Multiscale dynamics of tight junction remodeling

Rho Flares Repair Local Tight Junction Leaks

(2019) Rachel E. Stephenson et al.   DEVELOPMENTAL CELL

Newly synthesized claudins but not occludin are added to the basal side of the tight junction

(2019) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity

(2019) Tetsuhisa Otani et al.   JOURNAL OF CELL BIOLOGY

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

(2019) Oliver Beutel et al.   CELL

Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow

(2019) Cornelia Schwayer et al.   CELL

Tensile Forces and Mechanotransduction at Cell–Cell Junctions

(2018) Guillaume Charras et al.   CURRENT BIOLOGY

Branched actin networks push against each other at adherens junctions to maintain cell–cell adhesion

(2018) Nadia Efimova et al.   JOURNAL OF CELL BIOLOGY

The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo.

(2018) Matthew A Odenwald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical Force-Driven Adherens Junction Remodeling and Epithelial Dynamics

(2018) Diana Pinheiro et al.   DEVELOPMENTAL CELL

A Mechanosensitive RhoA Pathway that Protects Epithelia against Acute Tensile Stress

(2018) Bipul R. Acharya et al.   DEVELOPMENTAL CELL

Comprehensive analysis of formin localization in Xenopus epithelial cells

(2018) Tomohito Higashi et al.   MOLECULAR BIOLOGY OF THE CELL

Super-resolution microscopy demystified

(2018) Lothar Schermelleh et al.   NATURE CELL BIOLOGY

Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function

(2017) Torey R. Arnold et al.   EXPERIMENTAL CELL RESEARCH

Tricellular junctions: how to build junctions at the TRICkiest points of epithelial cells

(2017) Tomohito Higashi et al.   MOLECULAR BIOLOGY OF THE CELL

Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1

(2017) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Epithelial cell extrusion: Pathways and pathologies

(2017) Swapna Aravind Gudipaty et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction

(2016) Natalie J. Ronaghan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Maintenance of the Epithelial Barrier and Remodeling of Cell-Cell Junctions during Cytokinesis

(2016) Tomohito Higashi et al.   CURRENT BIOLOGY

Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

(2016) Anny-Claude Luissint et al.   GASTROENTEROLOGY

Remodeling the zonula adherens in response to tension and the role of afadin in this response

(2016) Wangsun Choi et al.   JOURNAL OF CELL BIOLOGY

Navigating challenges in the application of superresolution microscopy

(2016) Talley J. Lambert et al.   JOURNAL OF CELL BIOLOGY

A novel method for imaging sites of paracellular passage of macromolecules in epithelial sheets

(2016) Jan F. Richter et al.   JOURNAL OF CONTROLLED RELEASE

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Claudins: vital partners in transcellular and paracellular transport coupling

(2016) Dorothee Günzel   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Developing pressures: fluid forces driving morphogenesis

(2015) Adam Navis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Occludin Content Modulates Hydrogen Peroxide-Induced Increase in Renal Epithelial Paracellular Permeability

(2015) Danielle Janosevic et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction

(2015) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Towards a Dynamic Understanding of Cadherin-Based Mechanobiology

(2015) Brenton D. Hoffman et al.   TRENDS IN CELL BIOLOGY

Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism

(2014) Geetha Samak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins

(2014) Christopher T. Capaldo et al.   MOLECULAR BIOLOGY OF THE CELL

The role of molecular remodeling in differential regulation of tight junction permeability

(2014) Jerrold R. Turner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Force-dependent conformational switch of α-catenin controls vinculin binding

(2014) Mingxi Yao et al.   Nature Communications

Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1

(2013) L. S. Rodgers et al.   JOURNAL OF CELL SCIENCE

LKB1 Controls Human Bronchial Epithelial Morphogenesis through p114RhoGEF-Dependent RhoA Activation

(2013) X. Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux

(2013) Mary M. Buschmann et al.   MOLECULAR BIOLOGY OF THE CELL

Claudins and the Modulation of Tight Junction Permeability

(2013) Dorothee Günzel et al.   PHYSIOLOGICAL REVIEWS

Rho kinase signaling pathways during stretch in primary alveolar epithelia

(2012) Brian C. DiPaolo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization

(2012) J. Cording et al.   JOURNAL OF CELL SCIENCE

Visualization and Quantitative Analysis of Reconstituted Tight Junctions Using Localization Microscopy

(2012) Rainer Kaufmann et al.   PLoS One

Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells

(2011) Yanfang Guan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Tight Junction Pore and Leak Pathways: A Dynamic Duo

(2011) Le Shen et al.   Annual Review of Physiology

Cadherin–actin interactions at adherens junctions

(2011) Shigenobu Yonemura   CURRENT OPINION IN CELL BIOLOGY

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

(2011) Amanda M. Marchiando et al.   GASTROENTEROLOGY

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function

(2011) David R. Raleigh et al.   JOURNAL OF CELL BIOLOGY

Role of claudin species–specific dynamics in reconstitution and remodeling of the zonula occludens

(2011) Yuji Yamazaki et al.   MOLECULAR BIOLOGY OF THE CELL

Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia

(2011) Alan S. Fanning et al.   MOLECULAR BIOLOGY OF THE CELL

Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

(2011) Stephen J. Terry et al.   NATURE CELL BIOLOGY

Epithelial Barriers in Homeostasis and Disease

(2010) Amanda M. Marchiando et al.   Annual Review of Pathology-Mechanisms of Disease

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions

(2010) David R. Raleigh et al.   MOLECULAR BIOLOGY OF THE CELL

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function

(2010) D. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability

(2009) Susanne M. Krug et al.   MOLECULAR BIOLOGY OF THE CELL

ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton

(2009) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

(2008) Le Shen et al.   JOURNAL OF CELL BIOLOGY

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

(2008) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE