration of articular cartilage. Intervening from an early stage and controlling throughout life is important for OA treatment, and there is a focus on developing a new treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Luoyang Ma, Xiaoyan Zheng, Rui Lin, Antonia Rujia Sun, Jintong Song, Zhiqiang Ye, Dahong Liang, Min Zhang, Jia Tian, Xin Zhou, Liao Cui, Yuyu Liu, Yanzhi Liu
Summary: Drug delivery for osteoarthritis (OA) treatment is a persistent challenge due to low bioavailability and rapid clearance of drugs in the joints. Intra-articular (IA) drug delivery, as a common strategy, largely relies on the effectiveness of the drug-delivery system used for treating OA.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Francesca Guida, Monica Rocco, Livio Luongo, Pietro Persiani, Maria Chiara Vulpiani, Sveva Maria Nusca, Sabatino Maione, Flaminia Coluzzi
Summary: Neuroinflammation is a target in chronic degenerative and autoimmune diseases, and Adelmidrol has been shown to reduce MC infiltration and inflammation, as well as improve cartilage degeneration.
Article
Chemistry, Multidisciplinary
Sean K. Bedingfield, Juan M. Colazo, Martina Di Francesco, Fang Yu, Danielle D. Liu, Valentina Di Francesco, Lauren E. Himmel, Mukesh K. Gupta, Hongsik Cho, Karen A. Hasty, Paolo Decuzzi, Craig L. Duvall
Summary: Prolonged RNA interference of MMP13 as a potential disease-modifying therapy for post-traumatic osteoarthritis, reducing MMP13 expression and joint damage to alleviate pain and maintain function.
Review
Biochemistry & Molecular Biology
Antimo Moretti, Marco Paoletta, Sara Liguori, Walter Ilardi, Francesco Snichelotto, Giuseppe Toro, Francesca Gimigliano, Giovanni Iolascon
Summary: Clodronate has shown positive effects in managing osteoarthritis by impacting inflammation, joint swelling, proteoglycan loss, and improving pain and joint mobility in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Biomedical
Lina M. Mancipe Castro, Andres J. Garcia, Robert E. Guldberg
Summary: Osteoarthritis is a leading cause of disability, with current treatments limited to pain management. Intra-articular drug delivery is considered a promising administration route, but faces challenges and difficulties.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Juan Wen, Huimin Li, Huan Dai, Shu Hua, Xing Long, Huang Li, Saso Ivanovski, Chun Xu
Summary: This review systematically summarizes nanoparticle-based therapies for the management of osteoarthritis (OA) and rheumatoid arthritis (RA). The interaction between nanoparticles and joint tissues, including articular fluids and cells, is explored. Current nanoparticles designed for OA/RA treatment are analyzed, and challenges and future clinical translation of nanoparticle-based therapies are discussed.
MATERIALS TODAY BIO
(2023)
Review
Nanoscience & Nanotechnology
Xu Li, Bingyang Dai, Jiaxin Guo, Lizhen Zheng, Quanyi Guo, Jiang Peng, Jiankun Xu, Ling Qin
Summary: The review discusses the pathological features of osteoarthritis, the design concept for accurate drug localization within cartilage, interactions of nanoparticles with cartilage microenvironment, and advances in therapeutic schemes. The emphasis is on developing smart bioresponsive and multiple modality nanoparticles to interact with pathological signals.
NANO-MICRO LETTERS
(2021)
Review
Rheumatology
Jacqueline Uson, Sebastian Cruz Rodriguez-Garcia, Raul Castellanos-Moreira, Terence W. O'Neill, Michael Doherty, Mikael Boesen, Hemant Pandit, Ingrid Moller Parera, Valentina Vardanyan, Lene Terslev, Willm Uwe Kampen, Maria-Antonietta D'agostino, Francis Berenbaum, Elena Nikiphorou, Irene A. Pitsillidou, Jenny de la Torre-Aboki, Loreto Carmona, Esperanza Naredo
Summary: The study established evidence and expert opinion-based recommendations to guide health professionals using intra-articular therapies in adult patients with peripheral arthropathies. The recommendations focus on practical aspects to guide health professionals before, during, and after IAT in adult patients, covering a wide range of considerations that should be taken into account in practice.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Chemistry, Applied
Viorica Patrulea, Bee-Ha Gan, Karl Perron, Xingguang Cai, Philippe Abdel-Sayed, Emmanuelle Sublet, Verena Ducret, Natalia Porroche Nerhot, Lee Ann Applegate, Gerrit Borchard, Jean-Louis Reymond, Olivier Jordan
Summary: We report a new chemical platform for coupling chitosan derivatives to antimicrobial peptide dendrimers, which enables synergistic antimicrobial activity and preservation of activity when incorporated into various biopolymer formulations. This platform could be used for the development of new membrane disruptive therapeutics to eradicate pathogens in wounds.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Paula Gonzalez-Fernandez, Carlos Rodriguez-Nogales, Olivier Jordan, Eric Allemann
Summary: The therapeutic potential of mesenchymal stem cells (MSCs) remains to be fully explored in the treatment of osteoarthritis (OA). Hydrogels can enhance the function and survival of MSCs and improve the therapeutic effects in OA treatment. This review provides an up-to-date overview of MSCs entrapped into hydrogels, combined with bioactive/small molecules in OA treatment.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Alexandre Porcello, Paula Gonzalez-Fernandez, Olivier Jordan, Eric Allemann
Summary: This study proposes the use of thermoresponsive nanoforming hyaluronic acid derivatives for the treatment of osteoarthritis pain through injection in the joints. By adding specific chemicals, the residence time of the hydrogel in the body can be prolonged and it exhibits improved resistance to degradation and optimal viscoelastic properties. The results demonstrate the significant potential of these engineered hyaluronic acid derivatives as next-generation long-acting viscosupplementation products for osteoarthritic patients.
Article
Integrative & Complementary Medicine
Borel Ndezo Bisso, Christian Ramses Tokam Kuate, Nathalie Boulens, Eric Allemann, Florence Delie, Jean Paul Dzoyem
Summary: The study found that thymol-loaded PLGA nanoparticles (Thy-NPs) alone and in combination with streptomycin exhibit synergistic antibacterial activity against Klebsiella pneumoniae biofilms, suggesting a promising approach for controlling biofilm-associated infections caused by K. pneumoniae.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Adele Rakotonirina, Tatiana Galperine, Eric Allemann
Summary: The role of gut microbiota in health and disease has been emphasized in recent years. Fecal microbiota transplantation (FMT) has shown promising results for treating Clostridioides difficile infection (CDI), but technical challenges hinder its implementation. Pharmaceutical technology approaches could improve the effectiveness of FMT.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2022)
Article
Infectious Diseases
Christian Ramses Kuate Tokam, Borel Bisso Ndezo, Nathalie Boulens, Eric Allemann, Florence Delie, Jean Paul Dzoyem
Summary: This study aimed to investigate the antibiofilm activity of thymol-loaded poly(lactic-co-glycolic acid) nanoparticles (TH-NPs) and their synergism when used in combination with amikacin antibiotics. Results showed that TH-NPs exhibited more efficient antibacterial activity against planktonic cells of Salmonella enterica serovars compared to thymol alone. The combination of TH-NPs with amikacin showed synergistic activity in the inhibition and eradication of Salmonella enterica serovar biofilm.
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexis Laurent, Alexandre Porcello, Annick Jeannerat, Cedric Peneveyre, Agathe Coeur, Philippe Abdel-Sayed, Corinne Scaletta, Murielle Michetti, Anthony de Buys Roessingh, Olivier Jordan, Eric Allemann, Wassim Raffoul, Nathalie Hirt-Burri, Lee Ann Applegate
Summary: The aim of this study was to prepare and characterize stabilized cell-free progenitor tenocyte extracts for use in complex injectable preparations. Comparative and functional-oriented characterizations were performed, showing that the extracts retained significant antioxidant properties compared to the cellular starting materials. This study provides robust control methodologies for stabilized cell-free progenitor tenocyte extracts, allowing for the conservation of critical biological extract attributes.
Article
Pharmacology & Pharmacy
Adele Rakotonirina, Tatiana Galperine, Maxime Audry, Marie Kroemer, Aurelie Baliff, Laurent Carrez, Farshid Sadeghipour, Jacques Schrenzel, Benoit Guery, Eric Allemann
Summary: Clostridioides difficile infection (CDI) is a severe nosocomial infection with a high mortality rate. Although antibiotic treatment is the standard of care, the relapse rate is high and less effective against recurrent infection. Fecal microbiota transplantation (FMT) is a recommended treatment with a high efficacy. The formulation of diluted donor stool needs innovation, and the administration routes should be optimized.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Alexandre Porcello, Paula Gonzalez-Fernandez, Annick Jeannerat, Cedric Peneveyre, Philippe Abdel-Sayed, Corinne Scaletta, Wassim Raffoul, Nathalie Hirt-Burri, Lee Ann Applegate, Eric Allemann, Alexis Laurent, Olivier Jordan
Summary: The first aim of this study was to characterize the performance of various combination product formulas through in vitro testing, while the second aim was to assess the effectiveness of these combinations in a rodent model of knee osteoarthritis. The results showed that the combination of modified hyaluronan-based hydrogels and FE002 human chondroprogenitor cells was suitable and resistant to degradation, and it showed potential in inhibiting the development of knee osteoarthritis.
Article
Chemistry, Multidisciplinary
Cintia Marques, Mohammad Javad Hajipour, Ceilia Marets, Alexandra Oudot, Reihaneh Safavi-sohi, Melanie Guillemin, Gerrit Borchard, Olivier Jordan, Lucien Saviot, Lionel Maurizi
Summary: The therapeutic efficacy and side effects of nanoparticles (NPs) depend on their circulation time in the body. The adsorbed coronaproteins on NPs determine their plasma half-lives, and it is important to identify the proteins that influence their circulation time. This study analyzed the in vivo circulation time and protein composition of superparamagnetic iron oxide nanoparticles (SPIONs) with different surface charges/chemistries. SPIONs with neutral and positive charges had the longest and shortest circulation times, respectively. The composition of the corona-coated NPs also affected their circulation time, with certain proteins playing a role in determining their systemic circulation time.
Article
Polymer Science
Alexandre Porcello, Farid Hadjab, Maryam Ajouaou, Virginie Philippe, Robin Martin, Philippe Abdel-Sayed, Nathalie Hirt-Burri, Corinne Scaletta, Wassim Raffoul, Lee Ann Applegate, Eric Allemann, Olivier Jordan, Alexis Laurent
Summary: This study aimed to evaluate the functional attributes of four commercially available hyaluronan-based viscosupplements and found that the Innoryos product showed the best overall functional behavior. The study highlighted the importance of formulation development and control methodology optimization for enhancing the functional attributes and clinical effectiveness of these products.
Review
Clinical Neurology
Anne F. F. Cayron, Sandrine Morel, Eric Allemann, Philippe Bijlenga, Brenda R. R. Kwak
Summary: This review article summarizes the existing in vivo imaging techniques used in animal models to visualize intracranial aneurysms (IA). Six imaging techniques were identified, including conventional catheter angiography, computed tomography angiography, magnetic resonance angiography, hemodynamic imaging, optical coherence tomography, and fluorescence imaging. The advantages and disadvantages of each technique are discussed to guide future IA studies in selecting the most suitable imaging modality and animal model.
NEUROSURGICAL REVIEW
(2023)
Article
Polymer Science
Tamara Melnik, Alexandre Porcello, Francois Saucy, Florence Delie, Olivier Jordan
Summary: Intimal hyperplasia (IH) is a pathology that occurs after bypass surgery, and topically applied atorvastatin (ATV) has been shown to slow down this process. Encapsulating ATV in a 2-component system with both rapid release hyaluronic acid-dopamine bioadhesive gel and sustained release biodegradable microparticles showed good rheological properties and bioadhesion. The release profile demonstrated an initial burst followed by sustained release for 8 weeks, and preliminary evaluation in rats indicated good tolerability of the gel.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)