Review
Pharmacology & Pharmacy
Dongyang Zhou, Fengjin Zhou, Shihao Sheng, Yan Wei, Xiao Chen, Jiacan Su
Summary: Osteoarthritis (OA) is characterized by progressive cartilage degeneration. Drug delivery via intra-articular administration (IA) can be restricted by various challenges. Nanodrug delivery systems, such as liposomes, micelles, and nanoparticles (NPs), have shown great potential to overcome these challenges and improve OA treatment.
DRUG DISCOVERY TODAY
(2023)
Article
Engineering, Biomedical
Rapeepat Sangsuwan, Jasper H. N. Yik, Matthew Owen, Gang -Yu Liu, Dominik R. Haudenschild, Jamal S. Lewis
Summary: This study demonstrates the potential of using poly(lactic-co-glycolic acid) microparticles encapsulating flavopiridol as a strategy for sustained delivery of small molecule drugs to the knee joint. The microparticles showed good injectability, sustained release behavior, and reduced the severity of post-traumatic osteoarthritis in a rat model.
ACTA BIOMATERIALIA
(2022)
Article
Biotechnology & Applied Microbiology
Kaamini M. Dhanabalan, Ameya A. Dravid, Smriti Agarwal, Ramanath K. Sharath, Ashok Kumar Padmanabhan, Rachit Agarwal
Summary: Trauma to the knee joint can lead to cartilage degeneration and bone erosion, causing osteoarthritis. Current treatments focus on symptom relief. Modulating autophagy and targeting senescence pathways show potential as treatment strategies. A study found that rapamycin-loaded microparticles can effectively mitigate cartilage damage and inflammation, potentially preventing the progression of post-traumatic osteoarthritis.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Luoyang Ma, Xiaoyan Zheng, Rui Lin, Antonia Rujia Sun, Jintong Song, Zhiqiang Ye, Dahong Liang, Min Zhang, Jia Tian, Xin Zhou, Liao Cui, Yuyu Liu, Yanzhi Liu
Summary: Drug delivery for osteoarthritis (OA) treatment is a persistent challenge due to low bioavailability and rapid clearance of drugs in the joints. Intra-articular (IA) drug delivery, as a common strategy, largely relies on the effectiveness of the drug-delivery system used for treating OA.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Materials Science, Multidisciplinary
Alejandro Forigua, Arash Dalili, Rebecca Kirsch, Stephanie M. Willerth, Katherine S. Elvira
Summary: Drug releasing microparticles are important for precise drug delivery. Microfluidic technologies offer better control over microparticle size and distribution compared to bulk production methods. This study demonstrates the formation of polycaprolactone (PCL) microparticles with therapeutically relevant cargo using a microfluidic platform, and investigates the effect of cargo on microparticle size and distribution.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Xu Li, Bingyang Dai, Jiaxin Guo, Lizhen Zheng, Quanyi Guo, Jiang Peng, Jiankun Xu, Ling Qin
Summary: The review discusses the pathological features of osteoarthritis, the design concept for accurate drug localization within cartilage, interactions of nanoparticles with cartilage microenvironment, and advances in therapeutic schemes. The emphasis is on developing smart bioresponsive and multiple modality nanoparticles to interact with pathological signals.
NANO-MICRO LETTERS
(2021)
Article
Pharmacology & Pharmacy
Niranjan G. Kotla, Jean-Baptiste Langlois, Andreas Fisch, Ina Kramer, Christine Halleux
Summary: This study reports the formulation and characterization of surface modified PLGA microparticles that can interact with synovial fluid glycosaminoglycans to reduce local inflammatory response in the knee joint. The microparticles showed preferential adhesion with anionic glycosaminoglycans and released the model drug triamcinolone acetonide over a period of 10 weeks. The surface modification did not affect cell viability or inflammatory response in vitro. These findings suggest that surface-modified PLGA microparticles have potential as long-acting injectables.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Engineering, Biomedical
Lina M. Mancipe Castro, Andres J. Garcia, Robert E. Guldberg
Summary: Osteoarthritis is a leading cause of disability, with current treatments limited to pain management. Intra-articular drug delivery is considered a promising administration route, but faces challenges and difficulties.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Juan Wen, Huimin Li, Huan Dai, Shu Hua, Xing Long, Huang Li, Saso Ivanovski, Chun Xu
Summary: This review systematically summarizes nanoparticle-based therapies for the management of osteoarthritis (OA) and rheumatoid arthritis (RA). The interaction between nanoparticles and joint tissues, including articular fluids and cells, is explored. Current nanoparticles designed for OA/RA treatment are analyzed, and challenges and future clinical translation of nanoparticle-based therapies are discussed.
MATERIALS TODAY BIO
(2023)
Review
Pharmacology & Pharmacy
Yifeng Cao, Yifeng Ma, Yi Tao, Weifeng Lin, Ping Wang
Summary: OA is a common joint disease, and current clinical treatments are limited to pain relief and anti-inflammation, emphasizing the need to develop disease-modifying drugs for more efficient treatment. Intra-articular injection delivers drugs directly to the joints, increasing drug concentration and reducing side effects, calling for proper design of drug delivery systems to prolong retention time and improve targeting.
Review
Biotechnology & Applied Microbiology
Soumayeh Amirsaadat, Halimeh Amirazad, Ramin Hashemihesar, Nosratollah Zarghami
Summary: Osteoarthritis is a common progressive condition that mainly affects the knees and hips. Knee osteoarthritis presents symptoms like stiffness, pain, dysfunction, and deformity that significantly impact quality of life. Current treatments primarily focus on symptomatic relief using corticosteroids and hyaluronic acid, but factors like the placebo effect play a crucial role in their effectiveness. Novel intra-articular therapies, including biological and gene/cell therapies, show promise, and the development of drug nanocarriers and delivery systems could improve treatment outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Jomarien Garcia-Couce, Timo Schomann, Chih Kit Chung, Ivo Que, Carla Jorquera-Cordero, Gaston Fuentes, Amisel Almirall, Alan Chan, Luis J. Cruz
Summary: In recent years, there has been significant interest in intra-articular drug administration and modified drugs for the treatment of osteoarthritis. This study successfully prepared injectable-thermosensitive hydrogels for intra-articular administration of Etanercept (ETA) and demonstrated their cytocompatibility and controlled release of ETA. In vivo studies also showed their potential for localized treatment of joints in osteoarthritic mice.
Review
Pharmacology & Pharmacy
Huirong Huang, Yujie Lin, Yiling Jiang, Qing Yao, Ruijie Chen, Ying-Zheng Zhao, Longfa Kou
Summary: Osteoarthritis (OA) is a common chronic degenerative joint disease that weakens motor function and has a significant economic burden. Current medications for OA do not meet the needs for treatment. Recombinant protein drugs (RPDs) show promise as disease-modifying OA drugs (DMOADs) by inhibiting inflammation, regulating metabolism, and promoting cartilage repair. However, their short half-life and rapid clearance in the joint cavity restrict their clinical translation. Reliable drug delivery systems are necessary for their further development.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Engineering, Biomedical
Xueli Mei, Ian J. Villamagna, Tony Nguyen, Frank Beier, C. Thomas Appleton, Elizabeth R. Gillies
Summary: Osteoarthritis is a progressive disease with no disease-modifying pharmaceutical treatment currently available. Research is focusing on delivering drugs selectively to joints with targeted approaches. Various polymer-based particle systems are being explored for intra-articular treatment, but challenges such as particle size, biodegradability, and mechanical properties still need to be addressed.
BIOMEDICAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Yujie Liang, Xiao Xu, Limei Xu, Indira Prasadam, Li Duan, Yin Xiao, Jiang Xia
Summary: Intra-articular drug delivery is a conservative treatment method that improves the bioavailability of therapeutic composites in OA joint cavity. New targeted nano-based drug delivery systems and gene delivery for OA therapy show promising prospects.
JOURNAL OF DRUG TARGETING
(2021)
Review
Medicine, Research & Experimental
Muhammad Qasim, Pala Arunkumar, Heather M. Powell, Mahmood Khan
Article
Clinical Neurology
Himanshu Shekhar, Arunkumar Palaniappan, Tao Peng, Maxime Lafond, Melanie R. Moody, Kevin J. Haworth, Shaoling Huang, David D. McPherson, Christy K. Holland
Article
Multidisciplinary Sciences
Himanshu Shekhar, Robert T. Kleven, Tao Peng, Arunkumar Palaniappan, Kuria B. Karani, Shaoling Huang, David D. McPherson, Christy K. Holland
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Multidisciplinary
Pala Arunkumar, Julie A. Dougherty, Jessica Weist, Naresh Kumar, Mark G. Angelos, Heather M. Powell, Mahmood Khan
Article
Pharmacology & Pharmacy
Maxime Lafond, Himanshu Shekhar, Warunya Panmanee, Sydney D. Collins, Arunkumar Palaniappan, Cameron T. McDaniel, Daniel J. Hassett, Christy K. Holland
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Materials Science, Biomaterials
Divya Sridharan, Arunkumar Palaniappan, Britani N. Blackstone, Julie A. Dougherty, Naresh Kumar, Polani B. Seshagiri, Nazish Sayed, Heather M. Powell, Mahmood Khan
Summary: The study demonstrates that coaxial PCL-gelatin nanofibrous scaffolds can be used as a 3D culture platform for efficient differentiation of hiPSCs to functional cardiomyocytes. While there were no significant differences in the morphology and immunofluorescence staining of cardiomyocytes between 2D and 3D cultures, gene expression data showed increased expression of cardiac progenitor genes in 3D cultures and cardiomyocytes markers in 2D cultures.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Naresh Kumar, Divya Sridharan, Arunkumar Palaniappan, Julie A. Dougherty, Andras Czirok, Dona Greta Isai, Muhamad Mergaye, Mark G. Angelos, Heather M. Powell, Mahmood Khan
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Indulekha Singaravelu, Henry Spitz, Mary Mahoney, Zhongyun Dong, Nalinikanth Kotagiri
Summary: This study found that the combination of the antiandrogen drug bicalutamide with F-18-FDG can enhance the treatment of triple-negative breast cancer (TNBC), and this effect was confirmed through in vitro and in vivo experiments in cell and mouse tumor models.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Polymer Science
Anupama Devi V. K, Rohin Shyam, Arunkumar Palaniappan, Amit Kumar Jaiswal, Tae-Hwan Oh, Arputharaj Joseph Nathanael
Summary: The review highlights the importance of smart self-healing hydrogels, their self-healing mechanisms, evaluation methods, and applications. It also discusses the use of composite materials to enhance mechanical properties, as well as methods for evaluating self-healing properties and recent advancements in 3D bioprinting. Finally, it presents current challenges and future perspectives in the field.
Review
Chemistry, Medicinal
Purnimajayasree Ramesh, Arunkumar Palaniappan
Summary: The review focuses on the extraction, medicinal properties, green synthesis of nanoparticles, and formulation applications of Terminalia arjuna (TA). It emphasizes the significance of understanding TA as a cardioprotective medicinal plant and its role in green nanotechnology and formulations.
Article
Biotechnology & Applied Microbiology
Pearlin Amaan Khan, Aravind Kumar Thoutam, Vasanth Gopal, Aswin Gurumallesh, Shrikant Joshi, Arunkumar Palaniappan, Nicolaie Markocsan, Geetha Manivasagam
Summary: Axial suspension plasma spraying (ASPS) is an alternative technique to atmospheric plasma spraying (APS) that uses a suspension of finer powders as the feedstock. This paper investigates the impact of incorporated graphene nanoplatelets (GNPs) on the behavior of ASPS hydroxyapatite (HAp) coatings. The study characterizes the coatings using various techniques and evaluates their mechanical properties, biocompatibility, and gene expression changes.
BIOENGINEERING-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Selvaganapathy Ganesan, Kalaipriya Ramajayam, Thangavelu Kokulnathan, Arunkumar Palaniappan
Summary: Recent studies have found a high correlation between the concentrations of analytes in sweat and blood, making sweat an attractive medium for disease diagnosis and health monitoring. However, low analyte concentrations in sweat pose a challenge, requiring high-performing sensors. MXenes, a recently developed nanomaterial, show promise as a material of choice for bio-electrochemical sensors due to their tunable electrical properties and biocompatibility. This review discusses the progress in MXene-based sensors and their applications, as well as the challenges and future perspectives in sweat-sensing.
Review
Engineering, Multidisciplinary
Kalaipriya Ramajayam, Selvaganapathy Ganesan, Purnimajayasree Ramesh, Maya Beena, Thangavelu Kokulnathan, Arunkumar Palaniappan
Summary: Molecularly imprinted polymers (MIPs) have gained attention in sensor development applications due to their biomimetic artificial receptor system inspired by antibody-antigen reactions. They enhance the sensitivity and specificity of optical and electrochemical sensors through precise binding to analytes. This review discusses polymerization chemistries, synthesis strategies, imprinting parameters, recent developments, and applications of MIPs in biomarker detection, environmental monitoring, and bioimaging.
Article
Polymer Science
Bhaumik Patel, Ravi Manne, Devang B. Patel, Shashank Gorityala, Arunkumar Palaniappan, Mallesh Kurakula
Summary: Chitosan, an important biomaterial, shows great potential in tissue engineering for cardiac repair due to its structure and biological functions. Recent studies indicate that chitosan coupled with innovative technologies can effectively deliver drugs or stem cells to repair damaged heart tissue in various cardiac therapies.
Meeting Abstract
Clinical Neurology
Christy K. Holland, Arunkumar Palaniappan, Himanshu Shekhar
Article
Engineering, Biomedical
Mehlika Karamanlioglu, Serap Yesilkir-Baydar
Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata
Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi
Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng
Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)