Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

The Angiopoietin-Tie2 Pathway in Critical Illness

(2020) Kelsey D. Sack et al.   CRITICAL CARE CLINICS

Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins

(2020) Lars Winkler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Connexins: Key Players in the Control of Vascular Plasticity and Function

(2020) Ulrich Pohl   PHYSIOLOGICAL REVIEWS

Local microvascular leakage promotes trafficking of activated neutrophils to remote organs

(2020) Charlotte Owen-Woods et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

(2020) Ross O Smith et al.   eLife

Safety and Efficacy of Different Doses and Regimens of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration

(2020) Jayashree Sahni et al.   JAMA Ophthalmology

Endothelium structure and function in kidney health and disease

(2019) Noemie Jourde-Chiche et al.   Nature Reviews Nephrology

The Functional Implications of Endothelial Gap Junctions and Cellular Mechanics in Vascular Angiogenesis

(2019) Takayuki Okamoto et al.   Cancers

Angiopoietin-1 and Angiopoietin-2 Inhibitors: Clinical Development

(2019) Jessica Gillen et al.   Current Oncology Reports

Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier Function

(2019) Fadi E. Pulous et al.   CIRCULATION RESEARCH

VE‐PTP inhibition stabilizes endothelial junctions by activating FGD5

(2019) Laura J Braun et al.   EMBO REPORTS

Development and Cell Biology of the Blood-Brain Barrier

(2019) Urs H. Langen et al.   Annual Review of Cell and Developmental Biology

Cell Adhesion Structures in Epithelial Cells Are Formed in Dynamic and Cooperative Ways

(2019) Kenta Shigetomi et al.   BIOESSAYS

Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation

(2019) Nina Wettschureck et al.   PHYSIOLOGICAL REVIEWS

Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

(2019) Emily E. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force Sensing by Piezo Channels in Cardiovascular Health and Disease

(2019) David J. Beech et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transcytosis at the blood–brain barrier

(2019) Swathi Ayloo et al.   CURRENT OPINION IN NEUROBIOLOGY

Multiscale dynamics of tight junction remodeling

(2019) Saranyaraajan Varadarajan et al.   JOURNAL OF CELL SCIENCE

Interference With ESAM (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation

(2019) Cao Nguyen Duong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment

(2018) Candice E. Van Skike et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Adherens junctions influence tight junction formation via changes in membrane lipid composition

(2018) Kenta Shigetomi et al.   JOURNAL OF CELL BIOLOGY

Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events

(2018) Naoki Honkura et al.   Nature Communications

Endothelial Activation: The Ang/Tie Axis in Sepsis

(2018) Aleksandra Leligdowicz et al.   Frontiers in Immunology

Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders

(2018) Shivani Verma et al.   Current Molecular Pharmacology

Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway

(2018) Jun Yin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis

(2018) John P. Reilly et al.   INTENSIVE CARE MEDICINE

Lacteal junction zippering protects against diet-induced obesity

(2018) Feng Zhang et al.   SCIENCE

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability

(2018) Kevin Kruse et al.   JOURNAL OF CELL BIOLOGY

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation

(2017) Alessandro Fantin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

(2017) Hellmut G. Augustin et al.   SCIENCE

Hold Me, but Not Too Tight—Endothelial Cell–Cell Junctions in Angiogenesis

(2017) Anna Szymborska et al.   Cold Spring Harbor Perspectives in Biology

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

(2017) Martin Teichert et al.   Nature Communications

Disorders of Vascular Permeability

(2016) Cindy Park-Windhol et al.   Annual Review of Pathology-Mechanisms of Disease

Substance P and its Inhibition in Ocular Inflammation

(2016) Fabio Bignami et al.   CURRENT DRUG TARGETS

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

(2016) Minah Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Tie1 controls angiopoietin function in vascular remodeling and inflammation

(2016) Emilia A. Korhonen et al.   JOURNAL OF CLINICAL INVESTIGATION

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

(2016) Xiujuan Li et al.   Nature Communications

Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer

(2016) Florence T. H. Wu et al.   Scientific Reports

Changes in endothelial connexin 43 expression inversely correlate with microvessel permeability and VE-cadherin expression in endotoxin-challenged lungs

(2015) Kathirvel Kandasamy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors

(2015) K. P. Papadopoulos et al.   CLINICAL CANCER RESEARCH

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

(2015) Olga Tornavaca et al.   JOURNAL OF CELL BIOLOGY

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1

(2015) I. Timmerman et al.   JOURNAL OF CELL SCIENCE

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

(2015) Maike Frye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection

(2015) Yung-Chun Chuang et al.   MEDIATORS OF INFLAMMATION

Integrin β1 controls VE-cadherin localization and blood vessel stability

(2015) Hiroyuki Yamamoto et al.   Nature Communications

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

(2015) Laura Hakanpaa et al.   Nature Communications

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

(2015) Constantinos M. Mikelis et al.   Nature Communications

Dynamic phosphorylation of VE-cadherin Y685 throughout mouse estrous cycle in ovary and uterus

(2014) Adama Sidibé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

VE-cadherin Y685F knock-in mouse is sensitive to vascular permeability in recurrent angiogenic organs

(2014) Adama Sidibé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP)

(2014) Owain Llŷr Roberts et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

(2014) Christine Jean et al.   JOURNAL OF CELL BIOLOGY

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

Tonic regulation of vascular permeability

(2013) F.-R. E. Curry et al.   Acta Physiologica

Endothelial adherens junctions at a glance

(2013) E. Dejana et al.   JOURNAL OF CELL SCIENCE

Loss of Focal Adhesion Kinase Enhances Endothelial Barrier Function and Increases Focal Adhesions

(2013) Kimberly M. Arnold et al.   MICROCIRCULATION

VEGF-Induced Vascular Permeability Is Mediated by FAK

(2012) Xiao Lei Chen et al.   DEVELOPMENTAL CELL

Protein Kinase C  Phosphorylates Occludin Regulating Tight Junction Trafficking in Vascular Endothelial Growth Factor-Induced Permeability In Vivo

(2012) T. Murakami et al.   DIABETES

VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx

(2012) Siu P. Ngok et al.   JOURNAL OF CELL BIOLOGY

Fibroblast Growth Factor Signaling Potentiates VE-Cadherin Stability at Adherens Junctions by Regulating SHP2

(2012) Kunihiko Hatanaka et al.   PLoS One

Hepatocyte Growth Factor Increases Vascular Endothelial Growth Factor-A Production in Human Synovial Fibroblasts through c-Met Receptor Pathway

(2012) Yu-Min Lin et al.   PLoS One

Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo

(2012) Fabrizio Orsenigo et al.   Nature Communications

Pericyte Requirement for Anti-Leak Action of Angiopoietin-1 and Vascular Remodeling in Sustained Inflammation

(2011) Jonas Fuxe et al.   AMERICAN JOURNAL OF PATHOLOGY

Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability

(2011) Dörte Schulte et al.   EMBO JOURNAL

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Adhesion molecule signalling: not always a sticky business

(2011) Ugo Cavallaro et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge

(2010) F.-R. E. Curry et al.   CARDIOVASCULAR RESEARCH

Endothelial Functions of Sphingosine-1-phosphate

(2010) Susann Lucke et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Src-induced Tyrosine Phosphorylation of VE-cadherin Is Not Sufficient to Decrease Barrier Function of Endothelial Monolayers

(2010) Alejandro P. Adam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Nitrosylation of β-Catenin by eNOS-Derived NO Promotes VEGF-Induced Endothelial Cell Permeability

(2010) Sébastien Thibeault et al.   MOLECULAR CELL

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Vascular Endothelial-Cadherin Stabilizes at Cell–Cell Junctions by Anchoring to Circumferential Actin Bundles through α- and β-Catenins in Cyclic AMP-Epac-Rap1 Signal-activated Endothelial Cells

(2009) Kazuomi Noda et al.   MOLECULAR BIOLOGY OF THE CELL

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

(2009) A. Di Lorenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The receptor protein-tyrosine phosphatase, Dep1, acts in arterial/venous cell fate decisions in zebrafish development

(2008) Fiona Rodriguez et al.   DEVELOPMENTAL BIOLOGY

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

(2008) Andrea Taddei et al.   NATURE CELL BIOLOGY