Improving target assessment in biomedical research: the GOT-IT recommendations

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?

(2020) Donato Gemmati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enigmatic MELK: The controversy surrounding its complex role in cancer

(2020) Ian M McDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin‐converting enzyme‐2 ( ACE2 ), SARS‐CoV ‐2 and pathophysiology of coronavirus disease 2019 ( COVID ‐19)

(2020) Arno R. Bourgonje et al.   JOURNAL OF PATHOLOGY

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

(2020) Yanwei Li et al.   PHARMACOLOGICAL RESEARCH

Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?

(2020) Fabio Perrotta et al.   RESPIRATORY MEDICINE

Why the sexes don’t feel pain the same way

(2019) Amber Dance   NATURE

Moving to a World Beyond “p 

(2019) Ronald L. Wasserstein et al.   AMERICAN STATISTICIAN

The Importance of Predefined Rules and Prespecified Statistical Analyses

(2019) John P. A. Ioannidis   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

FAIRsharing as a community approach to standards, repositories and policies

(2019) Susanna-Assunta Sansone et al.   NATURE BIOTECHNOLOGY

Trends in clinical success rates and therapeutic focus

(2019) Helen Dowden et al.   NATURE REVIEWS DRUG DISCOVERY

Future unmet medical need as a guiding principle for pharmaceutical R&D

(2019) Matthias Vennemann et al.   DRUG DISCOVERY TODAY

The p value wars (again)

(2019) Ulrich Dirnagl   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease

(2019) Wouter N. Leonhard et al.   EBioMedicine

An omics perspective on drug target discovery platforms

(2019) Jussi Paananen et al.   BRIEFINGS IN BIOINFORMATICS

The conditional nature of gene essentiality

(2019) Katherine E Larrimore et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Understanding drug targets: no such thing as bad news

(2018) Ruth A. Roberts   DRUG DISCOVERY TODAY

Discovery and development of new antibacterial drugs: learning from experience?

(2018) Nicole Jackson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Impact of a five-dimensional framework on R&D productivity at AstraZeneca

(2018) Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic-Driven Druggable Target Identification and Validation

(2018) Matteo Floris et al.   TRENDS IN GENETICS

Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries

(2018) Marcus C. Parrish et al.   Annual Review of Pharmacology and Toxicology

Optimized arylomycins are a new class of Gram-negative antibiotics

(2018) Peter A. Smith et al.   NATURE

Therapeutic Tolerance in Autoimmune Disease

(2018) Fiona Rayner et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

(2018) Xiangbo Meng et al.   NATURE

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Applications of CRISPR genome editing technology in drug target identification and validation

(2017) Quinn Lu et al.   Expert Opinion on Drug Discovery

Fostering reproducibility in industry-academia research

(2017) B. R. Jasny et al.   SCIENCE

Research data management in academic institutions: A scoping review

(2017) Laure Perrier et al.   PLoS One

Redox-Dependent HMGB1 Isoforms as Pivotal Co-Ordinators of Drug-Induced Liver Injury: Mechanistic Biomarkers and Therapeutic Targets

(2016) Jonathan D. Lea et al.   ANTIOXIDANTS & REDOX SIGNALING

Rescuing the Lost in Translation

(2016) Sinje Gehr et al.   CELL

Bridging the translational gap: collaborative drug development and dispelling the stigma of commercialization

(2016) Helen W.H. Yu   DRUG DISCOVERY TODAY

Translational Medicine Guide transforms drug development processes: the recent Merck experience

(2016) Hugues Dolgos et al.   DRUG DISCOVERY TODAY

Risk mitigation in academic drug discovery

(2016) Bernhard Ellinger et al.   Expert Opinion on Drug Discovery

An industry perspective on drug target validation

(2016) Lyn H. Jones   Expert Opinion on Drug Discovery

Droplet microfluidics for microbiology: techniques, applications and challenges

(2016) Tomasz S. Kaminski et al.   LAB ON A CHIP

Direct-acting antivirals for the treatment of hepatitis C virus infection: optimizing current IFN-free treatment and future perspectives

(2016) Tarik Asselah et al.   LIVER INTERNATIONAL

Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans

(2016) Tarjinder Sahota et al.   MUTAGENESIS

Reproducibility: Team up with industry

(2016) Aled Edwards   NATURE

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

European Lead Factory hits its stride

(2016) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Open Targets: a platform for therapeutic target identification and validation

(2016) Gautier Koscielny et al.   NUCLEIC ACIDS RESEARCH

Translational Safety Genetics

(2016) Priyasma Bhoumik et al.   TOXICOLOGIC PATHOLOGY

Drug Tolerance: A Known Unknown in Translational Neuroscience

(2016) Anton Bespalov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Importance of Physiologically Relevant Cell Lines for Studying Virus–Host Interactions

(2016) David Hare et al.   Viruses-Basel

Appropriate Targets for Antibacterial Drugs

(2016) Lynn L. Silver   Cold Spring Harbor Perspectives in Medicine

Drug Target Identification and Validation

(2016) Tobias Bergauer et al.   Therapeutic Innovation & Regulatory Science

The FAIR Guiding Principles for scientific data management and stewardship

(2016) Mark D. Wilkinson et al.   Scientific Data

When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

(2016) Jack W. Scannell et al.   PLoS One

Target Engagement in Lead Generation

(2015) Timothy B. Durham et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Toxicology Strategies for Drug Discovery: Present and Future

(2015) Eric A. G. Blomme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The impact of CRISPR–Cas9 on target identification and validation

(2015) Jonathan D. Moore   DRUG DISCOVERY TODAY

Academic drug discovery: current status and prospects

(2015) Jeremy R Everett   Expert Opinion on Drug Discovery

The environment and disease: association or causation?

(2015) Austin Bradford Hill   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE

Allele, phenotype and disease data at Mouse Genome Informatics: improving access and analysis

(2015) Susan M. Bello et al.   MAMMALIAN GENOME

Know your target, know your molecule

(2015) Mark E Bunnage et al.   Nature Chemical Biology

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Mitigating risk in academic preclinical drug discovery

(2015) Jayme L. Dahlin et al.   NATURE REVIEWS DRUG DISCOVERY

Developing predictive assays: The phenotypic screening “rule of 3”

(2015) Fabien Vincent et al.   Science Translational Medicine

Target (In)Validation: A Critical, Sometimes Unheralded, Role of Modern Medicinal Chemistry

(2015) Ramzi F. Sweis   ACS Medicinal Chemistry Letters

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Targeting Bacterial Central Metabolism for Drug Development

(2014) Paul Murima et al.   CHEMISTRY & BIOLOGY

Chemical biology approaches to target validation in cancer

(2014) Julian Blagg et al.   CURRENT OPINION IN PHARMACOLOGY

Is target validation all we need?

(2014) Melanie M Frigault et al.   CURRENT OPINION IN PHARMACOLOGY

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

(2014) Eric S. Fischer et al.   NATURE

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Paving the critical path of drug development: the CDER perspective

(2014) Janet Woodcock   NATURE REVIEWS DRUG DISCOVERY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Common misconceptions about data analysis and statistics

(2014) Harvey J. Motulsky   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Decision-making in product portfolios of pharmaceutical research and development – managing streams of innovation in highly regulated markets

(2014) Antii Jekunen   Drug Design Development and Therapy

Distinguishing between Exploratory and Confirmatory Preclinical Research Will Improve Translation

(2014) Jonathan Kimmelman et al.   PLOS BIOLOGY

Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors

(2014) Timothy H Ciesielski et al.   BioData Mining

High-resolution deep imaging of live cellular spheroids with light-sheet-based fluorescence microscopy

(2013) Francesco Pampaloni et al.   CELL AND TISSUE RESEARCH

MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells

(2013) Suyoun Chung et al.   CELL CYCLE

Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how

(2013) Jorrit J. Hornberg et al.   DRUG DISCOVERY TODAY

Target validation using chemical probes

(2013) Mark E Bunnage et al.   Nature Chemical Biology

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

(2013) Thomas R. Ioerger et al.   PLoS One

Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development

(2013) Jessica J. Vamathevan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

How academic labs can approach the drug discovery process as a way to synergize with big pharma

(2013) Arianna Loregian et al.   TRENDS IN MICROBIOLOGY

Systems biology-embedded target validation: improving efficacy in drug discovery

(2013) Drieke Vandamme et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Drug discovery in academic institutions

(2013) S. V. Frye   Hematology-American Society of Hematology Education Program

Net present value approaches for drug discovery

(2013) Andreas M Svennebring et al.   SpringerPlus

Targeting the host or the virus: Current and novel concepts for antiviral approaches against influenza virus infection

(2012) Suki Man-Yan Lee et al.   ANTIVIRAL RESEARCH

Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors

(2012) Koc-Kan Ho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanisms of cardiotoxicity associated with ErbB2 inhibitors

(2012) Carmine Fedele et al.   BREAST CANCER RESEARCH AND TREATMENT

Putative Impact of RNA Editing on Drug Discovery

(2012) Niels Decher et al.   Chemical Biology & Drug Design

Structural Biology and Drug Discovery of Difficult Targets: The Limits of Ligandability

(2012) Sachin Surade et al.   CHEMISTRY & BIOLOGY

Development of a Rule-Based Method for the Assessment of Protein Druggability

(2012) Emanuele Perola et al.   Journal of Chemical Information and Modeling

A call for transparent reporting to optimize the predictive value of preclinical research

(2012) Story C. Landis et al.   NATURE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

On-target and Off-target-based Toxicologic Effects

(2012) Daniel G. Rudmann   TOXICOLOGIC PATHOLOGY

Direct affinity screening chromatography–mass spectrometry assay for identification of antibacterial agents from natural product sources

(2011) Kevin A. Schug et al.   ANALYTICA CHIMICA ACTA

Chemical genetics

(2011) Cornelius J. O' Connor et al.   CHEMICAL SOCIETY REVIEWS

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Recommendations for Planning Pilot Studies in Clinical and Translational Research

(2011) Charity G. Moore et al.   CTS-Clinical and Translational Science

What makes a good drug target?

(2011) Isabella Gashaw et al.   DRUG DISCOVERY TODAY

Target validation

(2011) Steve Carney   DRUG DISCOVERY TODAY

Getting pharmaceutical R&D back on target

(2011) Mark E Bunnage   Nature Chemical Biology

Reliability of 'new drug target' claims called into question

(2011) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Probing the Probes: Fitness Factors For Small Molecule Tools

(2010) Paul Workman et al.   CHEMISTRY & BIOLOGY

All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High Receptors

(2010) Philip Seeman   CNS Neuroscience & Therapeutics

The translatability of animal models for clinical development: biomarkers and disease models

(2010) Alexandra Wendler et al.   CURRENT OPINION IN PHARMACOLOGY

Overcoming psychological barriers to good discovery decisions

(2010) Andrew T. Chadwick et al.   DRUG DISCOVERY TODAY

Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development

(2010) F. Peter Guengerich   Drug Metabolism and Pharmacokinetics

Drug discovery in academia: the third way?

(2010) Julie Frearson et al.   Expert Opinion on Drug Discovery

Postgenomic strategies in antibacterial drug discovery

(2010) Heike Brötz-Oesterhelt et al.   Future Microbiology

Integration of Small-Molecule Discovery in Academic Biomedical Research

(2010) Michael Ohlmeyer et al.   MOUNT SINAI JOURNAL OF MEDICINE

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Cardiotoxicity Associated with Targeting Kinase Pathways in Cancer

(2010) Howard R. Mellor et al.   TOXICOLOGICAL SCIENCES

Triclosan Resistance of Pseudomonas aeruginosa PAO1 Is Due to FabV, a Triclosan-Resistant Enoyl-Acyl Carrier Protein Reductase

(2009) L. Zhu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation: Table 1

(2009) Philip Cohen   BIOCHEMICAL JOURNAL

The kinase TNIK is an essential activator of Wnt target genes

(2009) Tokameh Mahmoudi et al.   EMBO JOURNAL

Accelerating Drug Development Using Biomarkers: A Case Study with Sitagliptin, A Novel DPP4 Inhibitor for Type 2 Diabetes

(2008) Rajesh Krishna et al.   AAPS Journal

The FDA Critical Path Initiative and Its Influence on New Drug Development

(2008) Janet Woodcock et al.   Annual Review of Medicine

Identification of the cellular targets of bioactive small organic molecules using affinity reagents

(2008) Benjamin J. Leslie et al.   CHEMICAL SOCIETY REVIEWS

Drug discovery: new models for industry–academic partnerships

(2008) Cathy J. Tralau-Stewart et al.   DRUG DISCOVERY TODAY

A structural biology view of target drugability

(2008) Ursula Egner et al.   Expert Opinion on Drug Discovery

Reach-through claims for drug target patents: Rx for pharmaceutical policy

(2008) Robert A Bohrer   NATURE BIOTECHNOLOGY

Strategic Approach to Fit-for-Purpose Biomarkers in Drug Development

(2007) John A. Wagner   Annual Review of Pharmacology and Toxicology