Optimized arylomycins are a new class of Gram-negative antibiotics

Scalable Access to Arylomycins via C–H Functionalization Logic

(2018) David S. Peters et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

(2014) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efforts toward broadening the spectrum of arylomycin antibiotic activity

(2013) Jian Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

(2012) Alex G. Therien et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Bacterial type I signal peptidases as antibiotic targets

(2011) Smitha Rao CV et al.   Future Microbiology

Initial Efforts toward the Optimization of Arylomycins for Antibiotic Activity

(2011) Tucker C. Roberts et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Characterization of the Arylomycin Lipoglycopeptide Antibiotics and the Crystallographic Analysis of Their Complex with Signal Peptidase

(2011) Jian Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

In VitroActivities of Arylomycin Natural-Product Antibiotics againstStaphylococcus epidermidisand Other Coagulase-Negative Staphylococci

(2010) Peter A. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Broad-Spectrum Antibiotic Activity of the Arylomycin Natural Products Is Masked by Natural Target Mutations

(2010) Peter A. Smith et al.   CHEMISTRY & BIOLOGY

In Vitro Activity of NXL104 in Combination with  -Lactams against Klebsiella pneumoniae Isolates Producing KPC Carbapenemases

(2009) A. Endimiani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Proteolytic processing of Escherichia coli twin-arginine signal peptides by LepB

(2009) Iris Lüke et al.   ARCHIVES OF MICROBIOLOGY

Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A2and a β-Sultam Inhibitor

(2009) Chuanyun Luo et al.   BIOCHEMISTRY

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY