The Functional Heterogeneity of Neutrophil-Derived Extracellular Vesicles Reflects the Status of the Parent Cell

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium

(2020) Ingrid Gomez et al.   Nature Communications

Phenotypic analysis of extracellular vesicles: a review on the applications of fluorescence

(2020) Maria S. Panagopoulou et al.   Journal of Extracellular Vesicles

MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments

(2020) Joshua A. Welsh et al.   Journal of Extracellular Vesicles

Effect of extracellular vesicles from S. aureus ‐challenged human neutrophils on macrophages

(2020) Edwina R. Allen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human Neutrophils Produce Antifungal Extracellular Vesicles against Aspergillus fumigatus

(2020) Iordana A. Shopova et al.   mBio

Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4+ CAR T Cell Efficacy

(2020) Solin Ali et al.   Frontiers in Immunology

Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges

(2020) Vadims Parfejevs et al.   Cells

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications

(2020) Austin Gowen et al.   Frontiers in Cell and Developmental Biology

Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils

(2020) Yumi Kumagai et al.   Innate Immunity

Significance of neutrophil microparticles in ischaemia‐reperfusion: Pro‐inflammatory effectors of endothelial senescence and vascular dysfunction

(2020) Ali El Habhab et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Technologies and Standardization in Research on Extracellular Vesicles

(2020) Srujan Gandham et al.   TRENDS IN BIOTECHNOLOGY

Extracellular Vesicles: A Potential Biomarker for Quick Identification of Infectious Osteomyelitis

(2020) Songyun Deng et al.   Frontiers in Cellular and Infection Microbiology

Extracellular Vesicles in Essential Hypertension: Hidden Messengers

(2020) Sabrina La Salvia et al.   CURRENT HYPERTENSION REPORTS

A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?

(2020) Karim Sidhom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

(2020) Yi Zhang et al.   International Journal of Nanomedicine

Neutrophils produce proinflammatory or anti‐inflammatory extracellular vesicles depending on the environmental conditions

(2020) Ferenc Kolonics et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Exosomes in Sepsis

(2020) Atsushi Murao et al.   Frontiers in Immunology

Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients

(2020) Ebru Karasu et al.   Frontiers in Immunology

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

(2019) Kristopher R. Genschmer et al.   CELL

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

(2019) Veronika Butin-Israeli et al.   JOURNAL OF CLINICAL INVESTIGATION

Freeze-dried and GMP-compliant pharmaceuticals containing exosomes for acellular mesenchymal stromal cell immunomodulant therapy

(2019) Elia Bari et al.   Nanomedicine

Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: potential involvement of immune cell cross talk

(2019) Suchita Nadkarni et al.   CLINICAL SCIENCE

Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles

(2019) Sushma Anand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke

(2019) Xinyue Dong et al.   ACS Nano

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

Liquid Biopsy of Extracellular Microvesicles Predicts Future Major Ischemic Events in Genetically Characterized Familial Hypercholesterolemia Patients

(2019) Rosa Suades et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Extracellular vesicles in type 2 diabetes mellitus: key roles in pathogenesis, complications, and therapy

(2019) Yongwei Xiao et al.   Journal of Extracellular Vesicles

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

Cell-derived microvesicles in infective endocarditis: Role in diagnosis and potential for risk stratification at hospital admission

(2019) Milton Henriques Guimarães Júnior et al.   JOURNAL OF INFECTION

Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles

(2019) Aled Clayton et al.   Journal of Extracellular Vesicles

Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro

(2019) Anjana Ajikumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Generation, purification and engineering of extracellular vesicles and their biomedical applications

(2019) Jin Gao et al.   METHODS

Towards a pro-resolving concept in systemic lupus erythematosus

(2019) Sebastian Boeltz et al.   Seminars in Immunopathology

Extracellular vesicles in chronic obstructive pulmonary disease (COPD)

(2019) Hannah E. O’Farrell et al.   Journal of Thoracic Disease

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

(2019) Laurence Macia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Platelets and platelet extracellular vesicles in hemostasis and sepsis

(2019) Elizabeth W J Kerris et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Different Calcium and Src Family Kinase Signaling in Mac-1 Dependent Phagocytosis and Extracellular Vesicle Generation

(2019) Ákos M. Lőrincz et al.   Frontiers in Immunology

Role of Mac-1 integrin in generation of extracellular vesicles with antibacterial capacity from neutrophilic granulocytes

(2019) Ákos M. Lőrincz et al.   Journal of Extracellular Vesicles

Targeting Inflammatory Vasculature by Extracellular Vesicles

(2018) Sihan Wang et al.   AAPS Journal

Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial InfarctionNovelty and Significance

(2018) Xavier Loyer et al.   CIRCULATION RESEARCH

Tumor-derived exosomes modulate T cell function through transfer of RNA

(2018) Imran G. House et al.   FEBS Journal

MicroRNA-4443 regulates mast cell activation by T cell–derived microvesicles

(2018) Irit Shefler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

New flow cytometry-based method for the assessment of the antibacterial effect of immune cells and subcellular particles

(2018) Ákos M. Lőrincz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Extracellular vesicles compartment in liquid biopsies: Clinical application

(2018) Noemi Garcia-Romero et al.   MOLECULAR ASPECTS OF MEDICINE

Technical challenges of working with extracellular vesicles

(2018) Marcel I. Ramirez et al.   Nanoscale

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis

(2018) Hazem M.S. Lashin et al.   SHOCK

Neutrophil extracellular trap-microparticle complexes enhance thrombin generation via the intrinsic pathway of coagulation in mice

(2018) Yongzhi Wang et al.   Scientific Reports

Extracellular Vesicles as Markers and Mediators in Sepsis

(2018) Pierre Raeven et al.   Theranostics

Extracellular Vesicles Released from Mycobacterium tuberculosis-Infected Neutrophils Promote Macrophage Autophagy and Decrease Intracellular Mycobacterial Survival

(2018) Violeta D. Alvarez-Jiménez et al.   Frontiers in Immunology

Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages

(2018) Hefin I. Rhys et al.   EBioMedicine

A Prospective Adaptive Utility Trial to Validate Performance of a Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer in Patients with Prostate-specific Antigen 2–10 ng/ml at Initial Biopsy

(2018) James McKiernan et al.   EUROPEAN UROLOGY

Downregulation of Microparticle Release and Pro-Inflammatory Properties of Activated Human Polymorphonuclear Neutrophils by LMW Fucoidan

(2018) João Alfredo Moraes et al.   Journal of Innate Immunity

Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability

(2017) Stephen R. Thom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mesenchymal stem/stromal cell extracellular vesicles: From active principle to next generation drug delivery system

(2017) Barbara Crivelli et al.   JOURNAL OF CONTROLLED RELEASE

Plant extracellular vesicles are incorporated by a fungal pathogen and inhibit its growth

(2017) Mariana Regente et al.   JOURNAL OF EXPERIMENTAL BOTANY

Neutrophil Microparticles Deliver Active Myeloperoxidase to Injured Mucosa To Inhibit Epithelial Wound Healing

(2017) Thomas W. Slater et al.   JOURNAL OF IMMUNOLOGY

Exosomes from eosinophils autoregulate and promote eosinophil functions

(2017) José Antonio Cañas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microvesicle transfer of kinin B1-receptors is a novel inflammatory mechanism in vasculitis

(2017) Robin Kahn et al.   KIDNEY INTERNATIONAL

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

Exosomes: New players in cancer

(2017) Wei Guo et al.   ONCOLOGY REPORTS

Extracellular vesicles from activated platelets: a semiquantitative cryo-electron microscopy and immuno-gold labeling study

(2017) Alain R. Brisson et al.   PLATELETS

Enhanced survival of Leishmania major in neutrophil granulocytes in the presence of apoptotic cells

(2017) Natallia Salei et al.   PLoS One

Neutrophil-Derived Exosomes: A New Mechanism Contributing to Airway Smooth Muscle Remodeling

(2016) Amandine Vargas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients

(2016) Gonzalo J. Martínez et al.   BIOSCIENCE REPORTS

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration

(2016) Veronika Butin-Israeli et al.   FASEB JOURNAL

Luminal Extracellular Vesicles (EVs) in Inflammatory Bowel Disease (IBD) Exhibit Proinflammatory Effects on Epithelial Cells and Macrophages

(2016) Shuji Mitsuhashi et al.   INFLAMMATORY BOWEL DISEASES

The emerging roles of exosomes in tumor–stroma interaction

(2016) Hailong Fu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Distinct Subtypes of Microparticle-containing Immune Complexes Are Associated with Disease Activity, Damage, and Carotid Intima-media Thickness in Systemic Lupus Erythematosus

(2016) P. R. Fortin et al.   JOURNAL OF RHEUMATOLOGY

Circulating Microvesicles Are Elevated Acutely following Major Burns Injury and Associated with Clinical Severity

(2016) Kieran P. O’Dea et al.   PLoS One

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil-derived chemokines on the road to immunity

(2016) Cristina Tecchio et al.   SEMINARS IN IMMUNOLOGY

Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response

(2016) Jan Rossaint et al.   Nature Communications

Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis

(2016) Ritankar Majumdar et al.   PLOS BIOLOGY

Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome

(2015) Arun Cumpelik et al.   ANNALS OF THE RHEUMATIC DISEASES

Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

(2015) Bence György et al.   Annual Review of Pharmacology and Toxicology

Immunomodulatory role of microRNAs transferred by extracellular vesicles

(2015) Lola Fernández-Messina et al.   BIOLOGY OF THE CELL

Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles

(2015) Nina Heldring et al.   HUMAN GENE THERAPY

Ectosomes from neutrophil-like cells down-regulate nickel-induced dendritic cell maturation and promote Th2 polarization

(2015) Isabelle Turbica et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Functionally and morphologically distinct populations of extracellular vesicles produced by human neutrophilic granulocytes

(2015) A. M. Lorincz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differentiating sepsis from non-infectious systemic inflammation based on microvesicle-bacteria aggregation

(2015) I. K. Herrmann et al.   Nanoscale

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells

(2014) Thassila Pitanga et al.   BMC CELL BIOLOGY

Polymorphonuclear Neutrophil-Derived Ectosomes Interfere with the Maturation of Monocyte-Derived Dendritic Cells

(2014) C. Eken et al.   JOURNAL OF IMMUNOLOGY

Apoptotic Cells Protect Mice against Lipopolysaccharide-Induced Shock

(2014) Y. Ren et al.   JOURNAL OF IMMUNOLOGY

Erythrocyte-Derived Microparticles Supporting Activated Protein C-Mediated Regulation of Blood Coagulation

(2014) Ruzica Livaja Koshiar et al.   PLoS One

Nef Neutralizes the Ability of Exosomes from CD4+ T Cells to Act as Decoys during HIV-1 Infection

(2014) Julianne V. de Carvalho et al.   PLoS One

Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C

(2014) Sofia Somajo et al.   THROMBOSIS RESEARCH

Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

(2013) Konstantinos Kambas et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil microparticles modulate cytokine production by natural killer cells

(2013) Boris K. Pliyev et al.   CYTOKINE

Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis

(2013) Jesmond Dalli et al.   EMBO Molecular Medicine

Pro-inflammatory effect of cystic fibrosis sputum microparticles in the murine lung

(2013) Chiara Porro et al.   Journal of Cystic Fibrosis

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

(2013) Attila Mócsai   JOURNAL OF EXPERIMENTAL MEDICINE

Heterogeneity in Neutrophil Microparticles Reveals Distinct Proteome and Functional Properties

(2013) Jesmond Dalli et al.   MOLECULAR & CELLULAR PROTEOMICS

Changing world of neutrophils

(2013) Csaba I. Timár et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Extravasating Neutrophil-derived Microparticles Preserve Vascular Barrier Function in Inflamed Tissue

(2013) Kihong Lim et al.   Immune Network

Extracellular vesicles - vehicles that spread cancer genes

(2012) Janusz Rak et al.   BIOESSAYS

Antibacterial effect of microvesicles released from human neutrophilic granulocytes

(2012) C. I. Timar et al.   BLOOD

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Immune Cell-derived Vesicles: Modulators and Mediators of Inflammation

(2012) Esther N.M. Nolte-‘t Hoen et al.   CURRENT PHARMACEUTICAL DESIGN

The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes

(2012) Nathalie Cloutier et al.   EMBO Molecular Medicine

Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis

(2012) R. Lacroix et al.   HAEMATOLOGICA

Transfer of extracellular vesicles during immune cell-cell interactions

(2012) Cristina Gutiérrez-Vázquez et al.   IMMUNOLOGICAL REVIEWS

Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa

(2012) P. E. J. VAN DER MEIJDEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Human microparticles generated during sepsis in patients with critical illness are neutrophil-derived and modulate the immune response

(2012) Priya S. Prakash et al.   Journal of Trauma and Acute Care Surgery

Mycobacterium tuberculosis-induced neutrophil ectosomes decrease macrophage activation

(2012) Tonya Azevedo Duarte et al.   TUBERCULOSIS

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

(2012) Shayne A. Bellingham et al.   Frontiers in Physiology

Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands

(2011) C Bardelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microparticles in Hemostasis and Thrombosis

(2011) A. Phillip Owens et al.   CIRCULATION RESEARCH

Anti-Neutrophil Cytoplasmic Antibodies Stimulate Release of Neutrophil Microparticles

(2011) Y. Hong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

(2011) S. Gatti et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Monocyte- and Endothelial-Derived Microparticles Induce an Inflammatory Phenotype in Human Podocytes

(2011) Jeanette Eyre et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

(2011) Ruenn Chai Lai et al.   Regenerative Medicine

Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

(2011) Leo Timmers et al.   Stem Cell Research

Role of Neutrophil Apoptosis in the Resolution of Inflammation

(2011) Driss El Kebir et al.   TheScientificWorldJOURNAL

Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters

(2010) B. Gyorgy et al.   BLOOD

Ectosomes Released by Polymorphonuclear Neutrophils Induce a MerTK-dependent Anti-inflammatory Pathway in Macrophages

(2010) Ceylan Eken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

(2009) Mehmet Kesimer et al.   FASEB JOURNAL

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

(2008) J. Dalli et al.   BLOOD

Expression, activation, and function of integrin  M 2 (Mac-1) on neutrophil-derived microparticles

(2008) E. Pluskota et al.   BLOOD

Stimulated T cells generate microparticles, which mimic cellular contact activation of human monocytes: differential regulation of pro- and anti-inflammatory cytokine production by high-density lipoproteins

(2008) A. Scanu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Nitric Oxide Regulates Neutrophil Migration through Microparticle Formation

(2007) Sarah Nolan et al.   AMERICAN JOURNAL OF PATHOLOGY