Review
Cardiac & Cardiovascular Systems
Niels M. R. van der Sangen, Rik Rozemeijer, Dean R. P. P. Chan Pin Yin, Marco Valgimigli, Stephan Windecker, Stefan K. James, Sergio Buccheri, Jurrien M. ten Berg, Jose P. S. Henriques, Michiel Voskuil, Wouter J. Kikkert
Summary: Dual antiplatelet therapy is the standard of care for patients with chronic coronary syndrome and acute coronary syndrome undergoing percutaneous coronary intervention, but selecting the optimal duration and composition of treatment poses a major challenge. Current guidelines recommend risk stratification for tailoring treatment, yet various risk scoring methods and testing approaches have not been widely adopted in clinical practice. Further research and validation are needed to determine the effectiveness of these risk stratification methods in improving clinical outcomes.
EUROPEAN HEART JOURNAL
(2021)
Article
Urology & Nephrology
Joseph Lunyera, Robert M. Clare, Karen Chiswell, Julia J. Scialla, Patrick H. Pun, Kevin L. Thomas, Monique A. Starks, Clarissa J. Diamantidis
Summary: This study found that Black patients had a significantly higher risk of developing AKI after percutaneous coronary intervention compared to White patients, with no significant difference observed in other racial groups. Investigation into factors predisposing Black individuals to increased AKI risk after this procedure is needed.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sathish Parasuraman, Azfar G. Zaman, Mohaned Egred, Alan Bagna, Paul A. Broadhurst, Javed Ahmed, Richard Edwards, Raj Das, Deepak Garg, Ian Purcell, Awsan Noman
Summary: This study aimed to evaluate the impact of smoking on short and intermediate mortality following PCI. The results showed that there was no significant difference in mortality between ex-smokers and never-smokers after PCI, but current smokers had higher short-term mortality rates. These findings emphasize the importance of smoking cessation for improving outcomes following PCI.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Physiology
Yuhui Lin, Wenjun Dai, Yongquan Chen, Xiaoqing He, Yunhong Xu
Summary: This study evaluated the value of neutrophil-to-platelet ratio (NPR) in predicting all-cause mortality in patients with ST-elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI). The results showed that NPR could predict all-cause death in patients with STEMI after primary PCI, suggesting its potential application in risk stratification and individualized treatment.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kah Yong Peck, Nick Andrianopoulos, Diem Dinh, Louise Roberts, Stephen J. Duffy, Martin Sebastian, David Clark, Angela Brennan, Ernesto Oqueli, Andrew E. Ajani, Christopher M. Reid, Melanie Freeman, Andrew W. Teh
Summary: The study showed that in patients undergoing percutaneous coronary intervention for acute coronary syndrome, the use of beta blockers was associated with lower mortality rates, especially in patients with lower left ventricular ejection fraction.
Article
Cardiac & Cardiovascular Systems
Johny Nicolas, Bimmer E. Claessen, Davide Cao, Mauro Chiarito, Samantha Sartori, Hanbo Qiu, Ridhima Goel, Matteo Nardin, Anastasios Roumeliotis, Birgit Vogel, Ali Turfah, Rishi Chandiramani, Usman Baber, Nitin Barman, Joseph Sweeny, Prakash Krishnan, Annapoorna Kini, Samin K. Sharma, George D. Dangas, Roxana Mehran
Summary: Despite presenting with more comorbidities, women undergoing CPCI had less complex coronary anatomy compared to men. However, women had a higher risk of myocardial infarction at one year post-CPCI.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Alexander G. Truesdell, Mirvat A. Alasnag, Prashant Kaul, Syed Tanveer Rab, Robert F. Riley, Michael N. Young, Wayne B. Batchelor, Akiko Maehara, Frederick G. Welt, Ajay J. Kirtane, ACC Interventional Counci
Summary: Coronary angiography has been the standard for diagnosing coronary artery disease and guiding percutaneous coronary intervention (PCI). Intravascular imaging (IVI) technologies are used in conjunction with angiography to better assess plaque morphology and optimize PCI. IVI has utility in preintervention assessment, procedural guidance, and postintervention evaluation. IVI's role in reducing major adverse cardiac events in complex lesions is emerging, and further studies are underway. This paper provides an overview of available IVI technologies, reviews evidence supporting their use in PCI, and advocates for broader utilization.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Victor Galusko, Majd Protty, Hasan N. Haboubi, Sarah Verhemel, Shantu Bundhoo, Andrew D. Yeoman
Summary: Gastrointestinal bleeding occurred infrequently in patients post-PCI on DAPT. Risk assessment scores, such as Glasgow-Blatchford and Rockall scores, are useful tools to assess the urgency of OGD and need for endoscopic therapy.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Thomas Jensen, Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Morten Wurtz, Jens Cosedis Nielsen, Lisette Okkels Jensen, Morten Madsen, Troels Thim, Steen Dalby Kristensen, Gregory Y. H. Lip, Michael Maeng
Summary: The CHA(2)DS(2)-VASc score implementation in the 2010 European guidelines on AF was associated with increased utilization of oral anticoagulation and triple therapy among AF patients undergoing PCI. These changes were linked to a gradual decline in the risk of major adverse cardiac events, while the risk of hospitalized bleeding remained stable.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Lior Lupu, Hytham Abukatash, Ariel Banai, Keren-Lee Rozenfeld, Dana Lewit, Ilan Merdler, Itamar Loewenstein, Gil Bornstein, Shmuel Banai, Yacov Shacham
Summary: This study found that baseline serum NGAL levels in CKD patients can effectively identify a high-risk population for CI-AKI following PCI, and NGAL levels performed better than eGFR in predicting CI-AKI. NGAL levels greater than 127 ng/mL were independently associated with CI-AKI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Wenguang Lai, Xiaoli Zhao, Sijia Yu, Ziling Mai, Yang Zhou, Zhidong Huang, Qiang Li, Haozhang Huang, Huanqiang Li, Haiyan Wei, Dachuan Guo, Yun Xie, Shanggang Li, Hongyu Lu, Jin Liu, Shiqun Chen, Yong Liu
Summary: This study aimed to investigate the impact of chronic kidney disease (CKD) on the development of heart failure with reduced ejection fraction (HFrEF) in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). The study found that CKD was associated with a higher risk of incident HFrEF in patients undergoing PCI, and CKD was an independent risk factor for HFrEF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Matthew E. Lapa, Gretchen M. Swabe, Bruce L. Rollman, Matthew F. Muldoon, Rebecca C. Thurston, Jared W. Magnani
Summary: Depression is associated with lower adherence to guideline-directed medical therapies following percutaneous coronary intervention.
Article
Cardiac & Cardiovascular Systems
Tineke H. Pinxterhuis, Eline H. Ploumen, Paolo Zocca, Carine J. M. Doggen, Carl E. Schotborgh, Rutger L. Anthonio, Ariel Roguin, Peter W. Danse, Edouard Benit, Adel Aminian, Marc Hartmann, Gerard C. M. Linssen, Clemens von Birgelen
Summary: This study assessed the risk profile and 3-year outcome differences between patients undergoing percutaneous coronary intervention (PCI) for premature and non-premature coronary artery disease (CAD). The results showed that patients with premature CAD had fewer risk factors, but higher rates of smoking and overweight. Additionally, premature CAD patients had lower all-cause mortality risk but higher risks of target vessel revascularization and stent thrombosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Akshay Bagai, Mina Madan, Christopher Overgaard, Joan Porter, Lu Han, Asim N. Cheema, Andrew T. Yan, Padma Kaul, Shaun G. Goodman, Dennis Ko
Summary: This population-based study on patients undergoing percutaneous coronary intervention (PCI) found that individuals who received cardiac stress testing (CST) had a slightly lower risk of cardiovascular events. Further research is needed to confirm these findings and determine specific aspects of care that may contribute to improved clinical outcomes.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Giuseppe Ando, Giulia Azzurra De Santis, Antonio Greco, Lorenzo Pistelli, Bruno Francaviglia, Davide Capodanno, Raffaele De Caterina, Piera Capranzano
Summary: This study compares the effectiveness of aspirin vs P2Y(12) inhibitor (P2Y(12)-I) monotherapy after dual antiplatelet therapy (DAPT) discontinuation in patients undergoing percutaneous coronary intervention (PCI). The results show that P2Y(12)-I monotherapy following DAPT discontinuation is associated with a significantly lower risk for myocardial infarction (MI) compared to aspirin monotherapy, with similar risks for major bleeding (MB).
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Tian X. Zhao, Muhammad Aetesam-Ur-Rahman, Andrew P. Sage, Saji Victor, Rincy Kurian, Sarah Fielding, Hafid Ait-Oufella, Yi-Da Chiu, Christoph J. Binder, Mikel Mckie, Stephen P. Hoole, Ziad Mallat
Summary: The use of Rituximab in patients with acute ST-elevation myocardial infarction (STEMI) appears to be safe and has a substantial impact on circulating B-cell subsets. These findings provide important new insights on the feasibility and pharmacodynamics of Rituximab in acute STEMI, which will inform further clinical translation of this potential therapy.
CARDIOVASCULAR RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jennifer Y. Barraclough, Jie Yu, Gemma A. Figtree, Vlado Perkovic, Hiddo J. L. Heerspink, Brendon L. Neuen, Christopher P. Cannon, Kenneth W. Mahaffey, Aletta E. Schutte, Bruce Neal, Clare Arnott
Summary: This study aimed to assess the proportional and absolute benefits of the SGLT2 inhibitor canagliflozin in patients with type 2 diabetes (T2D) with and without peripheral arterial disease (PAD). The results showed that canagliflozin had similar relative benefits in patients with and without PAD, but the absolute benefits were higher in patients with PAD.
DIABETES OBESITY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Yanyi Sun, Cristina Pinto, Stephane Camus, Vincent Duval, Paul Alayrac, Ivana Zlatanova, Xavier Loyer, Jose Vilar, Mathilde Lemitre, Angelique Levoye, Meritxell Nus, Hafid Ait-Oufella, Ziad Mallat, Jean-Sebastien Silvestre
Summary: This study reveals the important role of follicular B cells and marginal zone B cells in the recovery of cardiac function after acute myocardial infarction (MI). The miR21/HIF-alpha pathway plays a critical role in B-cell functions. Activation of the miR21/HIF-1 alpha pathway in marginal zone B cells is associated with the recruitment of inflammatory monocytes and adverse cardiac remodeling.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Eliano P. Navarese, Klaudyna Grzelakowska, Francesco Mangini, Jacek Kubica, Maciej Banach, Marianne Benn, Christoph J. Binder, Jan Boren, Alberico Catapano, Florian Kronenberg, Ziad Mallat, Philippe Moulin, Katariina Oorni, Kausik K. Ray, Jeanine E. Roeters van Lennep, Stefano Romeo, Lale Tokgozoglu, Arnold von Eckardstein, Alberto Zambon, Paolo Raggi
Summary: The healthcare system in Ukraine was already facing challenges before the war, but the aggressive war started by Russia will have long-lasting consequences for the health of Ukrainians. Ukrainians have a high risk of noncommunicable diseases, especially cardiovascular diseases. Limited access to healthcare and interruptions in the supply of medicines and resources due to the conflict pose a significant health risk. The poorly treated noncommunicable diseases are expected to contribute to a higher mortality rate during the COVID-19 pandemic.
Article
Cardiac & Cardiovascular Systems
Barry A. Borlaug, John Blair, Martin W. Bergmann, Heiko Bugger, Dan Burkhoff, Leonhard Bruch, David S. Celermajer, Brian Claggett, John G. F. Cleland, Donald E. Cutlip, Ira Dauber, Jean-Christophe Eicher, Qi Gao, Thomas M. Gorter, Finn Gustafsson, Chris Hayward, Jan van der Heyden, Gerd Hasenfuss, Scott L. Hummel, David M. Kaye, Jan Komtebedde, Joseph M. Massaro, Jeremy A. Mazurek, Scott McKenzie, Shamir R. Mehta, Mark C. Petrie, Marco C. Post, Ajith Nair, Andreas Rieth, Frank E. Silvestry, Scott D. Solomon, Jean-Noel Trochu, Dirk J. Van Veldhuisen, Ralf Westenfeld, Martin B. Leon, Sanjiv J. Shah
Summary: In heart failure patients, those with latent pulmonary vascular disease may worsen with atrial shunt therapy, while those without latent pulmonary vascular disease may benefit.
Article
Endocrinology & Metabolism
Chao Li, Jie Yu, Carinna Hockham, Vlado Perkovic, Brendon L. Neuen, Sunil Badve, Lauren Houston, Vivian Y. J. Lee, Jennifer Y. Barraclough, Robert A. Fletcher, Kenneth W. Mahaffey, Hiddo J. L. Heerspink, Christopher P. Cannon, Bruce Neal, Clare Arnott
Summary: The effects of canagliflozin on the incidence of atrial fibrillation/atrial flutter (AF/AFL) and other key cardiorenal outcomes were evaluated in a pooled analysis of the CANVAS and CREDENCE trials. The results showed that canagliflozin did not have a significant effect on AF/AFL incidence overall, but there was a possible reduction in those with no prior history. Additionally, meta-analysis revealed that SGLT2 inhibition reduces the incidence of AF/AFL.
DIABETES OBESITY & METABOLISM
(2022)
Article
Peripheral Vascular Disease
Raul R. Rodrigues-Diez, Antonio Tejera-Munoz, Vanesa Esteban, Lasse B. Steffensen, Raquel Rodrigues-Diez, Macarena Orejudo, Sandra Rayego-Mateos, Lucas L. Falke, Pablo Cannata-Ortiz, Alberto Ortiz, Jesus Egido, Ziad Mallat, M. Briones Ana, M. Auxiliadora Bajo, Roel Goldschmeding, Marta Ruiz-Ortega
Summary: This study reveals the critical involvement of CCN2 in the homeostasis and response to vascular injury of the aorta, particularly under Ang II-induced stress. CCN2 deletion leads to rapid development and rupture of aortic aneurysms, with the maintenance of aortic integrity partially dependent on the aldosterone pathway.
Article
Multidisciplinary Sciences
Sarajo K. Mohanta, Li Peng, Yuanfang Li, Shu Lu, Ting Sun, Lorenzo Carnevale, Marialuisa Perrotta, Zhe Ma, Benjamin Forstera, Karen Stanic, Chuankai Zhang, Xi Zhang, Piotr Szczepaniak, Mariaelvy Bianchini, Borhan R. Saeed, Raimondo Carnevale, Desheng Hu, Ryszard Nosalski, Fabio Pallante, Michael Beer, Donato Santovito, Ali Erturk, Thomas C. Mettenleiter, Barbara G. Klupp, Remco T. A. Megens, Sabine Steffens, Jaroslav Pelisek, Hans-Henning Eckstein, Robert Kleemann, Livia Habenicht, Ziad Mallat, Jean-Baptiste Michel, Jurgen Bernhagen, Martin Dichgans, Giuseppe D'Agostino, Tomasz J. Guzik, Peder S. Olofsson, Changjun Yin, Christian Weber, Giuseppe Lembo, Daniela Carnevale, Andreas J. R. Habenicht
Summary: This study discovered the presence of widespread neuroimmune cardiovascular interfaces (NICIs) in the adventitia of atherosclerosis-diseased arteries, suggesting a direct interaction between the peripheral nervous system and diseased arteries. Through anatomical and functional studies, it was found that NICIs play a crucial role in the formation of an artery-brain circuit (ABC). Therapeutic intervention in the ABC was shown to attenuate atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Michael Daley, Edward Buratto, Gregory King, Leeanne Grigg, Ajay Iyengar, Nelson Alphonso, Andrew Bullock, David S. Celermajer, Julian Ayer, Terry Robertson, Yves d'Udekem, Igor E. Konstantinov
Summary: In the Australia and New Zealand Fontan cohort, there was no significant difference in long-term survival or freedom from failure between patients with and without fenestration, but higher incidence of long-term thromboembolic events was observed in patients with fenestration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Letter
Hematology
Yifan Zhou, Ruba Shalhoub, Stephanie N. Rogers, Shiqin Yu, Muxin Gu, Margarete A. Fabre, Pedro M. Quiros, Tae-Hoon Shin, Arch Diangson, Wenhan Deng, Shubha Anand, Wenhua Lu, Matthew Cullen, Anna L. Godfrey, Jacobus Preller, Jerome Hadjadj, Emmanuelle Jouanguy, Aurelie Cobat, Laurent Abel, Frederic Rieux-Laucat, Benjamin Terrier, Alain Fischer, Lara Novik, Ingelise J. Gordon, Larisa Strom, Martin R. Gaudinski, Andrea Lisco, Irini Sereti, Thomas J. Gniadek, Andrea Biondi, Paolo Bonfanti, Luisa Imberti, Clifton L. Dalgard, Yu Zhang, Kerry Dobbs, Helen C. Su, Luigi D. Notarangelo, Colin O. Wu, Peter J. M. Openshaw, Malcolm G. Semple, Ziad Mallat, Kenneth Baillie, Cynthia E. Dunbar, George S. Vassiliou
Article
Cardiac & Cardiovascular Systems
Jing-Wei Li, Clare Arnott, Hiddo J. L. Heerspink, Qiang Li, Christopher P. Cannon, David C. Wheeler, David M. Charytan, Jennifer Barraclough, Gemma A. Figtree, Rajiv Agarwal, George Bakris, Dick de Zeeuw, Tom Greene, Adeera Levin, Carol Pollock, Hong Zhang, Bernard Zinman, Kenneth W. Mahaffey, Vlado Perkovic, Bruce Neal, Meg J. Jardine
Summary: In this post hoc analysis of the CREDENCE trial, it was found that canagliflozin reduced cardiovascular events in patients with type 2 diabetes and nephropathy, with a larger effect on total cardiovascular events compared to first events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Farrah Othman, Brian Bailey, Nicholas Collins, Edmund Lau, David Tanous, Karan Rao, David Celermajer, Rachael Cordina
Summary: Patent foramen ovale (PFO)-associated platypnea-orthodeoxia syndrome is characterized by dyspnea and hypoxemia when upright. This study retrospectively reviewed 14 cases and found that the condition can be cured by closing the PFO for patients without pulmonary hypertension.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Rouchelle Sriranjan, Tian Xiao Zhao, Jason Tarkin, Annette Hubsch, Joanna Helmy, Evangelia Vamvaka, Navazh Jalaludeen, Simon Bond, Stephen P. Hoole, Philip Knott, Samantha Buckenham, Victoria Warnes, Nick Bird, Heok Cheow, Heike Templin, Paul Cacciottolo, James H. F. Rudd, Ziad Mallat, Joseph Cheriyan
Summary: The study aims to evaluate the effects of low-dose IL-2 on vascular inflammation in patients with acute coronary syndromes (ACS) in a double-blind, randomized, placebo-controlled phase II clinical trial. Sixty ACS patients will be recruited across two centers, with primary and secondary endpoints measured using PET/CT scans.
Review
Cardiac & Cardiovascular Systems
David S. Celermajer, David W. Baker, Rachael L. Cordina, Michael Gatzoulis, Craig S. Broberg
Summary: Due to advances in cardiac care, more patients with congenital heart disease are able to reach adulthood. It is important for general cardiologists to have a good understanding of adult congenital heart disease, including common errors and when to refer to a specialist center. This review provides case studies to help healthcare providers address common issues in adult congenital heart disease.
EUROPEAN HEART JOURNAL
(2023)
Article
Nutrition & Dietetics
Nicholas A. Koemel, Alistair M. Senior, David S. Celermajer, Amanda Grech, Tim P. Gill, Stephen J. Simpson, David Raubenheimer, Michael R. Skilton
Summary: This study evaluated the associations between macronutrient intake and all-cause, cardiovascular, and cancer mortality. It found that a high-calorie diet consisting of moderately high protein, moderate fat, and moderate carbohydrate levels was associated with the highest mortality risk. Lower mortality risk was observed in two separate regions consisting of higher protein, higher carbohydrate, and lower fat levels or lower protein, moderate carbohydrate, and higher fat levels. These findings highlight the complex nonlinear and interactive association between macronutrients and all-cause mortality.
