Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

HIF2α signaling inhibits adherens junctional disruption in acute lung injury

(2015) Haixia Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

(2015) Laura Hakanpaa et al.   Nature Communications

Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature

(2014) Jikui Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin

(2013) M. Vockel et al.   BLOOD

Substrate Specificity of R3 Receptor-like Protein-tyrosine Phosphatase Subfamily toward Receptor Protein-tyrosine Kinases

(2013) Juichi Sakuraba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization

(2013) Koji Ando et al.   JOURNAL OF CELL BIOLOGY

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression

(2013) Shom Goel et al.   JNCI-Journal of the National Cancer Institute

Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29

(2013) A. Post et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

(2013) Makoto Hayashi et al.   Nature Communications

Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells

(2012) C. Giampietro et al.   BLOOD

VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx

(2012) Siu P. Ngok et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo

(2012) Fabrizio Orsenigo et al.   Nature Communications

Angiopoietin-1 Requires IQ Domain GTPase-Activating Protein 1 to Activate Rac1 and Promote Endothelial Barrier Defense

(2011) Sascha David et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability

(2011) Dörte Schulte et al.   EMBO JOURNAL

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Vascular Integrity Mediated by Vascular Endothelial Cadherin and Regulated by Sphingosine 1-Phosphate and Angiopoietin-1

(2009) Naoki Mochizuki   CIRCULATION JOURNAL

Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis

(2009) Sofie Mellberg et al.   FASEB JOURNAL

The Regulation of Vascular Endothelial Growth Factor-induced Microvascular Permeability Requires Rac and Reactive Oxygen Species

(2009) Elizabeth Monaghan-Benson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VE-PTP controls blood vessel development by balancing Tie-2 activity

(2009) Mark Winderlich et al.   JOURNAL OF CELL BIOLOGY

Improved Survival and Reduced Vascular Permeability by Eliminating or Blocking 12/15-Lipoxygenase in Mouse Models of Acute Lung Injury (ALI)

(2009) A. Zarbock et al.   JOURNAL OF IMMUNOLOGY

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

Efficient, inducible Cre-recombinase activation in vascular endothelium

(2008) Suzanne Claxton et al.   GENESIS

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

(2008) Shigetomo Fukuhara et al.   NATURE CELL BIOLOGY

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

(2008) Andrea Taddei et al.   NATURE CELL BIOLOGY

Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration

(2007) P. Turowski et al.   JOURNAL OF CELL SCIENCE